DK297185A - Fremstilling af biologisk aktive proteiner, sammensat af flere underenheder, ved rekombinant metodologi - Google Patents

Fremstilling af biologisk aktive proteiner, sammensat af flere underenheder, ved rekombinant metodologi Download PDF

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Publication number
DK297185A
DK297185A DK297185A DK297185A DK297185A DK 297185 A DK297185 A DK 297185A DK 297185 A DK297185 A DK 297185A DK 297185 A DK297185 A DK 297185A DK 297185 A DK297185 A DK 297185A
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Denmark
Prior art keywords
preparation
hormone
biological active
active proteins
recombinant methodology
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DK297185A
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English (en)
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DK171489B1 (da
DK297185D0 (da
Inventor
Vemuri B Reddy
Nancy Hsiung
Anton K Beck
Edward George Bernstine
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Integrated Genetics Inc
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Application filed by Integrated Genetics Inc filed Critical Integrated Genetics Inc
Publication of DK297185A publication Critical patent/DK297185A/da
Publication of DK297185D0 publication Critical patent/DK297185D0/da
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)
DK297185A 1983-11-02 1985-07-01 Fremgangsmåde til fremstilling af et biologisk aktivt, posttranslationelt modificeret proteinhormon sammensat af flere underenheder, eukaryotisk celle, som er transficeret med en eller flere udtrykkelsesvektorer og er i stand til at producere et sådant hormon, udtrykkelsesvektor omfattende heterolog DNA, som koder for underenhederne af hormonet, et sæt af udtrykkelsesvektorer, hvor hver vektor omf DK171489B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54821183A 1983-11-02 1983-11-02
US54821183 1983-11-02
US8401771 1984-10-31
PCT/US1984/001771 WO1985001959A1 (en) 1983-11-02 1984-10-31 Production of heterodimeric human fertlity hormones

Publications (3)

Publication Number Publication Date
DK297185A true DK297185A (da) 1985-07-01
DK297185D0 DK297185D0 (da) 1985-07-01
DK171489B1 DK171489B1 (da) 1996-11-25

Family

ID=24187868

Family Applications (2)

Application Number Title Priority Date Filing Date
DK297185A DK171489B1 (da) 1983-11-02 1985-07-01 Fremgangsmåde til fremstilling af et biologisk aktivt, posttranslationelt modificeret proteinhormon sammensat af flere underenheder, eukaryotisk celle, som er transficeret med en eller flere udtrykkelsesvektorer og er i stand til at producere et sådant hormon, udtrykkelsesvektor omfattende heterolog DNA, som koder for underenhederne af hormonet, et sæt af udtrykkelsesvektorer, hvor hver vektor omf
DK297285A DK297285D0 (da) 1983-11-02 1985-07-01 Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK297285A DK297285D0 (da) 1983-11-02 1985-07-01 Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi

Country Status (8)

Country Link
EP (3) EP0578328B1 (da)
AT (2) ATE190461T1 (da)
DE (4) DE10199035I2 (da)
DK (2) DK171489B1 (da)
LU (1) LU90770I2 (da)
MX (1) MX9203334A (da)
NL (1) NL300044I2 (da)
WO (1) WO1985001959A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
JPS60145098A (ja) * 1984-01-09 1985-07-31 Suntory Ltd 糖付加ポリペプチドの製造法
WO1986007383A1 (en) * 1985-06-04 1986-12-18 Biotechnology Research Partners, Ltd. Autoantigen vaccines
CA1340740C (en) * 1987-12-08 1999-09-14 Eileen R. Mulvihill Co-expression in eukaryotic cells
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US6225449B1 (en) 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
EP0461200B1 (en) * 1989-02-21 1997-01-22 Washington University Modified forms of reproductive hormones
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6028177A (en) * 1991-10-04 2000-02-22 Washington University Methods of detecting single-chain forms of the glycoprotein hormone quartet
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6238890B1 (en) 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
MX9601320A (es) * 1994-08-12 1997-05-31 Univ Washington Formas de cadena unica de cuarteto de hormona de glicoproteina.
DK0725795T3 (da) * 1994-08-12 2004-05-17 Univ Washington Enkelt-kæde form af glycoprotein-hormon-kvartetten
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
EP1013281A1 (en) 1998-12-15 2000-06-28 Applied Research Systems ARS Holding N.V. hCG therapy for the treatment of breast cancer
JP2002541213A (ja) 1999-04-13 2002-12-03 インヘール セラピューティック システムズ， インコーポレイテッド 不妊症の処置のための乾燥粉末処方物の肺投与
JP2005509652A (ja) * 2001-11-08 2005-04-14 モイル，ウィリアム，アール 蛋白質の瘤
US7081446B2 (en) 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
EA200800755A1 (ru) 2005-09-07 2008-10-30 Лаборатуар Сероно С.А. Ikk ингибиторы, предназначенные для лечения эндометриоза

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048894A (en) * 1979-05-11 1980-12-17 Gist Brocades Nv Plasmid
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations

Also Published As

Publication number Publication date
DE3486469T2 (de) 1999-04-15
LU90770I2 (fr) 2001-07-03
ATE169334T1 (de) 1998-08-15
MX9203334A (es) 1992-09-01
EP0578328B1 (en) 1999-12-29
EP0160699A1 (en) 1985-11-13
DK171489B1 (da) 1996-11-25
WO1985001959A1 (en) 1985-05-09
DE3486469D1 (de) 1998-09-10
DE3486474D1 (de) 2000-02-03
DK297185D0 (da) 1985-07-01
EP0160699B1 (en) 1992-08-12
EP0578328A1 (en) 1994-01-12
NL300044I2 (nl) 2001-12-01
DE10199028I1 (de) 2001-09-20
ATE190461T1 (de) 2000-04-15
NL300044I1 (nl) 2001-07-02
EP0957167A1 (en) 1999-11-17
DE10199035I1 (de) 2001-11-08
DE10199028I2 (de) 2004-07-01
EP0160699A4 (en) 1987-10-20
DE10199035I2 (de) 2006-03-16
DK297285A (da) 1985-07-01
DK297285D0 (da) 1985-07-01
DE3486474T2 (de) 2000-08-03

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