DK297185D0 - Fremstilling af biologisk aktive proteiner, sammensat af flere underenheder, ved rekombinant metodologi - Google Patents
Fremstilling af biologisk aktive proteiner, sammensat af flere underenheder, ved rekombinant metodologiInfo
- Publication number
- DK297185D0 DK297185D0 DK297185A DK297185A DK297185D0 DK 297185 D0 DK297185 D0 DK 297185D0 DK 297185 A DK297185 A DK 297185A DK 297185 A DK297185 A DK 297185A DK 297185 D0 DK297185 D0 DK 297185D0
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- biological active
- active proteins
- recombinant methodology
- hormone
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 2
- 102000009151 Luteinizing Hormone Human genes 0.000 abstract 2
- 108010073521 Luteinizing Hormone Proteins 0.000 abstract 2
- 102000011923 Thyrotropin Human genes 0.000 abstract 2
- 108010061174 Thyrotropin Proteins 0.000 abstract 2
- 229940028334 follicle stimulating hormone Drugs 0.000 abstract 2
- 229940040129 luteinizing hormone Drugs 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54821183A | 1983-11-02 | 1983-11-02 | |
US54821183 | 1983-11-02 | ||
US8401771 | 1984-10-31 | ||
PCT/US1984/001771 WO1985001959A1 (en) | 1983-11-02 | 1984-10-31 | Production of heterodimeric human fertlity hormones |
Publications (3)
Publication Number | Publication Date |
---|---|
DK297185D0 true DK297185D0 (da) | 1985-07-01 |
DK297185A DK297185A (da) | 1985-07-01 |
DK171489B1 DK171489B1 (da) | 1996-11-25 |
Family
ID=24187868
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK297185A DK171489B1 (da) | 1983-11-02 | 1985-07-01 | Fremgangsmåde til fremstilling af et biologisk aktivt, posttranslationelt modificeret proteinhormon sammensat af flere underenheder, eukaryotisk celle, som er transficeret med en eller flere udtrykkelsesvektorer og er i stand til at producere et sådant hormon, udtrykkelsesvektor omfattende heterolog DNA, som koder for underenhederne af hormonet, et sæt af udtrykkelsesvektorer, hvor hver vektor omf |
DK297285A DK297285A (da) | 1983-11-02 | 1985-07-01 | Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK297285A DK297285A (da) | 1983-11-02 | 1985-07-01 | Fremstilling af heterodimere humane fertilitetshormoner ved rekombinant metodologi |
Country Status (8)
Country | Link |
---|---|
EP (3) | EP0957167A1 (da) |
AT (2) | ATE169334T1 (da) |
DE (4) | DE10199028I2 (da) |
DK (2) | DK171489B1 (da) |
LU (1) | LU90770I2 (da) |
MX (1) | MX9203334A (da) |
NL (1) | NL300044I2 (da) |
WO (1) | WO1985001959A1 (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4923805A (en) * | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
US5639639A (en) * | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
JPS60145098A (ja) * | 1984-01-09 | 1985-07-31 | Suntory Ltd | 糖付加ポリペプチドの製造法 |
EP0224574A4 (en) * | 1985-06-04 | 1988-04-26 | Biotech Res Partners Ltd | SELF-ANTIGEN VACCINES. |
CA1340740C (en) * | 1987-12-08 | 1999-09-14 | Eileen R. Mulvihill | Co-expression in eukaryotic cells |
US5648254A (en) * | 1988-01-15 | 1997-07-15 | Zymogenetics, Inc. | Co-expression in eukaryotic cells |
US5705478A (en) * | 1989-02-21 | 1998-01-06 | Washington University | Covalently linked β subunits of the glycoprotein hormones as antagonists |
EP0461200B1 (en) * | 1989-02-21 | 1997-01-22 | Washington University | Modified forms of reproductive hormones |
US5792460A (en) * | 1989-02-21 | 1998-08-11 | Washington University | Modified glycoprotein hormones having a CTP at the amino terminus |
US6225449B1 (en) | 1991-10-04 | 2001-05-01 | Washington University | Hormone analogs with multiple CTP extensions |
US6028177A (en) * | 1991-10-04 | 2000-02-22 | Washington University | Methods of detecting single-chain forms of the glycoprotein hormone quartet |
IT1250075B (it) * | 1991-12-18 | 1995-03-30 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti gonadotropine. |
US6737515B2 (en) | 1993-11-19 | 2004-05-18 | Washington University | Follicle stimulating hormone-glycosylation analogs |
US6238890B1 (en) | 1994-02-18 | 2001-05-29 | Washington University | Single chain forms of the glycoprotein hormone quartet |
BR9506313A (pt) * | 1994-08-12 | 1997-08-05 | Univ Washington | Formas de cadeia simples do quarteto de hormônio de glicoproteína |
CN1157408C (zh) * | 1994-08-12 | 2004-07-14 | 华盛顿大学 | 以糖蛋白激素四成员家族的单链形式存在的糖蛋白激素活性的促效剂或拮抗剂 |
US6103501A (en) * | 1997-11-17 | 2000-08-15 | Washington University | Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof |
US6635256B1 (en) | 1998-10-19 | 2003-10-21 | Washington University | Glycoprotein hormone compositions comprising two β subunits and methods of use thereof |
EP1013281A1 (en) | 1998-12-15 | 2000-06-28 | Applied Research Systems ARS Holding N.V. | hCG therapy for the treatment of breast cancer |
JP2002541213A (ja) | 1999-04-13 | 2002-12-03 | インヘール セラピューティック システムズ, インコーポレイテッド | 不妊症の処置のための乾燥粉末処方物の肺投与 |
JP2005509652A (ja) * | 2001-11-08 | 2005-04-14 | モイル,ウィリアム,アール | 蛋白質の瘤 |
US7081446B2 (en) | 2002-01-31 | 2006-07-25 | The Trustees Of Columbia University In The City Of New York | Long-acting follicle stimulating hormone analogues and uses thereof |
BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 jnk 억제제 |
WO2007030362A1 (en) | 2005-09-07 | 2007-03-15 | Laboratoires Serono Sa. | Ikk inhibitors for the treatment of endometriosis |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2048894A (en) * | 1979-05-11 | 1980-12-17 | Gist Brocades Nv | Plasmid |
US4419446A (en) * | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
-
1984
- 1984-10-31 DE DE2001199028 patent/DE10199028I2/de active Active
- 1984-10-31 EP EP99107952A patent/EP0957167A1/en not_active Withdrawn
- 1984-10-31 DE DE3486469T patent/DE3486469T2/de not_active Expired - Lifetime
- 1984-10-31 AT AT92200198T patent/ATE169334T1/de active
- 1984-10-31 EP EP85900268A patent/EP0160699B1/en not_active Expired - Lifetime
- 1984-10-31 MX MX9203334A patent/MX9203334A/es unknown
- 1984-10-31 DE DE2001199035 patent/DE10199035I2/de active Active
- 1984-10-31 EP EP93202294A patent/EP0578328B1/en not_active Expired - Lifetime
- 1984-10-31 AT AT93202294T patent/ATE190461T1/de active
- 1984-10-31 WO PCT/US1984/001771 patent/WO1985001959A1/en active IP Right Grant
- 1984-10-31 DE DE3486474T patent/DE3486474T2/de not_active Expired - Lifetime
-
1985
- 1985-07-01 DK DK297185A patent/DK171489B1/da not_active IP Right Cessation
- 1985-07-01 DK DK297285A patent/DK297285A/da not_active Application Discontinuation
-
2001
- 2001-05-03 LU LU90770C patent/LU90770I2/fr unknown
- 2001-05-10 NL NL300044C patent/NL300044I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DE3486474T2 (de) | 2000-08-03 |
DE10199028I2 (de) | 2004-07-01 |
EP0957167A1 (en) | 1999-11-17 |
EP0578328A1 (en) | 1994-01-12 |
ATE169334T1 (de) | 1998-08-15 |
WO1985001959A1 (en) | 1985-05-09 |
DE3486469D1 (de) | 1998-09-10 |
LU90770I2 (fr) | 2001-07-03 |
DE10199028I1 (de) | 2001-09-20 |
EP0160699A4 (en) | 1987-10-20 |
EP0578328B1 (en) | 1999-12-29 |
DE10199035I1 (de) | 2001-11-08 |
NL300044I1 (nl) | 2001-07-02 |
ATE190461T1 (de) | 2000-04-15 |
DK297285D0 (da) | 1985-07-01 |
MX9203334A (es) | 1992-09-01 |
EP0160699B1 (en) | 1992-08-12 |
DK171489B1 (da) | 1996-11-25 |
NL300044I2 (nl) | 2001-12-01 |
DE10199035I2 (de) | 2006-03-16 |
DE3486474D1 (de) | 2000-02-03 |
DK297285A (da) | 1985-07-01 |
DE3486469T2 (de) | 1999-04-15 |
EP0160699A1 (en) | 1985-11-13 |
DK297185A (da) | 1985-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |