DE3486053T2 - Regulierung von gen-expression durch translationshemmung unter verwendung von m-rns hinderndem komplementaer-rns. - Google Patents

Regulierung von gen-expression durch translationshemmung unter verwendung von m-rns hinderndem komplementaer-rns.

Info

Publication number
DE3486053T2
DE3486053T2 DE8484112647T DE3486053T DE3486053T2 DE 3486053 T2 DE3486053 T2 DE 3486053T2 DE 8484112647 T DE8484112647 T DE 8484112647T DE 3486053 T DE3486053 T DE 3486053T DE 3486053 T2 DE3486053 T2 DE 3486053T2
Authority
DE
Germany
Prior art keywords
rns
gene
complementary
regulation
gene expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8484112647T
Other languages
English (en)
Other versions
DE3486053D1 (de
DE3486053T3 (de
Inventor
Masayori Inouye
Takeshi Mizuno
Mei-Yin Chou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of State University of New York
Original Assignee
Research Foundation of State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27067361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3486053(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Foundation of State University of New York filed Critical Research Foundation of State University of New York
Publication of DE3486053D1 publication Critical patent/DE3486053D1/de
Publication of DE3486053T2 publication Critical patent/DE3486053T2/de
Application granted granted Critical
Publication of DE3486053T3 publication Critical patent/DE3486053T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
DE3486053T 1983-10-20 1984-10-19 Regulierung von Gen-Expression durch Translationshemmung unter Verwendung von m-RNS hinderndem Komplementär-RNS. Expired - Lifetime DE3486053T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54352883A 1983-10-20 1983-10-20
US543528 1983-10-20
US58528284A 1984-03-01 1984-03-01
US585282 1984-03-01

Publications (3)

Publication Number Publication Date
DE3486053D1 DE3486053D1 (de) 1993-03-11
DE3486053T2 true DE3486053T2 (de) 1993-05-19
DE3486053T3 DE3486053T3 (de) 2004-01-08

Family

ID=27067361

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3486053T Expired - Lifetime DE3486053T3 (de) 1983-10-20 1984-10-19 Regulierung von Gen-Expression durch Translationshemmung unter Verwendung von m-RNS hinderndem Komplementär-RNS.
DE3486479T Expired - Lifetime DE3486479T2 (de) 1983-10-20 1984-10-19 Regulierung der Genexpression durch Translationshemmung unter Verwendung von mRNA hindernder Komplementär-RNA

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3486479T Expired - Lifetime DE3486479T2 (de) 1983-10-20 1984-10-19 Regulierung der Genexpression durch Translationshemmung unter Verwendung von mRNA hindernder Komplementär-RNA

Country Status (5)

Country Link
EP (2) EP0467349B1 (de)
JP (2) JP2651442B2 (de)
AT (1) ATE198350T1 (de)
CA (1) CA1341091C (de)
DE (2) DE3486053T3 (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751181A (en) * 1984-12-31 1988-06-14 Duke University Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
DE3650756T2 (de) * 1985-03-21 2001-10-04 Cornell Res Foundation Inc Vom parasit abgeleiteter widerstand
US5580716A (en) * 1985-03-21 1996-12-03 Stephen A. Johnston Parasite-derived resistance
US6617496B1 (en) 1985-10-16 2003-09-09 Monsanto Company Effecting virus resistance in plants through the use of negative strand RNAs
US5107065A (en) * 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
US5453566A (en) * 1986-03-28 1995-09-26 Calgene, Inc. Antisense regulation of gene expression in plant/cells
US5276019A (en) * 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
CA2105595A1 (en) * 1992-09-23 1994-03-24 Ramaswamy Narayanan Antisense polynucleotides
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
WO1998014567A2 (en) * 1996-10-01 1998-04-09 Advanced Research & Technology Institute Methods and compositions for inhibiting bacterial growth
US6139817A (en) * 1996-10-15 2000-10-31 Smithkline Beecham Corporation Method for determining gene essentiality in a pathogen
EP0837142A1 (de) * 1996-10-15 1998-04-22 Smithkline Beecham Corporation Verfahren zum Nachweis essentieller Gene eines Erregers
JP2001505417A (ja) * 1996-11-06 2001-04-24 スミスクライン・ビーチャム・コーポレイション 生物の成長に必須の遺伝子の同定方法
US7008776B1 (en) 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
US6884430B1 (en) 1997-02-10 2005-04-26 Aventis Pharma S.A. Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
AU738272B2 (en) 1997-02-21 2001-09-13 Dupont Nutrition Biosciences Aps Antisense intron inhibition of starch branching enzyme expression
ID21013A (id) * 1997-03-10 1999-04-08 Japan Tobacco Inc Deret nukleotida antipeka
US6586661B1 (en) 1997-06-12 2003-07-01 North Carolina State University Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid
CZ299473B6 (cs) 1997-06-30 2008-08-06 Rhone-Poulenc Rorer S. A. Nukleová kyselina a elektrické pole jako sdruženýprodukt pro prenos nukleové kyseliny do bunek prícne pruhovaného svalstva
JP2002500039A (ja) 1998-01-08 2002-01-08 アベンティス ファーマスーティカルズ プロダクツ インコーポレイテッド 機能あるヒトリポタンパク質（ａ）を発現するトランスジェニックウサギ
CA2487328A1 (en) 1998-03-20 1999-09-30 Benitec Australia Ltd. Sirna for control of gene expression
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US8598332B1 (en) 1998-04-08 2013-12-03 Bayer Cropscience N.V. Methods and means for obtaining modified phenotypes
US20040214330A1 (en) 1999-04-07 2004-10-28 Waterhouse Peter Michael Methods and means for obtaining modified phenotypes
CN1202246C (zh) 1998-04-08 2005-05-18 联邦科学和工业研究组织 获得修饰表型的方法和措施
US7148400B1 (en) 1999-04-20 2006-12-12 Bayer Bioscience N.V. Methods and means for delivering inhibitory RNA to plants and applications thereof
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
FR2799472B1 (fr) 1999-10-07 2004-07-16 Aventis Pharma Sa Preparation d'adenovirus recombinants et de banques adenovirales
GB0018307D0 (en) 2000-07-26 2000-09-13 Aventis Pharm Prod Inc Polypeptides
MXPA02009481A (es) 2000-03-31 2004-05-14 Aventis Pharma Inc Factor inductor del factor nuclear kb.
DK1301213T3 (en) 2000-07-21 2017-03-27 Revance Therapeutics Inc MULTI-COMPONENT SYSTEMS FOR BIOLOGICAL TRANSPORT
CA2420724A1 (en) 2000-08-30 2002-03-07 North Carolina State University Transgenic plants containing molecular decoys that alter protein content therein
PT1331845E (pt) 2000-11-09 2012-04-12 Commw Scient Ind Res Org Cevada com reduzida atividade ssii e produtos contendo amido com um conteúdo de amilopectina reduzido
EP1406518A4 (de) 2001-06-08 2006-03-29 Vector Tobacco Ltd Modifikation von nicotin- und nitrosaminkonzentrationen in tabak
US7491506B2 (en) 2001-06-21 2009-02-17 The Regents Of The University Of California Inhibition of B-cell maturation and antibody production
FR2829136B1 (fr) 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
HUE036402T2 (hu) 2002-01-17 2018-07-30 Alfa Laval Corp Ab Merülõpárologtató, amely lemezes hõcserélõt és hengeres házat tartalmaz, ahol a lemezes hõcserélõ el van helyezve
AU2003209814B2 (en) 2002-03-14 2008-12-04 Commonwealth Scientific & Industrial Research Organisation Modified gene-silencing RNA and uses thereof
DE10212892A1 (de) 2002-03-20 2003-10-09 Basf Plant Science Gmbh Konstrukte und Verfahren zur Regulation der Genexpression
WO2005001098A1 (en) 2003-06-30 2005-01-06 Commonwealth Scientific And Industrial Research Organisation Wheat with altered branching enzyme activity and starch and starch containing products derived thereform
EP1685236A4 (de) 2003-09-29 2008-01-23 Univ California Verfahren zur änderung der adhäsion, differenzierung und migration hämatopoetischer vorläuferzellen
US7129042B2 (en) 2003-11-03 2006-10-31 Diagnostic Hybrids, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus
JP5638736B2 (ja) 2004-12-30 2014-12-10 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション 腸の健康を改善する方法および手段
FR2881143B1 (fr) 2005-01-27 2010-12-17 Librophyt Systeme de production de terpenoides dans les plantes
WO2007092471A2 (en) 2006-02-03 2007-08-16 The Regents Of The University Of California Methods for inhibition of lymphangiogenesis and tumor metastasis
WO2007141790A2 (en) 2006-06-07 2007-12-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Plant expression constructs and methods of utilizing same
US8329669B2 (en) 2006-07-28 2012-12-11 Sanofi Composition and method for treatment of tumors
EP2222859A2 (de) 2007-12-21 2010-09-01 Keygene N.V. Trichomspezifische promotoren
EP2100962A1 (de) 2008-03-12 2009-09-16 Biogemma Pflanzen mit verbesserter Widerstandsfähigkeit gegen Pathogene
EP2331071A1 (de) 2008-09-05 2011-06-15 Institut National De La Sante Et De La Recherche Medicale Neue multimodulare anordnung zur intrazellulären abgabe
EP2249160A1 (de) 2009-04-27 2010-11-10 Centre National de la Recherche Scientifique VDAC3-S als ein Zellmarker
CN102459615B (zh) 2009-06-08 2017-05-03 纽海姆有限公司 耐旱植物
CN103220905A (zh) 2010-05-28 2013-07-24 纽海姆有限公司 果实大小增大的植物
EP2525224A1 (de) 2011-05-19 2012-11-21 Centre National de la Recherche Scientifique VDAC1-S als ein Zellmarker
FR2986803A1 (fr) 2012-02-13 2013-08-16 Apex Biosolutions Cytomegalovirus humain oncogenique
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016075314A1 (fr) 2014-11-13 2016-05-19 Institut National De La Recherche Agronomique Identification de facteurs de transcription de yarrowia lipolytica affectant la production de proteines
FR3028527A1 (fr) 2014-11-13 2016-05-20 Pivert Identification de facteurs de transcription de yarrowia lipolytica
CA2996806A1 (en) 2015-09-04 2017-03-09 Keygene N.V. Diplospory gene
FR3081169B1 (fr) 2018-05-15 2020-06-19 Messenger Biopharma Substitution de la coiffe des arn messagers par deux sequences d'arn introduites a leur extremite 5'

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS581451Y2 (ja) * 1979-11-13 1983-01-11 浜野 純一 自動充填機における袋供給送り装置

Also Published As

Publication number Publication date
EP0140308A3 (en) 1987-05-27
ATE198350T1 (de) 2001-01-15
EP0467349A1 (de) 1992-01-22
DE3486053D1 (de) 1993-03-11
JP2694924B2 (ja) 1997-12-24
JPH09135686A (ja) 1997-05-27
EP0467349B1 (de) 2000-12-27
JP2651442B2 (ja) 1997-09-10
CA1341091C (en) 2000-09-05
JPS60232092A (ja) 1985-11-18
DE3486479D1 (de) 2001-02-01
EP0140308A2 (de) 1985-05-08
EP0140308B1 (de) 1993-01-27
EP0140308B2 (de) 2001-10-17
DE3486053T3 (de) 2004-01-08
DE3486479T2 (de) 2001-09-20

Similar Documents

Publication Publication Date Title
DE3486053D1 (de) Regulierung von gen-expression durch translationshemmung unter verwendung von m-rns hinderndem komplementaer-rns.
Besnard et al. Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein.
ES2056799T3 (es) Moleculas de adn codante para las regiones de control fmdh y gen estructural para una proteina que tiene una actividad de fmdh y su uso.
ATE27000T1 (de) Expression von polypeptiden in hefen.
ES2085245T1 (es) Procedimiento para aislar acido nucleico.
AU560340B2 (en) Rennin from recombinant dna
DK97784D0 (da) Dna-segment
MX428A (es) Region regulatoria para expresion de gen heterologa en levadura.
DE3851399D1 (de) Transientes Expressionssystem zur Herstellung von rekombinantem Protein.
DE3854125T3 (de) VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON FAKTOR VIII:c-TYP-PROTEINEN.
ATE353970T1 (de) Methode zur selektion hoch-exprimierender wirtszellen
DE3688336T2 (de) Verfahren zur Herstellung von organischen Säuren unter Verwendung von Mikroorganismen.
ATE113656T1 (de) Hühner-beta-actin-genpromoter enthaltender vektor zur expression eines erwünschten gens.
CA2169631A1 (en) A novel homeobox factor which stimulates insulin expression in pancreatic islet cells
DE69126053T2 (de) Modifizierte Transkriptionskontrolleinheit und ihre Verwendung
ES2013353A6 (es) Metodo de adn recombonante para producir proteinas fijadoras de oxigeno, particularmente hemoglobinas.
EP0837931A4 (de) Methode zur expression in und isolation von biologisch aktiven molekülen aus urin
ES2078243T3 (es) Mejoras en o relativas a la expresion eucariotica.
DK125289D0 (da) Dna-struktur, omfattende en aktivator-stimuleret promotor til udtrykkelse af et oensket protein, samt fremgangsmaade til udtrykkelse af proteinet ved hjaelp af dna-strukturen
ATA282386A (de) Verfahren zur expression von genen in hefe und dna-fragmente und diese dna-fragmente enthaltende plasmide zur verwendung bei diesem verfahren
Costanzo et al. PKC-dependent phosphorylation of the p97 repressor regulates the transcription of aldolase A L-type promoter
DE59911877D1 (de) Verfahren zur verbesserung des gentransfers von genetischem material in säugerzellen durch die verwendung von p21 (waf-1)
DE58909205D1 (de) Expressionsvektor und Verfahren zur regulierbaren Herstellung von Proteinen in Eukaryonten.
ATE85078T1 (de) Regulierung von gen-expression durch translationshemmung unter verwendung von m-rns hinderndem komplementaer-rns.
WO2003018803A1 (fr) Precurseurs de cellules adipeuses etablis, procede de fourniture, et procede d'utilisation

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings