DE3482479D1 - Ultrareine hyaluronsaeure und verfahren zu deren herstellung. - Google Patents

Ultrareine hyaluronsaeure und verfahren zu deren herstellung.

Info

Publication number
DE3482479D1
DE3482479D1 DE8484113716T DE3482479T DE3482479D1 DE 3482479 D1 DE3482479 D1 DE 3482479D1 DE 8484113716 T DE8484113716 T DE 8484113716T DE 3482479 T DE3482479 T DE 3482479T DE 3482479 D1 DE3482479 D1 DE 3482479D1
Authority
DE
Germany
Prior art keywords
hyaluronic acid
ultrareine
production
hyaluronidase
mammals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8484113716T
Other languages
English (en)
Inventor
Karen K Brown
Linda L Clem Ruiz
Ivo Vanderijn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of DE3482479D1 publication Critical patent/DE3482479D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE8484113716T 1983-11-25 1984-11-14 Ultrareine hyaluronsaeure und verfahren zu deren herstellung. Expired - Lifetime DE3482479D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55522483A 1983-11-25 1983-11-25

Publications (1)

Publication Number Publication Date
DE3482479D1 true DE3482479D1 (de) 1990-07-19

Family

ID=24216466

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484113716T Expired - Lifetime DE3482479D1 (de) 1983-11-25 1984-11-14 Ultrareine hyaluronsaeure und verfahren zu deren herstellung.

Country Status (18)

Country Link
US (1) US4782046A (de)
EP (1) EP0144019B1 (de)
JP (1) JPS60133894A (de)
KR (1) KR880001763B1 (de)
AT (1) ATE53607T1 (de)
AU (1) AU573768B2 (de)
CA (1) CA1270219A (de)
CS (1) CS249531B2 (de)
DE (1) DE3482479D1 (de)
DK (1) DK558884A (de)
ES (1) ES537938A0 (de)
FI (1) FI79555C (de)
HU (1) HU192617B (de)
IE (1) IE57688B1 (de)
IL (1) IL73605A (de)
NO (1) NO161573C (de)
NZ (1) NZ210300A (de)
ZA (1) ZA849025B (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
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NO160722C (no) * 1983-11-25 1989-05-24 Miles Inc Fremgangsmaate for fremstilling av ultraren hyaluronsyre.
US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
SE8501723L (sv) * 1985-04-09 1986-10-10 Pharmacia Ab Preparation att anvendas vid behandling av ledinflammation
AU593556B2 (en) * 1985-05-09 1990-02-15 David Cullis-Hill High purity hyaluronic acid from synovial fluid
JPS6279790A (ja) * 1985-09-30 1987-04-13 Toyo Jozo Co Ltd 改質されたヒアルロン酸の製造法
US4808576A (en) 1986-04-28 1989-02-28 Mobay Corporation Remote administration of hyaluronic acid to mammals
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPH072117B2 (ja) * 1986-10-09 1995-01-18 三菱レイヨン株式会社 ヒアルロン酸の製造法
US5079236A (en) * 1987-05-27 1992-01-07 Hyal Pharmaceutical Corporation Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use
FR2617849B1 (fr) * 1987-07-10 1992-05-15 Pf Medicament Nouveau procede d'obtention d'acide hyaluronique d'origine bacterienne
JPH0813847B2 (ja) * 1987-08-11 1996-02-14 日本化薬株式会社 ヒアルロン酸の分画法
JPS6467196A (en) * 1987-09-08 1989-03-13 Yakult Honsha Kk Production of hyaluronic acid and strain used therefor
JP2938880B2 (ja) * 1988-10-12 1999-08-25 電気化学工業株式会社 ヒアルロン酸の精製法
HU203372B (en) 1989-02-24 1991-07-29 Richter Gedeon Vegyeszet Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
US5015577A (en) * 1989-08-29 1991-05-14 Board Of Regents, The University Of Texas System DNA encoding hyaluronate synthase
AU7312291A (en) * 1990-02-13 1991-09-03 Gere S. Dizerega Peritoneal induced medicaments
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid
CA2060223C (en) * 1991-02-12 1999-07-20 Clarence C. Lee Injectable medical lubricating fluid composition and method of use
IT1247175B (it) * 1991-04-19 1994-12-12 Fidia Spa Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
AU3065192A (en) * 1991-12-20 1993-07-28 Howmedica Inc. Ultra-pure polysaccharide materials for medical use
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
CA2061567C (en) * 1992-02-20 1998-02-03 Rudolf E. Falk Use of hyaluronic acid to repair ischemia reperfusion damage
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
IT1268954B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
SE9401806D0 (sv) * 1994-05-26 1994-05-26 Pharmacia Ab Method and means for the production of hyaluronic acid
US6951743B2 (en) 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US7091008B1 (en) 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6455304B1 (en) 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
KR19980080116A (ko) * 1997-03-27 1998-11-25 히라따 다다시 히알루론산 나트륨의 정제법
CN101113436B (zh) * 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
DK1025211T3 (da) 1997-10-31 2005-04-04 Univ Oklahoma Hyaluronansyntasegen og anvendelser deraf
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US6987023B2 (en) 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US7223571B2 (en) 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7094581B2 (en) 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
WO2000044367A2 (en) 1999-02-01 2000-08-03 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US20050287638A1 (en) * 2000-04-25 2005-12-29 Weigel Paul H Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
US20040126853A1 (en) * 2002-06-20 2004-07-01 Novozymes A/S Flocculation with divalent salt
BR0311485A (pt) * 2002-06-20 2005-03-15 Novozymes Biopolymer As Método para flocular uma célula de bacillus e/ou remover contaminantes de peso molecular alto
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US7803787B2 (en) * 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
US20080003258A1 (en) * 2002-10-16 2008-01-03 Marcum Frank D Composition and Method for Treating Rheumatoid Arthritis
US7485629B2 (en) * 2002-10-16 2009-02-03 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treatment of joint damage
US7002007B2 (en) * 2004-05-28 2006-02-21 Calcigen Corporation Production of high molecular weight hyaluronates
KR100577075B1 (ko) * 2004-06-16 2006-05-08 주식회사 티앤라이프시스템 칼슘염 및 인산염, 또는 인산칼슘염을 이용한 히아루론산정제방법
EP1772052A1 (de) 2005-10-05 2007-04-11 Bayer CropScience GmbH Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan
JP5210165B2 (ja) 2005-10-05 2013-06-12 バイエル・クロップサイエンス・アーゲー 増加したアミノ糖含量を有する植物
US9186375B2 (en) 2007-06-21 2015-11-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan compositions in combination with stem cells
US8147759B2 (en) * 2007-08-29 2012-04-03 Cem Corporation Automated protein analyzer
US8852948B2 (en) * 2007-08-29 2014-10-07 Cem Corporation Colorimetric protein analysis method
EP2036983A1 (de) 2007-09-12 2009-03-18 Bayer CropScience AG Pflanzen, die erhöhte Mengen an Glucosaminglycanen synthetisieren
ES2622834T3 (es) * 2007-11-13 2017-07-07 Bio-Technology General (Israel) Ltd. Procedimiento de esterilización por filtración en estado diluido para biopolímeros viscoelásticos
KR101322227B1 (ko) 2011-09-30 2013-10-28 일동제약주식회사 스트렙토코커스 디스갈락티애 ｉｄ9103 균주 및 이를 이용한 히알루론산 생산 방법
EP2886104A1 (de) 2013-12-11 2015-06-24 Patir, Suleyman Intraartikuläres Gel
CA2896038C (en) * 2015-07-03 2022-08-09 Glycobiosciences Inc. Polymer matrix compositions comprising a high concentration of bio-fermented sodium hyaluronate and uses thereof
CA3008848A1 (en) 2015-12-18 2017-06-22 Tega Therapeutics, Inc. Cellular glycosaminoglycan compositions and methods of making and using
DE102015226456A1 (de) * 2015-12-22 2017-06-22 Heraeus Medical Gmbh Verfahren zur Sterilisation von wässrigen Polysaccharidlösungen und sterile wässrige Polysaccharidlösungen
DE102016208567A1 (de) * 2016-05-19 2017-11-23 Heraeus Medical Gmbh Polymerlösung zur Viscosupplementation

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US2599172A (en) * 1948-11-29 1952-06-03 Searle & Co Sulfuric acid esters of hyaluronic acid and processes for the production thereof
US2975104A (en) * 1959-05-21 1961-03-14 American Home Prod Medium and method for producing and isolating hyaluronic acid
AT252264B (de) * 1965-03-17 1967-02-10 Etapharm Chem Pharm Lab Ges M Verfahren zur Herstellung eines reinen hochviskosen Hyaluronsäurepräparates
FR2298599A2 (fr) * 1975-01-24 1976-08-20 Sifrance Nouvelles compositions detergentes solides non corrosives
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US4303676A (en) 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
US4328803B1 (en) 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
JPS5837001A (ja) * 1981-08-27 1983-03-04 Green Cross Corp:The ヒアルロン酸の製造法
JPS5857319A (ja) * 1981-09-30 1983-04-05 Green Cross Corp:The 高粘性ヒアルロン酸製剤
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
NO160722C (no) * 1983-11-25 1989-05-24 Miles Inc Fremgangsmaate for fremstilling av ultraren hyaluronsyre.

Also Published As

Publication number Publication date
HU192617B (en) 1987-06-29
EP0144019A2 (de) 1985-06-12
NO161573C (no) 1989-08-30
US4782046A (en) 1988-11-01
ATE53607T1 (de) 1990-06-15
CA1270219A (en) 1990-06-12
CS249531B2 (en) 1987-03-12
IE57688B1 (en) 1993-02-24
JPS60133894A (ja) 1985-07-17
FI844597L (fi) 1985-05-26
KR880001763B1 (ko) 1988-09-12
AU573768B2 (en) 1988-06-23
IE843003L (en) 1985-05-25
FI844597A0 (fi) 1984-11-22
EP0144019B1 (de) 1990-06-13
NZ210300A (en) 1989-06-28
AU3580684A (en) 1985-05-30
NO161573B (no) 1989-05-22
IL73605A (en) 1992-03-29
FI79555B (fi) 1989-09-29
HUT36180A (en) 1985-08-28
IL73605A0 (en) 1985-02-28
ES8603578A1 (es) 1985-12-16
DK558884A (da) 1985-05-26
ES537938A0 (es) 1985-12-16
DK558884D0 (da) 1984-11-23
NO844493L (no) 1985-05-28
EP0144019A3 (en) 1986-10-08
FI79555C (fi) 1990-01-10
ZA849025B (en) 1985-07-31
KR850004983A (ko) 1985-08-19

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