IL73605A - Bacterial preparation and purification of narrow-range high-molecular-weight hyaluronic acid and sterile compositions containing it - Google Patents
Bacterial preparation and purification of narrow-range high-molecular-weight hyaluronic acid and sterile compositions containing itInfo
- Publication number
- IL73605A IL73605A IL73605A IL7360584A IL73605A IL 73605 A IL73605 A IL 73605A IL 73605 A IL73605 A IL 73605A IL 7360584 A IL7360584 A IL 7360584A IL 73605 A IL73605 A IL 73605A
- Authority
- IL
- Israel
- Prior art keywords
- hyaluronic acid
- purification
- narrow
- molecular
- compositions containing
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 230000001580 bacterial effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 108010003272 Hyaluronate lyase Proteins 0.000 abstract 1
- 102000001974 Hyaluronidases Human genes 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 229960002773 hyaluronidase Drugs 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55522483A | 1983-11-25 | 1983-11-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL73605A0 IL73605A0 (en) | 1985-02-28 |
| IL73605A true IL73605A (en) | 1992-03-29 |
Family
ID=24216466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL73605A IL73605A (en) | 1983-11-25 | 1984-11-23 | Bacterial preparation and purification of narrow-range high-molecular-weight hyaluronic acid and sterile compositions containing it |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4782046A (de) |
| EP (1) | EP0144019B1 (de) |
| JP (1) | JPS60133894A (de) |
| KR (1) | KR880001763B1 (de) |
| AT (1) | ATE53607T1 (de) |
| AU (1) | AU573768B2 (de) |
| CA (1) | CA1270219A (de) |
| CS (1) | CS249531B2 (de) |
| DE (1) | DE3482479D1 (de) |
| DK (1) | DK558884A (de) |
| ES (1) | ES537938A0 (de) |
| FI (1) | FI79555C (de) |
| HU (1) | HU192617B (de) |
| IE (1) | IE57688B1 (de) |
| IL (1) | IL73605A (de) |
| NO (1) | NO161573C (de) |
| NZ (1) | NZ210300A (de) |
| ZA (1) | ZA849025B (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5093487A (en) * | 1986-01-06 | 1992-03-03 | Mobay Corporation | Low viscosity high molecular weight filter sterilizable hyaluronic acid |
| NO160722C (no) * | 1983-11-25 | 1989-05-24 | Miles Inc | Fremgangsmaate for fremstilling av ultraren hyaluronsyre. |
| US4780414A (en) * | 1985-01-18 | 1988-10-25 | Bio-Technology General Corp. | Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus |
| SE8501723L (sv) * | 1985-04-09 | 1986-10-10 | Pharmacia Ab | Preparation att anvendas vid behandling av ledinflammation |
| IL78720A (en) * | 1985-05-09 | 1990-01-18 | Hill David Cullis | Preparation of high-purity hyaluronic acid from synovial fluid |
| JPS6279790A (ja) * | 1985-09-30 | 1987-04-13 | Toyo Jozo Co Ltd | 改質されたヒアルロン酸の製造法 |
| US4808576A (en) * | 1986-04-28 | 1989-02-28 | Mobay Corporation | Remote administration of hyaluronic acid to mammals |
| US5023175A (en) * | 1986-05-01 | 1991-06-11 | Kabushiki Kaisha Yakult Honsha | Novel production process of hyaluronic acid and bacterium strain therefor |
| JPH072117B2 (ja) * | 1986-10-09 | 1995-01-18 | 三菱レイヨン株式会社 | ヒアルロン酸の製造法 |
| US5079236A (en) * | 1987-05-27 | 1992-01-07 | Hyal Pharmaceutical Corporation | Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use |
| FR2617849B1 (fr) * | 1987-07-10 | 1992-05-15 | Pf Medicament | Nouveau procede d'obtention d'acide hyaluronique d'origine bacterienne |
| JPH0813847B2 (ja) * | 1987-08-11 | 1996-02-14 | 日本化薬株式会社 | ヒアルロン酸の分画法 |
| JPS6467196A (en) * | 1987-09-08 | 1989-03-13 | Yakult Honsha Kk | Production of hyaluronic acid and strain used therefor |
| JP2938880B2 (ja) * | 1988-10-12 | 1999-08-25 | 電気化学工業株式会社 | ヒアルロン酸の精製法 |
| HU203372B (en) | 1989-02-24 | 1991-07-29 | Richter Gedeon Vegyeszet | Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient |
| US5015577A (en) | 1989-08-29 | 1991-05-14 | Board Of Regents, The University Of Texas System | DNA encoding hyaluronate synthase |
| ES2146200T3 (es) * | 1990-02-13 | 2000-08-01 | Ethicon Inc | Medicamentos inducidos peritonealmente. |
| US5990096A (en) * | 1990-09-18 | 1999-11-23 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US5824658A (en) * | 1990-09-18 | 1998-10-20 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| CA2061703C (en) * | 1992-02-20 | 2002-07-02 | Rudolf E. Falk | Formulations containing hyaluronic acid |
| US5910489A (en) * | 1990-09-18 | 1999-06-08 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| GB9024223D0 (en) * | 1990-11-07 | 1990-12-19 | Fermentech Ltd | Production of hyaluronic acid |
| AU652022B2 (en) * | 1991-02-12 | 1994-08-11 | C.R. Bard Inc. | Injectable medical device |
| IT1247175B (it) * | 1991-04-19 | 1994-12-12 | Fidia Spa | Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. |
| US5234914A (en) * | 1991-06-11 | 1993-08-10 | Patent Biopharmaceutics, Inc. | Methods of treating hemorrhoids and anorecial disease |
| US5977088A (en) * | 1991-07-03 | 1999-11-02 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| US6103704A (en) * | 1991-07-03 | 2000-08-15 | Hyal Pharmaceutical Corporation | Therapeutic methods using hyaluronic acid |
| US5792753A (en) * | 1991-07-03 | 1998-08-11 | Hyal Pharmaceutical Corporation | Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs |
| AU3065192A (en) * | 1991-12-20 | 1993-07-28 | Howmedica Inc. | Ultra-pure polysaccharide materials for medical use |
| US6218373B1 (en) | 1992-02-20 | 2001-04-17 | Hyal Pharmaceutical Corporation | Formulations containing hyaluronic acid |
| CA2061567C (en) * | 1992-02-20 | 1998-02-03 | Rudolf E. Falk | Use of hyaluronic acid to repair ischemia reperfusion damage |
| US5767106A (en) * | 1992-02-21 | 1998-06-16 | Hyal Pharmaceutical Corporation | Treatment of disease and conditions associated with macrophage infiltration |
| IT1268954B1 (it) * | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche |
| US5888984A (en) | 1994-05-12 | 1999-03-30 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
| SE9401806D0 (sv) | 1994-05-26 | 1994-05-26 | Pharmacia Ab | Method and means for the production of hyaluronic acid |
| US6951743B2 (en) | 1997-10-31 | 2005-10-04 | University Of Oklahoma Board Of Regents | Hyaluronan synthase genes and expression thereof in bacillus hosts |
| US7091008B1 (en) | 1994-07-01 | 2006-08-15 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthase genes and expression thereof in Bacillus hosts |
| US6455304B1 (en) | 1994-07-01 | 2002-09-24 | The Board Of Regents Of The University Of Oklahoma | Hyaluronate synthase gene and uses thereof |
| KR19980080116A (ko) * | 1997-03-27 | 1998-11-25 | 히라따 다다시 | 히알루론산 나트륨의 정제법 |
| EP1522579A3 (de) | 1997-10-31 | 2007-11-07 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan-Synthase-Gen und Verwendung davon |
| CN101113436B (zh) * | 1997-10-31 | 2013-02-06 | 俄克拉何马大学董事会 | 透明质酸合酶基因及其应用 |
| US20080108110A1 (en) * | 1998-04-02 | 2008-05-08 | Deangelis Paul L | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
| US20060188966A1 (en) * | 1998-04-02 | 2006-08-24 | Deangelis Paul L | Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same |
| US6987023B2 (en) | 1998-04-02 | 2006-01-17 | The Board Of Regents Of The University Of Oklahoma | DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use |
| US7223571B2 (en) | 1998-04-02 | 2007-05-29 | The Board Of Regents Of The Universtiy Of Oklahoma | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
| US7094581B2 (en) | 1998-10-26 | 2006-08-22 | The Board Of Regents Of The University Of Oklahoma | Hyaluronan synthases and methods of making and using same |
| CA2361268C (en) | 1999-02-01 | 2014-06-10 | Dermal Research Laboratories, Inc. | A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
| US20050287638A1 (en) * | 2000-04-25 | 2005-12-29 | Weigel Paul H | Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same |
| US7879824B2 (en) * | 2001-07-31 | 2011-02-01 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
| US20020172712A1 (en) * | 2001-03-19 | 2002-11-21 | Alan Drizen | Antiemetic, anti-motion sustained release drug delivery system |
| US20070020737A1 (en) * | 2001-12-03 | 2007-01-25 | Pummill Philip E | Hyaluronan synthases and methods of making and using same |
| ATE352637T1 (de) * | 2002-06-20 | 2007-02-15 | Novozymes Biopolymer As | Ausflockung mit zweiwertigem salz |
| US20040126853A1 (en) * | 2002-06-20 | 2004-07-01 | Novozymes A/S | Flocculation with divalent salt |
| US20080003258A1 (en) * | 2002-10-16 | 2008-01-03 | Marcum Frank D | Composition and Method for Treating Rheumatoid Arthritis |
| US7485629B2 (en) * | 2002-10-16 | 2009-02-03 | Arthrodynamic Technologies, Animal Health Division, Inc. | Composition and method for treatment of joint damage |
| US7803787B2 (en) * | 2002-10-16 | 2010-09-28 | Arthrodynamic Technologies, Animal Health Division, Inc. | Composition and method for treating connective tissue damage by transmucosal administration |
| US8455458B2 (en) | 2002-10-16 | 2013-06-04 | Arthrodynamic Technologies, Animal Health Division, Inc. | Composition and method for treating connective tissue damage |
| US7002007B2 (en) * | 2004-05-28 | 2006-02-21 | Calcigen Corporation | Production of high molecular weight hyaluronates |
| KR100577075B1 (ko) * | 2004-06-16 | 2006-05-08 | 주식회사 티앤라이프시스템 | 칼슘염 및 인산염, 또는 인산칼슘염을 이용한 히아루론산정제방법 |
| EP1951879B1 (de) | 2005-10-05 | 2015-12-02 | Bayer Intellectual Property GmbH | Pflanzen mit erhöhtem aminozuckergehalt |
| EP1772052A1 (de) | 2005-10-05 | 2007-04-11 | Bayer CropScience GmbH | Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan |
| US9186375B2 (en) | 2007-06-21 | 2015-11-17 | Arthrodynamic Technologies, Animal Health Division, Inc. | Glycosaminoglycan compositions in combination with stem cells |
| US8147759B2 (en) * | 2007-08-29 | 2012-04-03 | Cem Corporation | Automated protein analyzer |
| US8852948B2 (en) * | 2007-08-29 | 2014-10-07 | Cem Corporation | Colorimetric protein analysis method |
| EP2036983A1 (de) | 2007-09-12 | 2009-03-18 | Bayer CropScience AG | Pflanzen, die erhöhte Mengen an Glucosaminglycanen synthetisieren |
| CA2705850C (en) * | 2007-11-13 | 2016-07-19 | Bio-Technology General (Israel) Ltd. | Dilute filtration sterilization process for viscoelastic biopolymers |
| KR101322227B1 (ko) | 2011-09-30 | 2013-10-28 | 일동제약주식회사 | 스트렙토코커스 디스갈락티애 ｉｄ9103 균주 및 이를 이용한 히알루론산 생산 방법 |
| EP2886104A1 (de) | 2013-12-11 | 2015-06-24 | Patir, Suleyman | Intraartikuläres Gel |
| CA2896038C (en) * | 2015-07-03 | 2022-08-09 | Glycobiosciences Inc. | Polymer matrix compositions comprising a high concentration of bio-fermented sodium hyaluronate and uses thereof |
| AU2016369595B2 (en) | 2015-12-18 | 2022-11-24 | Tega Therapeutics, Inc. | Cellular glycosaminoglycan compositions and methods of making and using |
| DE102015226456A1 (de) * | 2015-12-22 | 2017-06-22 | Heraeus Medical Gmbh | Verfahren zur Sterilisation von wässrigen Polysaccharidlösungen und sterile wässrige Polysaccharidlösungen |
| DE102016208567A1 (de) * | 2016-05-19 | 2017-11-23 | Heraeus Medical Gmbh | Polymerlösung zur Viscosupplementation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2599172A (en) * | 1948-11-29 | 1952-06-03 | Searle & Co | Sulfuric acid esters of hyaluronic acid and processes for the production thereof |
| US2975104A (en) * | 1959-05-21 | 1961-03-14 | American Home Prod | Medium and method for producing and isolating hyaluronic acid |
| AT252264B (de) * | 1965-03-17 | 1967-02-10 | Etapharm Chem Pharm Lab Ges M | Verfahren zur Herstellung eines reinen hochviskosen Hyaluronsäurepräparates |
| FR2298599A2 (fr) * | 1975-01-24 | 1976-08-20 | Sifrance | Nouvelles compositions detergentes solides non corrosives |
| US4141973A (en) | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4303676A (en) | 1980-03-21 | 1981-12-01 | Balazs Endre A | Hyaluronate based compositions and cosmetic formulations containing same |
| US4328803B1 (en) | 1980-10-20 | 1994-01-11 | Opthalmic Systems, Inc. | Opthalmological procedures |
| JPS5837001A (ja) * | 1981-08-27 | 1983-03-04 | Green Cross Corp:The | ヒアルロン酸の製造法 |
| JPS5857319A (ja) * | 1981-09-30 | 1983-04-05 | Green Cross Corp:The | 高粘性ヒアルロン酸製剤 |
| US4517295A (en) * | 1983-02-18 | 1985-05-14 | Diagnostic, Inc. | Hyaluronic acid from bacterial culture |
| NO160722C (no) * | 1983-11-25 | 1989-05-24 | Miles Inc | Fremgangsmaate for fremstilling av ultraren hyaluronsyre. |
-
1984
- 1984-11-09 NO NO844493A patent/NO161573C/no not_active IP Right Cessation
- 1984-11-14 DE DE8484113716T patent/DE3482479D1/de not_active Expired - Lifetime
- 1984-11-14 EP EP84113716A patent/EP0144019B1/de not_active Expired - Lifetime
- 1984-11-14 AT AT84113716T patent/ATE53607T1/de not_active IP Right Cessation
- 1984-11-20 ZA ZA849025A patent/ZA849025B/xx unknown
- 1984-11-22 FI FI844597A patent/FI79555C/fi active IP Right Grant
- 1984-11-22 AU AU35806/84A patent/AU573768B2/en not_active Expired
- 1984-11-22 CA CA000468446A patent/CA1270219A/en not_active Expired - Lifetime
- 1984-11-23 NZ NZ210300A patent/NZ210300A/xx unknown
- 1984-11-23 ES ES537938A patent/ES537938A0/es active Granted
- 1984-11-23 CS CS848998A patent/CS249531B2/cs unknown
- 1984-11-23 IL IL73605A patent/IL73605A/xx not_active IP Right Cessation
- 1984-11-23 HU HU844359A patent/HU192617B/hu unknown
- 1984-11-23 IE IE3003/84A patent/IE57688B1/en not_active IP Right Cessation
- 1984-11-23 DK DK558884A patent/DK558884A/da not_active Application Discontinuation
- 1984-11-24 KR KR1019840007377A patent/KR880001763B1/ko not_active Expired
- 1984-11-24 JP JP59247046A patent/JPS60133894A/ja active Pending
-
1986
- 1986-09-18 US US06/910,246 patent/US4782046A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0144019A3 (en) | 1986-10-08 |
| ES8603578A1 (es) | 1985-12-16 |
| FI79555B (fi) | 1989-09-29 |
| IE57688B1 (en) | 1993-02-24 |
| NZ210300A (en) | 1989-06-28 |
| AU573768B2 (en) | 1988-06-23 |
| JPS60133894A (ja) | 1985-07-17 |
| IL73605A0 (en) | 1985-02-28 |
| CA1270219A (en) | 1990-06-12 |
| CS249531B2 (en) | 1987-03-12 |
| KR880001763B1 (ko) | 1988-09-12 |
| EP0144019A2 (de) | 1985-06-12 |
| ATE53607T1 (de) | 1990-06-15 |
| NO161573C (no) | 1989-08-30 |
| EP0144019B1 (de) | 1990-06-13 |
| HUT36180A (en) | 1985-08-28 |
| NO844493L (no) | 1985-05-28 |
| DK558884A (da) | 1985-05-26 |
| DE3482479D1 (de) | 1990-07-19 |
| FI79555C (fi) | 1990-01-10 |
| FI844597A0 (fi) | 1984-11-22 |
| ZA849025B (en) | 1985-07-31 |
| KR850004983A (ko) | 1985-08-19 |
| HU192617B (en) | 1987-06-29 |
| AU3580684A (en) | 1985-05-30 |
| IE843003L (en) | 1985-05-25 |
| NO161573B (no) | 1989-05-22 |
| FI844597L (fi) | 1985-05-26 |
| US4782046A (en) | 1988-11-01 |
| DK558884D0 (da) | 1984-11-23 |
| ES537938A0 (es) | 1985-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL73605A (en) | Bacterial preparation and purification of narrow-range high-molecular-weight hyaluronic acid and sterile compositions containing it | |
| AU568067B2 (en) | Oligonucleotide therapeutic agent and methods of making same | |
| ES8507535A1 (es) | Acidos 7-amino-1-ciclopropil-6,8-difluor-1,4-dihidro-4-oxo-quinolincarboxilicos | |
| IL112585A (en) | N-terminally chemically modified G-CSF and analogs process for their preparation and pharmaceutical compositions containing them | |
| BR8205954A (pt) | Sequencia de dna,plasmidio recombinante,cultura bacteriana e microorganismos | |
| DE3689196D1 (de) | Verfahren zur Herstellung von Amiden unter Verwendung von Mikroorganismen. | |
| IL84911A (en) | Processes for the preparation of collagen products, and pharmaceutical compositions containing the same | |
| HUT49379A (en) | Process for producing demannosyl teichoplanin derivatives and pharmaceutical compositions comprising same | |
| EP1449849A3 (de) | Protease-resistentes Thrombomodulinanalog | |
| AU6745287A (en) | Dna sequences coding for proteins having the biological activity of husi-type i inhibitors, biotechnological methods for the preparation of said proteins and pharmaceutical compositions containing said proteins | |
| YU45708B (sh) | Postopek za pripravo l-karnitina na mikrobiološki način in mikroorganizmi uporabni za ta postopek | |
| FR2607517B2 (fr) | Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu | |
| AU1413788A (en) | Dihydropyridinamides process for their preparation, and their use in medicaments | |
| HUT35013A (en) | Process for producing active ingredents of pharmaceutical compositions of immunoregulating activity | |
| HUT60326A (en) | Process for producing lesion-induced dna deriving from solanum tuberosum | |
| EP0193883A3 (en) | Well forming apparatus | |
| MY102317A (en) | Novel microorganisms and a method for production of glutamic acid using the same. | |
| ES2034327T3 (es) | Agentes antiparasitarios, procedimiento de obtencion de estos productos y composiciones antiparasitarias, en particular antimalaricas, conteniendo dichos productos. | |
| GB9305158D0 (en) | Expression of heterologous proteins in lactic acid bacteria | |
| IE881914L (en) | Promoters for the expression of foreign dna in¹methylotrophic bacteria |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| EXP | Patent expired |