DE3438830A1 - Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung - Google Patents

Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung

Info

Publication number
DE3438830A1
DE3438830A1 DE19843438830 DE3438830A DE3438830A1 DE 3438830 A1 DE3438830 A1 DE 3438830A1 DE 19843438830 DE19843438830 DE 19843438830 DE 3438830 A DE3438830 A DE 3438830A DE 3438830 A1 DE3438830 A1 DE 3438830A1
Authority
DE
Germany
Prior art keywords
nifedipine
liquid
mixture
polyethylene glycols
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19843438830
Other languages
German (de)
English (en)
Other versions
DE3438830C2 (OSRAM
Inventor
Hans Dipl Chem Dr Koehne
Wolfgang Lahr
Hein Uwe Dr Schmersahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Rentschler & Co Medizin Kg 88471 Lauphe GmbH
Original Assignee
Dr Rentschler Arzneimittel GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6248592&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3438830(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dr Rentschler Arzneimittel GmbH and Co KG filed Critical Dr Rentschler Arzneimittel GmbH and Co KG
Priority to DE19843438830 priority Critical patent/DE3438830A1/de
Priority to EP85109688A priority patent/EP0182007B1/de
Priority to DE8585109688T priority patent/DE3580154D1/de
Priority to AT85109688T priority patent/ATE57470T1/de
Priority to JP60206703A priority patent/JPS61100528A/ja
Priority to US06/783,862 priority patent/US4894235A/en
Publication of DE3438830A1 publication Critical patent/DE3438830A1/de
Application granted granted Critical
Publication of DE3438830C2 publication Critical patent/DE3438830C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
DE19843438830 1984-10-23 1984-10-23 Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung Granted DE3438830A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE19843438830 DE3438830A1 (de) 1984-10-23 1984-10-23 Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung
EP85109688A EP0182007B1 (de) 1984-10-23 1985-08-01 Nifedipin enthaltende Darreichungsform und Verfahren zu ihrer Herstellung
DE8585109688T DE3580154D1 (de) 1984-10-23 1985-08-01 Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung.
AT85109688T ATE57470T1 (de) 1984-10-23 1985-08-01 Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung.
JP60206703A JPS61100528A (ja) 1984-10-23 1985-09-20 ニフエジピン含有薬剤組成物とその製造方法
US06/783,862 US4894235A (en) 1984-10-23 1985-10-03 Nifedipine-containing form of administration and method for its production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843438830 DE3438830A1 (de) 1984-10-23 1984-10-23 Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
DE3438830A1 true DE3438830A1 (de) 1986-04-30
DE3438830C2 DE3438830C2 (OSRAM) 1991-04-11

Family

ID=6248592

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19843438830 Granted DE3438830A1 (de) 1984-10-23 1984-10-23 Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung
DE8585109688T Expired - Lifetime DE3580154D1 (de) 1984-10-23 1985-08-01 Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8585109688T Expired - Lifetime DE3580154D1 (de) 1984-10-23 1985-08-01 Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung.

Country Status (5)

Country Link
US (1) US4894235A (OSRAM)
EP (1) EP0182007B1 (OSRAM)
JP (1) JPS61100528A (OSRAM)
AT (1) ATE57470T1 (OSRAM)
DE (2) DE3438830A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525355A (en) * 1993-09-14 1996-06-11 Euro-Celtique, S.A. Laxative compositions

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GB8522453D0 (en) * 1985-09-11 1985-10-16 Lilly Industries Ltd Chewable capsules
IT1187751B (it) * 1985-10-15 1987-12-23 Eurand Spa Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute
DE3635522A1 (de) * 1986-10-18 1988-04-28 Euro Celtique Sa Pharmazeutische zusammensetzung
EP0272336B1 (de) * 1986-12-18 1991-10-23 Kurt H. Prof. Dr. Bauer Gegenüber Lichteinfluss stabilisiertes Nifedipin-Konzentrat und Verfahren zu seiner Herstellung
HU203041B (en) * 1989-03-14 1991-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin
DE4015794A1 (de) * 1989-05-16 1990-11-29 Puetter Medice Chem Pharm Pharmazeutische zubereitung
CA2056032A1 (en) * 1990-11-29 1992-05-30 Minoru Aoki Hard capsule preparation
US5145859A (en) * 1991-03-20 1992-09-08 Case Western Reserve University Methods of treating interstitial cystitis and urethral syndrome
GB9200607D0 (en) * 1992-01-13 1992-03-11 Ethical Pharma Ltd Pharmaceutical compositions containing nifedipine and process for the preparation thereof
US5281420A (en) * 1992-05-19 1994-01-25 The Procter & Gamble Company Solid dispersion compositions of tebufelone
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
US5773025A (en) * 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US6726930B1 (en) * 1993-09-09 2004-04-27 Penwest Pharmaceuticals Co. Sustained release heterodisperse hydrogel systems for insoluble drugs
ATE417604T1 (de) 1996-07-08 2009-01-15 Penwest Pharmaceuticals Co Matrix mit verzögerter freisetzung für hochdosierte unlösliche arzneistoffe
US6056977A (en) 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
US6537504B1 (en) 1998-04-06 2003-03-25 Li Young Method and apparatus for concurrent and sequential multi-step reactions for producing a plurality of different chemical compounds
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ATE480226T1 (de) * 2001-06-22 2010-09-15 Bend Res Inc Pharmazeutische zusammensetzung enthaltend schwer lösliche und säureempfindliche arzneistoffe und neutralisierte anionische polymere
ES2333645T3 (es) * 2001-06-22 2010-02-25 Bend Research, Inc. Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros.
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DE2209526A1 (de) * 1972-02-29 1973-09-06 Bayer Ag Coronarmittel in spezieller form sowie verfahren zu seiner herstellung
GB1456618A (en) * 1974-01-09 1976-11-24 Bayer Ag Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided form
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.

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GB1456618A (en) * 1974-01-09 1976-11-24 Bayer Ag Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided form
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Non-Patent Citations (1)

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Title
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525355A (en) * 1993-09-14 1996-06-11 Euro-Celtique, S.A. Laxative compositions

Also Published As

Publication number Publication date
EP0182007A3 (en) 1987-04-22
DE3580154D1 (de) 1990-11-22
DE3438830C2 (OSRAM) 1991-04-11
US4894235A (en) 1990-01-16
EP0182007B1 (de) 1990-10-17
ATE57470T1 (de) 1990-11-15
JPH0579651B2 (OSRAM) 1993-11-04
JPS61100528A (ja) 1986-05-19
EP0182007A2 (de) 1986-05-28

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