DE3262698D1 - Antifibrinolytically active compounds - Google Patents

Antifibrinolytically active compounds

Info

Publication number
DE3262698D1
DE3262698D1 DE8282850206T DE3262698T DE3262698D1 DE 3262698 D1 DE3262698 D1 DE 3262698D1 DE 8282850206 T DE8282850206 T DE 8282850206T DE 3262698 T DE3262698 T DE 3262698T DE 3262698 D1 DE3262698 D1 DE 3262698D1
Authority
DE
Germany
Prior art keywords
carbon atoms
image
groups containing
active compounds
alkyl groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282850206T
Other languages
German (de)
English (en)
Inventor
Carl Magnus Erik Svahn
Ferenc Merenyi
Lennart Elof Karlsson
Gunnar Hanshoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Kabi Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia AB filed Critical Kabi Pharmacia AB
Application granted granted Critical
Publication of DE3262698D1 publication Critical patent/DE3262698D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/89—Benzo [c] furans; Hydrogenated benzo [c] furans with two oxygen atoms directly attached in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)
  • Compression Or Coding Systems Of Tv Signals (AREA)
  • Lubricants (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE8282850206T 1981-11-17 1982-10-21 Antifibrinolytically active compounds Expired DE3262698D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8106818 1981-11-17

Publications (1)

Publication Number Publication Date
DE3262698D1 true DE3262698D1 (en) 1985-04-25

Family

ID=20345052

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282850206T Expired DE3262698D1 (en) 1981-11-17 1982-10-21 Antifibrinolytically active compounds

Country Status (10)

Country Link
US (1) US4483867A (en:Method)
EP (1) EP0079872B1 (en:Method)
JP (1) JPS5892611A (en:Method)
AT (1) ATE12224T1 (en:Method)
CA (1) CA1202637A (en:Method)
DE (1) DE3262698D1 (en:Method)
DK (1) DK159148C (en:Method)
FI (1) FI73969C (en:Method)
HK (1) HK49688A (en:Method)
NO (1) NO160778C (en:Method)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67445A (en) * 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
DE3580406D1 (de) * 1984-07-11 1990-12-13 Merck Patent Gmbh Fluessigkristall-phase.
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
JPH0725724B2 (ja) * 1992-06-23 1995-03-22 財団法人生産開発科学研究所 トラネキサム酸亜鉛化合物
SE9300013L (sv) * 1992-12-30 1994-07-01 Kabi Pharmacia Ab Nytt förfarande och mellanprodukter för framställning av pro- läkemedel
US5720948A (en) * 1995-11-07 1998-02-24 Helene Curtis Inc. Non-ionic surfactant emulsion vehicles and their use for deposition of drug into and across skin
US6110970A (en) * 1997-03-11 2000-08-29 Beacon Laboratories, Inc. Nitrogen-containing oxyalkylene esters and uses thereof
DE19943635A1 (de) * 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US20090214644A1 (en) * 2003-07-31 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations with reduced adverse effects
US20050025825A1 (en) * 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
PT1660440E (pt) 2003-08-20 2012-05-15 Xenoport Inc Pró-fármacos de aciloxialquilcarbamato, métodos de síntese e utilização
JP4927563B2 (ja) 2003-12-30 2012-05-09 ゼノポート，インコーポレイティド アシルオキシアルキルカルバメートプロドラッグ及び中間体の合成
US20050244495A1 (en) 2004-03-04 2005-11-03 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US8022106B2 (en) * 2004-03-04 2011-09-20 Ferring B.V. Tranexamic acid formulations
US20090215898A1 (en) * 2004-03-04 2009-08-27 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
US7947739B2 (en) 2004-03-04 2011-05-24 Ferring B.V. Tranexamic acid formulations
DE602006014694D1 (de) * 2005-06-20 2010-07-15 Xenoport Inc Acyloxyalkylcarbamat-prodrugs von tranexansäure und anwendung
US20100280117A1 (en) * 2009-04-30 2010-11-04 Xanodyne Pharmaceuticals, Inc. Menorrhagia Instrument and Method for the Treatment of Menstrual Bleeding Disorders
US20110060040A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
WO2011091164A1 (en) * 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
AU2013292076B2 (en) * 2012-07-18 2017-02-23 Proyecto De Biomedicina Cima, S.L. New antifibrinolytic compounds
WO2018211876A1 (ja) 2017-05-17 2018-11-22 国立研究開発法人農業・食品産業技術総合研究機構 ビトリゲル膜乾燥体の製造方法及び製造装置
CN108976146B (zh) * 2017-05-31 2020-11-27 首都医科大学 氨基正己酰氨甲环酰氨基正己酰芳香氨基酸，其合成，活性和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB949512A (en) * 1961-05-15 1964-02-12 Mitsubishi Chem Ind Pharmaceutical compositions containing 4-(aminomethyl)-cyclohexane-1-carboxylic acid
US3939200A (en) * 1966-01-06 1976-02-17 Rohm And Haas Company Aliphatic acyl-containing amine hydrochlorides
CA929942A (en) * 1968-10-14 1973-07-10 Okano Atsuji Esters and their production
US3995055A (en) * 1975-02-28 1976-11-30 Daiichi Seiyaku Co., Ltd. Method for treating peptic ulcers
GB1580783A (en) * 1978-04-27 1980-12-03 Daiichi Seiyaku Co Process for producing 4' - (2 - carboxyethyl)phenyl trans - 4 - aminomethyl-cyclohexanecarboxylate or the acid-additsalts thereof and intermediates for producing the same

Also Published As

Publication number Publication date
HK49688A (en) 1988-07-15
EP0079872B1 (en) 1985-03-20
FI73969B (fi) 1987-08-31
NO160778B (no) 1989-02-20
JPH0326183B2 (en:Method) 1991-04-10
ATE12224T1 (de) 1985-04-15
US4483867A (en) 1984-11-20
JPS5892611A (ja) 1983-06-02
FI73969C (fi) 1987-12-10
DK509382A (da) 1983-05-18
EP0079872A1 (en) 1983-05-25
NO160778C (no) 1989-05-31
NO823836L (no) 1983-05-18
DK159148B (da) 1990-09-10
CA1202637A (en) 1986-04-01
FI823923L (fi) 1983-05-18
FI823923A0 (fi) 1982-11-16
DK159148C (da) 1991-02-11

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