DE3248900C2 - - Google Patents

Info

Publication number
DE3248900C2
DE3248900C2 DE3248900T DE3248900T DE3248900C2 DE 3248900 C2 DE3248900 C2 DE 3248900C2 DE 3248900 T DE3248900 T DE 3248900T DE 3248900 T DE3248900 T DE 3248900T DE 3248900 C2 DE3248900 C2 DE 3248900C2
Authority
DE
Germany
Prior art keywords
hexafluoro
vitamin
calcium
acoet
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3248900T
Other languages
German (de)
English (en)
Other versions
DE3248900T1 (de
Inventor
Hector F Deluca
Yoko Tanaka
Nobuo Ikekawa
Yoshiro Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of DE3248900T1 publication Critical patent/DE3248900T1/de
Application granted granted Critical
Publication of DE3248900C2 publication Critical patent/DE3248900C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE823248900T 1981-07-27 1982-07-06 26,26,26,27,27,27-hexafluoro-1(alpha),25-dihydroxycholecalciferol und ein verfahren zu dessen herstellung Granted DE3248900T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/286,790 US4358406A (en) 1981-07-27 1981-07-27 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
PCT/US1982/000909 WO1983000335A1 (en) 1981-07-27 1982-07-06 26,26,26,27,27,27-HEXAFLUORO-1'alpha',25-DIHYDROXYCHOLECALCIFEROL AND PROCESS FOR PREPARING SAME

Publications (2)

Publication Number Publication Date
DE3248900T1 DE3248900T1 (de) 1983-07-07
DE3248900C2 true DE3248900C2 (US06653308-20031125-C00197.png) 1990-12-13

Family

ID=23100174

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3250034A Expired - Lifetime DE3250034C2 (US06653308-20031125-C00197.png) 1981-07-27 1982-07-06
DE823248900T Granted DE3248900T1 (de) 1981-07-27 1982-07-06 26,26,26,27,27,27-hexafluoro-1(alpha),25-dihydroxycholecalciferol und ein verfahren zu dessen herstellung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3250034A Expired - Lifetime DE3250034C2 (US06653308-20031125-C00197.png) 1981-07-27 1982-07-06

Country Status (14)

Country Link
US (1) US4358406A (US06653308-20031125-C00197.png)
JP (1) JPS58501176A (US06653308-20031125-C00197.png)
AU (2) AU552210B2 (US06653308-20031125-C00197.png)
BE (1) BE893943A (US06653308-20031125-C00197.png)
CH (2) CH655307A5 (US06653308-20031125-C00197.png)
DE (2) DE3250034C2 (US06653308-20031125-C00197.png)
DK (2) DK162282C (US06653308-20031125-C00197.png)
FR (1) FR2510566B1 (US06653308-20031125-C00197.png)
GB (2) GB2102806B (US06653308-20031125-C00197.png)
IE (2) IE54370B1 (US06653308-20031125-C00197.png)
IL (5) IL66351A (US06653308-20031125-C00197.png)
IT (1) IT1157309B (US06653308-20031125-C00197.png)
NL (1) NL8220265A (US06653308-20031125-C00197.png)
WO (1) WO1983000335A1 (US06653308-20031125-C00197.png)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4411833A (en) * 1982-05-26 1983-10-25 Wisconsin Alumni Research Foundation Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US4448726A (en) * 1983-05-11 1984-05-15 Wisconsin Alumni Research Foundation Ring A- and triene-modified vitamin D compounds
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
ZA859138B (en) * 1984-12-19 1986-08-27 Hoffmann La Roche Cholecalciferol derivatives
EP0205025A1 (en) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorine derivatives of vitamin D3 and cell differentiation-inducing agents containing the same as an active ingredient
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
CA1314872C (en) 1986-04-25 1993-03-23 Toshio Nishizawa Fluorine derivatives of vitamin d _and process for producing the same
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
AU5185790A (en) * 1989-02-16 1990-09-05 University Of Georgia Research Foundation, Inc., The Treatment of tibial dyschondroplasia
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
DE69233250T2 (de) * 1991-05-06 2004-08-26 The Procter & Gamble Company, Cincinnati Kombinationen aus calzium und vitamin d
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5726330A (en) * 1992-10-16 1998-03-10 Chugai Seiyaku Kabushiki Kaisha Highly crystalline 22-oxavitamin D derivatives
BR9405735A (pt) * 1993-02-19 1995-12-05 Wisconsin Alumni Res Found Uso de 26,26,26,27,27,27-hexaflúor-1-alfa 25-dihidróxi colecalciferol para o tratamento de distúrbios do metabolismo do cálcio
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
IL139241A0 (en) * 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
US6080879A (en) * 1998-05-19 2000-06-27 Tetrionics, Inc. Hexafluoro-vitamin synthesis and crystallization method, solvent and product
US7718637B2 (en) * 2007-12-28 2010-05-18 Wisconsin Alumni Research Foundation (20S)-23,23-difluoro-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs
MX339746B (es) 2009-01-27 2016-06-08 Berg Llc Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia.
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
ES2536256B2 (es) * 2013-11-20 2016-02-01 Universidade De Santiago De Compostela Análogos de vitamina d con interés farmacéutico
CN111960938B (zh) * 2020-08-20 2022-06-17 甘肃皓天医药科技有限责任公司 用于制备氟骨化醇的中间体的制备方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
US4199518A (en) * 1978-03-30 1980-04-22 Diamond Shamrock Corporation 1α,3β-Dihydroxy-steroid-5-enes from 1α,2α-epoxy-steroid-4,6-dien-3-ones
PH16989A (en) * 1978-11-07 1984-05-04 Res Inst Medicine Chem Process for the preparation of 1-hydroxylated vitamin d compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226788A (en) * 1979-03-28 1980-10-07 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol

Also Published As

Publication number Publication date
DK165695C (da) 1993-06-07
IT8222574A0 (it) 1982-07-26
DK554084A (da) 1984-11-22
DE3248900T1 (de) 1983-07-07
DK162282B (da) 1991-10-07
AU6056086A (en) 1986-12-18
AU586267B2 (en) 1989-07-06
DK137083D0 (da) 1983-03-25
NL8220265A (nl) 1983-06-01
IE54369B1 (en) 1989-09-13
JPH0348903B2 (US06653308-20031125-C00197.png) 1991-07-25
GB2102806A (en) 1983-02-09
DK162282C (da) 1992-03-16
IE821797L (en) 1983-01-27
JPS58501176A (ja) 1983-07-21
DE3250034C2 (US06653308-20031125-C00197.png) 1991-02-28
GB2118556B (en) 1985-02-27
IL66351A0 (en) 1982-11-30
BE893943A (fr) 1982-11-16
IE891226L (en) 1983-01-27
AU8760582A (en) 1983-03-17
US4358406A (en) 1982-11-09
CH656134A5 (de) 1986-06-13
AU552210B2 (en) 1986-05-22
DK137083A (da) 1983-03-25
GB2118556A (en) 1983-11-02
IL76090A (en) 1987-12-31
GB2102806B (en) 1985-02-27
DK165695B (da) 1993-01-04
DK554084D0 (da) 1984-11-22
IL66351A (en) 1987-12-31
IL76090A0 (en) 1985-12-31
CH655307A5 (de) 1986-04-15
GB8311517D0 (en) 1983-06-02
FR2510566A1 (fr) 1983-02-04
IL76091A (en) 1987-12-31
FR2510566B1 (fr) 1985-06-28
IE54370B1 (en) 1989-09-13
WO1983000335A1 (en) 1983-02-03
IL76091A0 (en) 1985-12-31
IT1157309B (it) 1987-02-11

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