DE3239817A1 - Neue glycerinderivate zur synthese von phospholipiden - Google Patents

Neue glycerinderivate zur synthese von phospholipiden

Info

Publication number
DE3239817A1
DE3239817A1 DE19823239817 DE3239817A DE3239817A1 DE 3239817 A1 DE3239817 A1 DE 3239817A1 DE 19823239817 DE19823239817 DE 19823239817 DE 3239817 A DE3239817 A DE 3239817A DE 3239817 A1 DE3239817 A1 DE 3239817A1
Authority
DE
Germany
Prior art keywords
alkyl
carbon atoms
benzyl
group
allyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19823239817
Other languages
German (de)
English (en)
Inventor
Hansjörg Prof. Dr. 3406 Bovenden Eibl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to DE19823239817 priority Critical patent/DE3239817A1/de
Priority to PCT/DE1983/000124 priority patent/WO1984000367A1/de
Priority to DE8383106626T priority patent/DE3373906D1/de
Priority to AT83106626T priority patent/ATE30030T1/de
Priority to JP58502270A priority patent/JPS59501211A/ja
Priority to EP83902086A priority patent/EP0112872A1/de
Priority to EP83106626A priority patent/EP0099068B1/de
Publication of DE3239817A1 publication Critical patent/DE3239817A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE19823239817 1982-07-06 1982-10-27 Neue glycerinderivate zur synthese von phospholipiden Withdrawn DE3239817A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19823239817 DE3239817A1 (de) 1982-07-06 1982-10-27 Neue glycerinderivate zur synthese von phospholipiden
PCT/DE1983/000124 WO1984000367A1 (fr) 1982-07-06 1983-07-06 Nouveaux derives de la glycerine pour la synthese de phospholipides
DE8383106626T DE3373906D1 (en) 1982-07-06 1983-07-06 Glycerine derivatives for phospholipids synthesis
AT83106626T ATE30030T1 (de) 1982-07-06 1983-07-06 Neue glycerinderivate zur synthese von phospholipiden.
JP58502270A JPS59501211A (ja) 1982-07-06 1983-07-06 燐脂質合成用の新規グリセリン誘導体
EP83902086A EP0112872A1 (de) 1982-07-06 1983-07-06 Neue glycerinderivate zur synthese von phospholipiden
EP83106626A EP0099068B1 (de) 1982-07-06 1983-07-06 Neue Glycerinderivate zur Synthese von Phospholipiden

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3225213 1982-07-06
DE19823239817 DE3239817A1 (de) 1982-07-06 1982-10-27 Neue glycerinderivate zur synthese von phospholipiden

Publications (1)

Publication Number Publication Date
DE3239817A1 true DE3239817A1 (de) 1984-01-12

Family

ID=25802858

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19823239817 Withdrawn DE3239817A1 (de) 1982-07-06 1982-10-27 Neue glycerinderivate zur synthese von phospholipiden
DE8383106626T Expired DE3373906D1 (en) 1982-07-06 1983-07-06 Glycerine derivatives for phospholipids synthesis

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8383106626T Expired DE3373906D1 (en) 1982-07-06 1983-07-06 Glycerine derivatives for phospholipids synthesis

Country Status (5)

Country Link
EP (2) EP0112872A1 (enExample)
JP (1) JPS59501211A (enExample)
AT (1) ATE30030T1 (enExample)
DE (2) DE3239817A1 (enExample)
WO (1) WO1984000367A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE452466B (sv) * 1983-03-24 1987-11-30 Paul Gunnar Embring Blandning av vattenlosliga 3-fosfatidylestrar och kolin, sett att framstella denna och ett rektalt administrerbart preparat for tomning av grovtarm
CA1260393A (en) * 1984-10-16 1989-09-26 Lajos Tarcsay Liposomes of synthetic lipids
EP0225129B1 (en) * 1985-11-29 1989-05-24 Takeda Chemical Industries, Ltd. Phospholipid derivatives, their production and use
JPH01203330A (ja) * 1988-02-05 1989-08-16 Rikagaku Kenkyusho 制癌剤
JPH01203331A (ja) * 1988-02-05 1989-08-16 Rikagaku Kenkyusho 制癌剤
IT1239474B (it) * 1989-10-27 1993-11-02 Depha Team Srl Composizioni farmaceutiche a base di l-alfa-glicerofosforil-d-myo- inositolo o suoi sali alcalini o alcalino-terrosi per la terapia delleneuropatie periferiche di origine dismetabolica o tossica, e delle cerebropatie su base organica e funzionale
IT1244546B (it) * 1991-02-01 1994-07-15 Mediolanum Farmaceutici Spa Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica
DE4208527A1 (de) * 1992-03-17 1993-09-23 Max Planck Gesellschaft Liposomen mit negativer ueberschussladung
US5651981A (en) * 1994-03-29 1997-07-29 Northwestern University Cationic phospholipids for transfection
JPH10506093A (ja) * 1994-06-22 1998-06-16 メガバイオス・コーポレイション カチオン性両親媒性化合物
JPH10318539A (ja) * 1997-05-20 1998-12-04 Tokai:Kk 液体燃料用燃焼器具
WO2008074487A2 (en) * 2006-12-19 2008-06-26 Novosom Ag Lipids and lipid assemblies comprising transfection enhancer elements
US8420848B2 (en) * 2009-01-09 2013-04-16 Sigma-Aldrich Co. Llc Process for the synthesis of beta glycerol phosphate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2009342C3 (de) * 1970-02-27 1980-12-18 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Verwendung von Glycerin-alkyläther-(l)-phosphorsäure-(3)-monocholinestern
DE2619686C2 (de) * 1976-05-04 1986-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verwendung eines Lysolecithins zur Tumorbehandlung
DE3011738A1 (de) * 1980-03-26 1981-10-01 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue glycerin-3-phosphorsaeurehalogenalkylester
US4329302A (en) * 1980-06-27 1982-05-11 Board Of Regents, The University Of Texas System Synthetic phosphoglycerides possessing platelet activating properties
US4493832A (en) * 1981-07-03 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same
DE3130867A1 (de) * 1981-08-04 1983-02-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Zwischenprodukte zur herstellung von glycerinderivaten
DE3141472A1 (de) * 1981-10-20 1983-05-05 A. Nattermann & Cie GmbH, 5000 Köln O-acyl-o-alkyl-glycero-2-phosphocholine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4562179A (en) * 1982-04-19 1985-12-31 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, and pharmaceutical composition of the same
US4585762A (en) * 1982-07-30 1986-04-29 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same

Also Published As

Publication number Publication date
JPH041759B2 (enExample) 1992-01-14
ATE30030T1 (de) 1987-10-15
EP0099068A1 (de) 1984-01-25
DE3373906D1 (en) 1987-11-05
EP0099068B1 (de) 1987-09-30
EP0112872A1 (de) 1984-07-11
WO1984000367A1 (fr) 1984-02-02
JPS59501211A (ja) 1984-07-12

Similar Documents

Publication Publication Date Title
EP0116566B1 (de) Neue d-mannit-abkömmlinge als vorprodukte zur synthese von phospholipiden
DE2820893C2 (de) Strukturanaloga von natürlichen Phospholipiden und Verfahren zur Herstellung dieser Verbindungen
JP3218313B2 (ja) エルシル−、ブラシジル−およびネルボニル誘導体、その製造方法、それを含有する腫瘍および原虫によるおよび菌類による疾患に対抗するための医薬および自己免疫疾患および骨髄障害の治療のための医薬およびその医薬の製造方法
DD299067A5 (de) Verfahren zur herstellung von zwischenprodukten fuer epipodophyllotoxinglucosid-4'-phosphat-derivate
DE3239817A1 (de) Neue glycerinderivate zur synthese von phospholipiden
WO1987003478A2 (en) Medicaments
EP0036583A2 (de) Glycerin-3-phosphorsäurehalogenalkylester und Verfahren zu ihrer Herstellung und Weiterverarbeitung
AT398423B (de) Glyzerinderivate, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
EP0072531A1 (de) Neue Cyclophosphamid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0112871B1 (de) Derivate des n.n-bis(2-chlor-äthyl)-phosphorsäureamids
EP0229128B1 (de) Glycero-3(2)-phospho-l-serinderivate und diese enthaltende pharmazeutischen präparate
EP0579939B1 (de) Neue Phospholipidderivate
DE60116081T2 (de) Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel
EP0072940B1 (de) Zwischenprodukte zur Herstellung von Glycerinderivaten
EP0391850A2 (de) Ungesättigte Aminodicarbonsäurederivate
AT393505B (de) Arzneimittel, welche alkylphosphoamine in kombination mit einem alkylglycerin enthalten
EP0663918A1 (de) Enantiomerenreine phosphorsaureestern als phospholipase a2-inhibitoren
DE2331081A1 (de) Neue cyclopentanderivate und verfahren zu ihrer herstellung
EP0248858B1 (de) Neue phosphorverbindungen und diese enthaltende arzneimittel
DD252541A5 (de) Verfahren zur herstellung von phosphoverbindungen enthaltenden arzneimitteln fuer die tumorbehandlung
DE19832238A1 (de) Fluorierte Etherlipide, Verfahren zu deren Herstellung und Verwendung als Arzneimittel
DE4133080A1 (de) Plasmalogenanaloga
DD238979A1 (de) Verfahren zur herstellung von o-alkylglycerophosphoserin-analogen
DD279677A1 (de) Verfahren zur herstellung neuer, hochwirksamer antagonisten des plaettchen-aktivierenden faktors mit phospholipidstruktur
DE2011092A1 (de) Herstellung von Phosphonsäuren

Legal Events

Date Code Title Description
8141 Disposal/no request for examination