DE3229674A1 - Verfahren zur herstellung von humaninsulin, threoninderivaten, salzen oder komplexen davon - Google Patents

Verfahren zur herstellung von humaninsulin, threoninderivaten, salzen oder komplexen davon

Info

Publication number
DE3229674A1
DE3229674A1 DE19823229674 DE3229674A DE3229674A1 DE 3229674 A1 DE3229674 A1 DE 3229674A1 DE 19823229674 DE19823229674 DE 19823229674 DE 3229674 A DE3229674 A DE 3229674A DE 3229674 A1 DE3229674 A1 DE 3229674A1
Authority
DE
Germany
Prior art keywords
acid
formula
reaction mixture
insulin
threonine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19823229674
Other languages
German (de)
English (en)
Other versions
DE3229674C2 (enExample
Inventor
Jan 730 Herlev Markussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri AS filed Critical Novo Industri AS
Publication of DE3229674A1 publication Critical patent/DE3229674A1/de
Application granted granted Critical
Publication of DE3229674C2 publication Critical patent/DE3229674C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE19823229674 1981-08-10 1982-08-09 Verfahren zur herstellung von humaninsulin, threoninderivaten, salzen oder komplexen davon Granted DE3229674A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK353781A DK353781A (da) 1981-08-10 1981-08-10 Fremgangsmaade til fremstilling af insulinderivater

Publications (2)

Publication Number Publication Date
DE3229674A1 true DE3229674A1 (de) 1983-02-17
DE3229674C2 DE3229674C2 (enExample) 1992-07-09

Family

ID=8124014

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19823229674 Granted DE3229674A1 (de) 1981-08-10 1982-08-09 Verfahren zur herstellung von humaninsulin, threoninderivaten, salzen oder komplexen davon

Country Status (20)

Country Link
US (1) US4489159A (enExample)
JP (1) JPS5836399A (enExample)
AT (1) AT374683B (enExample)
AU (1) AU549066B2 (enExample)
BE (1) BE894070A (enExample)
CA (1) CA1174973A (enExample)
CH (1) CH661746A5 (enExample)
DE (1) DE3229674A1 (enExample)
DK (1) DK353781A (enExample)
ES (1) ES8306181A1 (enExample)
FI (1) FI79142C (enExample)
FR (1) FR2511036B1 (enExample)
GB (1) GB2105342B (enExample)
GR (1) GR77999B (enExample)
IE (1) IE53712B1 (enExample)
IT (1) IT1152492B (enExample)
LU (1) LU84327A1 (enExample)
NL (1) NL182964C (enExample)
NO (1) NO157506C (enExample)
SE (1) SE451073B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776693A (en) * 1990-06-08 1998-07-07 Institut Pasteur Specific detection of the mycobacterium tuberculosis
TR200001050T2 (tr) 1997-10-24 2000-08-21 Eli Lilly And Company Çözünmez insülin bileşimleri
CO4970787A1 (es) 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
US20080085298A1 (en) * 2004-03-12 2008-04-10 Biodel, Inc. Rapid Mucosal Gel or Film Insulin Compositions
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
US7713929B2 (en) * 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
AU2007238114B2 (en) 2006-04-12 2010-10-14 Biodel, Inc. Rapid acting and long acting insulin combination formulations
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US20120123089A1 (en) * 2009-07-09 2012-05-17 Biocon Limited Preparative non-linear gradient based chromatographic method and purified products thereof
WO2011090971A2 (en) 2010-01-19 2011-07-28 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for male reproductive disorders
US10052364B2 (en) 2013-03-15 2018-08-21 The Trustees Of Columbia University In The City Of New York Osteocalcin as a treatment for cognitive disorders
US10611813B2 (en) * 2013-12-23 2020-04-07 Biocon Research Limited Method of production of human insulin methyl ester
EP3783009A1 (en) * 2017-02-10 2021-02-24 Mitsubishi Chemical Corporation Separating agent for human insulin purification and human insulin purification method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017938A1 (en) * 1979-04-13 1980-10-29 Shionogi & Co., Ltd. Process for preparing a B30-threonine insulin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
JPS55138392A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
JPS55138391A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd New synthetic method of peptide derivative
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
WO1983002772A1 (en) * 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017938A1 (en) * 1979-04-13 1980-10-29 Shionogi & Co., Ltd. Process for preparing a B30-threonine insulin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRANDENBURG, D., WOLLMER, A. (Herausgeber), Insulin Chemistry, Structure and Function of Insulin and Related Hormones, Proceedings of the Second International Insulin Symposium Aachen, Verlag de Gruyter, Berlin, 1980, S.117-123 *

Also Published As

Publication number Publication date
US4489159A (en) 1984-12-18
FI822773L (fi) 1983-02-11
FR2511036B1 (fr) 1986-08-22
FI822773A0 (fi) 1982-08-09
FI79142C (fi) 1989-11-10
NO157506B (no) 1987-12-21
LU84327A1 (de) 1983-06-07
IT8222784A1 (it) 1984-02-09
AU8697482A (en) 1983-02-17
ATA303582A (de) 1983-10-15
AU549066B2 (en) 1986-01-09
IE53712B1 (en) 1989-01-18
DK353781A (da) 1983-02-11
NL182964C (nl) 1988-06-16
NO157506C (no) 1988-03-30
ES514845A0 (es) 1983-05-01
GB2105342A (en) 1983-03-23
GB2105342B (en) 1985-06-26
DE3229674C2 (enExample) 1992-07-09
IE821911L (en) 1983-02-10
FI79142B (fi) 1989-07-31
SE451073B (sv) 1987-08-31
AT374683B (de) 1984-05-25
JPS5836399A (ja) 1983-03-03
JPH0587239B2 (enExample) 1993-12-15
CA1174973A (en) 1984-09-25
SE8204627D0 (sv) 1982-08-09
IT1152492B (it) 1986-12-31
IT8222784A0 (it) 1982-08-09
FR2511036A1 (fr) 1983-02-11
NL8203137A (nl) 1983-03-01
BE894070A (fr) 1983-02-09
SE8204627L (sv) 1983-02-11
GR77999B (enExample) 1984-09-26
NO822704L (no) 1983-02-11
ES8306181A1 (es) 1983-05-01
CH661746A5 (de) 1987-08-14

Similar Documents

Publication Publication Date Title
DE3229674A1 (de) Verfahren zur herstellung von humaninsulin, threoninderivaten, salzen oder komplexen davon
EP0142739B1 (de) Aminosäurederivate und Verfahren zu ihrer Herstellung
EP0056951B1 (de) Verfahren zur Herstellung von Humaninsulin oder dessen Derivaten aus Schweineinsulin oder dessen Derivaten
DE3104949A1 (de) Verfahren zur herstellung von threonin(pfeil hoch)b(pfeil hoch)(pfeil hoch)3(pfeil hoch)(pfeil hoch)0(pfeil hoch)-estern menschlichen insulins sowie threonin(pfeil hoch)b(pfeil hoch)(pfeil hoch)3(pfeil hoch)(pfeil hoch)0(pfeil hoch)-ester menschlichen insulins
EP0354507A2 (de) Verfahren zur Herstellung von Des-B30-Insulinen und Des-B30-Insulinderivaten
DE1963645C3 (de) Verfahren zur Herstellung von Penicillinen
DE2945497C2 (enExample)
DE2930542A1 (de) Neue insulinderivate und verfahren zu ihrer herstellung
DE2518160C2 (enExample)
DE1239692B (de) Verfahren zur Herstellung von 3-(alpha-Arylalkyl)-sydnoniminen, ihren Salzen und N-Acylderivaten
DE3150288A1 (de) Verfahren zur herstellung von n-acylcarnosin
DE69200795T2 (de) Verfahren zur Herstellung von L-Prolinederivaten.
CH616651A5 (enExample)
EP0316725A2 (de) Verfahren zur enzymatischen Peptidsynthese mit mindestens einer nicht-proteinogenen Aminsäure sowie die neuen, bei der Synthese anfallenden Peptide
DE1958383C3 (de) Leupeptine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE1670539C3 (de) Diacylthiamine und Verfahren zu deren Herstellung
DE1668876C3 (de) N-Acyl geschützte Aminosäuren und Peptide, Verfahren zu ihrer Herstellung und ihre Verwendung bei Peptidsynthesen
DE9116462U1 (de) Stabilisierte, metallionenaktivierte L-Arginase (L-Arginin Amidinohydrolase; E.C. 3.5.3.1.)
WO1991013068A1 (de) Verfahren zur herstellung von dikalium-ascorbat-2-sulfat
DE1065424B (de) Verfahren zur Herstellung von Pepfiden
DE2064113C3 (de) N,N'-Dlacylhydrazinderivate, Verfahren zur Herstellung derselben und diese enthaltende Arzneimittel
DE2242781C3 (de) Chlorphenesin-Ester des Glycins und Alanins, Verfahren zu deren Herstellung und diese Ester enthaltende Arzneimittel
DE3213501A1 (de) Verfahren zur herstellung von lysin-tryptophan-oligopeptiden und deren physiologisch annehmbaren derivaten und salzen
DE1243204B (de) Verfahren zur Herstellung von alpha-Aminosaeure-p-nitroaniliden
DE2404587A1 (de) Verfahren zur herstellung von 6-aminopenicillansaeurederivaten

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee