DE3101001A1 - Verfahren zur konzentration und reinigung des antihaemophilie-faktors oder faktor viii - Google Patents
Verfahren zur konzentration und reinigung des antihaemophilie-faktors oder faktor viiiInfo
- Publication number
- DE3101001A1 DE3101001A1 DE19813101001 DE3101001A DE3101001A1 DE 3101001 A1 DE3101001 A1 DE 3101001A1 DE 19813101001 DE19813101001 DE 19813101001 DE 3101001 A DE3101001 A DE 3101001A DE 3101001 A1 DE3101001 A1 DE 3101001A1
- Authority
- DE
- Germany
- Prior art keywords
- cryoprecipitate
- factor viii
- viii
- approx
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229960000301 factor viii Drugs 0.000 title claims description 29
- 238000000034 method Methods 0.000 title claims description 26
- 238000004140 cleaning Methods 0.000 title description 3
- 108010054218 Factor VIII Proteins 0.000 claims description 27
- 102000001690 Factor VIII Human genes 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000000108 ultra-filtration Methods 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 11
- 239000012141 concentrate Substances 0.000 claims description 11
- 238000005406 washing Methods 0.000 claims description 10
- 239000003708 ampul Substances 0.000 claims description 9
- 235000002639 sodium chloride Nutrition 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 108010049003 Fibrinogen Proteins 0.000 claims description 6
- 102000008946 Fibrinogen Human genes 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 6
- 229940012952 fibrinogen Drugs 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 108010094028 Prothrombin Proteins 0.000 claims description 4
- 102100027378 Prothrombin Human genes 0.000 claims description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 229940039716 prothrombin Drugs 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 241001146702 Candidatus Entotheonella factor Species 0.000 claims 2
- 239000000243 solution Substances 0.000 description 15
- 239000000047 product Substances 0.000 description 9
- 210000002381 plasma Anatomy 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000185 hemagglutinin Substances 0.000 description 2
- 239000008176 lyophilized powder Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- YBHYYFYQHRADCQ-UHFFFAOYSA-N 2-aminoacetic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound NCC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O YBHYYFYQHRADCQ-UHFFFAOYSA-N 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- -1 hydroxy- Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002608 ionic liquid Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/113,283 US4302445A (en) | 1980-01-18 | 1980-01-18 | Method for concentrating and purifying antihemophilic factor or factor VIII |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3101001A1 true DE3101001A1 (de) | 1981-12-03 |
Family
ID=22348567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19813101001 Ceased DE3101001A1 (de) | 1980-01-18 | 1981-01-15 | Verfahren zur konzentration und reinigung des antihaemophilie-faktors oder faktor viii |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US4302445A (en, 2012) |
| DE (1) | DE3101001A1 (en, 2012) |
| FR (1) | FR2473886A1 (en, 2012) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE13633T1 (de) * | 1981-10-12 | 1985-06-15 | Armour Pharma | Verfahren zur herstellung von hochgereinigtem antihaemophiliefaktor. |
| USRE32011E (en) * | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| DE3379030D1 (en) * | 1983-05-27 | 1989-03-02 | Miles Inc | Antihemophilic factor concentrate and process for its preparation |
| US4710381A (en) * | 1984-05-22 | 1987-12-01 | The Blood Center Of Southeastern Wisconsin | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
| US5149787A (en) * | 1984-05-22 | 1992-09-22 | The Blood Center Research Foundation | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
| US5043428A (en) * | 1984-08-31 | 1991-08-27 | Behringwerke Aktiengesellschaft | Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production |
| WO1989009784A1 (en) * | 1988-04-08 | 1989-10-19 | Commonwealth Serum Laboratories Commission | Production of heat-stable factor viii concentrate |
| JPH0719215B2 (ja) * | 1989-06-01 | 1995-03-06 | 三菱電機株式会社 | マイクロプロセッサ |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1507198A (en) * | 1974-04-12 | 1978-04-12 | Squibb & Sons Inc | Antihemophilic factor |
| DE2459291C3 (de) * | 1974-12-14 | 1981-06-04 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines antihämophiles Globulin A enthaltenden Konzentrats neben einem Prothrombin- Komplex und einer Lösung von lagerstabilen Serumproteinen |
| US4188318A (en) * | 1975-06-16 | 1980-02-12 | Edward Shanbrom | Simplified method for preparation of high yield, high purity Factor VIII concentrate |
| CA1054052A (en) * | 1976-08-14 | 1979-05-08 | Edward Shanbrom | Simplified method for preparation of high yield, high purity factor viii concentrate |
| FR2363577A1 (fr) * | 1976-09-03 | 1978-03-31 | Recherches Hematologiques | Procede simplifie pour preparer avec un rendement eleve du concentre de facteur antihemophilique pur |
| LU75741A1 (en, 2012) * | 1976-09-07 | 1977-04-28 | ||
| US4104266A (en) * | 1977-04-14 | 1978-08-01 | American National Red Cross | Method for preparation of antihemophilic factor |
| US4170639A (en) * | 1978-07-10 | 1979-10-09 | Warner-Lambert Company | Antihemophilic factor concentrate and its production |
-
1980
- 1980-01-18 US US06/113,283 patent/US4302445A/en not_active Expired - Lifetime
-
1981
- 1981-01-15 DE DE19813101001 patent/DE3101001A1/de not_active Ceased
- 1981-01-16 FR FR8100741A patent/FR2473886A1/fr active Granted
Non-Patent Citations (1)
| Title |
|---|
| Acta Medicotechnica 24.Jahrgang, Nr.1, 1976 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2473886B1 (en, 2012) | 1984-03-09 |
| US4302445A (en) | 1981-11-24 |
| FR2473886A1 (fr) | 1981-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |