DE3100365C2 - - Google Patents
Info
- Publication number
- DE3100365C2 DE3100365C2 DE3100365A DE3100365A DE3100365C2 DE 3100365 C2 DE3100365 C2 DE 3100365C2 DE 3100365 A DE3100365 A DE 3100365A DE 3100365 A DE3100365 A DE 3100365A DE 3100365 C2 DE3100365 C2 DE 3100365C2
- Authority
- DE
- Germany
- Prior art keywords
- adsorbent
- reservoir
- cation exchange
- isotope
- exchange resin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 239000003463 adsorbent Substances 0.000 claims description 34
- 229950009740 molybdenum mo-99 Drugs 0.000 claims description 28
- ZOKXTWBITQBERF-AKLPVKDBSA-N Molybdenum Mo-99 Chemical compound [99Mo] ZOKXTWBITQBERF-AKLPVKDBSA-N 0.000 claims description 27
- 239000003729 cation exchange resin Substances 0.000 claims description 14
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 13
- 238000010828 elution Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000011347 resin Substances 0.000 claims description 11
- 229920005989 resin Polymers 0.000 claims description 11
- 238000003776 cleavage reaction Methods 0.000 claims description 9
- 239000003480 eluent Substances 0.000 claims description 8
- 239000011521 glass Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 230000007017 scission Effects 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- -1 polyethylene Polymers 0.000 claims description 7
- 239000012217 radiopharmaceutical Substances 0.000 claims description 7
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 claims description 6
- 229940121896 radiopharmaceutical Drugs 0.000 claims description 6
- 230000002799 radiopharmaceutical effect Effects 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 230000002378 acidificating effect Effects 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000011152 fibreglass Substances 0.000 claims 1
- 239000000463 material Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 230000002285 radioactive effect Effects 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 238000005341 cation exchange Methods 0.000 description 5
- 239000000356 contaminant Substances 0.000 description 5
- 229910052750 molybdenum Inorganic materials 0.000 description 5
- 239000011733 molybdenum Substances 0.000 description 5
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000002504 physiological saline solution Substances 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 2
- 229910052768 actinide Inorganic materials 0.000 description 2
- 150000001255 actinides Chemical class 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000004992 fission Effects 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 239000011491 glass wool Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011045 prefiltration Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000011684 sodium molybdate Substances 0.000 description 2
- 235000015393 sodium molybdate Nutrition 0.000 description 2
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 229940056501 technetium 99m Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- 241000448280 Elates Species 0.000 description 1
- QXZQCEHVJRTSKD-UHFFFAOYSA-N OP1(=O)OCCOP(O1)=O Chemical compound OP1(=O)OCCOP(O1)=O QXZQCEHVJRTSKD-UHFFFAOYSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- ZMIGMASIKSOYAM-UHFFFAOYSA-N cerium Chemical compound [Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce] ZMIGMASIKSOYAM-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229910052593 corundum Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical class [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 238000009828 non-uniform distribution Methods 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 238000004816 paper chromatography Methods 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- VBHKTXLEJZIDJF-UHFFFAOYSA-N quinalizarin Chemical compound C1=CC(O)=C2C(=O)C3=C(O)C(O)=CC=C3C(=O)C2=C1O VBHKTXLEJZIDJF-UHFFFAOYSA-N 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 229910052959 stibnite Inorganic materials 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229910001845 yogo sapphire Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0042—Technetium
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8000125A NL8000125A (nl) | 1980-01-09 | 1980-01-09 | Werkwijze ter bereiding van een een radioisotoop bevattende vloeistof voor radiofarmaceutische toepassing en isotopengenerator geschikt om deze vloeistof te bereiden. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3100365A1 DE3100365A1 (de) | 1981-12-17 |
| DE3100365C2 true DE3100365C2 (US06373033-20020416-M00071.png) | 1990-10-31 |
Family
ID=19834646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19813100365 Granted DE3100365A1 (de) | 1980-01-09 | 1981-01-08 | Verfahren zur herstellung einer ein radioisotop enthaltenden fluessigkeit |
Country Status (16)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU541543B1 (en) * | 1984-02-24 | 1985-01-10 | Australian Atomic Energy Commission | Treatment of technetium containing solutions |
| DE4231997C1 (de) * | 1992-09-24 | 1994-01-05 | Kernforschungsz Karlsruhe | Verfahren zum Abtrennen von Spaltmolybdän |
| US7329400B2 (en) | 2002-06-19 | 2008-02-12 | Lynntech, Inc. | Generator for rhenium-188 |
| AU2003245546A1 (en) * | 2002-06-19 | 2004-01-06 | Lynntech, Inc. | Generator for 188re |
| CN101389405B (zh) * | 2004-08-30 | 2011-07-06 | 布拉科诊断公司 | 用于药剂的尤其在放射同位素发生器中使用的改进容器 |
| DE102004057225B4 (de) | 2004-11-26 | 2006-10-12 | Johannes-Gutenberg-Universität Mainz | Verfahren und Vorrichtung zur Isolierung eines chemisch und radiochemisch gereinigten 68Ga-Radionuklids und zum Markieren eines Markierungsvorläufers mit dem 68Ga-Radionuklid |
| DE102006058542A1 (de) * | 2006-12-12 | 2008-06-19 | Isotopen Technologien München AG | Säulensystem zur Herstellung einer Lösung mit hoher spezifischer Aktivität |
| AT505410B1 (de) | 2007-08-07 | 2009-01-15 | Frauscher Josef | Kolbenmaschine |
| US8699651B2 (en) * | 2009-04-15 | 2014-04-15 | Ge-Hitachi Nuclear Energy Americas Llc | Method and system for simultaneous irradiation and elution capsule |
| DE102009049108B4 (de) * | 2009-10-12 | 2016-12-08 | Johannes Gutenberg-Universität Mainz | Verfahren und Vorrichtung zur Gewinnung eines Radionuklids |
| US9240253B2 (en) * | 2010-04-07 | 2016-01-19 | Ge-Hitachi Nuclear Energy Americas Llc | Column geometry to maximize elution efficiencies for molybdenum-99 |
| RU2525127C1 (ru) * | 2012-12-27 | 2014-08-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный машиностроительный университет (МАМИ)" | Способ сорбционного извлечения молибдена |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7008953A (US06373033-20020416-M00071.png) * | 1969-06-20 | 1970-12-22 | ||
| US3749556A (en) * | 1971-08-19 | 1973-07-31 | Medi Physics Inc | Radiopharmaceutical generator kit |
| US3902849A (en) * | 1971-08-19 | 1975-09-02 | Medi Physics Inc | Radioisotope and radiopharmaceutical generators |
| NL165872C (nl) * | 1973-02-20 | 1981-05-15 | Byk Mallinckrodt Cil Bv | Isotopengenerator voor de produktie van 99m tc bevattende vloeistoffen. |
| US4001387A (en) * | 1973-07-30 | 1977-01-04 | Medi-Physics, Inc. | Process for preparing radiopharmaceuticals |
| GB1531985A (en) * | 1975-03-06 | 1978-11-15 | Radiochemical Centre Ltd | Technetium-99m |
| US4280053A (en) * | 1977-06-10 | 1981-07-21 | Australian Atomic Energy Commission | Technetium-99m generators |
| US4401646A (en) * | 1981-05-08 | 1983-08-30 | University Patents Inc. | Method and apparatus for purifying materials radiolabeled with technetium-99m |
-
1980
- 1980-01-09 NL NL8000125A patent/NL8000125A/nl not_active Application Discontinuation
-
1981
- 1981-01-08 BR BR8100111A patent/BR8100111A/pt unknown
- 1981-01-08 DE DE19813100365 patent/DE3100365A1/de active Granted
- 1981-01-09 YU YU34/81A patent/YU41756B/xx unknown
- 1981-01-09 CA CA000368191A patent/CA1185898A/en not_active Expired
- 1981-01-09 AT AT0005581A patent/AT374035B/de not_active IP Right Cessation
- 1981-01-09 GB GB8100647A patent/GB2067343B/en not_active Expired
- 1981-01-09 DK DK009781A patent/DK154370C/da not_active IP Right Cessation
- 1981-01-09 SE SE8100108A patent/SE8100108L/ not_active Application Discontinuation
- 1981-01-09 IT IT67014/81A patent/IT1143258B/it active
- 1981-01-09 BE BE0/203455A patent/BE887034A/fr not_active IP Right Cessation
- 1981-01-09 JP JP254681A patent/JPS56104250A/ja active Granted
- 1981-01-09 ES ES498419A patent/ES498419A0/es active Granted
- 1981-01-09 FR FR8100335A patent/FR2473722B1/fr not_active Expired
- 1981-01-09 CH CH137/81A patent/CH661215A5/de not_active IP Right Cessation
- 1981-01-09 AU AU66116/81A patent/AU535382B2/en not_active Ceased
-
1983
- 1983-05-30 YU YU01196/83A patent/YU119683A/xx unknown
-
1988
- 1988-01-18 SE SE8800142A patent/SE8800142D0/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| YU41756B (en) | 1987-12-31 |
| AT374035B (de) | 1984-03-12 |
| FR2473722B1 (fr) | 1985-08-16 |
| JPS56104250A (en) | 1981-08-19 |
| DK154370B (da) | 1988-11-07 |
| SE8800142L (sv) | 1988-01-18 |
| YU3481A (en) | 1983-10-31 |
| AU535382B2 (en) | 1984-03-15 |
| DK9781A (da) | 1981-07-10 |
| AU6611681A (en) | 1982-07-15 |
| ES8204212A1 (es) | 1982-04-16 |
| BE887034A (fr) | 1981-05-04 |
| ES498419A0 (es) | 1982-04-16 |
| ATA5581A (de) | 1983-07-15 |
| JPH0119102B2 (US06373033-20020416-M00071.png) | 1989-04-10 |
| SE8100108L (sv) | 1981-07-10 |
| BR8100111A (pt) | 1981-07-21 |
| GB2067343A (en) | 1981-07-22 |
| YU119683A (en) | 1985-04-30 |
| DE3100365A1 (de) | 1981-12-17 |
| DK154370C (da) | 1989-04-10 |
| CA1185898A (en) | 1985-04-23 |
| FR2473722A1 (fr) | 1981-07-17 |
| SE8800142D0 (sv) | 1988-01-18 |
| GB2067343B (en) | 1984-09-19 |
| IT1143258B (it) | 1986-10-22 |
| IT8167014A0 (it) | 1981-01-09 |
| CH661215A5 (de) | 1987-07-15 |
| NL8000125A (nl) | 1981-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: MALLINCKRODT DIAGNOSTICA (HOLLAND) B.V., PETTEN, N |
|
| 8110 | Request for examination paragraph 44 | ||
| 8172 | Supplementary division/partition in: |
Ref country code: DE Ref document number: 3153607 Format of ref document f/p: P |
|
| Q171 | Divided out to: |
Ref country code: DE Ref document number: 3153607 |
|
| D2 | Grant after examination | ||
| 8363 | Opposition against the patent | ||
| 8331 | Complete revocation |