DE3065190D1 - Enzyme derivatives, and their preparation - Google Patents

Enzyme derivatives, and their preparation

Info

Publication number
DE3065190D1
DE3065190D1 DE8080303797T DE3065190T DE3065190D1 DE 3065190 D1 DE3065190 D1 DE 3065190D1 DE 8080303797 T DE8080303797 T DE 8080303797T DE 3065190 T DE3065190 T DE 3065190T DE 3065190 D1 DE3065190 D1 DE 3065190D1
Authority
DE
Germany
Prior art keywords
preparation
enzyme derivatives
enzyme
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080303797T
Other languages
German (de)
English (en)
Inventor
Richard Anthony Godwin Smith
John Gordon Winchester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roberts Laboratories Inc
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3065190D1 publication Critical patent/DE3065190D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8080303797T 1979-11-05 1980-10-27 Enzyme derivatives, and their preparation Expired DE3065190D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7938279 1979-11-05

Publications (1)

Publication Number Publication Date
DE3065190D1 true DE3065190D1 (en) 1983-11-10

Family

ID=10508982

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080303797T Expired DE3065190D1 (en) 1979-11-05 1980-10-27 Enzyme derivatives, and their preparation

Country Status (18)

Country Link
US (1) US4808405A (cg-RX-API-DMAC7.html)
EP (1) EP0028489B1 (cg-RX-API-DMAC7.html)
JP (1) JPS5678590A (cg-RX-API-DMAC7.html)
AR (1) AR224786A1 (cg-RX-API-DMAC7.html)
CA (1) CA1174621A (cg-RX-API-DMAC7.html)
CS (2) CS391991A3 (cg-RX-API-DMAC7.html)
DE (1) DE3065190D1 (cg-RX-API-DMAC7.html)
DK (1) DK158994C (cg-RX-API-DMAC7.html)
ES (1) ES496586A0 (cg-RX-API-DMAC7.html)
GR (1) GR72121B (cg-RX-API-DMAC7.html)
HK (1) HK65886A (cg-RX-API-DMAC7.html)
HU (1) HU185223B (cg-RX-API-DMAC7.html)
IE (1) IE50174B1 (cg-RX-API-DMAC7.html)
IL (1) IL61408A (cg-RX-API-DMAC7.html)
NL (1) NL930029I2 (cg-RX-API-DMAC7.html)
NO (1) NO163867C (cg-RX-API-DMAC7.html)
NZ (1) NZ195469A (cg-RX-API-DMAC7.html)
ZA (1) ZA806641B (cg-RX-API-DMAC7.html)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3361610D1 (en) * 1982-04-07 1986-02-06 Beecham Group Plc Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
GB8430253D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US5231006A (en) * 1986-10-16 1993-07-27 Behringwerke Aktiengesellschaft Method for the determination of plasminogen
US5256642A (en) * 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
JPH0296536A (ja) * 1988-09-29 1990-04-09 Green Cross Corp:The プラスミノゲン乾燥製剤
AU647391B2 (en) * 1989-05-01 1994-03-24 University Of Notre Dame Du Lac, The Methods and materials for expression of human plasminogen in a eukaryotic cell system
EP0397366A1 (en) * 1989-05-09 1990-11-14 The Board Of Regents Of The University Of Oklahoma Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same
WO1990014078A1 (en) * 1989-05-17 1990-11-29 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5087572A (en) * 1989-12-01 1992-02-11 Genentech, Inc. Dna encoding human plasminogen modified at the cleavage site
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
GB8928163D0 (en) * 1989-12-13 1990-02-14 Beecham Group Plc Novel treatment
US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
US5187069A (en) * 1990-08-06 1993-02-16 Henry Ford Health System Active site labelling of plasminogen
AU1873092A (en) * 1991-04-09 1992-11-17 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
US5520912A (en) * 1993-07-02 1996-05-28 Immuno Aktiengesellschaft Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen
DE4411143C2 (de) * 1994-03-30 1996-08-01 Immuno Ag Thrombosemittel
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
US6004955A (en) * 1996-08-15 1999-12-21 Dupont Pharmaceuticals Company Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
BR9810151A (pt) 1997-06-19 2000-08-08 Du Pont Pharm Co Composto, composição farmacêutica e método para tratamento ou prevenção de uma desordem tromoboembólica
EP1203026A4 (en) * 1999-07-29 2005-03-16 Dyax Corp FRACTIONS BINDING FIBRIN
US6388073B1 (en) 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
KR20010000669A (ko) * 2000-10-12 2001-01-05 김기환 스트렙토키나제와 사람 혈청알부민의 포합체를유효성분으로 함유하는 전신투여용 지속성 혈전 용해제
US6984373B2 (en) * 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
KR100909141B1 (ko) 2001-09-21 2009-07-23 브리스톨-마이어스스퀴브컴파니 인자 Ｘａ 억제제로서의 락탐-함유 화합물 및 그의 유도체
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US7459564B2 (en) 2005-01-13 2008-12-02 Bristol-Myers Squibb Company Substituted biaryl compounds as factor XIa inhibitors
AU2006206611A1 (en) 2005-01-19 2006-07-27 Bristol-Myers Squibb Company 2-phenoxy-N- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as P2Y1 receptor inhibitors for the treatment of thromboembolic disorders
AR056867A1 (es) 2005-06-27 2007-10-31 Bristol Myers Squibb Co Antagonistas heterociclicos n- enlazados del receptor de p2y1 utiles en el tratamiento de condiciones tromboticas. composiciones farmaceuticas.
WO2007002634A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
ATE485269T1 (de) 2005-06-27 2010-11-15 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden
EP1896417B1 (en) 2005-06-27 2011-03-23 Bristol-Myers Squibb Company Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
EP2061756B1 (en) 2006-06-08 2013-09-25 Bristol-Myers Squibb Company 2-aminocarbonylphenylamino-2-phenilacetamides as factor viia inhibitors useful as anticoagulants
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
EP2102189B1 (en) 2006-12-15 2015-07-29 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
PE20081775A1 (es) 2006-12-20 2008-12-18 Bristol Myers Squibb Co Compuestos macrociclicos como inhibidores del factor viia
CL2008001724A1 (es) 2007-06-13 2008-08-08 Bristol Myers Squibb Co Compuestos derivados de analogos dipeptidos, inhibidores del factor de coagulacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de un trastorno tromboembolico, infarto de miocardio, trombosis, ate
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
EP2300435A2 (en) 2008-05-19 2011-03-30 Schering Corporation Heterocyclic compounds as factor ixa inhibitors
SMT202000093T1 (it) 2009-06-16 2020-03-13 Pfizer Forme di dosaggio di apixaban
TWI393716B (zh) 2009-08-04 2013-04-21 Merck Sharp & Dohme 作為ｉｘａ因子抑制劑之雜環化合物
TWI577665B (zh) 2010-02-11 2017-04-11 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之巨環類
TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
TW201319068A (zh) 2011-08-05 2013-05-16 必治妥美雅史谷比公司 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑
EP2766345B1 (en) 2011-10-14 2016-03-16 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
RS56168B1 (sr) 2011-10-14 2017-11-30 Bristol Myers Squibb Co Supstituisana jedinjenja tetrahidroizohinolina kao inhibitori xia faktora
WO2013056034A1 (en) 2011-10-14 2013-04-18 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
BR112014011254A2 (pt) 2011-11-11 2017-05-16 Pfizer 2-tiopirimidinonas
SG11201405477XA (en) 2012-04-06 2014-11-27 Pfizer Diacylglycerol acyltransferase 2 inhibitors
BR112015002081A2 (pt) 2012-08-03 2017-07-04 Bristol Myers Squibb Co di-hidropiridona p1 como inibidores de fator xia
US9376444B2 (en) 2012-08-03 2016-06-28 Bristol-Myers Squibb Company Dihydropyridone P1 as factor XIa inhibitors
ES2712699T3 (es) 2013-03-25 2019-05-14 Bristol Myers Squibb Co Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa
ES2665153T3 (es) 2013-10-09 2018-04-24 Pfizer Inc. Antagonistas del receptor EP3 de prostaglandina
SG10201908467RA (en) 2014-01-31 2019-10-30 Bristol Myers Squibb Co Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
NO2760821T3 (cg-RX-API-DMAC7.html) 2014-01-31 2018-03-10
TR201809388T4 (tr) 2014-03-17 2018-07-23 Pfizer Metabolik ve ilişkili hastalıkların tedavisinde kullanılmaya yönelik diasilgliserol asiltransferaz 2 inhibitörleri.
HUE044180T2 (hu) 2014-04-04 2019-10-28 Pfizer Biciklusos kondenzált heteroaril- vagy aril-vegyületek és ezek alkalmazása IRAK4 inhibitorokként
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
NO2721243T3 (cg-RX-API-DMAC7.html) 2014-10-01 2018-10-20
BR112017022340A2 (pt) 2015-05-05 2018-07-10 Pfizer 2-tiopirimidinonas
UA125334C2 (uk) 2015-06-17 2022-02-23 Пфайзер Інк. Трициклічні сполуки та їх застосування як інгібіторів фосфодіестерази
WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
EP3328852B1 (en) 2015-07-29 2021-04-28 Bristol-Myers Squibb Company Factor xia macrocyclic inhibitors bearing a non-aromatic p2' group
US10336730B2 (en) 2015-08-05 2019-07-02 Bristol-Myers Squibb Company Substituted glycine derived FXIA inhibitors
JP6804524B2 (ja) 2015-08-27 2020-12-23 ファイザー・インク Ｉｒａｋ４モジュレーターとしての二環式縮合ヘテロアリールまたはアリール化合物
WO2017151746A1 (en) 2016-03-02 2017-09-08 Bristol-Myers Squibb Company Diamide macrocycles having factor xia inhibiting activity
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
CN112955147A (zh) 2018-08-31 2021-06-11 辉瑞公司 用于治疗nash/nafld和相关疾病的组合
WO2020234726A1 (en) 2019-05-20 2020-11-26 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
WO2022018156A1 (en) 2020-07-22 2022-01-27 Janssen Pharmaceutica Nv Compounds useful as factor xia inhibitors
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
WO2024118524A1 (en) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Azaindole compounds and their use as phosphodiesterase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178368A (en) * 1971-09-30 1979-12-11 Behringwerke Aktiengesellschaft Method for the treatment of thromboembolism
JPS5325775A (en) * 1976-08-24 1978-03-09 Miller Fluid Power Corp Module type fluid flow control element
US4082612A (en) * 1976-09-24 1978-04-04 Michael Reese Research Foundation Plasminogen activator complex
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions

Also Published As

Publication number Publication date
NO163867C (no) 1990-08-01
IE50174B1 (en) 1986-02-19
JPH0316114B2 (cg-RX-API-DMAC7.html) 1991-03-04
ES8204467A1 (es) 1982-05-01
US4808405A (en) 1989-02-28
DK158994C (da) 1991-01-07
CA1174621A (en) 1984-09-18
CS391991A3 (en) 1992-06-17
HU185223B (en) 1984-12-28
AU534017B2 (en) 1983-12-22
AU6401180A (en) 1981-05-14
NL930029I2 (nl) 1993-12-01
JPS5678590A (en) 1981-06-27
NO163867B (no) 1990-04-23
HK65886A (en) 1986-09-12
DK158994B (da) 1990-08-13
NO803304L (no) 1981-05-06
AR224786A1 (es) 1982-01-15
EP0028489B1 (en) 1983-10-05
IL61408A0 (en) 1980-12-31
EP0028489A1 (en) 1981-05-13
GR72121B (cg-RX-API-DMAC7.html) 1983-09-16
NL930029I1 (nl) 1993-06-01
NZ195469A (en) 1984-05-31
IL61408A (en) 1983-10-31
CS391191A3 (en) 1992-08-12
IE802277L (en) 1981-05-05
ES496586A0 (es) 1982-05-01
DK468880A (da) 1981-05-06
ZA806641B (en) 1981-10-28

Similar Documents

Publication Publication Date Title
DE3065190D1 (en) Enzyme derivatives, and their preparation
DE3065181D1 (en) Cephalosporin derivatives, their preparation and their use
AU544352B2 (en) Starch hydrolysate-process for its preparation, and its use
DE3061226D1 (en) Quinone derivatives, their production and use
IL59667A (en) 4-amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives and their preparation
DE3061468D1 (en) 6-deoxyglucosamine-peptide derivatives, their production and use
AU518432B2 (en) 3,4,5-trisubstituted-oxazolid and thiazolid-2-ones
GB2059415B (en) Antibiotic u-59,761 and its microbiological preparation
ZA802155B (en) Penem-3-carboxylic acid derivatives, their preparation and use
IL56882A0 (en) Acylated1-azolyl-2-hydroxy-butane derivatives,their preparation and their use asfungicides
IL59123A0 (en) 1-carbamoyl-pyrazole derivatives,their preparation and their use as pesticides
GB2051062B (en) 3-vinyl-cephalosporin derivatives and their preparation
DE3560679D1 (en) 4-hydroxy-2h-1-benzothiopyran-2-one derivatives, their preparation and uses
AU535880B2 (en) 5h-furanone-2 and 3h-dihydrofuranone-2 derivatives
IL59538A0 (en) 3-substituted pyridine derivatives,their preparation and their use as funigicides
IL58525A (en) 24,24-difluoro-25-hydroxychole-calciferol and its preparation
GB2048254B (en) 19,20 -didehydro-19-hydroxy and 19-oxo-prostaglandin derivatives
DE3064789D1 (en) New 25-hydroxy-24-oxocholestane derivatives and preparation thereof
JPS55162784A (en) Hydroxyaminooeburnane derivatives and their manufacture
DE2967095D1 (en) Phenyliminomethyl-3-pyridine derivatives, their preparation and use
IL60541A0 (en) Tallysomicin derivatives and their preparation
CY1334A (en) 17-cycloalkylmethyl-6-methylene-morphinane derivatives and their preparation
DE3062022D1 (en) Dihydronicotinic acid derivatives, their preparation and use
KE3610A (en) Enzyme derivatives,and their preparation
AU529932B2 (en) 3:,4:-diepi-4:-0-methyl-daunorubicin and derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ROBERTS LABORATORIES INC., EATONTOWN, N.J., US

8328 Change in the person/name/address of the agent

Free format text: PATENT- UND RECHTSANWALTSKANZLEI SROKA, DRES. FEDER, SROKA, 40545 DUESSELDORF

8339 Ceased/non-payment of the annual fee