DE3014160A1 - Kristallisationsverfahren - Google Patents
KristallisationsverfahrenInfo
- Publication number
- DE3014160A1 DE3014160A1 DE19803014160 DE3014160A DE3014160A1 DE 3014160 A1 DE3014160 A1 DE 3014160A1 DE 19803014160 DE19803014160 DE 19803014160 DE 3014160 A DE3014160 A DE 3014160A DE 3014160 A1 DE3014160 A1 DE 3014160A1
- Authority
- DE
- Germany
- Prior art keywords
- solution
- nicotinamide
- shear force
- solid
- cooling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims description 20
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 36
- 239000000243 solution Substances 0.000 claims description 25
- 238000001816 cooling Methods 0.000 claims description 19
- 235000005152 nicotinamide Nutrition 0.000 claims description 18
- 239000011570 nicotinamide Substances 0.000 claims description 18
- 229960003966 nicotinamide Drugs 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 17
- 239000002002 slurry Substances 0.000 claims description 13
- 239000007787 solid Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 11
- 239000007864 aqueous solution Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000006193 liquid solution Substances 0.000 claims description 2
- 230000000007 visual effect Effects 0.000 claims 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 28
- 235000001968 nicotinic acid Nutrition 0.000 description 14
- 239000011664 nicotinic acid Substances 0.000 description 14
- 229960003512 nicotinic acid Drugs 0.000 description 14
- 239000013078 crystal Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 238000001914 filtration Methods 0.000 description 8
- 238000002425 crystallisation Methods 0.000 description 7
- 230000008025 crystallization Effects 0.000 description 7
- 238000001556 precipitation Methods 0.000 description 6
- ONJIBHRZSUEBDS-UHFFFAOYSA-N azane;pyridine-3-carboxylic acid Chemical compound [NH4+].[O-]C(=O)C1=CC=CN=C1 ONJIBHRZSUEBDS-UHFFFAOYSA-N 0.000 description 5
- 239000012452 mother liquor Substances 0.000 description 5
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 229960002715 nicotine Drugs 0.000 description 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- -1 nicotine nitrile Chemical class 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000010583 slow cooling Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3009179A | 1979-04-16 | 1979-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3014160A1 true DE3014160A1 (de) | 1980-10-30 |
Family
ID=21852450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803014160 Ceased DE3014160A1 (de) | 1979-04-16 | 1980-04-12 | Kristallisationsverfahren |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5913881B2 (es) |
| CH (1) | CH646069A5 (es) |
| DE (1) | DE3014160A1 (es) |
| ES (1) | ES8301470A1 (es) |
| GB (1) | GB2050190B (es) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10218110A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Arzneimittelhilfsstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| DE10218106A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Arzneimittelwirkstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| WO2013150090A1 (en) | 2012-04-04 | 2013-10-10 | Lonza Ltd | Nicotinamide powder and process and device for its production |
-
1980
- 1980-04-12 DE DE19803014160 patent/DE3014160A1/de not_active Ceased
- 1980-04-14 GB GB8012222A patent/GB2050190B/en not_active Expired
- 1980-04-15 JP JP5023480A patent/JPS5913881B2/ja not_active Expired
- 1980-04-15 CH CH289580A patent/CH646069A5/de not_active IP Right Cessation
- 1980-04-15 ES ES490585A patent/ES8301470A1/es not_active Expired
Non-Patent Citations (1)
| Title |
|---|
| Vauck, Wilhelm R.A. - Müller, Hermann A.: Grundoperatorien chemischer Verfahrens- technik, Leipzig 1978, S. 536-537 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10218110A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Arzneimittelhilfsstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| DE10218106A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Arzneimittelwirkstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| WO2013150090A1 (en) | 2012-04-04 | 2013-10-10 | Lonza Ltd | Nicotinamide powder and process and device for its production |
Also Published As
| Publication number | Publication date |
|---|---|
| ES490585A0 (es) | 1982-12-01 |
| JPS55139801A (en) | 1980-11-01 |
| ES8301470A1 (es) | 1982-12-01 |
| GB2050190B (en) | 1983-08-03 |
| GB2050190A (en) | 1981-01-07 |
| JPS5913881B2 (ja) | 1984-04-02 |
| CH646069A5 (de) | 1984-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |