DE3011809A1 - Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung - Google Patents

Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung

Info

Publication number
DE3011809A1
DE3011809A1 DE19803011809 DE3011809A DE3011809A1 DE 3011809 A1 DE3011809 A1 DE 3011809A1 DE 19803011809 DE19803011809 DE 19803011809 DE 3011809 A DE3011809 A DE 3011809A DE 3011809 A1 DE3011809 A1 DE 3011809A1
Authority
DE
Germany
Prior art keywords
formula
pyrimidyl
carbon atoms
quinazoline
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803011809
Other languages
German (de)
English (en)
Inventor
Heinz Dr. 6000 Frankfurt Bender
Helmut Dr. 4710 Lüdinghausen Bohn
Piero Dr. 6380 Bad Homburg Martorana
Thomas Dr. 6451 Rodenbach Raabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Cassella AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella AG filed Critical Cassella AG
Priority to DE19803011809 priority Critical patent/DE3011809A1/de
Priority to GR64485A priority patent/GR71870B/el
Priority to DK115581A priority patent/DK115581A/da
Priority to NO810870A priority patent/NO810870L/no
Priority to FI810778A priority patent/FI810778L/fi
Priority to EP81102088A priority patent/EP0037495A1/de
Priority to PT72724A priority patent/PT72724B/pt
Priority to JP4257181A priority patent/JPS56150088A/ja
Priority to PL23032081A priority patent/PL230320A1/xx
Priority to PL23388281A priority patent/PL233882A1/xx
Priority to CS812182A priority patent/CS219898B2/cs
Priority to SU813261941A priority patent/SU1052158A3/ru
Priority to DD81228589A priority patent/DD157614A5/de
Priority to AR284752A priority patent/AR227542A1/es
Priority to AU68774/81A priority patent/AU6877481A/en
Priority to IL62495A priority patent/IL62495A0/xx
Priority to ZA00812034A priority patent/ZA812034B/xx
Priority to ES500738A priority patent/ES500738A0/es
Priority to CA000373945A priority patent/CA1156656A/en
Publication of DE3011809A1 publication Critical patent/DE3011809A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catching Or Destruction (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
DE19803011809 1980-03-27 1980-03-27 Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung Withdrawn DE3011809A1 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DE19803011809 DE3011809A1 (de) 1980-03-27 1980-03-27 Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung
GR64485A GR71870B (enExample) 1980-03-27 1980-12-15
DK115581A DK115581A (da) 1980-03-27 1981-03-13 Fremgangsmaade til fremstilling af pyrimidylquinazoliner
NO810870A NO810870L (no) 1980-03-27 1981-03-13 Fremgangsmaate til fremstilling av pyrimidylkinazoliner
FI810778A FI810778L (fi) 1980-03-27 1981-03-13 Foerfarande foer framstaellning av pyrimidinylkinazoliner
EP81102088A EP0037495A1 (de) 1980-03-27 1981-03-20 Pyrimidyl-chinazoline, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate
PT72724A PT72724B (de) 1980-03-27 1981-03-24 Verfahren zur herstellung von pyrimidyl-chinazolinen
JP4257181A JPS56150088A (en) 1980-03-27 1981-03-25 Pyrimidyl-quinazoline,its manufacture and pharmaceutical blend containing it
PL23032081A PL230320A1 (enExample) 1980-03-27 1981-03-25
PL23388281A PL233882A1 (enExample) 1980-03-27 1981-03-25
CS812182A CS219898B2 (en) 1980-03-27 1981-03-25 Method of making the pyrimidylchinazoline
SU813261941A SU1052158A3 (ru) 1980-03-27 1981-03-25 Способ получени производных пиримидилхиназолина или их солей (его варианты)
DD81228589A DD157614A5 (de) 1980-03-27 1981-03-25 Verfahren zur herstellung von pyrimidyl-chinazolinen
AR284752A AR227542A1 (es) 1980-03-27 1981-03-26 Procedimiento para preparar derivados de 4-(4-amino-6,7-dimetoxi-quinazolin-2-il)-1-(2,4-dioxo-2,2,3,4-tetrahidro-pirimidin-6-il)-piperazina
AU68774/81A AU6877481A (en) 1980-03-27 1981-03-26 Pyrimidyl-quinazolines
IL62495A IL62495A0 (en) 1980-03-27 1981-03-26 Pyrimidyl-quinazolines,their preparation and pharmaceutical compositions containing them
ZA00812034A ZA812034B (en) 1980-03-27 1981-03-26 Phrimidyl-quinazolines,process for their preparation pharmaceutical formulations containing these compounds,and their use
ES500738A ES500738A0 (es) 1980-03-27 1981-03-26 Procedimiento para preparar pirimidil-quinazolinas
CA000373945A CA1156656A (en) 1980-03-27 1981-03-26 Process for the preparation of pyrimidyl-chinazolines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803011809 DE3011809A1 (de) 1980-03-27 1980-03-27 Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung

Publications (1)

Publication Number Publication Date
DE3011809A1 true DE3011809A1 (de) 1981-10-01

Family

ID=6098481

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803011809 Withdrawn DE3011809A1 (de) 1980-03-27 1980-03-27 Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung

Country Status (18)

Country Link
EP (1) EP0037495A1 (enExample)
JP (1) JPS56150088A (enExample)
AR (1) AR227542A1 (enExample)
AU (1) AU6877481A (enExample)
CA (1) CA1156656A (enExample)
CS (1) CS219898B2 (enExample)
DD (1) DD157614A5 (enExample)
DE (1) DE3011809A1 (enExample)
DK (1) DK115581A (enExample)
ES (1) ES500738A0 (enExample)
FI (1) FI810778L (enExample)
GR (1) GR71870B (enExample)
IL (1) IL62495A0 (enExample)
NO (1) NO810870L (enExample)
PL (2) PL230320A1 (enExample)
PT (1) PT72724B (enExample)
SU (1) SU1052158A3 (enExample)
ZA (1) ZA812034B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6267077A (ja) * 1985-09-18 1987-03-26 Mitsui Petrochem Ind Ltd キナゾリン誘導体及び医薬
JPS61140568A (ja) * 1984-12-14 1986-06-27 Mitsui Petrochem Ind Ltd キナゾリン誘導体及びそれを有効成分とする血圧降下剤
KR101071390B1 (ko) * 2004-03-15 2011-10-07 다케다 야쿠힌 고교 가부시키가이샤 디펩티딜 펩티다제 억제제
EP1778236B1 (en) * 2004-07-02 2010-07-14 Corcept Therapeutics, Inc. Modified pyrimidine glucocorticoid receptor modulators
MX347862B (es) 2011-03-18 2017-05-17 Corcept Therapeutics Inc Moduladores de receptores de glucocorticoides de pirimidina ciclohexilo.
CA3102099C (en) 2018-06-04 2023-09-26 Corcept Therapeutics Incorporated Pyrimidine cyclohexenyl glucocorticoid receptor modulators
MX2022006633A (es) 2019-12-11 2022-06-24 Corcept Therapeutics Inc Metodos de tratamiento del aumento de peso inducido por antipsicoticos con miricorilant.
WO2021226260A1 (en) 2020-05-06 2021-11-11 Corcept Therapeutics Incorporated Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
CN115515569A (zh) 2020-05-06 2022-12-23 科赛普特治疗公司 嘧啶环己基糖皮质激素受体调节剂的制剂
CA3202353A1 (en) 2020-12-21 2022-06-30 Jeffrey Mark Dener Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2007656B (en) * 1977-11-05 1982-05-19 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
FI810778A7 (fi) 1981-09-28
AR227542A1 (es) 1982-11-15
GR71870B (enExample) 1983-07-08
NO810870L (no) 1981-09-28
DK115581A (da) 1981-09-28
PT72724A (de) 1981-04-01
PL233882A1 (enExample) 1982-05-10
ES8202000A1 (es) 1982-01-16
CA1156656A (en) 1983-11-08
IL62495A0 (en) 1981-05-20
CS219898B2 (en) 1983-03-25
AU6877481A (en) 1981-10-01
FI810778L (fi) 1981-09-28
SU1052158A3 (ru) 1983-10-30
ES500738A0 (es) 1982-01-16
PT72724B (de) 1982-03-24
ZA812034B (en) 1982-05-26
EP0037495A1 (de) 1981-10-14
JPS56150088A (en) 1981-11-20
PL230320A1 (enExample) 1982-03-29
DD157614A5 (de) 1982-11-24

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee