DE2964130D1 - 4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them - Google Patents

4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them

Info

Publication number
DE2964130D1
DE2964130D1 DE7979300638T DE2964130T DE2964130D1 DE 2964130 D1 DE2964130 D1 DE 2964130D1 DE 7979300638 T DE7979300638 T DE 7979300638T DE 2964130 T DE2964130 T DE 2964130T DE 2964130 D1 DE2964130 D1 DE 2964130D1
Authority
DE
Germany
Prior art keywords
carboxhydrazides
preparation
formulations containing
desacetyl vlb
desacetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7979300638T
Other languages
German (de)
English (en)
Inventor
George Joseph Cullinan
Koert Gerzon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE2964130D1 publication Critical patent/DE2964130D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE7979300638T 1978-04-20 1979-04-18 4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them Expired DE2964130D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number Publication Date
DE2964130D1 true DE2964130D1 (en) 1983-01-05

Family

ID=25410402

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7979300638T Expired DE2964130D1 (en) 1978-04-20 1979-04-18 4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them

Country Status (32)

Country Link
US (1) US4166810A (https=)
EP (1) EP0005051B1 (https=)
JP (1) JPS54141798A (https=)
AR (1) AR228940A1 (https=)
AT (1) AT369010B (https=)
AU (1) AU527109B2 (https=)
BE (1) BE875652A (https=)
BG (3) BG33297A3 (https=)
CA (1) CA1097629A (https=)
CH (1) CH643269A5 (https=)
CS (3) CS218583B2 (https=)
DD (1) DD143075A5 (https=)
DE (1) DE2964130D1 (https=)
DK (1) DK147484C (https=)
EG (1) EG14867A (https=)
ES (2) ES479754A1 (https=)
FI (1) FI791286A7 (https=)
FR (1) FR2423495A1 (https=)
GB (1) GB2019396B (https=)
GR (1) GR69987B (https=)
HU (1) HU181431B (https=)
IE (1) IE48213B1 (https=)
IL (1) IL57168A (https=)
LU (1) LU81166A1 (https=)
NZ (1) NZ190213A (https=)
PH (1) PH14163A (https=)
PL (3) PL215911A1 (https=)
PT (1) PT69496A (https=)
RO (3) RO81114A (https=)
SU (3) SU1225490A3 (https=)
YU (1) YU93179A (https=)
ZA (1) ZA791856B (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DE3483336D1 (de) * 1983-03-30 1990-11-08 Lilly Industries Ltd Vincaleukoblastin-derivate.
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
ATE427948T1 (de) 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
CA2484640C (en) * 2002-05-15 2012-01-17 Endocyte, Inc. Vitamin-mitomycin conjugates
WO2004069159A2 (en) 2003-01-27 2004-08-19 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
CN101098854B (zh) * 2004-07-23 2012-12-05 恩多塞特公司 二价连接体及其轭合物
CN101175757B (zh) * 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
EP2382995A3 (en) 2005-08-19 2013-09-25 Endocyte, Inc. Ligand conjugates of Vinca alkaloids, analogs and derivatives
BRPI0615354A2 (pt) * 2005-08-19 2011-05-17 Endocyte, Inc. conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso
US20100087370A1 (en) * 2007-02-14 2010-04-08 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
AU2008224988A1 (en) * 2007-03-14 2008-09-18 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN101784565B (zh) 2007-06-25 2014-12-10 恩多塞特公司 含有亲水性间隔区接头的共轭物
CN101909441B (zh) 2007-10-25 2015-05-13 恩多塞特公司 微管蛋白抑制剂及其制备方法
EP2476414B1 (en) * 2009-09-07 2015-03-04 NIPRO Patch Co., Ltd. Transdermally absorbable preparation
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
BR112015008365A2 (pt) 2012-10-16 2017-07-04 Endocyte Inc composto da fórmula b-l(d)x, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composição de forma de dosagem unitária ou dose unitária, composição para tratar um câncer em um paciente, e método para tratar um câncer em um paciente

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
IL48685A (en) 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
PH14163A (en) 1981-03-19
ZA791856B (en) 1980-11-26
PL119416B1 (en) 1981-12-31
CS218584B2 (en) 1983-02-25
AR228940A1 (es) 1983-05-13
DK147484B (da) 1984-08-27
NZ190213A (en) 1982-12-21
GB2019396B (en) 1982-09-15
GR69987B (https=) 1982-07-22
RO81037A (ro) 1983-02-01
BG33297A3 (bg) 1983-01-14
AU527109B2 (en) 1983-02-17
JPS54141798A (en) 1979-11-05
DK147484C (da) 1985-03-25
CS218583B2 (en) 1983-02-25
YU93179A (en) 1983-01-21
HU181431B (en) 1983-07-28
BG33294A3 (bg) 1983-01-14
CS218585B2 (en) 1983-02-25
PL215911A1 (https=) 1980-03-24
EP0005051B1 (en) 1982-12-01
FI791286A7 (fi) 1981-01-01
PT69496A (en) 1979-05-01
ES479753A1 (es) 1980-08-16
IE790795L (en) 1979-10-20
CA1097629A (en) 1981-03-17
SU893135A3 (ru) 1981-12-23
IL57168A (en) 1983-10-31
ATA291279A (de) 1982-04-15
PL125470B1 (en) 1983-05-31
IE48213B1 (en) 1984-10-31
SU1225490A3 (ru) 1986-04-15
ES479754A1 (es) 1980-08-16
BE875652A (fr) 1979-10-18
AT369010B (de) 1982-11-25
US4166810A (en) 1979-09-04
IL57168A0 (en) 1979-07-25
SU1061698A3 (ru) 1983-12-15
EG14867A (en) 1986-09-30
LU81166A1 (fr) 1979-09-07
AU4609779A (en) 1979-10-25
EP0005051A1 (en) 1979-10-31
JPS6245873B2 (https=) 1987-09-29
FR2423495A1 (fr) 1979-11-16
RO81037B (ro) 1983-01-30
RO80084B (ro) 1983-01-30
GB2019396A (en) 1979-10-31
DK160679A (da) 1979-10-21
RO80084A (ro) 1983-02-01
DD143075A5 (de) 1980-07-30
CH643269A5 (fr) 1984-05-30
BG33296A3 (bg) 1983-01-14
RO81114A (ro) 1983-02-01
RO81114B (ro) 1983-01-30
FR2423495B1 (https=) 1983-02-11

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee