DE2951213A1 - Verwendung von n-aryl-n'-(2-imidazolidinyliden)-harnstoffen zur behandlung von hypertonie und intestinalen stoerungen - Google Patents

Verwendung von n-aryl-n'-(2-imidazolidinyliden)-harnstoffen zur behandlung von hypertonie und intestinalen stoerungen

Info

Publication number
DE2951213A1
DE2951213A1 DE19792951213 DE2951213A DE2951213A1 DE 2951213 A1 DE2951213 A1 DE 2951213A1 DE 19792951213 DE19792951213 DE 19792951213 DE 2951213 A DE2951213 A DE 2951213A DE 2951213 A1 DE2951213 A1 DE 2951213A1
Authority
DE
Germany
Prior art keywords
urea
imidazolidinylidene
treatment
general formula
content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19792951213
Other languages
German (de)
English (en)
Inventor
Chris Royce Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/972,579 external-priority patent/US4229462A/en
Priority claimed from US05/972,580 external-priority patent/US4239768A/en
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of DE2951213A1 publication Critical patent/DE2951213A1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19792951213 1978-12-22 1979-12-19 Verwendung von n-aryl-n'-(2-imidazolidinyliden)-harnstoffen zur behandlung von hypertonie und intestinalen stoerungen Ceased DE2951213A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/972,579 US4229462A (en) 1978-12-22 1978-12-22 Method for controlling hypertension and compositions
US05/972,580 US4239768A (en) 1978-12-22 1978-12-22 Method for relieving irritable bowel syndrome symptoms

Publications (1)

Publication Number Publication Date
DE2951213A1 true DE2951213A1 (de) 1980-07-10

Family

ID=27130555

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792951213 Ceased DE2951213A1 (de) 1978-12-22 1979-12-19 Verwendung von n-aryl-n'-(2-imidazolidinyliden)-harnstoffen zur behandlung von hypertonie und intestinalen stoerungen

Country Status (23)

Country Link
AT (1) AT373878B (fi)
AU (2) AU532332B2 (fi)
CA (1) CA1127651A (fi)
CH (1) CH647236A5 (fi)
DE (1) DE2951213A1 (fi)
DK (1) DK548179A (fi)
ES (1) ES487159A0 (fi)
FI (1) FI66354C (fi)
FR (2) FR2444462B1 (fi)
GB (2) GB2040681B (fi)
GR (1) GR68018B (fi)
HU (1) HU183013B (fi)
IL (1) IL59019A (fi)
IT (1) IT1126839B (fi)
NL (1) NL7909265A (fi)
NO (1) NO794249L (fi)
NZ (1) NZ192453A (fi)
PH (1) PH16571A (fi)
PT (1) PT70624A (fi)
SE (1) SE7910612L (fi)
SU (1) SU971098A3 (fi)
YU (1) YU314979A (fi)
ZW (1) ZW25379A1 (fi)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US11516649B2 (en) * 2018-10-29 2022-11-29 Apple Inc. Mechanism to activate and manage a standalone device for cellular service

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168520A (en) * 1960-08-05 1965-02-02 Geigy Chem Corp 2-imino-1, 3-disubstituted hexahydro-pyrimidines and imidazolidines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1296962A (fr) * 1960-08-05 1962-06-22 Geigy Ag J R Nouveaux composés 2-imino-1.3-di-aza et leur préparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168520A (en) * 1960-08-05 1965-02-02 Geigy Chem Corp 2-imino-1, 3-disubstituted hexahydro-pyrimidines and imidazolidines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Arzneimittel-Forschung, 28 (II), S.1435-41, 1978 *

Also Published As

Publication number Publication date
CA1127651A (en) 1982-07-13
CH647236A5 (de) 1985-01-15
IL59019A (en) 1984-05-31
IL59019A0 (en) 1980-03-31
NL7909265A (nl) 1980-06-24
FR2444462B1 (fr) 1986-08-29
FR2445321A1 (fi) 1980-07-25
AU5378079A (en) 1980-06-26
AU532332B2 (en) 1983-09-29
FI66354B (fi) 1984-06-29
GB2113204B (en) 1984-02-01
FR2444462A1 (fr) 1980-07-18
IT7951164A0 (it) 1979-12-21
YU314979A (en) 1983-02-28
PT70624A (en) 1980-01-01
AT373878B (de) 1984-02-27
NO794249L (no) 1980-06-24
PH16571A (en) 1983-11-18
GB2040681A (en) 1980-09-03
ES8101558A1 (es) 1980-12-16
FI66354C (fi) 1984-10-10
AU1640083A (en) 1983-11-17
NZ192453A (en) 1982-09-07
HU183013B (en) 1984-04-28
FR2445321B1 (fi) 1983-08-26
FI794036A (fi) 1980-06-23
GR68018B (fi) 1981-10-27
SU971098A3 (ru) 1982-10-30
SE7910612L (sv) 1980-06-23
GB2113204A (en) 1983-08-03
DK548179A (da) 1980-06-23
GB2040681B (en) 1983-04-13
ZW25379A1 (en) 1981-07-22
ATA808979A (de) 1983-07-15
IT1126839B (it) 1986-05-21
AU566013B2 (en) 1987-10-08
ES487159A0 (es) 1980-12-16

Similar Documents

Publication Publication Date Title
DE2557438C2 (fi)
DE3685608T2 (de) 8-phenylxanthine.
DE69304076T2 (de) N-cyano-n'-pyridylguanidine als serotoninantagonisten
EP0103796B1 (de) Neue Dihydropyrimidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung in Arzneimitteln
DE2656374A1 (de) Pyrazincarboxamide und verfahren zu ihrer herstellung
DD216929A5 (de) Verfahren zur herstellung von thiazolidinderivaten
DD224033A5 (de) Verfahren zur herstellung substituierter 1,2,4-triazine und deren salze
EP0104423A1 (de) 2-Nitro-1,1-ethendiamine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE1620138C3 (de) Substituierte 2-Piperazino-4-amino-6,7-dimethoxychinazoline und Verfahren zu deren Herstellung
CH664964A5 (de) Isoindolinyl-alkyl-piperazine.
DE2635961A1 (de) Therapeutisch wirksame verbindungen und verfahren zu ihrer herstellung
DE3940021C2 (de) Adenosin-Derivate, deren Herstellung und Verwendung
DE2804518C2 (de) 5-[3,6-Dihydro-1(2H)-Pyridyl]-2 oxo-2H-[1,2,4]-oxadiazolo-[2,3-a]-pyrimidin-7-carbamate
DE3439450A1 (de) 1,2,4-triazolo-carbamate und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DE2951213A1 (de) Verwendung von n-aryl-n'-(2-imidazolidinyliden)-harnstoffen zur behandlung von hypertonie und intestinalen stoerungen
DE2810036A1 (de) 3-(1-piperazinyl)-pyrido eckige klammer auf 2.3-b eckige klammer zu pyrazine
DE2313256B2 (de) 1 ^-Benzisoxazol-3-acetamidoxim, seine Salze, Verfahren zu seiner Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2912026C2 (fi)
DE2831671A1 (de) Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2548283A1 (de) 1,2,4-benzothiadiazin-1,1-dioxidderivate
CH579565A5 (en) Imidazolin-2-ylamino-2,1,3-benzothiadiazoles prodn. - by cyclising corresp. beta aminoethyl (thio) ureas, active against muscle tremors and rigor
DE3233380A1 (de) Substituierte pyridyl-cyanoguanidinverbindungen
DE3107599C2 (de) N-Cyan-N'-methyl-N"-{2-[(5-methylthio-imidazol-4-yl)-methylthio]-äthyl}-guanidin, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel
KR830002872B1 (ko) N-아릴-n'-(2-이미다졸리딘일리덴)-우레아의 제조방법
EP0004904B1 (de) 2-Amino-3a,4,5,6-tetrahydro-perimidin-Derivate, diese enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection