GB2113204B - N-(2,6-disubstituted phenyl)-n'-(2-imidazolidinylidene) ureas - Google Patents

N-(2,6-disubstituted phenyl)-n'-(2-imidazolidinylidene) ureas

Info

Publication number
GB2113204B
GB2113204B GB08221517A GB8221517A GB2113204B GB 2113204 B GB2113204 B GB 2113204B GB 08221517 A GB08221517 A GB 08221517A GB 8221517 A GB8221517 A GB 8221517A GB 2113204 B GB2113204 B GB 2113204B
Authority
GB
United Kingdom
Prior art keywords
imidazolidinylidene
ureas
disubstituted phenyl
disubstituted
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08221517A
Other versions
GB2113204A (en
Inventor
Chris Royce Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/972,579 external-priority patent/US4229462A/en
Priority claimed from US05/972,580 external-priority patent/US4239768A/en
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of GB2113204A publication Critical patent/GB2113204A/en
Application granted granted Critical
Publication of GB2113204B publication Critical patent/GB2113204B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB08221517A 1978-12-22 1982-07-26 N-(2,6-disubstituted phenyl)-n'-(2-imidazolidinylidene) ureas Expired GB2113204B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/972,579 US4229462A (en) 1978-12-22 1978-12-22 Method for controlling hypertension and compositions
US05/972,580 US4239768A (en) 1978-12-22 1978-12-22 Method for relieving irritable bowel syndrome symptoms

Publications (2)

Publication Number Publication Date
GB2113204A GB2113204A (en) 1983-08-03
GB2113204B true GB2113204B (en) 1984-02-01

Family

ID=27130555

Family Applications (2)

Application Number Title Priority Date Filing Date
GB7944114A Expired GB2040681B (en) 1978-12-22 1979-12-21 Use in the treatment of hypertension and intestinal disorders of certain n - aryl - n - (2-imidazolidinylidene)-urea
GB08221517A Expired GB2113204B (en) 1978-12-22 1982-07-26 N-(2,6-disubstituted phenyl)-n'-(2-imidazolidinylidene) ureas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB7944114A Expired GB2040681B (en) 1978-12-22 1979-12-21 Use in the treatment of hypertension and intestinal disorders of certain n - aryl - n - (2-imidazolidinylidene)-urea

Country Status (23)

Country Link
AT (1) AT373878B (en)
AU (2) AU532332B2 (en)
CA (1) CA1127651A (en)
CH (1) CH647236A5 (en)
DE (1) DE2951213A1 (en)
DK (1) DK548179A (en)
ES (1) ES487159A0 (en)
FI (1) FI66354C (en)
FR (2) FR2444462B1 (en)
GB (2) GB2040681B (en)
GR (1) GR68018B (en)
HU (1) HU183013B (en)
IL (1) IL59019A (en)
IT (1) IT1126839B (en)
NL (1) NL7909265A (en)
NO (1) NO794249L (en)
NZ (1) NZ192453A (en)
PH (1) PH16571A (en)
PT (1) PT70624A (en)
SE (1) SE7910612L (en)
SU (1) SU971098A3 (en)
YU (1) YU314979A (en)
ZW (1) ZW25379A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US11516649B2 (en) * 2018-10-29 2022-11-29 Apple Inc. Mechanism to activate and manage a standalone device for cellular service

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1296962A (en) * 1960-08-05 1962-06-22 Geigy Ag J R New 2-imino-1.3-di-aza compounds and their preparation
NL267923A (en) * 1960-08-05

Also Published As

Publication number Publication date
CA1127651A (en) 1982-07-13
CH647236A5 (en) 1985-01-15
IL59019A (en) 1984-05-31
IL59019A0 (en) 1980-03-31
NL7909265A (en) 1980-06-24
FR2444462B1 (en) 1986-08-29
FR2445321A1 (en) 1980-07-25
AU5378079A (en) 1980-06-26
AU532332B2 (en) 1983-09-29
FI66354B (en) 1984-06-29
FR2444462A1 (en) 1980-07-18
IT7951164A0 (en) 1979-12-21
YU314979A (en) 1983-02-28
PT70624A (en) 1980-01-01
AT373878B (en) 1984-02-27
DE2951213A1 (en) 1980-07-10
NO794249L (en) 1980-06-24
PH16571A (en) 1983-11-18
GB2040681A (en) 1980-09-03
ES8101558A1 (en) 1980-12-16
FI66354C (en) 1984-10-10
AU1640083A (en) 1983-11-17
NZ192453A (en) 1982-09-07
HU183013B (en) 1984-04-28
FR2445321B1 (en) 1983-08-26
FI794036A (en) 1980-06-23
GR68018B (en) 1981-10-27
SU971098A3 (en) 1982-10-30
SE7910612L (en) 1980-06-23
GB2113204A (en) 1983-08-03
DK548179A (en) 1980-06-23
GB2040681B (en) 1983-04-13
ZW25379A1 (en) 1981-07-22
ATA808979A (en) 1983-07-15
IT1126839B (en) 1986-05-21
AU566013B2 (en) 1987-10-08
ES487159A0 (en) 1980-12-16

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee