FR2444462B1 - COMPOSITIONS FOR CONTROLLING HYPERTENSION AND INTESTINAL DISORDERS COMPRISING AN N-ARYL N'2- (IMIDAZOLIDINYLIDENE) -URA DERIVATIVE - Google Patents

COMPOSITIONS FOR CONTROLLING HYPERTENSION AND INTESTINAL DISORDERS COMPRISING AN N-ARYL N'2- (IMIDAZOLIDINYLIDENE) -URA DERIVATIVE

Info

Publication number
FR2444462B1
FR2444462B1 FR7931473A FR7931473A FR2444462B1 FR 2444462 B1 FR2444462 B1 FR 2444462B1 FR 7931473 A FR7931473 A FR 7931473A FR 7931473 A FR7931473 A FR 7931473A FR 2444462 B1 FR2444462 B1 FR 2444462B1
Authority
FR
France
Prior art keywords
imidazolidinylidene
ura
aryl
derivative
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7931473A
Other languages
French (fr)
Other versions
FR2444462A1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho McNeil Pharmaceutical Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/972,580 external-priority patent/US4239768A/en
Priority claimed from US05/972,579 external-priority patent/US4229462A/en
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of FR2444462A1 publication Critical patent/FR2444462A1/en
Application granted granted Critical
Publication of FR2444462B1 publication Critical patent/FR2444462B1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR7931473A 1978-12-22 1979-12-21 COMPOSITIONS FOR CONTROLLING HYPERTENSION AND INTESTINAL DISORDERS COMPRISING AN N-ARYL N'2- (IMIDAZOLIDINYLIDENE) -URA DERIVATIVE Expired FR2444462B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/972,580 US4239768A (en) 1978-12-22 1978-12-22 Method for relieving irritable bowel syndrome symptoms
US05/972,579 US4229462A (en) 1978-12-22 1978-12-22 Method for controlling hypertension and compositions

Publications (2)

Publication Number Publication Date
FR2444462A1 FR2444462A1 (en) 1980-07-18
FR2444462B1 true FR2444462B1 (en) 1986-08-29

Family

ID=27130555

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7931473A Expired FR2444462B1 (en) 1978-12-22 1979-12-21 COMPOSITIONS FOR CONTROLLING HYPERTENSION AND INTESTINAL DISORDERS COMPRISING AN N-ARYL N'2- (IMIDAZOLIDINYLIDENE) -URA DERIVATIVE
FR8007757A Expired FR2445321B1 (en) 1978-12-22 1980-04-04

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8007757A Expired FR2445321B1 (en) 1978-12-22 1980-04-04

Country Status (23)

Country Link
AT (1) AT373878B (en)
AU (2) AU532332B2 (en)
CA (1) CA1127651A (en)
CH (1) CH647236A5 (en)
DE (1) DE2951213A1 (en)
DK (1) DK548179A (en)
ES (1) ES8101558A1 (en)
FI (1) FI66354C (en)
FR (2) FR2444462B1 (en)
GB (2) GB2040681B (en)
GR (1) GR68018B (en)
HU (1) HU183013B (en)
IL (1) IL59019A (en)
IT (1) IT1126839B (en)
NL (1) NL7909265A (en)
NO (1) NO794249L (en)
NZ (1) NZ192453A (en)
PH (1) PH16571A (en)
PT (1) PT70624A (en)
SE (1) SE7910612L (en)
SU (1) SU971098A3 (en)
YU (1) YU314979A (en)
ZW (1) ZW25379A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US11516649B2 (en) * 2018-10-29 2022-11-29 Apple Inc. Mechanism to activate and manage a standalone device for cellular service

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL288408A (en) * 1960-08-05
FR1296962A (en) * 1960-08-05 1962-06-22 Geigy Ag J R New 2-imino-1.3-di-aza compounds and their preparation

Also Published As

Publication number Publication date
NO794249L (en) 1980-06-24
CA1127651A (en) 1982-07-13
GR68018B (en) 1981-10-27
SE7910612L (en) 1980-06-23
CH647236A5 (en) 1985-01-15
GB2040681B (en) 1983-04-13
HU183013B (en) 1984-04-28
AU532332B2 (en) 1983-09-29
FI66354C (en) 1984-10-10
GB2113204B (en) 1984-02-01
FR2445321A1 (en) 1980-07-25
NL7909265A (en) 1980-06-24
DK548179A (en) 1980-06-23
IT7951164A0 (en) 1979-12-21
ATA808979A (en) 1983-07-15
IL59019A0 (en) 1980-03-31
ZW25379A1 (en) 1981-07-22
AU5378079A (en) 1980-06-26
AT373878B (en) 1984-02-27
SU971098A3 (en) 1982-10-30
GB2113204A (en) 1983-08-03
YU314979A (en) 1983-02-28
IL59019A (en) 1984-05-31
GB2040681A (en) 1980-09-03
IT1126839B (en) 1986-05-21
ES487159A0 (en) 1980-12-16
DE2951213A1 (en) 1980-07-10
FR2444462A1 (en) 1980-07-18
AU566013B2 (en) 1987-10-08
FR2445321B1 (en) 1983-08-26
AU1640083A (en) 1983-11-17
NZ192453A (en) 1982-09-07
ES8101558A1 (en) 1980-12-16
FI794036A (en) 1980-06-23
PT70624A (en) 1980-01-01
FI66354B (en) 1984-06-29
PH16571A (en) 1983-11-18

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Legal Events

Date Code Title Description
ST Notification of lapse