ES8101558A1 - Un procedimiento para la preparacion de n-aril-n'-(2-imida- zolidinilioden)ureas - Google Patents

Un procedimiento para la preparacion de n-aril-n'-(2-imida- zolidinilioden)ureas

Info

Publication number
ES8101558A1
ES8101558A1 ES487159A ES487159A ES8101558A1 ES 8101558 A1 ES8101558 A1 ES 8101558A1 ES 487159 A ES487159 A ES 487159A ES 487159 A ES487159 A ES 487159A ES 8101558 A1 ES8101558 A1 ES 8101558A1
Authority
ES
Spain
Prior art keywords
imidazolidinylidene
ureas
hypertension
aryl
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES487159A
Other languages
English (en)
Other versions
ES487159A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/972,579 external-priority patent/US4229462A/en
Priority claimed from US05/972,580 external-priority patent/US4239768A/en
Application filed by McNeilab Inc filed Critical McNeilab Inc
Publication of ES8101558A1 publication Critical patent/ES8101558A1/es
Publication of ES487159A0 publication Critical patent/ES487159A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical

Abstract

PROCEDIMIENTO DE OBTENCION DE N-ARIL-N''-(2-IMIDAZOLIDINILEDEN) UREAS. CONSTA DE LAS SIGUIENTES ETAPAS: 1) CALENTAMIENTO DEL ISOCIANATO Y LA TIOUREA A LA TEMPERATURA DEL BAÑO DE VAPOR DURANTE UN TIEMPO DE 2 A 12 HORAS, FORMANDOSE EL COMPUESTO TIOBIURET. 2) REACCION DEL N-ARIL-TIOBIURET Y UN AGENTE 5-METILANTE PARA PRODUCIR UN N''-(ARILAMINO) CARSONIL CARBAMIMIDOTIATO DE METILO EMPLEANDO UN DISOLVENTE, TAL COMO METANOL, ETANOL O ISOPROPANOL. 3) REACCION DE HIDROYODURO Y UNA ETILENDIAMINA PARA OBTENER LA N-ARIL-N''-IMIDAZOLIDINILI-DENUREA EN FORMA DE HIDROYODURO, LA REACCION SE LLEVA A CABO EN METANOL OTROS ALCANOLES INFERIORES. EL PRODUCTO ES RECUPERADO Y PURIFICADO POR PROCEDIMIENTOS CONVENCIONALES. CONTROL DE LA HIPERTENSION Y ALIVIO DE TRASTORNOS INTESTINALES.
ES487159A 1978-12-22 1979-12-20 Un procedimiento para la preparacion de n-aril-n'-(2-imida- zolidinilioden)ureas Granted ES487159A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/972,579 US4229462A (en) 1978-12-22 1978-12-22 Method for controlling hypertension and compositions
US05/972,580 US4239768A (en) 1978-12-22 1978-12-22 Method for relieving irritable bowel syndrome symptoms

Publications (2)

Publication Number Publication Date
ES8101558A1 true ES8101558A1 (es) 1980-12-16
ES487159A0 ES487159A0 (es) 1980-12-16

Family

ID=27130555

Family Applications (1)

Application Number Title Priority Date Filing Date
ES487159A Granted ES487159A0 (es) 1978-12-22 1979-12-20 Un procedimiento para la preparacion de n-aril-n'-(2-imida- zolidinilioden)ureas

Country Status (23)

Country Link
AT (1) AT373878B (es)
AU (2) AU532332B2 (es)
CA (1) CA1127651A (es)
CH (1) CH647236A5 (es)
DE (1) DE2951213A1 (es)
DK (1) DK548179A (es)
ES (1) ES487159A0 (es)
FI (1) FI66354C (es)
FR (2) FR2444462B1 (es)
GB (2) GB2040681B (es)
GR (1) GR68018B (es)
HU (1) HU183013B (es)
IL (1) IL59019A (es)
IT (1) IT1126839B (es)
NL (1) NL7909265A (es)
NO (1) NO794249L (es)
NZ (1) NZ192453A (es)
PH (1) PH16571A (es)
PT (1) PT70624A (es)
SE (1) SE7910612L (es)
SU (1) SU971098A3 (es)
YU (1) YU314979A (es)
ZW (1) ZW25379A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673680A (en) * 1985-09-18 1987-06-16 Pendleton Robert G α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility
US11516649B2 (en) * 2018-10-29 2022-11-29 Apple Inc. Mechanism to activate and manage a standalone device for cellular service

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1296962A (fr) * 1960-08-05 1962-06-22 Geigy Ag J R Nouveaux composés 2-imino-1.3-di-aza et leur préparation
NL288408A (es) * 1960-08-05

Also Published As

Publication number Publication date
CH647236A5 (de) 1985-01-15
IT1126839B (it) 1986-05-21
GR68018B (es) 1981-10-27
FR2444462B1 (fr) 1986-08-29
GB2040681B (en) 1983-04-13
FR2445321A1 (es) 1980-07-25
GB2040681A (en) 1980-09-03
NZ192453A (en) 1982-09-07
FI66354C (fi) 1984-10-10
IL59019A (en) 1984-05-31
ZW25379A1 (en) 1981-07-22
CA1127651A (en) 1982-07-13
SU971098A3 (ru) 1982-10-30
YU314979A (en) 1983-02-28
IL59019A0 (en) 1980-03-31
NO794249L (no) 1980-06-24
HU183013B (en) 1984-04-28
AT373878B (de) 1984-02-27
AU532332B2 (en) 1983-09-29
DK548179A (da) 1980-06-23
FR2445321B1 (es) 1983-08-26
FI794036A (fi) 1980-06-23
IT7951164A0 (it) 1979-12-21
GB2113204B (en) 1984-02-01
ATA808979A (de) 1983-07-15
AU566013B2 (en) 1987-10-08
GB2113204A (en) 1983-08-03
FR2444462A1 (fr) 1980-07-18
PT70624A (en) 1980-01-01
SE7910612L (sv) 1980-06-23
AU1640083A (en) 1983-11-17
NL7909265A (nl) 1980-06-24
FI66354B (fi) 1984-06-29
ES487159A0 (es) 1980-12-16
AU5378079A (en) 1980-06-26
DE2951213A1 (de) 1980-07-10
PH16571A (en) 1983-11-18

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