DE2912483A1 - Beta -lactamverbindungen, verfahren zu deren herstellung und arzneimittel - Google Patents

Beta -lactamverbindungen, verfahren zu deren herstellung und arzneimittel

Info

Publication number
DE2912483A1
DE2912483A1 DE19792912483 DE2912483A DE2912483A1 DE 2912483 A1 DE2912483 A1 DE 2912483A1 DE 19792912483 DE19792912483 DE 19792912483 DE 2912483 A DE2912483 A DE 2912483A DE 2912483 A1 DE2912483 A1 DE 2912483A1
Authority
DE
Germany
Prior art keywords
group
isocyanate
aryl
substituted
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19792912483
Other languages
German (de)
English (en)
Inventor
Robert Lewis Cundall
Derek Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DE2912483A1 publication Critical patent/DE2912483A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19792912483 1978-04-03 1979-03-29 Beta -lactamverbindungen, verfahren zu deren herstellung und arzneimittel Withdrawn DE2912483A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/893,092 US4322347A (en) 1978-04-03 1978-04-03 2-Carbamoyloxymethyl-penicillin derivatives

Publications (1)

Publication Number Publication Date
DE2912483A1 true DE2912483A1 (de) 1979-10-11

Family

ID=25401020

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792912483 Withdrawn DE2912483A1 (de) 1978-04-03 1979-03-29 Beta -lactamverbindungen, verfahren zu deren herstellung und arzneimittel

Country Status (15)

Country Link
US (1) US4322347A (US07714131-20100511-C00024.png)
JP (1) JPS54132594A (US07714131-20100511-C00024.png)
BE (1) BE875247A (US07714131-20100511-C00024.png)
CA (1) CA1140915A (US07714131-20100511-C00024.png)
CH (1) CH642080A5 (US07714131-20100511-C00024.png)
DE (1) DE2912483A1 (US07714131-20100511-C00024.png)
DK (1) DK129779A (US07714131-20100511-C00024.png)
FR (1) FR2421903B1 (US07714131-20100511-C00024.png)
GB (1) GB2017705B (US07714131-20100511-C00024.png)
IE (1) IE49046B1 (US07714131-20100511-C00024.png)
IT (1) IT1116851B (US07714131-20100511-C00024.png)
LU (1) LU81108A1 (US07714131-20100511-C00024.png)
NL (1) NL7902443A (US07714131-20100511-C00024.png)
SE (3) SE448239B (US07714131-20100511-C00024.png)
YU (5) YU41860B (US07714131-20100511-C00024.png)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374982A (en) * 1979-11-07 1983-02-22 Bristol-Myers Company Cepham compounds
IT1148888B (it) * 1980-07-15 1986-12-03 Schiena Ricerche Di Composti antibiotici
EP0367124A1 (en) * 1988-10-31 1990-05-09 F. Hoffmann-La Roche Ag Penicillanic acid derivatives
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
ES2636448T3 (es) 2011-12-20 2017-10-05 Riboscience Llc Derivados de nucleósido 2',4'-difluoro-2'-metil sustituidos como inhibidores de la replicación del ARN del VHC
US9708357B2 (en) 2011-12-20 2017-07-18 Riboscience, LLC 4′-azido, 3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
PE20160119A1 (es) 2013-05-16 2016-02-24 Riboscience Llc Derivados de nucleosido 4'-azido, 3'-desoxi-3'-fluoro sustituido
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
WO2014186637A1 (en) 2013-05-16 2014-11-20 Riboscience Llc 4'-fluor0-2'-methyl substituted nucleoside derivatives
JP7299897B2 (ja) 2017-09-21 2023-06-28 リボサイエンス リミティド ライアビリティ カンパニー Ｈｃｖのｒｎａ複製阻害剤としての４’－フルオロ－２’－メチル置換ヌクレオシド誘導体

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2311664A1 (de) * 1972-03-13 1973-10-04 Astra Laekemedel Ab Lactame, verfahren zu deren herstellung und sie enthaltende pharmazeutische mittel
DE2528556A1 (de) * 1974-06-27 1976-01-15 Toyama Chemical Co Ltd Bis-penicillinverbindungen, verfahren zur herstellung derselben und mittel mit einem gehalt derselben
DE2707577A1 (de) * 1976-02-25 1977-09-01 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl- cephalosporanate
DE2655949A1 (de) * 1976-12-10 1978-06-15 Gruenenthal Gmbh Neue cephalosporin- und penicillinderivate, verfahren zu deren herstellung und diese produkte enthaltende arzneimittel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275626A (en) * 1962-07-31 1966-09-27 Lilly Co Eli Penicillin conversion via sulfoxide
US3714156A (en) * 1970-06-22 1973-01-30 Univ California Lactam process
BE787618A (fr) 1971-08-17 1973-02-16 Gist Brocades Nv Procede pour preparer des composes heterocycliques
US4218374A (en) * 1972-10-20 1980-08-19 Fujisawa Pharmaceutical Company, Limited Penam derivatives
GB1465893A (en) * 1973-02-09 1977-03-02 Gist Brocades Nv I-carboxypropenyl-4-iminothio-azetidine-2-one derivatives methods for their preparation and use
DE2309599A1 (de) * 1973-02-26 1974-09-05 Bayer Ag Verfahren zur herstellung von 7-acylamino-desacetoxy-cephalosporansaeurederivaten
US4010156A (en) * 1973-04-19 1977-03-01 American Home Products Corporation Process for the rearrangement of penicillins to cephalosporins and intermediate compounds thereof
DE2320040A1 (de) 1973-04-19 1974-11-07 Bayer Ag Verfahren zur herstellung von 7acylamino-desacetoxy-cephalosporansaeureester
FR2340093A1 (fr) 1976-02-05 1977-09-02 Roussel Uclaf Derives de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
CA1125745A (en) * 1978-11-20 1982-06-15 Joseph Kaspi PROCESS FOR PREPARING .beta.-LACTAM ANTIBIOTICS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2311664A1 (de) * 1972-03-13 1973-10-04 Astra Laekemedel Ab Lactame, verfahren zu deren herstellung und sie enthaltende pharmazeutische mittel
DE2528556A1 (de) * 1974-06-27 1976-01-15 Toyama Chemical Co Ltd Bis-penicillinverbindungen, verfahren zur herstellung derselben und mittel mit einem gehalt derselben
DE2707577A1 (de) * 1976-02-25 1977-09-01 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl- cephalosporanate
DE2655949A1 (de) * 1976-12-10 1978-06-15 Gruenenthal Gmbh Neue cephalosporin- und penicillinderivate, verfahren zu deren herstellung und diese produkte enthaltende arzneimittel

Also Published As

Publication number Publication date
SE8402090L (sv) 1984-04-13
SE448239B (sv) 1987-02-02
US4322347A (en) 1982-03-30
IE790947L (en) 1979-10-03
YU75679A (en) 1983-01-21
YU42050B (en) 1988-04-30
BE875247A (fr) 1979-10-01
NL7902443A (nl) 1979-10-05
CA1140915A (en) 1983-02-08
YU220782A (en) 1983-01-21
YU220682A (en) 1983-01-21
YU42803B (en) 1988-12-31
SE8402090D0 (sv) 1984-04-13
JPH0217557B2 (US07714131-20100511-C00024.png) 1990-04-20
IE49046B1 (en) 1985-07-24
SE8402089D0 (sv) 1984-04-13
IT7948457A0 (it) 1979-03-23
IT1116851B (it) 1986-02-10
YU220482A (en) 1983-01-21
SE8402089L (sv) 1984-04-13
YU42802B (en) 1988-12-31
DK129779A (da) 1979-10-04
YU41860B (en) 1988-02-29
FR2421903A1 (fr) 1979-11-02
SE458610B (sv) 1989-04-17
FR2421903B1 (fr) 1986-08-29
JPS54132594A (en) 1979-10-15
LU81108A1 (de) 1979-11-07
SE7902916L (sv) 1979-10-04
YU43096B (en) 1989-02-28
YU220582A (en) 1983-01-21
SE458609B (sv) 1989-04-17
GB2017705A (en) 1979-10-10
GB2017705B (en) 1982-10-27
CH642080A5 (fr) 1984-03-30

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee