DE2861316D1 - Thienothiazine derivatives, their preparation and compositions containing them - Google Patents

Thienothiazine derivatives, their preparation and compositions containing them

Info

Publication number
DE2861316D1
DE2861316D1 DE7878100832T DE2861316T DE2861316D1 DE 2861316 D1 DE2861316 D1 DE 2861316D1 DE 7878100832 T DE7878100832 T DE 7878100832T DE 2861316 T DE2861316 T DE 2861316T DE 2861316 D1 DE2861316 D1 DE 2861316D1
Authority
DE
Germany
Prior art keywords
preparation
compositions containing
thienothiazine derivatives
thienothiazine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7878100832T
Other languages
German (de)
English (en)
Inventor
Rudolf Dr Pfister
Paul Dr Zeller
Dieter Prof Dr Binder
Otto Prof Dr Hromatka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hafslund Nycomed Pharma AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE2861316D1 publication Critical patent/DE2861316D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE7878100832T 1977-09-06 1978-09-06 Thienothiazine derivatives, their preparation and compositions containing them Expired DE2861316D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU78083 1977-09-06
CH790878 1978-07-21

Publications (1)

Publication Number Publication Date
DE2861316D1 true DE2861316D1 (en) 1982-01-14

Family

ID=25702440

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19782838851 Withdrawn DE2838851A1 (de) 1977-09-06 1978-09-06 Thiazinderivate
DE7878100832T Expired DE2861316D1 (en) 1977-09-06 1978-09-06 Thienothiazine derivatives, their preparation and compositions containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19782838851 Withdrawn DE2838851A1 (de) 1977-09-06 1978-09-06 Thiazinderivate

Country Status (28)

Country Link
US (1) US4180662A (enExample)
EP (1) EP0001113B1 (enExample)
JP (1) JPS5448792A (enExample)
AR (1) AR222472A1 (enExample)
AT (1) AT364851B (enExample)
AU (1) AU518216B2 (enExample)
BR (1) BR7805845A (enExample)
CA (1) CA1103246A (enExample)
CS (1) CS202019B2 (enExample)
DE (2) DE2838851A1 (enExample)
DK (1) DK148280C (enExample)
ES (1) ES473074A1 (enExample)
FI (1) FI63587C (enExample)
GB (1) GB2003877B (enExample)
GR (1) GR73066B (enExample)
HK (1) HK1085A (enExample)
HU (1) HU176979B (enExample)
IE (1) IE47261B1 (enExample)
IL (1) IL55465A (enExample)
IT (1) IT1099046B (enExample)
LU (1) LU90207I2 (enExample)
MC (1) MC1212A1 (enExample)
NL (1) NL7809015A (enExample)
NO (1) NO149174C (enExample)
NZ (1) NZ188320A (enExample)
PH (1) PH13949A (enExample)
PT (1) PT68515A (enExample)
SE (1) SE7809348L (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2838377A1 (de) * 1978-09-02 1980-03-20 Thomae Gmbh Dr K Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung
AU5811280A (en) * 1979-06-13 1980-12-18 F. Hoffmann-La Roche Ag Thiazine derivatives
JPS58109492A (ja) * 1981-12-22 1983-06-29 Mitsui Toatsu Chem Inc チエノチアジン誘導体およびそれを含有する医薬組成物
DE3371082D1 (de) * 1982-09-09 1987-05-27 Hoffmann La Roche Thieno(2,3-e)-1,2-thiazine derivatives
GR80576B (en) * 1983-10-17 1984-11-29 Fujisawa Pharmaceutical Co Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
DE3346526C2 (de) * 1983-12-22 1986-12-11 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
JPS60184077A (ja) * 1984-02-23 1985-09-19 フアイザー・インコーポレーテツド 抗炎症性オキシム前駆薬
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
MX174093B (es) * 1987-06-10 1994-04-21 Pfizer 1,1-DIOXIDOS DE 3,4-DIHIDRO-2-ALQUIL-3-OXO-N-ARIL-2H[1] BENZOTIENO[3,2-e]-1,2-TIAZINO-4-CARBOXIAMIDA
IL87951A (en) * 1987-10-29 1992-03-29 Chem Pharm Forsch Gmbh Carbonic acid esters of 6-chloro-4-(1-hydroxyethoxy)-2-methyl-n-(2-pyridyl)-2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide,their preparation and pharmaceutical compositions containing them
ATA39088A (de) 1988-02-18 1990-06-15 Binder Dieter Dr Basisch substituierte thienoisothiazol-3(2h)-on-1,1-dioxide und ihre pharmazeutisch vertraeglichen salze, verfahren zu ihrer herstellung und ihre verwendung
AT390060B (de) * 1988-05-02 1990-03-12 Cl Pharma Verfahren zur herstellung von 5-chlor-3chlorsulfonyl-2-thiophencarbonsaeureestern
JPH01316314A (ja) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd 湿布剤
JPH01316315A (ja) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd 硬膏剤
AT400437B (de) * 1993-12-14 1995-12-27 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
AT400568B (de) * 1994-05-18 1996-01-25 Chem Pharm Forsch Gmbh Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung
DE4141218A1 (de) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel
AT399880B (de) 1992-07-03 1995-08-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
AT400845B (de) * 1993-12-06 1996-03-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
DE19747625A1 (de) * 1997-10-29 1999-05-06 Bayer Ag Verfahren zur Herstellung von 3,5-Dimethylisoxazol-4-sulfochlorid
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
DE19933260A1 (de) 1999-07-15 2001-01-18 Bayer Ag Substituierte Thien-3-yl-sulfonylamino(thio)carbonyl-triazolin(thi)one
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
PL395097A1 (pl) * 2001-06-11 2011-10-10 Vertex Pharmaceuticals (Canada) Incorporated Sposób wytwarzania związku o wzorze A stanowiącego pochodną tiofenu
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
ES2345438T3 (es) * 2002-12-10 2010-09-23 Virochem Pharma Inc. Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.
AT413944B (de) * 2003-05-27 2006-07-15 Binder Eva Dkfm Verwendung von oxicam-verbindungen
CN1266155C (zh) * 2003-08-01 2006-07-26 浙江震元制药有限公司 6－氯－4－羟基－2－甲基－2H－噻吩并（2，3－e）－1，2－噻嗪－1，1－二氧化物－3－羧酸酯的合成方法
DE102004010812A1 (de) * 2004-03-05 2005-09-22 Bayer Cropscience Ag Unkrautbekämpfungsverfahren
ES2777924T3 (es) 2004-05-23 2020-08-06 Hmi Medical Innovations Llc Moduladores de teramuteína
EP2546246A3 (en) 2005-05-13 2013-04-24 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
AU2006318383A1 (en) * 2005-11-23 2007-05-31 Gerard M. Housey Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
JP5378221B2 (ja) 2006-10-11 2013-12-25 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するオキシカム及び関連化合物の正荷電水溶性プロドラッグ
EA201101492A1 (ru) 2006-11-15 2012-09-28 Вирокем Фарма Инк. Аналоги тиофена для лечения или предупреждения флавивирусных инфекций
WO2008149181A1 (en) * 2007-06-04 2008-12-11 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
CN101314598B (zh) * 2008-07-14 2012-03-21 浙江工业大学 5-氯-2-羧酸甲酯-3-甲胺基磺酰噻吩的合成新工艺
WO2010065936A1 (en) 2008-12-04 2010-06-10 Chongxi Yu High penetration compositions and their applications
CN104540504A (zh) 2012-01-18 2015-04-22 苏州泰飞尔医药有限公司 治疗肺部疾病的高穿透力前药组合物和医药组合物
ITUB20152229A1 (it) * 2015-07-16 2017-01-16 Edmond Pharma Srl Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam
CN108218895B (zh) * 2018-04-13 2019-06-18 北京金城泰尔制药有限公司沧州分公司 一锅法合成氯诺昔康中间体的方法
CN112125792B (zh) * 2020-09-24 2022-07-12 万华化学集团股份有限公司 一种联产羟基香茅醛和羟基香茅醇的方法
CN112661742A (zh) * 2020-12-25 2021-04-16 北京金城泰尔制药有限公司 氯诺昔康金属化活性中间体的合成方法
CN112645925A (zh) * 2020-12-25 2021-04-13 北京金城泰尔制药有限公司 氯诺昔康中间体5-氯-3-甲基磺酰胺噻吩-2-羧酸甲酯的合成方法
CN114213434A (zh) * 2021-12-29 2022-03-22 北京金城泰尔制药有限公司 氯诺昔康晶型及其制备方法
CN115894525B (zh) * 2023-01-04 2024-09-20 河北国龙制药有限公司 一种氯诺昔康中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1308533A (en) 1969-06-02 1973-02-21 Pfizer Benzothiazine dioxides as anti-thombotic agents
US3787324A (en) 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3821211A (en) * 1972-03-10 1974-06-28 Warner Lambert Co Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolycarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
CA1010990A (en) 1973-06-06 1977-05-24 Leopold H. O'donnell Video tape recording animation system
CA1066711A (en) * 1974-08-26 1979-11-20 Hoffmann-La Roche Limited Thiophene derivatives
IL47877A (en) 1974-08-26 1978-10-31 Sparamedica Ag Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them
MC1135A1 (fr) * 1976-02-23 1977-11-18 Hoffmann La Roche Derives de thiazine

Also Published As

Publication number Publication date
NO783032L (no) 1979-03-07
JPS6149318B2 (enExample) 1986-10-29
MC1212A1 (fr) 1979-05-18
IL55465A0 (en) 1978-10-31
ATA642178A (de) 1981-04-15
IT1099046B (it) 1985-09-18
BR7805845A (pt) 1979-04-24
DK392778A (da) 1979-03-07
AR222472A1 (es) 1981-05-29
IE47261B1 (en) 1984-02-08
GB2003877A (en) 1979-03-21
PH13949A (en) 1980-11-04
AU518216B2 (en) 1981-09-17
SE7809348L (sv) 1979-03-07
NZ188320A (en) 1981-01-23
DK148280C (da) 1985-11-18
JPS5448792A (en) 1979-04-17
NO149174C (no) 1984-02-29
DE2838851A1 (de) 1979-03-22
AU3938978A (en) 1980-03-06
GR73066B (enExample) 1984-01-30
NO149174B (no) 1983-11-21
ES473074A1 (es) 1979-10-16
EP0001113B1 (de) 1981-11-11
EP0001113A1 (de) 1979-03-21
NL7809015A (nl) 1979-03-08
AT364851B (de) 1981-11-25
IT7827396A0 (it) 1978-09-06
PT68515A (en) 1978-10-01
CS202019B2 (en) 1980-12-31
FI63587C (fi) 1983-07-11
US4180662A (en) 1979-12-25
HK1085A (en) 1985-01-11
FI63587B (fi) 1983-03-31
DK148280B (da) 1985-05-28
HU176979B (hu) 1981-06-28
GB2003877B (en) 1982-03-17
CA1103246A (en) 1981-06-16
IL55465A (en) 1982-02-28
LU90207I2 (fr) 1998-04-29
IE781788L (en) 1979-03-06
FI782737A7 (fi) 1979-03-07

Similar Documents

Publication Publication Date Title
DE2861316D1 (en) Thienothiazine derivatives, their preparation and compositions containing them
IL54842A (en) 1-piperidino-phthalazine derivatives,their preparation and pharmaceutical compositions containing them
IL55906A0 (en) Novel erythromycine derivatives,their preparation and phararmaceutical compositions containing them
IL56155A (en) Substituted alkanoylanilide derivatives,their preparation and pharmaceutical compositions comprising them
IL55770A (en) 4-phenyl-2-acylaminothiazole derivatives,their preparation and immunostimulant compositions containing them
IL56017A (en) 5-cyano-prostacyclin derivatives,their manufacture and pharmaceutical compositions containing them
IL55765A (en) Dehydropyridine derivatives,their preparation and pharmaceutical compositions containing them
IL55114A (en) 5-alkylthio-pyrimidine derivatives,their preparation and herbicidal compositions containing them
IL54535A0 (en) Novel -lactam derivatives, their preparation and pharmaceutical compositions containing them
IL53857A0 (en) New aminoalkoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
IL55115A0 (en) Novel indole derivatives,their preparation and pharmaceutiical compositions containing them
IL55832A0 (en) Novel 2-imino-imidazilidine derivatives,their manufacture and pharmacheutical compositions containing them
IL55254A (en) Bis-isoquinolinium compounds,their preparation and pharmaceutical compositions containing them
DE2860942D1 (en) Indanamines, processes for their preparation and compositions containing them
IL53766A0 (en) 4-diphenylmethylene-1-hydroxybenzyl-piperidine derivatives, their preparation and pharmaceutical compositions containing them
DE2860370D1 (en) Isopenicillins, processes for their preparation, and compositions containing them
IL55894A (en) 1-alkylenedithia (or oxathia) benzyl-4-heteroaryl-piperazine derivatives,their preparation and pharmaceutical compositions containing them
ZA783939B (en) New daunorubicin derivatives,their preparation,compositions containing them and their use
IL55857A (en) Benzodioxanylcarbonyl-piperazinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL53925A0 (en) Novel oxadiazolopyrimidine derivatives, their manufacture and pahrmaceutical compositions containing them
IL55168A0 (en) New imidazo-isoquinoline derivatives,their preparation andpharmaceutical compositions containing them
DE2860313D1 (en) Compositions containing aminoalkoxyamines, and processes for their preparation
IL53861A0 (en) Novel n-aralkylaniline derivatives, their preparation and pharmaceutical compositions containing them
EP0002939A3 (en) Novel carbothioamides, compositions containing them, their preparation and use
GB2001980B (en) Dioxazocine derivatives their preparation and compositions containing them

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: LENTIA GMBH, 8000 MUENCHEN, DE

8327 Change in the person/name/address of the patent owner

Owner name: HAFSLUND NYCOMED PHARMA AG, LINZ, AT

V448 Application of spc

Free format text: PRODUCT NAME: LORNOXICAM; REGISTRATION NO/DATE: DK/H/137/1-4, 19981104

Spc suppl protection certif: 199 75 003

Filing date: 19990108

V472 Application for supplementary protection certificate rejected

Free format text: PRODUCT NAME: LORNOXICAM; REGISTRATION NO/DATE: DK/H/137/1-4, 19981104

Spc suppl protection certif: 199 75 003

Filing date: 19990108