DE2837161A1 - Neue benzimidazole und deren verwendung - Google Patents

Neue benzimidazole und deren verwendung

Info

Publication number
DE2837161A1
DE2837161A1 DE19782837161 DE2837161A DE2837161A1 DE 2837161 A1 DE2837161 A1 DE 2837161A1 DE 19782837161 DE19782837161 DE 19782837161 DE 2837161 A DE2837161 A DE 2837161A DE 2837161 A1 DE2837161 A1 DE 2837161A1
Authority
DE
Germany
Prior art keywords
group
methyl
carbon atoms
hydrogen atom
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782837161
Other languages
German (de)
English (en)
Inventor
Volkhard Dipl Chem Dr Austel
Willi Dr Diederen
Wolfgang Dipl Chem Dr Eberlein
Walter Dr Haarmann
Joachim Dipl Chem Dr Heider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE19782837161 priority Critical patent/DE2837161A1/de
Priority to ES482789A priority patent/ES8101067A1/es
Priority to GR59689A priority patent/GR69998B/el
Priority to DE7979102758T priority patent/DE2962051D1/de
Priority to AT79102758T priority patent/ATE646T1/de
Priority to EP79102758A priority patent/EP0008391B1/de
Priority to FI792628A priority patent/FI66372C/fi
Priority to CA000334357A priority patent/CA1134362A/en
Priority to AU50279/79A priority patent/AU528825B2/en
Priority to DK354279A priority patent/DK152496C/da
Priority to JP10730779A priority patent/JPS5533479A/ja
Priority to IE1629/79A priority patent/IE48814B1/en
Priority to ZA00794472A priority patent/ZA794472B/xx
Publication of DE2837161A1 publication Critical patent/DE2837161A1/de
Priority to ES491970A priority patent/ES491970A0/es
Priority to US06/259,537 priority patent/US4361563A/en
Priority to PH25674A priority patent/PH17515A/en
Priority to SG2/85A priority patent/SG285G/en
Priority to HK505/85A priority patent/HK50585A/xx
Priority to CS914101A priority patent/CS410191A3/cs
Priority to MX9202731A priority patent/MX9202731A/es
Priority to BG098420A priority patent/BG60428B2/bg
Priority to NL980035C priority patent/NL980035I2/nl
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F8/00—Arrangements for software engineering
    • G06F8/30—Creation or generation of source code
    • G06F8/31—Programming languages or programming paradigms
    • G06F8/313—Logic programming, e.g. PROLOG programming language
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Software Systems (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19782837161 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung Withdrawn DE2837161A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung
ES482789A ES8101067A1 (es) 1978-08-25 1979-07-24 Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
GR59689A GR69998B (es) 1978-08-25 1979-07-25
DE7979102758T DE2962051D1 (en) 1978-08-25 1979-08-01 Benzimidazoles, their preparation and pharmaceutical compositions containing them
AT79102758T ATE646T1 (de) 1978-08-25 1979-08-01 Benzimidazole, deren herstellung und diese verbindungen enthaltende arzneimittel.
EP79102758A EP0008391B1 (de) 1978-08-25 1979-08-01 Benzimidazole, deren Herstellung und diese Verbindungen enthaltende Arzneimittel
FI792628A FI66372C (fi) 1978-08-25 1979-08-23 Foerfarande foer framstaellning av farmakologiskt verkande i 5- eller 6-staellning med en pyridazinonring substituerade besimidazoler
CA000334357A CA1134362A (en) 1978-08-25 1979-08-23 Benzimidazoles, their preparation and their use as pharmaceutical compositions
JP10730779A JPS5533479A (en) 1978-08-25 1979-08-24 Novel benzimidazole
ZA00794472A ZA794472B (en) 1978-08-25 1979-08-24 Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof
DK354279A DK152496C (da) 1978-08-25 1979-08-24 Analogifremgangsmaade til fremstilling af i 5- eller 6-stilling med en pyridazinonring substituerede benzimidazoler eller deres fysiologisk acceptable syreadditionssalte
AU50279/79A AU528825B2 (en) 1978-08-25 1979-08-24 (3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
IE1629/79A IE48814B1 (en) 1978-08-25 1979-08-24 New benzimidazoles,their preparation and their use as pharmaceutical compositions
ES491970A ES491970A0 (es) 1978-08-25 1980-05-29 Procedimiento para la preparacion de nuevos bencimidazoles, sustituidos en posicion 5 o 6 con un anillo de piridazinona
US06/259,537 US4361563A (en) 1978-08-25 1981-05-01 Pyridazinone-substituted benzimidazoles and salts
PH25674A PH17515A (en) 1978-08-25 1981-05-26 Pyridazinone-substituted benzimidazoles and salts thereof
SG2/85A SG285G (en) 1978-08-25 1985-01-03 Benzimidazoles,their preparation and pharmaceutical compositions containing them
HK505/85A HK50585A (en) 1978-08-25 1985-07-04 Benzimidazoles,their preparation and pharmaceutical compositions containing them
CS914101A CS410191A3 (en) 1978-08-25 1991-12-27 Benzimidazoles, process of their preparation and medicaments comprising said compounds
MX9202731A MX9202731A (es) 1978-08-25 1992-06-08 Nuevos bencimadizoles sustituidos en posicion 5 o 6 con un anillo de piridazinona.
BG098420A BG60428B2 (bg) 1978-08-25 1994-01-25 Бензимидазоли,метод за получаването им и лекарствени средства, които ги съдържат
NL980035C NL980035I2 (nl) 1978-08-25 1998-11-19 Benzimidazolen, de bereiding daarvan en deze verbindingen bevattende geneesmiddelen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung

Publications (1)

Publication Number Publication Date
DE2837161A1 true DE2837161A1 (de) 1980-03-06

Family

ID=6047905

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782837161 Withdrawn DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung

Country Status (3)

Country Link
JP (1) JPS5533479A (es)
DE (1) DE2837161A1 (es)
ZA (1) ZA794472B (es)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0339208A1 (de) * 1988-04-26 1989-11-02 HEUMANN PHARMA GMBH & CO 6-Oxo-pyridazinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4954501A (en) * 1988-02-12 1990-09-04 Heumann Pharma Gmbh & Co. Piperazine substituted 6-phenyldihydro-3(2H)-pyridazinones, and pharmaceutical preparations containing these
US5026705A (en) * 1985-02-19 1991-06-25 Merck Patent Gesellschaft Mit Beschrankter Haftung Benzimidazolylpyridazinones
US5108998A (en) * 1989-04-25 1992-04-28 Heumann Pharma Gmbh & Co. Cardiotonic thiadiazine derivatives
EP2088154A1 (en) 2004-03-09 2009-08-12 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
WO2011069038A2 (en) 2009-12-03 2011-06-09 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2013138352A1 (en) 2012-03-15 2013-09-19 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase c agonists and methods of use
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2810951A2 (en) 2008-06-04 2014-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP2998314A1 (en) 2007-06-04 2016-03-23 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839A1 (en) 2008-07-16 2017-11-08 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3805635A1 (de) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
DE4001622A1 (de) * 1990-01-20 1991-07-25 Thomae Gmbh Dr K Orale arzneimittelformen von pimobendan
JP4714921B2 (ja) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 ピモベンダンの製造法及びその中間体
CN101282929A (zh) * 2005-08-15 2008-10-08 Irm责任有限公司 用作tpo模拟物的化合物和组合物

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026705A (en) * 1985-02-19 1991-06-25 Merck Patent Gesellschaft Mit Beschrankter Haftung Benzimidazolylpyridazinones
US4954501A (en) * 1988-02-12 1990-09-04 Heumann Pharma Gmbh & Co. Piperazine substituted 6-phenyldihydro-3(2H)-pyridazinones, and pharmaceutical preparations containing these
EP0339208A1 (de) * 1988-04-26 1989-11-02 HEUMANN PHARMA GMBH & CO 6-Oxo-pyridazinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4968683A (en) * 1988-04-26 1990-11-06 Heumann Pharma Gmbh & Co. 6-oxo-pyridazine derivatives, a process for their preparation and medicaments containing these compounds
US5108998A (en) * 1989-04-25 1992-04-28 Heumann Pharma Gmbh & Co. Cardiotonic thiadiazine derivatives
EP2088154A1 (en) 2004-03-09 2009-08-12 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
EP2998314A1 (en) 2007-06-04 2016-03-23 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2810951A2 (en) 2008-06-04 2014-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839A1 (en) 2008-07-16 2017-11-08 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
EP2923706A1 (en) 2009-12-03 2015-09-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia
WO2011069038A2 (en) 2009-12-03 2011-06-09 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2013138352A1 (en) 2012-03-15 2013-09-19 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase c agonists and methods of use
EP4309673A2 (en) 2012-03-15 2024-01-24 Bausch Health Ireland Limited Formulations of guanylate cyclase c agonists and methods of use
EP3708179A1 (en) 2012-03-15 2020-09-16 Bausch Health Ireland Limited Formulations of guanylate cyclase c agonists and methods of use
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP3718557A2 (en) 2013-02-25 2020-10-07 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
EP4424697A2 (en) 2013-06-05 2024-09-04 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
EP3884935A1 (en) 2013-08-09 2021-09-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP3492106A1 (en) 2013-08-09 2019-06-05 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Also Published As

Publication number Publication date
ZA794472B (en) 1981-04-29
JPS5533479A (en) 1980-03-08
JPS6324996B2 (es) 1988-05-23

Similar Documents

Publication Publication Date Title
EP0008391B1 (de) Benzimidazole, deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2837161A1 (de) Neue benzimidazole und deren verwendung
DE2516040C2 (de) Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3224512A1 (de) Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE2927988A1 (de) Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
DE3522230A1 (de) Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE2927987A1 (de) Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
DE2905877A1 (de) Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3324115A1 (de) Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE2238504B2 (de) l-Phenoxy-3-alkylaminopropan-2-ol -Derivate
DE2427943C2 (de) Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3346575A1 (de) Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
EP0080176B1 (de) Triazolochinazoline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
EP0543263A2 (de) Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE1620016C3 (de) 3-{Piperazinoalkyl)-pyrazole und Verfahren zu ihrer Herstellung
DE3346640A1 (de) Neue imidazolderivate, deren herstellung und diese verbindungen enthaltende arzneimittel
DE2432269A1 (de) Basisch substituierte derivate des 4-hydroxybenzimidazols und verfahren zu ihrer herstellung
DE2850078A1 (de) Aminopropanolderivate des 6-hydroxy-2,3,4,5-tetrahydro-1h-1- benzazepin-2-ons
DE2732951A1 (de) Neue imidazo-isochinolin-dione
EP0137993B1 (de) Neue 11-Piperazinyl-5H-imidazo[2,1-c][1,4]benzodiazepine, Verfahren zu ihrer Herstellung und Zwischenprodukte und erstere enthaltende Arzneimittel
DE3639466A1 (de) Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE2922336A1 (de) Neue in 5- oder 6-stellung durch einen pyridazinonring substituierte benzimidazole und deren verwendung als arzneimittel
DE3346602A1 (de) Neue imidazo(4,5-c)pyridin-one, deren herstellung und diese verbindungen enthaltende arzneimittel
DE2102733A1 (en) 2-arylamino-2-imidazolines
EP0324988A1 (de) 4-Chlor-3-sulfamoyl-benzoesäure-hydrazide, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittelpräparate und Verwendung der neuen Verbindungen zur Herstellung von diuretischen und salzentziehend wirkenden Arzneimittelpräparaten

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee