DE2810918C2 - Taurin-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel - Google Patents
Taurin-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende ArzneimittelInfo
- Publication number
- DE2810918C2 DE2810918C2 DE2810918A DE2810918A DE2810918C2 DE 2810918 C2 DE2810918 C2 DE 2810918C2 DE 2810918 A DE2810918 A DE 2810918A DE 2810918 A DE2810918 A DE 2810918A DE 2810918 C2 DE2810918 C2 DE 2810918C2
- Authority
- DE
- Germany
- Prior art keywords
- acetyl
- taurine
- compounds
- preparation
- taurinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 title claims description 21
- 150000001875 compounds Chemical class 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 6
- 230000008569 process Effects 0.000 title claims description 6
- 239000003814 drug Substances 0.000 title claims description 4
- 238000002360 preparation method Methods 0.000 title claims description 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 15
- 239000011777 magnesium Substances 0.000 claims description 12
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 10
- 229910052749 magnesium Inorganic materials 0.000 claims description 10
- 229960003080 taurine Drugs 0.000 claims description 9
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical group [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 6
- 229910052744 lithium Inorganic materials 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims 2
- CXJAAWRLVGAKDV-UHFFFAOYSA-M acetyltaurine(1-) Chemical compound CC(=O)NCCS([O-])(=O)=O CXJAAWRLVGAKDV-UHFFFAOYSA-M 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 9
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 6
- 229940025084 amphetamine Drugs 0.000 description 6
- 230000002232 neuromuscular Effects 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- CXJAAWRLVGAKDV-UHFFFAOYSA-N acetyltaurine Chemical class CC(=O)NCCS(O)(=O)=O CXJAAWRLVGAKDV-UHFFFAOYSA-N 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 230000037007 arousal Effects 0.000 description 3
- 230000004899 motility Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 238000006640 acetylation reaction Methods 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000578 anorexic effect Effects 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 230000021824 exploration behavior Effects 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 230000002631 hypothermal effect Effects 0.000 description 2
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 2
- 108700039855 mouse a Proteins 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
- OROGUZVNAFJPHA-UHFFFAOYSA-N 3-hydroxy-2,4-dimethyl-2H-thiophen-5-one Chemical compound CC1SC(=O)C(C)=C1O OROGUZVNAFJPHA-UHFFFAOYSA-N 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000034308 Grand mal convulsion Diseases 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000001614 effect on membrane Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052808 lithium carbonate Inorganic materials 0.000 description 1
- 229940006487 lithium cation Drugs 0.000 description 1
- FUJCRWPEOMXPAD-UHFFFAOYSA-N lithium oxide Chemical compound [Li+].[Li+].[O-2] FUJCRWPEOMXPAD-UHFFFAOYSA-N 0.000 description 1
- 229910001947 lithium oxide Inorganic materials 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229960003151 mercaptamine Drugs 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000000701 neuroleptic effect Effects 0.000 description 1
- 208000018360 neuromuscular disease Diseases 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000002276 neurotropic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 125000001741 organic sulfur group Chemical group 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229960001639 penicillamine Drugs 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
- C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7708692A FR2384751A1 (fr) | 1977-03-23 | 1977-03-23 | Nouveaux derives de la taurine a activite neuro-musculaire renforcee |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2810918A1 DE2810918A1 (de) | 1978-09-28 |
| DE2810918C2 true DE2810918C2 (de) | 1985-06-20 |
Family
ID=9188473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2810918A Expired DE2810918C2 (de) | 1977-03-23 | 1978-03-14 | Taurin-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US4199601A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS53149928A (cg-RX-API-DMAC7.html) |
| AT (1) | AT356637B (cg-RX-API-DMAC7.html) |
| AU (1) | AU523705B2 (cg-RX-API-DMAC7.html) |
| BE (1) | BE865163A (cg-RX-API-DMAC7.html) |
| CA (1) | CA1095930A (cg-RX-API-DMAC7.html) |
| CH (1) | CH629479A5 (cg-RX-API-DMAC7.html) |
| DE (1) | DE2810918C2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES468201A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2384751A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1599962A (cg-RX-API-DMAC7.html) |
| GR (1) | GR62093B (cg-RX-API-DMAC7.html) |
| IT (1) | IT1111455B (cg-RX-API-DMAC7.html) |
| NL (1) | NL7803131A (cg-RX-API-DMAC7.html) |
| OA (1) | OA05914A (cg-RX-API-DMAC7.html) |
| SE (1) | SE443781B (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA781697B (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2457281A1 (fr) * | 1979-05-23 | 1980-12-19 | Meram Lab | Nouveaux derives de l'acide 3-aminopropanesulfonique ayant une activite membranaire renforcee |
| US4915685A (en) * | 1986-03-19 | 1990-04-10 | Petelenz Tomasz J | Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange |
| US5602150A (en) * | 1992-10-02 | 1997-02-11 | Research Foundation For Mental Hygiene, Inc. | Treatment of central nervous system disorders associated with psychotic behavior and dementia with a combination of neuroleptic drugs and taurine, or derivatives thereof, to prevent the development of tardive dyskinesia |
| US6099869A (en) | 1995-04-18 | 2000-08-08 | Nutrition 21 | Calcium taurate and antihypertensive drug for hypertension |
| IT1291127B1 (it) * | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
| ATE251129T1 (de) * | 1998-01-27 | 2003-10-15 | Merck Sante Sas | Derivatives of aminoalkane sulphonic, phosphonic and phosphinic acids, their preparation and their use as medicaments |
| CA2369997C (en) * | 1999-04-28 | 2009-11-17 | Queen's University At Kingston | Compositions and methods for treating amyloidosis |
| US6562836B1 (en) | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
| US6881750B2 (en) * | 2003-03-04 | 2005-04-19 | Nutrition Corp. Of America, Ltd. | Potassium taurate bicarbonate and ascorbate |
| US7414076B2 (en) * | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| AU2005310986A1 (en) * | 2004-11-12 | 2006-06-08 | Bellus Health (International) Limited | Methods and fluorinated compositions for treating amyloid-related diseases |
| AU2005310979A1 (en) * | 2004-11-16 | 2006-06-08 | Bellus Health (International) Limited | Compounds for the treatment of CNS and amyloid associated diseases |
| FR2878160B1 (fr) * | 2004-11-19 | 2008-07-25 | Jean Pierre Durlach | Utilisation du n-acetyl-taurinate de magnesium pour la preparation de medicaments inhibiteurs de l'hypersensiblite photique |
| EP1836161B1 (en) * | 2004-12-22 | 2016-07-20 | BHI Limited Partnership | Methods and compositions for treating amyloid-related diseases |
| SI2089417T1 (sl) | 2006-10-12 | 2015-04-30 | Bhi Limited Partnership | Metode, spojine, sestavki in vektorji za dostavo 3-amino-1-propansulfonske kisline |
| TW200924746A (en) * | 2007-09-07 | 2009-06-16 | Xenoport Inc | Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| WO2009033079A1 (en) * | 2007-09-07 | 2009-03-12 | Xenoport, Inc. | Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| US20090099253A1 (en) * | 2007-10-15 | 2009-04-16 | Xenoport, Inc. | Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use |
| FR2927809B1 (fr) | 2008-02-26 | 2011-01-14 | Tri Inov | Nouvelle utilisation de n-acetyl-taurinate de zinc. |
| RU2453310C1 (ru) * | 2010-12-09 | 2012-06-20 | Открытое акционерное общество "Всероссийский научный центр по безопасности биологически активных веществ" (ОАО "ВНЦ БАВ") | Средство, обладающее нейропротекторным действием в условиях ишемического поражения мозга и гипоксии, представляющее собой 2-аминоэтансульфонат магния, фармацевтические композиции |
| FR2973702B1 (fr) | 2011-04-08 | 2013-04-26 | Tri Inov | N-acetyl-taurinate de zinc pour le traitement du cancer de la prostate |
| BR112014012918A2 (pt) * | 2011-11-29 | 2017-06-13 | Basf Se | processo para preparar um sal de ácido, ácido, sal de sódio ácido, e, uso de um ácido |
| MX365366B (es) | 2015-06-17 | 2019-05-30 | Jean Profet Margaret | Formulaciones tópicas y orales que comprenden taurina y magnesio para la prevención y el tratamiento del acné. |
| CN112516123B (zh) * | 2015-12-25 | 2022-07-19 | 北京乳凝创智生物技术研发中心（有限合伙） | 一种保健品外用制剂 |
| BE1025644B1 (fr) * | 2017-10-13 | 2019-05-15 | Synapharm Industrial Synthesis | Compose pour le traitement d'une maladie ou d'un trouble du systeme nerveux central chez un sujet en stimulant et/ou en restaurant la plasticite neuronale |
| BE1025645B1 (fr) * | 2017-10-13 | 2019-05-15 | Synapharm Industrial Synthesis | Compose pour le traitement de la neurotoxicite due a l'hyperexcitabilite des recepteurs glutamatergiques ionotropes |
| EP3738588A1 (en) | 2019-05-13 | 2020-11-18 | Margaret Jean Profet | Topical and oral formulations comprising taurine and magnesium for use in the treatment of rosacea |
| WO2020229443A1 (fr) | 2019-05-16 | 2020-11-19 | Synapharm Industrial Synthesis | Composé et composition pour utilisation dans le traitement du syndrome prémenstruel et/ou du trouble dysphorique prémenstruel |
| ES2917623T3 (es) | 2019-05-16 | 2022-07-11 | Synapharm Ind Synthesis | Compuesto y composición para uso en el tratamiento del síndrome premenstrual y/o del trastorno disfórico premenstrual |
| BE1026955B1 (fr) * | 2019-06-11 | 2020-08-04 | Synapharm Ind Synthesis | Procédé de fabrication de N-acétyl-taurinate de magnésium |
| RU2730835C1 (ru) * | 2019-10-23 | 2020-08-26 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ФГБОУ ВО ВолгГМУ МЗ РФ | Дикалиевая соль N-(3-гидроксибензоил)таурина, обладающая антиагрегантной и антитромботической активностью в сочетании с церебропротективным действием |
| RU2731106C1 (ru) * | 2019-10-23 | 2020-08-28 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ФГБОУ ВО ВолгГМУ МЗ РФ | Дикалиевая соль N-(4-гидроксибензоил)таурина, обладающая антиагрегантной и антитромботической активностью |
| WO2021245697A1 (en) | 2020-06-01 | 2021-12-09 | Celagenex Research (India) Pvt. Ltd. | Novel synergistic medicinal compositions for treating dysfunctional d-serine signaling |
| WO2026013679A1 (en) * | 2024-07-11 | 2026-01-15 | Celagenex Research (India) Pvt. Ltd. | A conjugate compound for regulation of mbp expression and novel in-situ process for preparation thereof. |
| CN119504517B (zh) * | 2025-01-22 | 2025-04-18 | 浙江天启生化股份有限公司 | 一种乙酰牛磺酸镁的制备方法 |
| WO2026162765A1 (en) * | 2025-01-31 | 2026-08-06 | Synapharm Industrial Synthesis | Compound and compositions for weight management and related conditions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3232968A (en) * | 1959-12-01 | 1966-02-01 | Gen Aniline & Film Corp | Process for preparing n-acyl taurates using hypophosphorous acid as catalyst |
| US3344174A (en) * | 1962-08-21 | 1967-09-26 | Monsanto Co | Vicinal acylamido sulfonate compounds |
| DE1256650B (de) * | 1965-08-07 | 1967-12-21 | Dr Dieter Arlt | Verfahren zur Herstellung von N-acylierten 2-Amino-alkan-sulfonsaeuren-(1) bzw. von 2-Amino-alkan-sulfonsaeuren-(1) |
| US3544597A (en) * | 1969-06-12 | 1970-12-01 | Rohm & Haas | Process for manufacturing sulfonated amides |
| US3960918A (en) * | 1973-06-26 | 1976-06-01 | The Lubrizol Corporation | Preparation of esters of amidoalkanesulfonic acids |
-
1977
- 1977-03-23 FR FR7708692A patent/FR2384751A1/fr active Granted
-
1978
- 1978-03-06 GR GR55625A patent/GR62093B/el unknown
- 1978-03-14 DE DE2810918A patent/DE2810918C2/de not_active Expired
- 1978-03-16 SE SE7803032A patent/SE443781B/sv not_active IP Right Cessation
- 1978-03-17 GB GB10688/78A patent/GB1599962A/en not_active Expired
- 1978-03-20 OA OA56441A patent/OA05914A/xx unknown
- 1978-03-20 CA CA299,464A patent/CA1095930A/en not_active Expired
- 1978-03-20 US US05/888,202 patent/US4199601A/en not_active Expired - Lifetime
- 1978-03-22 AT AT202878A patent/AT356637B/de not_active IP Right Cessation
- 1978-03-22 IT IT67631/78A patent/IT1111455B/it active
- 1978-03-22 ES ES468201A patent/ES468201A1/es not_active Expired
- 1978-03-22 CH CH312778A patent/CH629479A5/fr not_active IP Right Cessation
- 1978-03-22 BE BE2056782A patent/BE865163A/xx not_active IP Right Cessation
- 1978-03-23 ZA ZA00781697A patent/ZA781697B/xx unknown
- 1978-03-23 NL NL7803131A patent/NL7803131A/xx not_active Application Discontinuation
- 1978-03-23 JP JP3398978A patent/JPS53149928A/ja active Granted
- 1978-03-31 AU AU34634/78A patent/AU523705B2/en not_active Expired
-
1979
- 1979-12-14 US US06/103,729 patent/US4271189A/en not_active Expired - Lifetime
- 1979-12-14 US US06/103,730 patent/US4267194A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AT356637B (de) | 1980-05-12 |
| IT1111455B (it) | 1986-01-13 |
| JPS53149928A (en) | 1978-12-27 |
| AU523705B2 (en) | 1982-08-12 |
| GR62093B (en) | 1979-02-22 |
| ZA781697B (en) | 1979-03-28 |
| IT7867631A0 (it) | 1978-03-22 |
| OA05914A (fr) | 1981-06-30 |
| SE443781B (sv) | 1986-03-10 |
| FR2384751A1 (fr) | 1978-10-20 |
| CA1095930A (en) | 1981-02-17 |
| NL7803131A (nl) | 1978-09-26 |
| GB1599962A (en) | 1981-10-07 |
| ES468201A1 (es) | 1978-12-01 |
| BE865163A (fr) | 1978-09-22 |
| US4271189A (en) | 1981-06-02 |
| JPS6256867B2 (cg-RX-API-DMAC7.html) | 1987-11-27 |
| SE7803032L (sv) | 1978-09-24 |
| ATA202878A (de) | 1979-10-15 |
| US4199601A (en) | 1980-04-22 |
| FR2384751B1 (cg-RX-API-DMAC7.html) | 1979-07-20 |
| DE2810918A1 (de) | 1978-09-28 |
| CH629479A5 (fr) | 1982-04-30 |
| AU3463478A (en) | 1979-10-04 |
| US4267194A (en) | 1981-05-12 |
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