DE2747496A1 - Verfahren und vorrichtung zur bestimmung pathogener mikroorganismen - Google Patents
Verfahren und vorrichtung zur bestimmung pathogener mikroorganismenInfo
- Publication number
- DE2747496A1 DE2747496A1 DE19772747496 DE2747496A DE2747496A1 DE 2747496 A1 DE2747496 A1 DE 2747496A1 DE 19772747496 DE19772747496 DE 19772747496 DE 2747496 A DE2747496 A DE 2747496A DE 2747496 A1 DE2747496 A1 DE 2747496A1
- Authority
- DE
- Germany
- Prior art keywords
- container
- pathogenic microorganisms
- forming agent
- liquid
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000000010 microbial pathogen Species 0.000 title claims description 89
- 238000000034 method Methods 0.000 title claims description 52
- 210000004369 blood Anatomy 0.000 claims description 128
- 239000008280 blood Substances 0.000 claims description 128
- 239000003795 chemical substances by application Substances 0.000 claims description 127
- 239000007788 liquid Substances 0.000 claims description 112
- 238000005119 centrifugation Methods 0.000 claims description 37
- 244000005700 microbiome Species 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 20
- 231100000252 nontoxic Toxicity 0.000 claims description 14
- 230000003000 nontoxic effect Effects 0.000 claims description 14
- 244000052769 pathogen Species 0.000 claims description 12
- 230000002209 hydrophobic effect Effects 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 239000003146 anticoagulant agent Substances 0.000 claims description 8
- 229940127219 anticoagulant drug Drugs 0.000 claims description 8
- 230000000295 complement effect Effects 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- 229930195733 hydrocarbon Natural products 0.000 claims description 7
- 150000002430 hydrocarbons Chemical class 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000004090 dissolution Methods 0.000 claims description 6
- 239000001963 growth medium Substances 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 3
- 230000001775 anti-pathogenic effect Effects 0.000 claims description 2
- 230000007480 spreading Effects 0.000 claims description 2
- 238000003892 spreading Methods 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 4
- 239000002609 medium Substances 0.000 description 45
- RVZRBWKZFJCCIB-UHFFFAOYSA-N perfluorotributylamine Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)N(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F RVZRBWKZFJCCIB-UHFFFAOYSA-N 0.000 description 17
- 239000000463 material Substances 0.000 description 14
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 13
- 229930006000 Sucrose Natural products 0.000 description 13
- 239000005720 sucrose Substances 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 12
- 238000011084 recovery Methods 0.000 description 11
- 206010040047 Sepsis Diseases 0.000 description 10
- 229920001971 elastomer Polymers 0.000 description 9
- 239000007864 aqueous solution Substances 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 239000012530 fluid Substances 0.000 description 7
- 230000001717 pathogenic effect Effects 0.000 description 7
- 229930182490 saponin Natural products 0.000 description 6
- 150000007949 saponins Chemical class 0.000 description 6
- 235000017709 saponins Nutrition 0.000 description 6
- 239000006161 blood agar Substances 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 239000000306 component Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 229920001463 polyanetholesulfonic acid sodium salt Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000009969 flowable effect Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000565 sealant Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000007330 chocolate agar Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940023064 escherichia coli Drugs 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 229920002050 silicone resin Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000012364 cultivation method Methods 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000013536 elastomeric material Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 238000007431 microscopic evaluation Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Centrifugal Separators (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/739,274 US4131512A (en) | 1976-11-05 | 1976-11-05 | Method for detecting microbial pathogens employing a cushioning agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2747496A1 true DE2747496A1 (de) | 1978-05-18 |
| DE2747496C2 DE2747496C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-03-17 |
Family
ID=24971572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772747496 Granted DE2747496A1 (de) | 1976-11-05 | 1977-10-22 | Verfahren und vorrichtung zur bestimmung pathogener mikroorganismen |
Country Status (20)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4212948A (en) * | 1978-10-18 | 1980-07-15 | J. K. And Susie L. Wadley Research Institute And Blood Bank | Apparatus for detecting microbial pathogens employing a cushioning agent |
| US4342724A (en) * | 1980-08-21 | 1982-08-03 | E. R. Squibb & Sons, Inc. | Red cell labeling vial |
| US5070014A (en) * | 1982-09-30 | 1991-12-03 | Wadley Technologies, Inc. | Stabilization of specimens for microbial analysis |
| US4581331A (en) * | 1983-09-29 | 1986-04-08 | E. I. Du Pont De Nemours And Company | Method for the rapid detection of virus and viral antigens |
| US4693972A (en) * | 1984-01-16 | 1987-09-15 | Becton, Dickinson And Company | Composition and method for rapid detection of microorganisms in clinical samples |
| US5043267A (en) * | 1984-05-18 | 1991-08-27 | E. I. Du Pont De Nemours And Company | Method for rapid detection of bacterial and fungal infection |
| AU679822B2 (en) * | 1993-12-03 | 1997-07-10 | Gordon L. Dorn | Method for improving quantitative recovery of microorganisms from specimens containing blood components |
| FR2732037B1 (fr) * | 1995-03-20 | 1997-05-30 | Dbv | Procede de detection de microorganismes par separation et culture sur un systeme gelifie, systeme gelifie et necessaire de dosage pour mettre en oeuvre ce procede, utilisation en microbiologie |
| DE19801090A1 (de) * | 1998-01-14 | 1999-07-15 | Gerhard Haase | Lysis-Filtrations-Assay LYFA |
| BRPI0919896A2 (pt) * | 2008-10-31 | 2016-02-16 | Bio Merieux Inc | metodos para a separacao,caracterizacao e/ou identificacao de micro-organismos por espectroscopia de massa. |
| MX2011004169A (es) * | 2008-10-31 | 2011-09-27 | Bio Merieux Inc | Metodos para la separacion y caracterizacion de microorganismos utilizando agentes identificadores. |
| BRPI0920586A2 (pt) * | 2008-10-31 | 2017-05-30 | Bio Merieux Inc | dispositivo de separacao para uso na separacao ,caracterizacao e/ou identificacao de micro-organismos. |
| EP2364447B1 (en) * | 2008-10-31 | 2019-06-12 | Biomerieux, Inc | Method for the identification of microorganisms |
| WO2010062350A1 (en) * | 2008-10-31 | 2010-06-03 | Biomerieux, Inc. | Methods for detection, characterization and/or identification of microorganisms in a sealed container |
| BRPI0919861A2 (pt) * | 2008-10-31 | 2017-04-04 | Bio Merieux Inc | metodos para a separacao, caracterizacao e/ou identificacao de micro-organismos por espectroscopia raman |
| RU2531225C2 (ru) * | 2008-10-31 | 2014-10-20 | Биомерье, Инк. | Способы идентификации микроорганизмов с помощью спектроскопии (варианты) |
| US8647835B2 (en) | 2008-10-31 | 2014-02-11 | BIO MéRIEUX, INC. | Methods for separation, characterization and/or identification of microorganisms using spectroscopy |
| US8975060B2 (en) | 2012-11-30 | 2015-03-10 | Qvella Corporation | Method for pretreatment of microbial samples |
| US9707555B2 (en) | 2012-11-30 | 2017-07-18 | Qvella Corporation | Method for pretreatment of microbial samples |
| EP3142796A4 (en) | 2014-05-16 | 2017-12-20 | Qvella Corporation | Apparatus, system and method for performing automated centrifugal separation |
| US10870110B2 (en) | 2015-12-11 | 2020-12-22 | Babson Diagnostics, Inc. | Specimen container and centrifugation method for separating serum or plasma from whole blood therewith |
| WO2018090030A2 (en) | 2016-11-14 | 2018-05-17 | Siemens Healthcare Diagnostics Inc. | Sample preparation device |
| WO2019023218A1 (en) * | 2017-07-24 | 2019-01-31 | Epitope Diagnostics, Inc. | DEVICE AND METHOD FOR COLLECTING FECAL SAMPLE AND EXTRACTING ANALYTE |
| EP3803326A4 (en) | 2018-05-25 | 2022-02-23 | Qvella Corporation | METHODS AND COMPOSITIONS FOR SELECTIVE LYSIS OF BLOOD CELLS AND SEPARATION OF MICROBIAL CELLS |
| US12050052B1 (en) | 2021-08-06 | 2024-07-30 | Babson Diagnostics, Inc. | Refrigerated carrier device for biological samples |
| EP4505185A1 (en) | 2022-04-06 | 2025-02-12 | Babson Diagnostics, Inc. | Automated centrifuge loader |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3875012A (en) * | 1974-01-30 | 1975-04-01 | Wadley Res Inst & Blood Bank | Apparatus and method for the detection of microbial pathogens |
| US3932222A (en) * | 1974-12-20 | 1976-01-13 | J. K. & Susie L. Wadley Research Institute And Blood Bank | For isolating pathogenic microorganisms |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL277884A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1961-05-02 | |||
| US3519400A (en) * | 1967-01-25 | 1970-07-07 | Atomic Energy Commission | Method of centrifugal separation and recovery of chemical species utilizing a liquid medium |
| US3928139A (en) * | 1973-02-12 | 1975-12-23 | Wadley Res Inst & Blood Bank | Detection of microbial pathogens |
-
1976
- 1976-11-05 US US05/739,274 patent/US4131512A/en not_active Expired - Lifetime
-
1977
- 1977-10-22 DE DE19772747496 patent/DE2747496A1/de active Granted
- 1977-10-24 AU AU29995/77A patent/AU519142B2/en not_active Expired
- 1977-10-28 FI FI773237A patent/FI60888C/fi not_active IP Right Cessation
- 1977-10-28 ZA ZA00776438A patent/ZA776438B/xx unknown
- 1977-10-28 CH CH1315177A patent/CH636128A5/de not_active IP Right Cessation
- 1977-10-31 IL IL53258A patent/IL53258A/xx unknown
- 1977-10-31 NZ NZ185557A patent/NZ185557A/xx unknown
- 1977-11-01 NL NLAANVRAGE7712022,A patent/NL180253C/xx not_active IP Right Cessation
- 1977-11-02 FR FR7732920A patent/FR2393063A1/fr active Granted
- 1977-11-04 BE BE182350A patent/BE860490A/xx not_active IP Right Cessation
- 1977-11-04 NO NO773796A patent/NO150521C/no unknown
- 1977-11-04 GB GB45958/77A patent/GB1546043A/en not_active Expired
- 1977-11-04 CA CA290,205A patent/CA1098429A/en not_active Expired
- 1977-11-04 SE SE7712508A patent/SE447485B/sv not_active IP Right Cessation
- 1977-11-04 DK DK492777A patent/DK153763C/da not_active IP Right Cessation
- 1977-11-04 IT IT51693/77A patent/IT1090428B/it active
- 1977-11-04 AT AT789477A patent/AT359207B/de not_active IP Right Cessation
- 1977-11-04 ES ES463854A patent/ES463854A1/es not_active Expired
- 1977-11-05 JP JP13297077A patent/JPS5386012A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3875012A (en) * | 1974-01-30 | 1975-04-01 | Wadley Res Inst & Blood Bank | Apparatus and method for the detection of microbial pathogens |
| US3932222A (en) * | 1974-12-20 | 1976-01-13 | J. K. & Susie L. Wadley Research Institute And Blood Bank | For isolating pathogenic microorganisms |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OB | Request for examination as to novelty | ||
| OC | Search report available | ||
| 8110 | Request for examination paragraph 44 | ||
| 8126 | Change of the secondary classification |
Ipc: C12N 1/02 |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Free format text: STOLBERG-WERNIGERODE, GRAF ZU, U., DIPL.-CHEM. DR.RER.NAT. SUCHANTKE, J., DIPL.-ING., PAT.-ANWAELTE, 2000 HAMBURG |