DE2740950A1 - Verfahren zur herstellung von flavonen - Google Patents

Verfahren zur herstellung von flavonen

Info

Publication number
DE2740950A1
DE2740950A1 DE19772740950 DE2740950A DE2740950A1 DE 2740950 A1 DE2740950 A1 DE 2740950A1 DE 19772740950 DE19772740950 DE 19772740950 DE 2740950 A DE2740950 A DE 2740950A DE 2740950 A1 DE2740950 A1 DE 2740950A1
Authority
DE
Germany
Prior art keywords
iodine
solvent
flavanone
glycoside
flavone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19772740950
Other languages
German (de)
English (en)
Other versions
DE2740950C2 (no
Inventor
Hartmut Dr Haertner
Hans-Walter Dr Voigtlaender
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE19772740950 priority Critical patent/DE2740950A1/de
Priority to FR7825878A priority patent/FR2402655A1/fr
Priority to CH942078A priority patent/CH636869A5/de
Priority to IT51027/78A priority patent/IT1107693B/it
Priority to ES473195A priority patent/ES473195A1/es
Publication of DE2740950A1 publication Critical patent/DE2740950A1/de
Application granted granted Critical
Publication of DE2740950C2 publication Critical patent/DE2740950C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
DE19772740950 1977-09-10 1977-09-10 Verfahren zur herstellung von flavonen Granted DE2740950A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE19772740950 DE2740950A1 (de) 1977-09-10 1977-09-10 Verfahren zur herstellung von flavonen
FR7825878A FR2402655A1 (fr) 1977-09-10 1978-09-08 Procede de preparation de flavones
CH942078A CH636869A5 (en) 1977-09-10 1978-09-08 Process for the preparation of flavones
IT51027/78A IT1107693B (it) 1977-09-10 1978-09-08 Procedimento per la produzione di flavoni
ES473195A ES473195A1 (es) 1977-09-10 1978-09-08 Procedimiento para la obtencion de flavonas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772740950 DE2740950A1 (de) 1977-09-10 1977-09-10 Verfahren zur herstellung von flavonen

Publications (2)

Publication Number Publication Date
DE2740950A1 true DE2740950A1 (de) 1979-03-22
DE2740950C2 DE2740950C2 (no) 1987-10-22

Family

ID=6018705

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772740950 Granted DE2740950A1 (de) 1977-09-10 1977-09-10 Verfahren zur herstellung von flavonen

Country Status (5)

Country Link
CH (1) CH636869A5 (no)
DE (1) DE2740950A1 (no)
ES (1) ES473195A1 (no)
FR (1) FR2402655A1 (no)
IT (1) IT1107693B (no)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352792A (en) * 1979-04-10 1982-10-05 Hoffmann-La Roche Inc. 3-Alkoxyflavone antiviral agents
EP0081621A1 (en) * 1981-12-14 1983-06-22 Pennwalt Corporation Chromones
FR2782518A1 (fr) * 1998-08-19 2000-02-25 Innokem Sarl Procede de fabrication industrielle de diosmine a partir de l'hesperidine par reaction avec de l'iode et de la pyridine
WO2010092592A2 (en) * 2009-02-11 2010-08-19 Elder Pharmaceuticals Ltd. Process for the preparation of diosmin
CN102875621A (zh) * 2012-10-26 2013-01-16 成都澜绮制药有限公司 地奥司明的合成方法
EP3053930A1 (en) 2015-02-03 2016-08-10 Interquim, S.A. Process for the preparation of diosmin
CN114306363A (zh) * 2022-01-05 2022-04-12 成都亚中生物制药有限责任公司 一种工业化制备柑橘黄酮原料药的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1134205B (it) * 1980-11-11 1986-08-13 Bonomelli Spa Processo per la produzione di derivati flavonici ad attivita' medicinale
FR2798932B1 (fr) * 1999-09-24 2001-12-07 Isochem Sa Procede de purification de la diosmine
CN103833810A (zh) * 2014-02-12 2014-06-04 李玉山 一种野漆树苷的制备新技术
CN113583063A (zh) * 2021-08-18 2021-11-02 陕西嘉禾生物科技股份有限公司 一种利用柚皮苷合成大波斯菊苷的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2844454A1 (de) * 1977-12-16 1979-06-21 Merck Patent Gmbh Verfahren zur herstellung von flavonglykosiden

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2844454A1 (de) * 1977-12-16 1979-06-21 Merck Patent Gmbh Verfahren zur herstellung von flavonglykosiden

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Chem. Ind. 1979, 315-316 *
GEISSMAN, T.A., "The Chemistry of Flavonoid Compounds", Pergamon Press, Oxford, 1962, S. 160-161, 193 *
J. Org. Chem. 30, 1965, 4346-4349 *
Testrahedron letters 1968 (13), 1635-1639 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352792A (en) * 1979-04-10 1982-10-05 Hoffmann-La Roche Inc. 3-Alkoxyflavone antiviral agents
EP0081621A1 (en) * 1981-12-14 1983-06-22 Pennwalt Corporation Chromones
FR2782518A1 (fr) * 1998-08-19 2000-02-25 Innokem Sarl Procede de fabrication industrielle de diosmine a partir de l'hesperidine par reaction avec de l'iode et de la pyridine
WO2000011009A3 (fr) * 1998-08-19 2000-06-29 Innokem Sarl Procede de fabrication industrielle de diosmine a partir de l'hesperidine par reaction avec de l'iode et de la pyridine
WO2010092592A2 (en) * 2009-02-11 2010-08-19 Elder Pharmaceuticals Ltd. Process for the preparation of diosmin
WO2010092592A3 (en) * 2009-02-11 2011-09-09 Elder Pharmaceuticals Ltd. Process for the preparation of diosmin
CN102875621A (zh) * 2012-10-26 2013-01-16 成都澜绮制药有限公司 地奥司明的合成方法
EP3053930A1 (en) 2015-02-03 2016-08-10 Interquim, S.A. Process for the preparation of diosmin
WO2016124585A1 (en) * 2015-02-03 2016-08-11 Interquim, S.A. Process for the preparation of diosmin
US10287310B2 (en) 2015-02-03 2019-05-14 Interquim, S.A. Process for the preparation of diosmin
EA032402B1 (ru) * 2015-02-03 2019-05-31 Интерким, С.А. Способ получения диосмина
US10711025B2 (en) 2015-02-03 2020-07-14 Interquim, S.A. Process for the preparation of diosmin
CN114306363A (zh) * 2022-01-05 2022-04-12 成都亚中生物制药有限责任公司 一种工业化制备柑橘黄酮原料药的方法
CN114306363B (zh) * 2022-01-05 2022-11-08 成都亚中生物制药有限责任公司 一种工业化制备柑橘黄酮原料药的方法

Also Published As

Publication number Publication date
FR2402655A1 (fr) 1979-04-06
FR2402655B1 (no) 1983-01-28
ES473195A1 (es) 1979-11-16
CH636869A5 (en) 1983-06-30
DE2740950C2 (no) 1987-10-22
IT1107693B (it) 1985-11-25
IT7851027A0 (it) 1978-09-08

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee