DE2706317C3 - Verfahren zur Herstellung eines Vlieses auf Kollagenbasis - Google Patents
Verfahren zur Herstellung eines Vlieses auf KollagenbasisInfo
- Publication number
- DE2706317C3 DE2706317C3 DE2706317A DE2706317A DE2706317C3 DE 2706317 C3 DE2706317 C3 DE 2706317C3 DE 2706317 A DE2706317 A DE 2706317A DE 2706317 A DE2706317 A DE 2706317A DE 2706317 C3 DE2706317 C3 DE 2706317C3
- Authority
- DE
- Germany
- Prior art keywords
- fibers
- fleece
- water
- acid
- collagen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000008186 Collagen Human genes 0.000 title claims description 29
- 108010035532 Collagen Proteins 0.000 title claims description 29
- 229920001436 collagen Polymers 0.000 title claims description 29
- 238000000034 method Methods 0.000 title claims description 21
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 239000004745 nonwoven fabric Substances 0.000 title description 35
- 239000000835 fiber Substances 0.000 claims description 92
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- 239000007788 liquid Substances 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 22
- 239000002002 slurry Substances 0.000 claims description 22
- 239000002253 acid Substances 0.000 claims description 20
- 238000004108 freeze drying Methods 0.000 claims description 7
- 230000002378 acidificating effect Effects 0.000 claims description 6
- 238000002386 leaching Methods 0.000 claims description 4
- 206010052428 Wound Diseases 0.000 description 24
- 208000027418 Wounds and injury Diseases 0.000 description 24
- -1 polypropylene Polymers 0.000 description 23
- 239000000463 material Substances 0.000 description 17
- 230000002439 hemostatic effect Effects 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 239000004744 fabric Substances 0.000 description 11
- 239000004743 Polypropylene Substances 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 230000001070 adhesive effect Effects 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 10
- 229920001155 polypropylene Polymers 0.000 description 10
- 239000000853 adhesive Substances 0.000 description 9
- 229920000139 polyethylene terephthalate Polymers 0.000 description 8
- 239000005020 polyethylene terephthalate Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 208000032843 Hemorrhage Diseases 0.000 description 7
- 230000000740 bleeding effect Effects 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 238000004299 exfoliation Methods 0.000 description 6
- 238000009736 wetting Methods 0.000 description 6
- 229920000742 Cotton Polymers 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 235000013351 cheese Nutrition 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 230000001427 coherent effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000002657 fibrous material Substances 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- MLIREBYILWEBDM-UHFFFAOYSA-N cyanoacetic acid Chemical compound OC(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-N 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000007655 standard test method Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- 240000006240 Linum usitatissimum Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
- 206010037867 Rash macular Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940095564 anhydrous calcium sulfate Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000006003 cornification Effects 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000009991 scouring Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0033—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/08—Collagen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S602/00—Surgery: splint, brace, or bandage
- Y10S602/90—Method of making bandage structure
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Nonwoven Fabrics (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/660,065 US4016877A (en) | 1976-02-23 | 1976-02-23 | Fibrous collagen derived web having hemostatic and wound sealing properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2706317A1 DE2706317A1 (de) | 1977-08-25 |
| DE2706317B2 DE2706317B2 (de) | 1981-07-16 |
| DE2706317C3 true DE2706317C3 (de) | 1982-04-29 |
Family
ID=24647989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2706317A Expired DE2706317C3 (de) | 1976-02-23 | 1977-02-15 | Verfahren zur Herstellung eines Vlieses auf Kollagenbasis |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4016877A (OSRAM) |
| JP (1) | JPS5941745B2 (OSRAM) |
| CA (1) | CA1079635A (OSRAM) |
| DE (1) | DE2706317C3 (OSRAM) |
| FR (1) | FR2341322A1 (OSRAM) |
| GB (1) | GB1561925A (OSRAM) |
| IT (1) | IT1086764B (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4167945A (en) * | 1977-01-31 | 1979-09-18 | Gottlieb Sheldon K | Method for enhancing the healing of grafted tissue |
| US4238480A (en) * | 1978-05-19 | 1980-12-09 | Sawyer Philip Nicholas | Method for preparing an improved hemostatic agent and method of employing the same |
| CA1156529A (en) * | 1980-06-12 | 1983-11-08 | Fred A. Serravallo | Fibrous collagenous hemostatic-adhesive webs |
| US4361552A (en) * | 1980-09-26 | 1982-11-30 | Board Of Regents, The University Of Texas System | Wound dressing |
| US4578067A (en) * | 1982-04-12 | 1986-03-25 | Alcon (Puerto Rico) Inc. | Hemostatic-adhesive, collagen dressing for severed biological surfaces |
| CA1209475A (en) * | 1982-04-12 | 1986-08-12 | Mamerto M. Cruz, Jr. | Hemostatic-adhesive collagen dressing for severed biological surfaces |
| US5725522A (en) * | 1990-06-15 | 1998-03-10 | Rare Earth Medical, Inc. | Laser suturing of biological materials |
| US5071417A (en) * | 1990-06-15 | 1991-12-10 | Rare Earth Medical Lasers, Inc. | Laser fusion of biological materials |
| US5540677A (en) * | 1990-06-15 | 1996-07-30 | Rare Earth Medical, Inc. | Endoscopic systems for photoreactive suturing of biological materials |
| JPH0783759B2 (ja) * | 1990-06-29 | 1995-09-13 | 株式会社高研 | コラーゲン繊維止血材及びその製造方法 |
| US6350274B1 (en) | 1992-05-11 | 2002-02-26 | Regen Biologics, Inc. | Soft tissue closure systems |
| US5326350A (en) * | 1992-05-11 | 1994-07-05 | Li Shu Tung | Soft tissue closure systems |
| US5383896A (en) * | 1993-05-25 | 1995-01-24 | Gershony; Gary | Vascular sealing device |
| US6017359A (en) * | 1993-05-25 | 2000-01-25 | Vascular Solutions, Inc. | Vascular sealing apparatus |
| US5868778A (en) * | 1995-10-27 | 1999-02-09 | Vascular Solutions, Inc. | Vascular sealing apparatus and method |
| US5554106A (en) * | 1994-10-13 | 1996-09-10 | Quinton Instrument Company | Hydrocolloid exit site dressing |
| US5569207A (en) * | 1994-10-13 | 1996-10-29 | Quinton Instrument Company | Hydrocolloid dressing |
| ATE244584T1 (de) * | 1995-01-16 | 2003-07-15 | Baxter Int | Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen |
| US20020131933A1 (en) * | 1996-01-16 | 2002-09-19 | Yves Delmotte | Biopolymer membrane and methods for its preparation |
| JP3799626B2 (ja) * | 1995-04-25 | 2006-07-19 | 有限会社ナイセム | 心臓血管修復材及びその製造方法 |
| EP0917444A1 (en) | 1996-07-12 | 1999-05-26 | Baxter Travenol Laboratories, Inc. | A fibrin delivery device and method for forming fibrin on a surface |
| US5827840A (en) * | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US6261582B1 (en) * | 1996-10-15 | 2001-07-17 | C. R. Bard, Inc. | Surgical method and composition therefor |
| ATE306935T1 (de) * | 1997-09-16 | 2005-11-15 | Integra Lifesciences Corp | Zusammensetzung zur förderung des wachstums von duralem oder meningealem gewebe enthaltend kollagen |
| US5997895A (en) * | 1997-09-16 | 1999-12-07 | Integra Lifesciences Corporation | Dural/meningeal repair product using collagen matrix |
| BE1012536A3 (fr) | 1998-11-04 | 2000-12-05 | Baxter Int | Element muni d'une couche de fibrine sa preparation et son utilisation. |
| US6361551B1 (en) | 1998-12-11 | 2002-03-26 | C. R. Bard, Inc. | Collagen hemostatic fibers |
| US6454787B1 (en) | 1998-12-11 | 2002-09-24 | C. R. Bard, Inc. | Collagen hemostatic foam |
| US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
| RU2243728C1 (ru) * | 2003-04-30 | 2005-01-10 | Кулик Ярослав Петрович | Устройство (протектор) для профилактики, остановки и контроля кровотечения при выполнении лапароскопических операций |
| JP4681214B2 (ja) * | 2003-06-10 | 2011-05-11 | グンゼ株式会社 | コラーゲンスポンジの製造方法及び人工皮膚の製造方法 |
| US20050283256A1 (en) * | 2004-02-09 | 2005-12-22 | Codman & Shurtleff, Inc. | Collagen device and method of preparing the same |
| WO2006107188A1 (en) | 2005-04-06 | 2006-10-12 | Fujifilm Manufacturing Europe B.V. | A non-porous film for culturing cells |
| US8227415B2 (en) * | 2005-04-06 | 2012-07-24 | Fujifilm Manufacturing Europe B.V. | Non-porous film for culturing cells |
| RU2287333C1 (ru) * | 2005-06-06 | 2006-11-20 | Леонид Прокофьевич Истранов | Гемостатический материал |
| US7429241B2 (en) | 2005-09-29 | 2008-09-30 | Codman & Shurtleff, Inc. | Dural graft and method of preparing the same |
| US9095569B2 (en) | 2008-04-18 | 2015-08-04 | Collplant Ltd. | Methods of generating and using procollagen |
| AU2009201541B2 (en) * | 2008-04-23 | 2014-12-04 | Integra Lifesciences Corporation | Flowable collagen material for dural closure |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3438374A (en) * | 1966-02-28 | 1969-04-15 | Us Health Education & Welfare | Method of bonding tissue surfaces and controlling hemorrhaging thereof using a tissue adhesive and hemostatic composition |
| US3563228A (en) * | 1969-02-28 | 1971-02-16 | Maurice Seiderman | Process of forming adherent films on animal tissue |
| US3742955A (en) * | 1970-09-29 | 1973-07-03 | Fmc Corp | Fibrous collagen derived product having hemostatic and wound binding properties |
| US3810473A (en) * | 1972-12-04 | 1974-05-14 | Avicon Inc | Liquid-laid, non-woven, fibrous collagen derived surgical web having hemostatic and wound sealing properties |
| US3892648A (en) * | 1974-04-16 | 1975-07-01 | Us Navy | Electrochemical deposition of bone |
-
1976
- 1976-02-23 US US05/660,065 patent/US4016877A/en not_active Expired - Lifetime
-
1977
- 1977-01-20 GB GB2397/77A patent/GB1561925A/en not_active Expired
- 1977-01-21 CA CA270,261A patent/CA1079635A/en not_active Expired
- 1977-01-24 IT IT7747776A patent/IT1086764B/it active
- 1977-02-15 DE DE2706317A patent/DE2706317C3/de not_active Expired
- 1977-02-16 FR FR7704429A patent/FR2341322A1/fr active Granted
- 1977-02-23 JP JP52019127A patent/JPS5941745B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1561925A (en) | 1980-03-05 |
| IT1086764B (it) | 1985-05-31 |
| US4016877A (en) | 1977-04-12 |
| JPS52102418A (en) | 1977-08-27 |
| DE2706317A1 (de) | 1977-08-25 |
| FR2341322B1 (OSRAM) | 1979-03-09 |
| CA1079635A (en) | 1980-06-17 |
| DE2706317B2 (de) | 1981-07-16 |
| JPS5941745B2 (ja) | 1984-10-09 |
| FR2341322A1 (fr) | 1977-09-16 |
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| DE2146790A1 (de) | Saugfaehige produkte und verfahren zu ihrer herstellung |
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