DE2646213A1 - Aroylphenylnaphthaline und verfahren zu ihrer herstellung - Google Patents

Aroylphenylnaphthaline und verfahren zu ihrer herstellung

Info

Publication number
DE2646213A1
DE2646213A1 DE19762646213 DE2646213A DE2646213A1 DE 2646213 A1 DE2646213 A1 DE 2646213A1 DE 19762646213 DE19762646213 DE 19762646213 DE 2646213 A DE2646213 A DE 2646213A DE 2646213 A1 DE2646213 A1 DE 2646213A1
Authority
DE
Germany
Prior art keywords
benzoyl
substituents
pyrrolidinoethoxy
dihydronaphthalene
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19762646213
Other languages
German (de)
English (en)
Other versions
DE2646213C2 (bg
Inventor
Charles David Jones
Tulio Suarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE2646213A1 publication Critical patent/DE2646213A1/de
Application granted granted Critical
Publication of DE2646213C2 publication Critical patent/DE2646213C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE19762646213 1975-10-28 1976-10-13 Aroylphenylnaphthaline und verfahren zu ihrer herstellung Granted DE2646213A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62599175A 1975-10-28 1975-10-28

Publications (2)

Publication Number Publication Date
DE2646213A1 true DE2646213A1 (de) 1977-05-12
DE2646213C2 DE2646213C2 (bg) 1987-02-12

Family

ID=24508491

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762646213 Granted DE2646213A1 (de) 1975-10-28 1976-10-13 Aroylphenylnaphthaline und verfahren zu ihrer herstellung

Country Status (30)

Country Link
JP (1) JPS6045191B2 (bg)
AR (1) AR214622A1 (bg)
AT (1) AT346321B (bg)
AU (1) AU509372B2 (bg)
BE (1) BE847716A (bg)
BG (1) BG27555A3 (bg)
CA (1) CA1078834A (bg)
CH (2) CH624398A5 (bg)
CS (1) CS235057B2 (bg)
DD (1) DD127460A5 (bg)
DE (1) DE2646213A1 (bg)
DK (1) DK484776A (bg)
ES (1) ES452735A1 (bg)
FR (1) FR2329264A1 (bg)
GB (1) GB1561687A (bg)
GR (1) GR61816B (bg)
HU (1) HU175227B (bg)
IE (1) IE43641B1 (bg)
IL (1) IL50772A (bg)
MX (1) MX4291E (bg)
NL (1) NL187164C (bg)
NZ (1) NZ182421A (bg)
PH (1) PH14538A (bg)
PL (2) PL111987B1 (bg)
PT (1) PT65752B (bg)
RO (1) RO70755A (bg)
SE (1) SE428689B (bg)
SU (2) SU791220A3 (bg)
YU (1) YU262276A (bg)
ZA (1) ZA766439B (bg)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0731093A1 (en) * 1995-03-10 1996-09-11 Eli Lilly And Company Naphthyl pharmaceutical compounds

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179558A (en) * 1978-01-30 1979-12-18 E. R. Squibb & Sons, Inc. Naphthalenone derivatives and analogs
DE3121175A1 (de) * 1981-05-27 1982-12-16 Klinge Pharma GmbH, 8000 München Erythro-1,2,3-triphenyl-1-pentanon-derivate sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPH0717589B2 (ja) * 1990-01-22 1995-03-01 ファイザー製薬株式会社 新規１，３―ジカルボニル化合物およびその組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0731093A1 (en) * 1995-03-10 1996-09-11 Eli Lilly And Company Naphthyl pharmaceutical compounds

Also Published As

Publication number Publication date
NL187164C (nl) 1991-06-17
JPS6045191B2 (ja) 1985-10-08
CH624376A5 (en) 1981-07-31
BG27555A3 (bg) 1979-11-12
CH624398A5 (en) 1981-07-31
AU509372B2 (en) 1980-05-08
RO70755A (ro) 1981-01-30
JPS5253845A (en) 1977-04-30
GB1561687A (en) 1980-02-27
ZA766439B (en) 1978-06-28
CS235057B2 (en) 1985-04-16
PT65752A (en) 1976-11-01
FR2329264B1 (bg) 1978-11-17
YU262276A (en) 1982-05-31
DE2646213C2 (bg) 1987-02-12
MX4291E (es) 1982-03-17
FR2329264A1 (fr) 1977-05-27
PL104551B1 (pl) 1979-08-31
SE428689B (sv) 1983-07-18
DK484776A (da) 1977-04-29
ATA800576A (de) 1978-03-15
IL50772A (en) 1980-11-30
NL187164B (nl) 1991-01-16
AU1900476A (en) 1978-05-04
DD127460A5 (bg) 1977-09-28
ES452735A1 (es) 1978-01-01
IE43641L (en) 1977-04-28
SE7611953L (sv) 1977-04-29
IL50772A0 (en) 1976-12-31
BE847716A (fr) 1977-04-28
PL111987B1 (en) 1980-09-30
PT65752B (en) 1978-04-20
HU175227B (hu) 1980-06-28
CA1078834A (en) 1980-06-03
IE43641B1 (en) 1981-04-22
AT346321B (de) 1978-11-10
NZ182421A (en) 1978-11-13
AR214622A1 (es) 1979-07-13
SU791220A3 (ru) 1980-12-23
GR61816B (en) 1979-01-22
PH14538A (en) 1981-09-24
NL7611974A (nl) 1977-05-02
SU818476A3 (ru) 1981-03-30

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8128 New person/name/address of the agent

Representative=s name: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 800

D2 Grant after examination
8364 No opposition during term of opposition