DE2510633C3 - Diagnostisches Mittel zum Nachweis von Eiweiß in Körperflüssigkeiten und dafür geeignete Indikatorfarbstoffe - Google Patents

Diagnostisches Mittel zum Nachweis von Eiweiß in Körperflüssigkeiten und dafür geeignete Indikatorfarbstoffe

Info

Publication number
DE2510633C3
DE2510633C3 DE2510633A DE2510633A DE2510633C3 DE 2510633 C3 DE2510633 C3 DE 2510633C3 DE 2510633 A DE2510633 A DE 2510633A DE 2510633 A DE2510633 A DE 2510633A DE 2510633 C3 DE2510633 C3 DE 2510633C3
Authority
DE
Germany
Prior art keywords
protein
indicator
polypropylene glycol
detection
approx
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2510633A
Other languages
German (de)
English (en)
Other versions
DE2510633A1 (de
DE2510633B2 (de
Inventor
Werner Dr.Rer.Nat. Guethlein
Hans-Georg Dr.Rer.Nat. Rey
Peter Dr.Rer.Nat. Rieckmann
Walter Dr.Rer.Nat. Rittersdorf
Wolfgang Dr.Rer.Nat. Werner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE2510633A priority Critical patent/DE2510633C3/de
Priority to SE7602134A priority patent/SE423754B/xx
Priority to DD191553A priority patent/DD125021A5/xx
Priority to DD7600198424A priority patent/DD129788A5/xx
Priority to US05/661,687 priority patent/US4013416A/en
Priority to SU762328363A priority patent/SU633501A3/ru
Priority to CS761458A priority patent/CS190526B2/cs
Priority to ES445808A priority patent/ES445808A1/es
Priority to FI760578A priority patent/FI59678C/fi
Priority to IL49167A priority patent/IL49167A/xx
Priority to YU00594/76A priority patent/YU59476A/xx
Priority to IT20968/76A priority patent/IT1056947B/it
Priority to NL7602442.A priority patent/NL164966C/xx
Priority to BE164993A priority patent/BE839363A/xx
Priority to DK103276A priority patent/DK144443C/da
Priority to HU76BO00001602A priority patent/HU172450B/hu
Priority to LU74519A priority patent/LU74519A1/xx
Priority to CH296376A priority patent/CH627000A5/de
Priority to PL1976187846A priority patent/PL103510B1/pl
Priority to GB27421/76A priority patent/GB1487718A/en
Priority to IE2561/77A priority patent/IE42507B1/en
Priority to AU11895/76A priority patent/AU501932B2/en
Priority to IE504/76A priority patent/IE42506B1/en
Priority to GB9734/76A priority patent/GB1487717A/en
Priority to FR7606937A priority patent/FR2304084A1/fr
Priority to IE772561A priority patent/IE42507L/xx
Priority to AT180576A priority patent/AT349153B/de
Priority to CA248,333A priority patent/CA1055824A/en
Priority to JP51027019A priority patent/JPS5278866A/ja
Publication of DE2510633A1 publication Critical patent/DE2510633A1/de
Priority to US05/740,462 priority patent/US4260777A/en
Priority to SU772482007A priority patent/SU625610A3/ru
Priority to CS776442A priority patent/CS196222B2/cs
Publication of DE2510633B2 publication Critical patent/DE2510633B2/de
Priority to CA306,133A priority patent/CA1055954A/en
Application granted granted Critical
Publication of DE2510633C3 publication Critical patent/DE2510633C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G01N33/6839—Total protein determination, e.g. albumin in urine involving dyes, e.g. Coomassie blue, bromcresol green

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE2510633A 1975-03-12 1975-03-12 Diagnostisches Mittel zum Nachweis von Eiweiß in Körperflüssigkeiten und dafür geeignete Indikatorfarbstoffe Expired DE2510633C3 (de)

Priority Applications (33)

Application Number Priority Date Filing Date Title
DE2510633A DE2510633C3 (de) 1975-03-12 1975-03-12 Diagnostisches Mittel zum Nachweis von Eiweiß in Körperflüssigkeiten und dafür geeignete Indikatorfarbstoffe
SE7602134A SE423754B (sv) 1975-03-12 1976-02-23 Diagnostiskt medel for pavisande av eggvita i kroppsvetskor
DD7600198424A DD129788A5 (de) 1975-03-12 1976-02-26 Verfahren zur herstellung von 3',3'',5',5''-tetrachlorphenol-3,4,5,6-tetrabromsulfophthalein bzw.3',3''-dibrom-5',5''-dichlorphenol-3,4,5,6-tetrachlorsulfophthalein
US05/661,687 US4013416A (en) 1975-03-12 1976-02-26 Diagnostic means for the detection of protein in body fluids
DD191553A DD125021A5 (enExample) 1975-03-12 1976-02-26
SU762328363A SU633501A3 (ru) 1975-03-12 1976-03-05 Реагент дл обнаружени белка в моче
CS761458A CS190526B2 (en) 1975-03-12 1976-03-05 Diagnostic means for detecting the protein in the bodily fluids
ES445808A ES445808A1 (es) 1975-03-12 1976-03-05 Procedimiento para la preparacion de agentes para diagnosti-co, para la deteccion de albumina en liquidos corporales.
FI760578A FI59678C (fi) 1975-03-12 1976-03-05 Diagnostiskt medel foer att paovisa aeggvita i kroppsvaetskor
IL49167A IL49167A (en) 1975-03-12 1976-03-05 Diagnostic agent for the detection of protein body fluids, containing a 3,3',3'',4,5,5',5'',6-octahalosulphophthalein protein error indicator, novel 3,3',3'',4,5,5',5'',6-oct-halosulphophtalein derivatives and processes for the preparation thereof
YU00594/76A YU59476A (en) 1975-03-12 1976-03-08 Analysis device for proving albumins in body liquids
IT20968/76A IT1056947B (it) 1975-03-12 1976-03-08 Mezzo diagnostico per l identificazione di sostanze proteiche in liquidi fisiologici
BE164993A BE839363A (fr) 1975-03-12 1976-03-09 Indicateurs pour la detection d'albumine dans les liquides corporels
NL7602442.A NL164966C (nl) 1975-03-12 1976-03-09 Werkwijze voor de bereiding van een diagnostisch middel voor het aantonen van eiwit in lichaamsvloeistoffen.
CH296376A CH627000A5 (enExample) 1975-03-12 1976-03-10
LU74519A LU74519A1 (enExample) 1975-03-12 1976-03-10
DK103276A DK144443C (da) 1975-03-12 1976-03-10 Diagnostisk middel til paavisning af aeggehvide i legemsvaesker og fremgangsmaade til fremstilling af midlet
HU76BO00001602A HU172450B (hu) 1975-03-12 1976-03-10 Diagnosticheskijj apparat dlja vyjavlenija proteinov v telovykh zhidkostjakh i dlja poluchenija komponentov indikatorov
IE772561A IE42507L (en) 1975-03-12 1976-03-11 Sulphophthaleins
IE2561/77A IE42507B1 (en) 1975-03-12 1976-03-11 Halogenated sulphophthaleins
AU11895/76A AU501932B2 (en) 1975-03-12 1976-03-11 Diagnostic agent for protein
IE504/76A IE42506B1 (en) 1975-03-12 1976-03-11 Diagnostic agent for the detection of protein in body fluids
GB9734/76A GB1487717A (en) 1975-03-12 1976-03-11 Diagnostic agent for the detection of protein in body fluids
FR7606937A FR2304084A1 (fr) 1975-03-12 1976-03-11 Agent de diagnostic pour la detection d'albumine dans des liquides physiologiques
PL1976187846A PL103510B1 (pl) 1975-03-12 1976-03-11 Srodek do wykrywania bialka oraz sposob wytwarzania srodka do wykrywania bialka
AT180576A AT349153B (de) 1975-03-12 1976-03-11 Diagnostisches mittel zum nachweis von eiweiss in koerperfluessigkeiten
GB27421/76A GB1487718A (en) 1975-03-12 1976-03-11 Halogenated sulphophthaleins
CA248,333A CA1055824A (en) 1975-03-12 1976-03-12 Diagnostic agent for the detection of protein in body fluids
JP51027019A JPS5278866A (en) 1975-03-12 1976-03-12 Production of octahalogenphenol sulphophthaleine and diagnostic agent containing the same for detecting protein
US05/740,462 US4260777A (en) 1975-03-12 1976-11-10 Diagnostic agent for the detection of protein in body fluids
SU772482007A SU625610A3 (ru) 1975-03-12 1977-05-23 Способ получени 3,3,5,5тетрахлорфенол-3,4,5,6тетрабромсульфофталеина или 3,3-дибром -5,5-дихлорфенол3,4,5,6-тетрахлорсульфофталеина
CS776442A CS196222B2 (cs) 1975-03-12 1977-10-05 Způsob výroby nových oktahalogensulfoftaleinů
CA306,133A CA1055954A (en) 1975-03-12 1978-06-23 Halogenated sulphophthaleins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2510633A DE2510633C3 (de) 1975-03-12 1975-03-12 Diagnostisches Mittel zum Nachweis von Eiweiß in Körperflüssigkeiten und dafür geeignete Indikatorfarbstoffe

Publications (3)

Publication Number Publication Date
DE2510633A1 DE2510633A1 (de) 1976-09-16
DE2510633B2 DE2510633B2 (de) 1977-11-10
DE2510633C3 true DE2510633C3 (de) 1978-07-13

Family

ID=5941061

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2510633A Expired DE2510633C3 (de) 1975-03-12 1975-03-12 Diagnostisches Mittel zum Nachweis von Eiweiß in Körperflüssigkeiten und dafür geeignete Indikatorfarbstoffe

Country Status (25)

Country Link
US (2) US4013416A (enExample)
JP (1) JPS5278866A (enExample)
AT (1) AT349153B (enExample)
AU (1) AU501932B2 (enExample)
BE (1) BE839363A (enExample)
CA (1) CA1055824A (enExample)
CH (1) CH627000A5 (enExample)
CS (1) CS190526B2 (enExample)
DD (2) DD125021A5 (enExample)
DE (1) DE2510633C3 (enExample)
DK (1) DK144443C (enExample)
ES (1) ES445808A1 (enExample)
FI (1) FI59678C (enExample)
FR (1) FR2304084A1 (enExample)
GB (2) GB1487717A (enExample)
HU (1) HU172450B (enExample)
IE (3) IE42506B1 (enExample)
IL (1) IL49167A (enExample)
IT (1) IT1056947B (enExample)
LU (1) LU74519A1 (enExample)
NL (1) NL164966C (enExample)
PL (1) PL103510B1 (enExample)
SE (1) SE423754B (enExample)
SU (2) SU633501A3 (enExample)
YU (1) YU59476A (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5513814A (en) * 1978-07-12 1980-01-31 Mitsui Toatsu Chem Inc Inspecting method for albumin
BR8108925A (pt) * 1980-12-19 1982-11-30 Minnesota Mining & Mfg Processo de teste e artigo para estimar a concentracao de acido livre em liquido
US4654309A (en) * 1980-12-19 1987-03-31 Minnesota Mining And Manufacturing Co. Test method and article for estimating the concentration of free acid in liquid
US4542750A (en) * 1982-08-13 1985-09-24 Primary Diagnostic Systems, Inc. Non-invasive method for diagnosing incipient or developed cancer tissue
US4568647A (en) * 1983-10-11 1986-02-04 Eastman Kodak Company Method and element for albumin assay
DE3345748A1 (de) * 1983-12-17 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Phenolsulfonphthaleinyl-ss-d-galactoside, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der ss-d-galactosidase
US5183742A (en) * 1984-02-24 1993-02-02 Dai Nippon Insatsu Kabushiki Kaisha Test device for detecting glucose, protein urobilinogen, and/or occult blood in body fluids and/or determining the PH thereof
DE3774570D1 (enExample) * 1987-04-22 1991-12-19 Pharmacia Diagnostics Inc., Fairfield, N.J., Us
CA1320420C (en) * 1988-03-25 1993-07-20 Dominique Thoraval Paper chemical agent detectors
US5194390A (en) * 1988-07-05 1993-03-16 Miles Inc. Composition for the assay of albumin
DE3823151C2 (de) * 1988-07-08 1997-07-10 Boehringer Mannheim Gmbh Verfahren zur Bestimmung der Ionenstärke oder des spezifischen Gewichts von wäßrigen Flüssigkeiten
US5049358A (en) * 1988-09-30 1991-09-17 Miles Inc. Composition and test device for assaying for proteins
US5077222A (en) * 1988-09-30 1991-12-31 Miles Inc. Method for assaying for proteins using a dual indicator reagent composition
JPH0752198B2 (ja) * 1989-08-30 1995-06-05 マイルス・インコーポレーテッド 変色を示す組成物、アルブミンの存在及び／又は濃度の測定方法及び検出具
US5187104A (en) * 1991-06-06 1993-02-16 Miles Inc. Nitro or nitroso substituted polyhalogenated phenolsulfonephthaleins as protein indicators in biological samples
US5264589A (en) * 1991-06-06 1993-11-23 Miles Inc. Merocyanine protein error indicators
DK0517050T3 (enExample) * 1991-06-06 1997-03-03 Bayer Ag
US5326707A (en) * 1991-11-29 1994-07-05 Miles Inc. Composition and device for urinary protein assay and method of using the same
US5424215A (en) * 1994-02-07 1995-06-13 Miles Inc. Assay for the determination of protein in a biological sample
US5593895A (en) * 1995-04-27 1997-01-14 Bayer Corporation Method for the detection of protein in urine
US5910421A (en) * 1995-12-21 1999-06-08 University Of Florida Rapid diagnostic method for distinguishing allergies and infections
US6551791B1 (en) 1995-12-21 2003-04-22 University Of Florida Rapid diagnostic method for distinguishing allergies and infections and nasal secretion collection unit
KR100318552B1 (ko) * 1998-12-24 2002-09-05 한국과학기술연구원 간질환관련표식물질의검출용스트립
DE60015832T2 (de) 1999-03-24 2005-10-27 JohnsonDiversey, Inc., Sturtevant Verfahren zum Nachweis von Protein und Kit dafür
EP1039299B1 (en) * 1999-03-24 2004-11-17 JohnsonDiversey, Inc. A method of detecting protein and a kit using the same
JP4489590B2 (ja) * 2002-08-09 2010-06-23 アークレイ株式会社 蛋白質測定用試験片およびその製造方法
EP1715347B1 (en) 2004-01-23 2011-09-21 ARKRAY, Inc. Method of protein measurement
US7727206B2 (en) * 2005-12-27 2010-06-01 Gorres Geoffrey H Device for monitoring a patient for a urinary tract infection
US8012761B2 (en) * 2006-12-14 2011-09-06 Kimberly-Clark Worldwide, Inc. Detection of formaldehyde in urine samples
US7846383B2 (en) * 2006-12-15 2010-12-07 Kimberly-Clark Worldwide, Inc. Lateral flow assay device and absorbent article containing same
GB0808557D0 (en) 2008-05-13 2008-06-18 3M Innovative Properties Co Sampling devices and methods of use
GB2460069A (en) * 2008-05-15 2009-11-18 Snell & Wilcox Ltd Sampling conversion between formats in digital image processing
EP2660597B1 (en) 2010-12-28 2017-09-13 ARKRAY, Inc. Method for determining condition of oral cavity and analytical tool, apparatus and program used for the method
US10793890B2 (en) 2012-07-06 2020-10-06 3M Innovative Properties Company Apparatus for detecting ATP in a liquid sample
WO2014007846A1 (en) 2012-07-06 2014-01-09 3M Innovative Properties Company Apparatus and methods for detecting atp in a liquid sample
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
KR20190027878A (ko) 2016-07-13 2019-03-15 리폼 바이오로직스, 엘엘씨 치료 단백질 제제용 안정화 부형제

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1786611A (en) * 1928-04-04 1930-12-30 Hynson Westcott & Dunning Inc Halogenated sulphone phthaleins
US3485587A (en) * 1956-02-29 1969-12-23 Miles Lab Protein indicator
US3095277A (en) * 1956-05-21 1963-06-25 Miles Lab Diagnostic composition
US2986453A (en) * 1957-11-13 1961-05-30 Miles Lab Diagnostic compositions
NL301192A (enExample) * 1963-01-18
GB1050880A (enExample) * 1964-11-13
US3533749A (en) * 1967-09-12 1970-10-13 Warner Lambert Pharmaceutical Method for the determination of total albumin
US3558278A (en) * 1967-12-26 1971-01-26 Baxter Laboratories Inc Determination of albumin
US3884637A (en) * 1973-03-21 1975-05-20 Pierce Chemical Co Method and composition for the determination of albumin
CH593503A5 (enExample) * 1973-07-09 1977-12-15 Oce Van Der Grinten Nv
US3873272A (en) * 1974-02-20 1975-03-25 Baxter Laboratories Inc Reagent and method for albumin determination

Also Published As

Publication number Publication date
IE42507B1 (en) 1980-08-27
IE42507L (en) 1976-09-12
JPS5751627B2 (enExample) 1982-11-02
SE7602134L (sv) 1976-09-13
SE423754B (sv) 1982-05-24
FI760578A7 (enExample) 1976-09-13
JPS5278866A (en) 1977-07-02
AU501932B2 (en) 1979-07-05
HU172450B (hu) 1978-09-28
DK144443B (da) 1982-03-08
LU74519A1 (enExample) 1976-09-01
NL164966B (nl) 1980-09-15
SU633501A3 (ru) 1978-11-15
BE839363A (fr) 1976-09-09
DE2510633A1 (de) 1976-09-16
FI59678C (fi) 1981-09-10
GB1487718A (en) 1977-10-05
IL49167A0 (en) 1976-05-31
AT349153B (de) 1979-03-26
NL7602442A (nl) 1976-09-14
NL164966C (nl) 1981-02-16
IE42506B1 (en) 1980-08-27
DD129788A5 (de) 1978-02-08
YU59476A (en) 1988-10-31
CA1055824A (en) 1979-06-05
CS190526B2 (en) 1979-05-31
DE2510633B2 (de) 1977-11-10
ATA180576A (de) 1978-08-15
IT1056947B (it) 1982-02-20
FI59678B (fi) 1981-05-29
US4013416A (en) 1977-03-22
US4260777A (en) 1981-04-07
CH627000A5 (enExample) 1981-12-15
DD125021A5 (enExample) 1977-03-23
IL49167A (en) 1978-08-31
PL103510B1 (pl) 1979-06-30
FR2304084B1 (enExample) 1981-06-26
AU1189576A (en) 1977-09-15
GB1487717A (en) 1977-10-05
DK144443C (da) 1982-08-23
FR2304084A1 (fr) 1976-10-08
IE42506L (en) 1976-09-12
ES445808A1 (es) 1977-06-01
SU625610A3 (ru) 1978-09-25
DK103276A (da) 1976-09-13

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)