DE2438456A1 - Neue aluminium- und/oder magnesiumsalze, deren herstellung und diese enthaltende zusammensetzungen - Google Patents
Neue aluminium- und/oder magnesiumsalze, deren herstellung und diese enthaltende zusammensetzungenInfo
- Publication number
- DE2438456A1 DE2438456A1 DE2438456A DE2438456A DE2438456A1 DE 2438456 A1 DE2438456 A1 DE 2438456A1 DE 2438456 A DE2438456 A DE 2438456A DE 2438456 A DE2438456 A DE 2438456A DE 2438456 A1 DE2438456 A1 DE 2438456A1
- Authority
- DE
- Germany
- Prior art keywords
- index
- subscripts
- aluminum
- new salt
- salt according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 title claims description 4
- 229910052782 aluminium Inorganic materials 0.000 title claims description 4
- 239000000203 mixture Substances 0.000 title description 17
- 159000000003 magnesium salts Chemical class 0.000 title description 4
- 150000003839 salts Chemical class 0.000 claims description 13
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 11
- SMZOGRDCAXLAAR-UHFFFAOYSA-N aluminium isopropoxide Chemical group [Al+3].CC(C)[O-].CC(C)[O-].CC(C)[O-] SMZOGRDCAXLAAR-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 7
- ZEMFXKPRUNUIIM-VIFPVBQESA-N (2s)-6-amino-2-(diacetylamino)hexanoic acid Chemical compound CC(=O)N(C(C)=O)[C@H](C(O)=O)CCCCN ZEMFXKPRUNUIIM-VIFPVBQESA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 150000002680 magnesium Chemical class 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical group [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 3
- 239000000347 magnesium hydroxide Substances 0.000 claims description 3
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 22
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 239000000843 powder Substances 0.000 description 8
- 239000004472 Lysine Substances 0.000 description 5
- 239000012429 reaction media Substances 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 201000005917 gastric ulcer Diseases 0.000 description 2
- 239000003701 inert diluent Substances 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 229960003104 ornithine Drugs 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000008167 Magnesium Deficiency Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- GANNOFFDYMSBSZ-UHFFFAOYSA-N [AlH3].[Mg] Chemical compound [AlH3].[Mg] GANNOFFDYMSBSZ-UHFFFAOYSA-N 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- YVZQFSNXOYLGMJ-UHFFFAOYSA-L chloro(2-hydroxyethyl)mercury;1-hexadecylpyridin-1-ium;bromide Chemical compound [Br-].OCC[Hg]Cl.CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YVZQFSNXOYLGMJ-UHFFFAOYSA-L 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000004764 magnesium deficiency Nutrition 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000018360 neuromuscular disease Diseases 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- LMHHRCOWPQNFTF-UHFFFAOYSA-N s-propan-2-yl azepane-1-carbothioate Chemical compound CC(C)SC(=O)N1CCCCCC1 LMHHRCOWPQNFTF-UHFFFAOYSA-N 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/06—Aluminium compounds
- C07F5/069—Aluminium compounds without C-aluminium linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7329163A FR2240018A1 (en) | 1973-08-09 | 1973-08-09 | Aluminium and/or magnesium salts of amino acids - prepd from diacetyl-ornithine or lysine, for ulcer treatment |
| FR7422228A FR2276034A1 (fr) | 1974-06-26 | 1974-06-26 | Sels d'aluminium et/ou de magnesium de la diacethyllysine, leur preparation et les compositions qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2438456A1 true DE2438456A1 (de) | 1975-02-20 |
Family
ID=26217887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2438456A Pending DE2438456A1 (de) | 1973-08-09 | 1974-08-09 | Neue aluminium- und/oder magnesiumsalze, deren herstellung und diese enthaltende zusammensetzungen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4013699A (enExample) |
| JP (1) | JPS5076216A (enExample) |
| AR (1) | AR201609A1 (enExample) |
| AT (1) | AT333718B (enExample) |
| CA (1) | CA1036170A (enExample) |
| CH (1) | CH591426A5 (enExample) |
| DE (1) | DE2438456A1 (enExample) |
| DK (1) | DK424074A (enExample) |
| ES (1) | ES429119A1 (enExample) |
| GB (1) | GB1433314A (enExample) |
| IE (1) | IE39661B1 (enExample) |
| NL (1) | NL7410373A (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2289179A1 (fr) | 1974-10-28 | 1976-05-28 | Morelle Jean | Sels metalliques de lipoaminoacides |
| US4675422A (en) * | 1985-10-23 | 1987-06-23 | Stepan Company | Organometallic compounds |
| US4900561A (en) * | 1989-01-03 | 1990-02-13 | Zinpro Corporation | Copper complexes of alpha-amino acids that contain terminal amino groups, and their use as nutritional supplements |
| US4948594A (en) * | 1989-01-03 | 1990-08-14 | Zinpro Corporation | Copper complexes of alpha-amino acids that contain terminal amino groups, and their use as nutritional supplements |
| WO2002094256A1 (en) * | 2001-05-23 | 2002-11-28 | Debatosh Datta | Lysine and/or analogues and/or polymers thereof for promoting wound healing and angiogenesis |
| AU2021248667A1 (en) * | 2020-04-03 | 2022-12-01 | Nutrition 21, Llc | Method and composition for enhancing the quality and benefits of sleep |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2480743A (en) * | 1946-05-03 | 1949-08-30 | Krantz | Basic aluminum salt of an aliphatic amino acid and method of preparing the same |
| US2588090A (en) * | 1950-04-14 | 1952-03-04 | Geza S Delmar | Process for the preparation of basic aluminum salts of alpha amino acids |
| US2907781A (en) * | 1956-06-08 | 1959-10-06 | Victor M Hermelin | Monohydroxy magnesium aluminum salt of an amino aliphatic acid and method of preparing same |
| NL127988C (enExample) * | 1965-06-04 | |||
| DE1296642B (de) * | 1965-10-01 | 1969-06-04 | Basf Ag | Verfahren zur Herstellung von ª, ªÏ-Diaminoalkancarbonsaeuren |
| FR2062873B1 (enExample) * | 1969-09-25 | 1973-07-13 | Choay Sa | |
| US3651137A (en) * | 1969-12-23 | 1972-03-21 | Atlantic Richfield Co | Selective conversion of nalpha nepsilon-diacetyllysine esters to nalpha -diacetyllysine |
| US3836551A (en) * | 1970-01-30 | 1974-09-17 | Roehm Gmbh | Method for making salts of n-acylamino carboxylic acids |
| NO131985C (enExample) * | 1970-06-05 | 1975-09-03 | Kyowa Hakko Kogyo Kk |
-
1974
- 1974-07-08 GB GB3502174A patent/GB1433314A/en not_active Expired
- 1974-08-01 NL NL7410373A patent/NL7410373A/xx not_active Application Discontinuation
- 1974-08-08 DK DK424074A patent/DK424074A/da unknown
- 1974-08-08 AR AR255110A patent/AR201609A1/es active
- 1974-08-08 CA CA206,631A patent/CA1036170A/en not_active Expired
- 1974-08-08 US US05/495,781 patent/US4013699A/en not_active Expired - Lifetime
- 1974-08-08 JP JP49090352A patent/JPS5076216A/ja active Pending
- 1974-08-08 IE IE1667/74A patent/IE39661B1/xx unknown
- 1974-08-08 CH CH1086374A patent/CH591426A5/xx not_active IP Right Cessation
- 1974-08-09 ES ES429119A patent/ES429119A1/es not_active Expired
- 1974-08-09 DE DE2438456A patent/DE2438456A1/de active Pending
- 1974-08-09 AT AT652774A patent/AT333718B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE39661B1 (en) | 1978-12-06 |
| IE39661L (en) | 1975-02-09 |
| ES429119A1 (es) | 1976-09-01 |
| NL7410373A (nl) | 1975-02-11 |
| DK424074A (enExample) | 1975-04-21 |
| CA1036170A (en) | 1978-08-08 |
| USB495781I5 (enExample) | 1976-03-23 |
| AT333718B (de) | 1976-12-10 |
| US4013699A (en) | 1977-03-22 |
| AR201609A1 (es) | 1975-03-31 |
| ATA652774A (de) | 1976-04-15 |
| GB1433314A (en) | 1976-04-28 |
| JPS5076216A (enExample) | 1975-06-21 |
| CH591426A5 (enExample) | 1977-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2165962C2 (de) | 4-Hydroxy-6-arylpyrimidine | |
| DE2634900C2 (de) | 3-Trihydroxygermylpropionsäure, ihre Salze und Verfahren zu deren Herstellung | |
| DE3634714A1 (de) | Komplex aus einem extrakt von teeblaettern und aktivem aluminiumhydroxid | |
| DE3406061C2 (enExample) | ||
| DE2438456A1 (de) | Neue aluminium- und/oder magnesiumsalze, deren herstellung und diese enthaltende zusammensetzungen | |
| DE2610225A1 (de) | Neue aluminiumsalze, ihre herstellung und die sie enthaltenden zusammensetzungen | |
| DE2431483A1 (de) | Verfahren zur herstellung von alkalioder ammoniuminsulinen | |
| DE2065312C3 (de) | Aminoäthansulfonylderivate und Verfahren zu ihrer Herstellung | |
| EP0100516B1 (de) | 3-Beta-(3'-(Carboxypropionyloxy))-ursa-9(11),12-dien-28-carbonsäure sowie ihre Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel | |
| DE2818351A1 (de) | Benzoesaeurederivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung | |
| DE2036935A1 (de) | Verfahren zur Herstellung von Isoniazid derivaten | |
| DE2702535A1 (de) | Neue cysteinderivate, ihre herstellung und verwendung | |
| DE69705405T2 (de) | Neue formen der organischen salze des n'n-diacetylcystins | |
| DE69012213T2 (de) | Phenylessigsäurederivat. | |
| EP0498011B1 (de) | Neue Salze der 2-(2,6-Dichloranilino)-phenylessigsäure, Verfahren zu ihrer Herstellung und ihre Verwendung für topisch anwendbare pharmazeutische Zubereitungen | |
| DE2542096C2 (de) | Symmetrische Dihydroxydithiahexadecane, Verfahren zuihrer Herstellung und diese enthaltende Heilmittel | |
| DE68916912T2 (de) | Zinncysteat, dessen Herstellung und dessen pharmazeutische und kosmetische Verwendungen. | |
| DE69500120T2 (de) | Verwendung von Dehydroalanin-Derivate zum Schutz der Haut, der Schleimhaut und/oder des Haares gegen oxidativen Stress, diese enthaltende kosmetische oder dermatologische Zusammensetzungen und ähnliche neue Verbindungen | |
| DE2163987B2 (de) | 5-(m-Carbäthoxyaminophenyl>5äthylmalonylharnstoff | |
| DE2155857A1 (de) | Neue chemische Verbindungen und Verfahren zu ihrer Herstellung | |
| AT204033B (de) | Verfahren zur Herstellung des neuen 3-(p-Amino-benzolsulfonamido)-2-phenyl-pyrazols | |
| DE2401605C3 (de) | Butacainpamoat, seine Herstellung und dieses enthaltende Arzneimittel | |
| DE2107657B2 (de) | Arzneimittel zur Behandlung der durch Eisenmangelerscheinungen und Ver fahren zur Herstellung des Natriumsalzes von o Carboxybenzoylferrocens | |
| DE2316914C3 (de) | 4-(p-Chlorphenoxyacetylamino) benzoesäurediäthylamino-äthylester-pchlorphenoxyisobutyrat Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel | |
| DE1792270C3 (de) | Antirheumatikum enthaltend ein Magnesium- oder Calciumsalz eines Malonsäurehydrazid s |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |