DE2427096A1 - 2-deoxystreptamin-aminoglycoside und verfahren zu ihrer herstellung - Google Patents

2-deoxystreptamin-aminoglycoside und verfahren zu ihrer herstellung

Info

Publication number
DE2427096A1
DE2427096A1 DE19742427096 DE2427096A DE2427096A1 DE 2427096 A1 DE2427096 A1 DE 2427096A1 DE 19742427096 DE19742427096 DE 19742427096 DE 2427096 A DE2427096 A DE 2427096A DE 2427096 A1 DE2427096 A1 DE 2427096A1
Authority
DE
Germany
Prior art keywords
radical
kanamycin
radicals
compounds
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19742427096
Other languages
German (de)
English (en)
Inventor
Brian Richard Fenner
John David Hardstone
Michael Raymond Graves Leeming
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Original Assignee
PFIZER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2671873A external-priority patent/GB1445871A/en
Priority claimed from GB2671973A external-priority patent/GB1445872A/en
Application filed by PFIZER filed Critical PFIZER
Publication of DE2427096A1 publication Critical patent/DE2427096A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19742427096 1973-06-05 1974-06-05 2-deoxystreptamin-aminoglycoside und verfahren zu ihrer herstellung Pending DE2427096A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2671873A GB1445871A (en) 1973-06-05 1973-06-05 Intermediates for the preparation of 2-deoxystreptamine-amino glycosides
GB2671973A GB1445872A (en) 1973-06-05 1973-06-05 2-deoxystreptamine-aminoglycosides and methods for their preparation paration

Publications (1)

Publication Number Publication Date
DE2427096A1 true DE2427096A1 (de) 1975-01-09

Family

ID=26258384

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742427096 Pending DE2427096A1 (de) 1973-06-05 1974-06-05 2-deoxystreptamin-aminoglycoside und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US4024332A (https=)
JP (1) JPS5035131A (https=)
DE (1) DE2427096A1 (https=)
DK (1) DK304574A (https=)
ES (1) ES426998A1 (https=)
FR (1) FR2232326B1 (https=)
LU (1) LU70223A1 (https=)
NL (1) NL7407483A (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0702003A2 (de) 1994-08-19 1996-03-20 Bayer Ag Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2712160A1 (de) * 1977-03-19 1978-09-28 Bayer Ag Pseudotrisaccharide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2730372A1 (de) * 1977-07-05 1979-01-25 Bayer Ag Pseudodisaccharide
JPS6030320B2 (ja) * 1978-01-13 1985-07-16 山之内製薬株式会社 新規抗生物質およびその製造法
FR2427341A1 (fr) * 1978-06-02 1979-12-28 Delalande Sa Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique
US4247687A (en) * 1979-06-12 1981-01-27 Farmitalia Carlo Erba S.P.A. Aminoglycoside antibiotic derivatives and process for their preparation
US4831123A (en) * 1985-10-15 1989-05-16 Schering Corporation Process for preparing netilmicin
DE4137271A1 (de) * 1991-11-13 1993-05-19 Bayer Ag Verfahren zur herstellung von n-(2-chlor-pyridin-5-yl-methyl)-ethylendiamin
AU2002953095A0 (en) * 2002-11-29 2002-12-19 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
EP2390255B1 (en) * 2006-04-03 2016-07-13 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
EP3344641A4 (en) 2015-09-02 2019-09-18 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
EP3344640A4 (en) 2015-09-02 2019-05-01 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
EP3350194A4 (en) 2015-09-02 2019-04-24 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
AU2018235441C1 (en) 2017-03-15 2024-10-24 Eloxx Pharmaceuticals Ltd. Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof
WO2020105054A1 (en) 2018-11-22 2020-05-28 Technion Research & Development Foundation Limited Modified aminoglycoside compounds and uses thereof in disabling bacterial ribosome
US12110310B2 (en) * 2020-01-23 2024-10-08 Utah State University Amphiphilic kanamycin compositions and methods

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE630462A (https=) * 1962-04-03

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0702003A2 (de) 1994-08-19 1996-03-20 Bayer Ag Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde

Also Published As

Publication number Publication date
DK304574A (https=) 1975-02-03
FR2232326A1 (https=) 1975-01-03
JPS5035131A (https=) 1975-04-03
FR2232326B1 (https=) 1977-11-10
NL7407483A (https=) 1974-12-09
ES426998A1 (es) 1976-09-01
LU70223A1 (https=) 1976-04-13
US4024332A (en) 1977-05-17

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