DE239313C - - Google Patents
Info
- Publication number
- DE239313C DE239313C DENDAT239313D DE239313DA DE239313C DE 239313 C DE239313 C DE 239313C DE NDAT239313 D DENDAT239313 D DE NDAT239313D DE 239313D A DE239313D A DE 239313DA DE 239313 C DE239313 C DE 239313C
- Authority
- DE
- Germany
- Prior art keywords
- codeine
- compound
- acid
- diethylbarbituric acid
- ecm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 20
- 229960004126 codeine Drugs 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 10
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 10
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 7
- 229960002319 barbital Drugs 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- RTZOEZPIPKDVLT-UHFFFAOYSA-N 5,5-diethyl-1,3-diazinane-2,4,6-trione;sodium Chemical compound [Na].CCC1(CC)C(=O)NC(=O)NC1=O RTZOEZPIPKDVLT-UHFFFAOYSA-N 0.000 description 1
- PCRHVEUKSOYQEE-FFHNEAJVSA-N CCC1(CC)C(=O)NC(=O)NC1=O.COc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O.COc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C PCRHVEUKSOYQEE-FFHNEAJVSA-N 0.000 description 1
- 235000001258 Cinchona calisaya Nutrition 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE239313C true DE239313C (cg-RX-API-DMAC7.html) |
Family
ID=498770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT239313D Active DE239313C (cg-RX-API-DMAC7.html) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE239313C (cg-RX-API-DMAC7.html) |
-
0
- DE DENDAT239313D patent/DE239313C/de active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE239313C (cg-RX-API-DMAC7.html) | ||
| DE604228C (de) | Verfahren zur Darstellung von in Wasser leicht loeslichen Praeparaten der in Wasser schwer bzw. unloeslichen Salze der Chinaalkaloide bzw. von deren waessrigen Loesungen | |
| DE116806C (cg-RX-API-DMAC7.html) | ||
| DE539178C (de) | Verfahren zur Darstellung von Hydrierten Amiden der Nicotinsaeure | |
| DE1445153B2 (de) | 1,2,3,4,5,6-hexahydro-3-(3-methyl-2butenyl)-6,11-dimethyl-8-hydroxy-2,6methano-3-benzazocin, seine saeureadditionssalze und verfahren zu ihrer herstellung | |
| DE224197C (cg-RX-API-DMAC7.html) | ||
| DE567924C (de) | Verfahren zur Herstellung von Sulfonsaeuren des Piperidins und seiner Alkylhomologen | |
| DE617237C (de) | Verfahren zur Darstellung von ªÏ-Methylsulfonsaeuren primaerer oder sekundaerer Pyrazolonamine | |
| DE278107C (cg-RX-API-DMAC7.html) | ||
| DE200203C (cg-RX-API-DMAC7.html) | ||
| DE644647C (de) | Verfahren zur Darstellung von Salzen der ªÏ-Methylfonsaeuren der Pyrazolonamine mit Ringstickstoffbasen | |
| DE181510C (cg-RX-API-DMAC7.html) | ||
| DE249332C (cg-RX-API-DMAC7.html) | ||
| DE1795830C3 (cg-RX-API-DMAC7.html) | ||
| DE175080C (cg-RX-API-DMAC7.html) | ||
| DE930171C (de) | Verfahren zur Herstellung waessriger Loesungen von Steroidhormonen | |
| DE2523208C3 (de) | Thienylessigsäureester, ein Verfahren zu ihrer Herstellung sowie Arzneimittel | |
| DE254094C (cg-RX-API-DMAC7.html) | ||
| AT265530B (de) | Verfahren zur Herstellung von neuen Isochinolinderivaten | |
| DE278111C (cg-RX-API-DMAC7.html) | ||
| DE62533C (de) | Verfahren zur Darstellung von Salicylsäureacetylamidophenylester | |
| DE633981C (de) | Verfahren zur Herstellung wohldefinierter kristalliner Nitrate des Phenylquecksilberhydroxyds | |
| DE1795506C3 (de) | 14.08.59 Dänemark 2919-59 2-Chlor-9-eckige Klammer auf 3'-(N'-2hydroxyäthylplperazin-N) propyIiden eckige Klammer zu- thiaxanthen, Verfahren zu seiner Herstellung und diese enthaltende Arzneimittel | |
| DE762123C (de) | Verfahren zur Herstellung von physiologisch wirksamen Abkoemmlingen des 2-Alkyl-1, 4-naphthochinons bzw. -hydrochinons | |
| DE282491C (cg-RX-API-DMAC7.html) |