DE2364104A1 - Verfahren zum umhuellen von tabletten zum pharmazeutischen gebrauch und neue umhuellte erzeugnisse - Google Patents
Verfahren zum umhuellen von tabletten zum pharmazeutischen gebrauch und neue umhuellte erzeugnisseInfo
- Publication number
- DE2364104A1 DE2364104A1 DE2364104A DE2364104A DE2364104A1 DE 2364104 A1 DE2364104 A1 DE 2364104A1 DE 2364104 A DE2364104 A DE 2364104A DE 2364104 A DE2364104 A DE 2364104A DE 2364104 A1 DE2364104 A1 DE 2364104A1
- Authority
- DE
- Germany
- Prior art keywords
- radicals
- core
- tablets
- solution
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 13
- 229920001577 copolymer Polymers 0.000 claims description 9
- -1 maleic acid ester Chemical class 0.000 claims description 5
- 239000004014 plasticizer Substances 0.000 claims description 5
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 239000011976 maleic acid Substances 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 229920006027 ternary co-polymer Polymers 0.000 claims description 3
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229920001897 terpolymer Polymers 0.000 claims description 2
- 238000007334 copolymerization reaction Methods 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010015946 Eye irritation Diseases 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010058667 Oral toxicity Diseases 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- HGWAKQDTQVDVRP-OKULMJQMSA-N butyl (z,12r)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)OCCCC HGWAKQDTQVDVRP-OKULMJQMSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000005253 cladding Methods 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- HSHMTDVEKPAEGS-UHFFFAOYSA-N diethyl 2-hexylpropanedioate Chemical compound CCCCCCC(C(=O)OCC)C(=O)OCC HSHMTDVEKPAEGS-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 231100000013 eye irritation Toxicity 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000003021 phthalic acid derivatives Chemical class 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2998—Coated including synthetic resin or polymer
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7246195A FR2211213B1 (en, 2012) | 1972-12-26 | 1972-12-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2364104A1 true DE2364104A1 (de) | 1974-06-27 |
Family
ID=9109268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2364104A Pending DE2364104A1 (de) | 1972-12-26 | 1973-12-21 | Verfahren zum umhuellen von tabletten zum pharmazeutischen gebrauch und neue umhuellte erzeugnisse |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3906088A (en, 2012) |
| JP (1) | JPS4986529A (en, 2012) |
| BE (1) | BE809009A (en, 2012) |
| CH (1) | CH579914A5 (en, 2012) |
| DE (1) | DE2364104A1 (en, 2012) |
| FR (1) | FR2211213B1 (en, 2012) |
| GB (1) | GB1403317A (en, 2012) |
| IT (1) | IT1009077B (en, 2012) |
| NL (1) | NL7317737A (en, 2012) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2612889B1 (de) * | 1976-03-26 | 1977-09-01 | Basf Ag | UEberzugsmittel fuer Arzneiformlinge |
| US4206065A (en) * | 1978-10-30 | 1980-06-03 | Xerox Corporation | Electrostatographic developer compositions using terpolymer coated carrier |
| US4683256A (en) * | 1980-11-06 | 1987-07-28 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
| DE3221425A1 (de) * | 1982-06-07 | 1983-12-08 | Boehringer Ingelheim KG, 6507 Ingelheim | Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette |
| US4832957A (en) * | 1987-12-11 | 1989-05-23 | Merck & Co., Inc. | Controlled release combination of carbidopa/levodopa |
| US6482516B1 (en) * | 1993-07-20 | 2002-11-19 | Banner Pharmacaps, Inc. | Enrobed tablet |
| US6113893A (en) * | 1993-07-28 | 2000-09-05 | Pfizer Inc. | Psoriasis treatment |
| US6432448B1 (en) | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
| US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
| EP1339395A2 (en) | 2000-11-28 | 2003-09-03 | Fmc Corporation | Edible pga (propylene glycol alginate) coating composition |
| US6932861B2 (en) | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3275589A (en) * | 1963-02-14 | 1966-09-27 | Grace W R & Co | Terpolymer of vinyl acetate, dialkyl ester and alkyl acrylate |
| DK116770B (da) * | 1966-11-25 | 1970-02-09 | Hoechst Ag | Laminat af metalplader med svingningsdæmpende, selvhæftende mellemlag af vinylacetatcopolymere. |
| DE1694088A1 (de) * | 1966-11-25 | 1971-08-26 | Hoechst Ag | Schwingungsdaempfende Verbundsysteme mit Zwischenschichten aus Vinylacetat/2-AEthyl-hexylacrylat/Dibutylmaleinat/Crotonsaeure-Copolymerisaten |
-
1972
- 1972-12-26 FR FR7246195A patent/FR2211213B1/fr not_active Expired
-
1973
- 1973-12-20 GB GB5926873A patent/GB1403317A/en not_active Expired
- 1973-12-21 IT IT70842/73A patent/IT1009077B/it active
- 1973-12-21 CH CH1800573A patent/CH579914A5/xx not_active IP Right Cessation
- 1973-12-21 BE BE139195A patent/BE809009A/xx unknown
- 1973-12-21 DE DE2364104A patent/DE2364104A1/de active Pending
- 1973-12-26 JP JP48144152A patent/JPS4986529A/ja active Pending
- 1973-12-26 US US427560A patent/US3906088A/en not_active Expired - Lifetime
- 1973-12-27 NL NL7317737A patent/NL7317737A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2211213B1 (en, 2012) | 1976-04-23 |
| BE809009A (fr) | 1974-04-16 |
| CH579914A5 (en, 2012) | 1976-09-30 |
| NL7317737A (en, 2012) | 1974-06-28 |
| FR2211213A1 (en, 2012) | 1974-07-19 |
| JPS4986529A (en, 2012) | 1974-08-19 |
| GB1403317A (en) | 1975-08-28 |
| IT1009077B (it) | 1976-12-10 |
| US3906088A (en) | 1975-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69002604T2 (de) | Pharmazeutische Zubereitung mit verzögerter Freisetzung und seine Herstellung. | |
| DE2031871C3 (de) | Überzugsmasse für Arzneiformen | |
| CH672736A5 (en, 2012) | ||
| DE2364104A1 (de) | Verfahren zum umhuellen von tabletten zum pharmazeutischen gebrauch und neue umhuellte erzeugnisse | |
| DE3815562A1 (de) | Pharmazeutische zusammensetzung | |
| DE1467906A1 (de) | Verfahren zur Herstellung von sich langsam loesenden Tabletten | |
| DE3915575A1 (de) | Ranitidinhydrochlorid-tablette | |
| DE2409665C3 (de) | Formkörper auf Basis eines Alkyläthers oder Hydroxyalkyläthers von Pullulan | |
| DE1292783B (de) | Verfahren zum Herstellen einer Tablette mit Depotwirkung | |
| DD266506A5 (de) | Verfahren zur herstellung einer pharmazeutischen band-zusammensetzung | |
| DE1617789B1 (de) | Feuchtigkeitbeständige Überzugsmasse für feste pharmazeutische Zubereitungsformen | |
| EP0184754B1 (de) | Pankreasenzympräparate und Verfahren zu deren Herstellung | |
| DE2721603A1 (de) | Beschichtete koernchen aus alkalimetallsalzen der polyacrylsaeure und verfahren zu ihrer herstellung | |
| DE1617671B2 (de) | Weichgelatine-kapseln mit erhoehter waermestabilitaet und verfahren zu deren herstellung | |
| DE2706660A1 (de) | Ascorbinsaeure enthaltende granulate und verfahren zu ihrer herstellung | |
| DE2529326A1 (de) | Verfahren zum ueberziehen von formgegenstaenden mit einem film | |
| DE2732335C2 (de) | Tablette zur enteralen Verabreichung von Indolyloxyalkanolamin-Derivaten | |
| DE1043588B (de) | Enterale UEberzugsmischungen | |
| DE2049935A1 (de) | Verfahren zum Überziehen von Tabletten mit Zucker | |
| DE3412868A1 (de) | Neue galenische formen fuer sulpirid | |
| DE3425007C2 (en, 2012) | ||
| DE662619C (de) | Verfahren zur Verbesserung der Haftfestigkeit von Schichten auf Traegern aus organischen Celluloseestern bei photographischen Filmen | |
| EP0559702B1 (de) | Retardzubereitung für urapidil | |
| DE1544775C (de) | Verfahren zur Herstellung klebfreier Polyvinyldlkoholfolien | |
| DE657861C (de) | Verfahren zur Herstellung festhaftender UEberzuege aus Celluloseestern auf Folien aus Leim bzw. Gelatine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |