DE2355210A1 - Verfahren zum epimerisieren von antibiotischen verbindungen mit beta-lactamstruktur - Google Patents

Verfahren zum epimerisieren von antibiotischen verbindungen mit beta-lactamstruktur

Info

Publication number
DE2355210A1
DE2355210A1 DE19732355210 DE2355210A DE2355210A1 DE 2355210 A1 DE2355210 A1 DE 2355210A1 DE 19732355210 DE19732355210 DE 19732355210 DE 2355210 A DE2355210 A DE 2355210A DE 2355210 A1 DE2355210 A1 DE 2355210A1
Authority
DE
Germany
Prior art keywords
acid
solvent
compound
hydrogen
methylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19732355210
Other languages
German (de)
English (en)
Inventor
Raymond Armond Firestone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2355210A1 publication Critical patent/DE2355210A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE19732355210 1972-11-06 1973-11-05 Verfahren zum epimerisieren von antibiotischen verbindungen mit beta-lactamstruktur Pending DE2355210A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30390672A 1972-11-06 1972-11-06

Publications (1)

Publication Number Publication Date
DE2355210A1 true DE2355210A1 (de) 1974-05-16

Family

ID=23174217

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19732355210 Pending DE2355210A1 (de) 1972-11-06 1973-11-05 Verfahren zum epimerisieren von antibiotischen verbindungen mit beta-lactamstruktur

Country Status (6)

Country Link
JP (1) JPS4976895A (cs)
CH (1) CH587262A5 (cs)
DE (1) DE2355210A1 (cs)
FR (1) FR2205518B1 (cs)
GB (1) GB1455017A (cs)
NL (1) NL7314706A (cs)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
US4108992A (en) 1975-05-10 1978-08-22 Beecham Group Limited Cephalosporin analogues and compositions
US4138486A (en) 1976-03-25 1979-02-06 Shionogi & Co., Ltd. Arylmalonamido-1-oxadethiacephalosporins
US4226866A (en) 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
US4234724A (en) * 1977-12-23 1980-11-18 Fujisawa Pharmaceutical Company, Limited Cephalosporin analogues and processes for the preparation thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS607635B2 (ja) * 1976-04-27 1985-02-26 塩野義製薬株式会社 オキサゾリジン化合物
JPS59104389A (ja) * 1982-12-06 1984-06-16 Shionogi & Co Ltd オキサセファム誘導体

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
US4108992A (en) 1975-05-10 1978-08-22 Beecham Group Limited Cephalosporin analogues and compositions
US4138486A (en) 1976-03-25 1979-02-06 Shionogi & Co., Ltd. Arylmalonamido-1-oxadethiacephalosporins
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
US4234724A (en) * 1977-12-23 1980-11-18 Fujisawa Pharmaceutical Company, Limited Cephalosporin analogues and processes for the preparation thereof
US4350694A (en) * 1977-12-23 1982-09-21 Fujisawa Pharmaceutical Co., Ltd. Cephalosporin analogues and antimicrobial compositions

Also Published As

Publication number Publication date
FR2205518B1 (cs) 1977-05-27
GB1455017A (en) 1976-11-10
CH587262A5 (cs) 1977-04-29
JPS4976895A (cs) 1974-07-24
NL7314706A (cs) 1974-05-08
FR2205518A1 (cs) 1974-05-31

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