DE2346535C3 - Verfahren zur Herstellung von 7-Dimethylamino-6-desmethyl-6-desoxytetracyclin über 9-tert.Butyl-6-desmethyl-6-desoxytetracyclin - Google Patents

Verfahren zur Herstellung von 7-Dimethylamino-6-desmethyl-6-desoxytetracyclin über 9-tert.Butyl-6-desmethyl-6-desoxytetracyclin

Info

Publication number
DE2346535C3
DE2346535C3 DE2346535A DE2346535A DE2346535C3 DE 2346535 C3 DE2346535 C3 DE 2346535C3 DE 2346535 A DE2346535 A DE 2346535A DE 2346535 A DE2346535 A DE 2346535A DE 2346535 C3 DE2346535 C3 DE 2346535C3
Authority
DE
Germany
Prior art keywords
desmethyl
deoxytetracycline
dimethylamino
tert
chj
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2346535A
Other languages
German (de)
English (en)
Other versions
DE2346535B2 (de
DE2346535A1 (de
Inventor
Vincenzo S. Cesario Lecce Milano Colonna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Farmaceutici Italia SpA filed Critical Farmitalia Carlo Erba SRL
Publication of DE2346535A1 publication Critical patent/DE2346535A1/de
Publication of DE2346535B2 publication Critical patent/DE2346535B2/de
Application granted granted Critical
Publication of DE2346535C3 publication Critical patent/DE2346535C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2346535A 1972-09-18 1973-09-15 Verfahren zur Herstellung von 7-Dimethylamino-6-desmethyl-6-desoxytetracyclin über 9-tert.Butyl-6-desmethyl-6-desoxytetracyclin Expired DE2346535C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2932872 1972-09-18

Publications (3)

Publication Number Publication Date
DE2346535A1 DE2346535A1 (de) 1974-04-11
DE2346535B2 DE2346535B2 (de) 1980-09-11
DE2346535C3 true DE2346535C3 (de) 1981-05-21

Family

ID=11226772

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2346535A Expired DE2346535C3 (de) 1972-09-18 1973-09-15 Verfahren zur Herstellung von 7-Dimethylamino-6-desmethyl-6-desoxytetracyclin über 9-tert.Butyl-6-desmethyl-6-desoxytetracyclin

Country Status (14)

Country Link
US (1) US3901942A (US07696358-20100413-C00002.png)
JP (1) JPS5741458B2 (US07696358-20100413-C00002.png)
AT (1) AT328613B (US07696358-20100413-C00002.png)
BE (1) BE804913A (US07696358-20100413-C00002.png)
CA (1) CA999855A (US07696358-20100413-C00002.png)
DE (1) DE2346535C3 (US07696358-20100413-C00002.png)
ES (1) ES418809A1 (US07696358-20100413-C00002.png)
FR (1) FR2208885B1 (US07696358-20100413-C00002.png)
GB (1) GB1413347A (US07696358-20100413-C00002.png)
HU (1) HU167850B (US07696358-20100413-C00002.png)
IE (1) IE38820B1 (US07696358-20100413-C00002.png)
NL (1) NL158172B (US07696358-20100413-C00002.png)
SU (1) SU574145A3 (US07696358-20100413-C00002.png)
ZA (1) ZA737317B (US07696358-20100413-C00002.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8318706B2 (en) 2006-12-21 2012-11-27 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US8513223B2 (en) 2006-12-21 2013-08-20 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437487A1 (de) * 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung
AU578068B2 (en) * 1984-03-08 1988-10-13 Nippon Zoki Pharmaceutical Co., Ltd. Hydantoin derivatives and pharmaceutical compositions containing them
JPH0737433B2 (ja) * 1987-06-11 1995-04-26 協和醗酵工業株式会社 ７−アミノ−６−デメチル−６−デオキシテトラサイクリンの製造法
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
JPH01116549U (US07696358-20100413-C00002.png) * 1988-01-29 1989-08-07
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
CA2318580A1 (en) * 1998-01-23 1999-07-29 Mark L. Nelson Pharmaceutically active compounds and methods of use thereof
EP2327686A3 (en) * 1999-09-14 2012-08-22 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
BRPI0112269B8 (pt) * 2000-07-07 2021-05-25 Paratek Pharm Innc composto de minociclina 9-aminometila substituída, e, composição farmacêutica
MXPA03000056A (es) 2000-07-07 2003-07-14 Tufts College Compuestos de tetraciclina sustituidos en posicion 7.
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP2298732A1 (en) * 2001-03-13 2011-03-23 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
ATE455092T1 (de) * 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP2311799A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN1649582A (zh) * 2002-03-08 2005-08-03 帕拉特克药品公司 氨基－甲基取代的四环素类化合物
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CN1845897A (zh) 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CA2597212A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
PT103661B (pt) * 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
US7935687B2 (en) 2007-04-12 2011-05-03 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
JP2011513404A (ja) 2008-03-05 2011-04-28 パラテック ファーマシューティカルズ インコーポレイテッド ミノサイクリン化合物およびその使用方法
TW202021946A (zh) * 2008-05-23 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
BR112019008897A2 (pt) 2016-11-01 2019-08-13 Paratek Pharm Innc método para tratar pneumonia bacteriana adquirida na comunidade.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895993A (en) * 1957-05-16 1959-07-21 Pfizer & Co C Alkyl substituted anhydrotetracycline compounds and process of preparing the same
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
US3029284A (en) * 1960-09-14 1962-04-10 Pfizer & Co C Nu-dealkylation of carboxamido-nu-alkyltetracycline and its analogs
US3239499A (en) * 1961-05-19 1966-03-08 Pfizer & Co C Tetracycline derivative
US3165551A (en) * 1961-06-26 1965-01-12 Pfizer & Co C New antibacterial agents
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3388162A (en) * 1966-03-14 1968-06-11 American Cyanamid Co 7-and/or 9-nitro or amino tetracyclines
US3403179A (en) * 1967-01-10 1968-09-24 American Cyanamid Co Novel 7-(1, 2-bis-substituted-hydrazino)-tetracyclines and methods of preparing same
US3483251A (en) * 1967-03-03 1969-12-09 American Cyanamid Co Reductive alkylation process
US3373196A (en) * 1967-03-21 1968-03-12 American Cyanamid Co 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8318706B2 (en) 2006-12-21 2012-11-27 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US8513223B2 (en) 2006-12-21 2013-08-20 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders

Also Published As

Publication number Publication date
JPS4969653A (US07696358-20100413-C00002.png) 1974-07-05
DE2346535B2 (de) 1980-09-11
DE2346535A1 (de) 1974-04-11
SU574145A3 (ru) 1977-09-25
AU6033373A (en) 1975-03-20
NL7312648A (US07696358-20100413-C00002.png) 1974-03-20
ES418809A1 (es) 1976-03-16
IE38820B1 (en) 1978-06-07
ATA799673A (de) 1975-06-15
US3901942A (en) 1975-08-26
NL158172B (nl) 1978-10-16
FR2208885B1 (US07696358-20100413-C00002.png) 1977-05-20
ZA737317B (en) 1974-09-25
JPS5741458B2 (US07696358-20100413-C00002.png) 1982-09-03
AT328613B (de) 1976-03-25
IE38820L (en) 1974-03-18
HU167850B (US07696358-20100413-C00002.png) 1975-12-25
CA999855A (en) 1976-11-16
GB1413347A (en) 1975-11-12
BE804913A (fr) 1974-03-18
FR2208885A1 (US07696358-20100413-C00002.png) 1974-06-28

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Legal Events

Date Code Title Description
OGA New person/name/address of the applicant
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee