ATA799673A - Verfahren zur herstellung von tetracyclinderivaten - Google Patents

Verfahren zur herstellung von tetracyclinderivaten

Info

Publication number
ATA799673A
ATA799673A AT799673A AT799673A ATA799673A AT A799673 A ATA799673 A AT A799673A AT 799673 A AT799673 A AT 799673A AT 799673 A AT799673 A AT 799673A AT A799673 A ATA799673 A AT A799673A
Authority
AT
Austria
Prior art keywords
tetracycline derivatives
producing tetracycline
producing
derivatives
tetracycline
Prior art date
Application number
AT799673A
Other languages
English (en)
Other versions
AT328613B (de
Inventor
Luigi Bernardi
Vincenzo Colonna
Roberto De Castiglione
Paolo Masi
Original Assignee
Farmaceutici S P A Soc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici S P A Soc filed Critical Farmaceutici S P A Soc
Publication of ATA799673A publication Critical patent/ATA799673A/de
Application granted granted Critical
Publication of AT328613B publication Critical patent/AT328613B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT799673A 1972-09-18 1973-09-17 Verfahren zur herstellung von tetracyclinderivaten AT328613B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2932872 1972-09-18

Publications (2)

Publication Number Publication Date
ATA799673A true ATA799673A (de) 1975-06-15
AT328613B AT328613B (de) 1976-03-25

Family

ID=11226772

Family Applications (1)

Application Number Title Priority Date Filing Date
AT799673A AT328613B (de) 1972-09-18 1973-09-17 Verfahren zur herstellung von tetracyclinderivaten

Country Status (14)

Country Link
US (1) US3901942A (de)
JP (1) JPS5741458B2 (de)
AT (1) AT328613B (de)
BE (1) BE804913A (de)
CA (1) CA999855A (de)
DE (1) DE2346535C3 (de)
ES (1) ES418809A1 (de)
FR (1) FR2208885B1 (de)
GB (1) GB1413347A (de)
HU (1) HU167850B (de)
IE (1) IE38820B1 (de)
NL (1) NL158172B (de)
SU (1) SU574145A3 (de)
ZA (1) ZA737317B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437487A1 (de) * 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung
AU578068B2 (en) * 1984-03-08 1988-10-13 Nippon Zoki Pharmaceutical Co., Ltd. Hydantoin derivatives and pharmaceutical compositions containing them
JPH0737433B2 (ja) * 1987-06-11 1995-04-26 協和醗酵工業株式会社 ７−アミノ−６−デメチル−６−デオキシテトラサイクリンの製造法
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
JPH01116549U (de) * 1988-01-29 1989-08-07
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
WO1999037306A1 (en) * 1998-01-23 1999-07-29 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
EP1666454B1 (de) * 1999-09-14 2011-09-07 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Hilfe von auf Übergangsmetalle basierten Chemikalien
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
EA201000496A1 (ru) * 2000-07-07 2010-10-29 Трастис Оф Тафтс Коллидж Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты)
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
CZ2003343A3 (cs) 2000-07-07 2003-05-14 Trustees Of Tufts College 7-Substituované tetracyklinové sloučeniny
HRP20030743A2 (en) * 2001-03-13 2005-06-30 Paratek Pharmaceuticals 7,9-substituted tetracycline compounds
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
ATE455092T1 (de) * 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
US7056902B2 (en) * 2002-01-08 2006-06-06 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP2316450A1 (de) * 2002-03-08 2011-05-04 Paratek Pharmaceuticals, Inc. Aminomethyl-substituierte Tetracyclin-Verbindungen
KR101083498B1 (ko) 2002-03-21 2011-11-16 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CN1845897A (zh) 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
EP1848685A1 (de) 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. 11a,12-derivate von tetracyclinverbindungen
ES2463457T3 (es) 2006-12-21 2014-05-28 Paratek Pharmaceuticals, Inc. Derivados de la tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
US8513223B2 (en) 2006-12-21 2013-08-20 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
PT103661B (pt) * 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
JP2010523684A (ja) 2007-04-12 2010-07-15 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法
CA2717703A1 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
TW202216656A (zh) * 2008-05-19 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
RU2019113715A (ru) 2016-11-01 2020-12-03 Паратек Фармасьютикалс, Инк. 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895993A (en) * 1957-05-16 1959-07-21 Pfizer & Co C Alkyl substituted anhydrotetracycline compounds and process of preparing the same
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
US3029284A (en) * 1960-09-14 1962-04-10 Pfizer & Co C Nu-dealkylation of carboxamido-nu-alkyltetracycline and its analogs
US3239499A (en) * 1961-05-19 1966-03-08 Pfizer & Co C Tetracycline derivative
US3165551A (en) * 1961-06-26 1965-01-12 Pfizer & Co C New antibacterial agents
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3388162A (en) * 1966-03-14 1968-06-11 American Cyanamid Co 7-and/or 9-nitro or amino tetracyclines
US3403179A (en) * 1967-01-10 1968-09-24 American Cyanamid Co Novel 7-(1, 2-bis-substituted-hydrazino)-tetracyclines and methods of preparing same
US3483251A (en) * 1967-03-03 1969-12-09 American Cyanamid Co Reductive alkylation process
US3373196A (en) * 1967-03-21 1968-03-12 American Cyanamid Co 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines

Also Published As

Publication number Publication date
US3901942A (en) 1975-08-26
HU167850B (de) 1975-12-25
DE2346535C3 (de) 1981-05-21
AU6033373A (en) 1975-03-20
JPS4969653A (de) 1974-07-05
ZA737317B (en) 1974-09-25
NL158172B (nl) 1978-10-16
FR2208885A1 (de) 1974-06-28
BE804913A (fr) 1974-03-18
IE38820B1 (en) 1978-06-07
IE38820L (en) 1974-03-18
FR2208885B1 (de) 1977-05-20
SU574145A3 (ru) 1977-09-25
DE2346535A1 (de) 1974-04-11
GB1413347A (en) 1975-11-12
NL7312648A (de) 1974-03-20
AT328613B (de) 1976-03-25
CA999855A (en) 1976-11-16
DE2346535B2 (de) 1980-09-11
JPS5741458B2 (de) 1982-09-03
ES418809A1 (es) 1976-03-16

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Legal Events

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ELJ Ceased due to non-payment of the annual fee