DE2331144A1 - Wasserloesliche extrakte von mycobacterien - Google Patents

Wasserloesliche extrakte von mycobacterien

Info

Publication number
DE2331144A1
DE2331144A1 DE2331144A DE2331144A DE2331144A1 DE 2331144 A1 DE2331144 A1 DE 2331144A1 DE 2331144 A DE2331144 A DE 2331144A DE 2331144 A DE2331144 A DE 2331144A DE 2331144 A1 DE2331144 A1 DE 2331144A1
Authority
DE
Germany
Prior art keywords
water
soluble
mycobacteria
lipids
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2331144A
Other languages
German (de)
English (en)
Inventor
Pierre Jolles
Geb Samour Daniele Migliore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7222208A external-priority patent/FR2189021A1/fr
Priority claimed from FR7316130A external-priority patent/FR2227862A1/fr
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Publication of DE2331144A1 publication Critical patent/DE2331144A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2331144A 1972-06-20 1973-06-19 Wasserloesliche extrakte von mycobacterien Pending DE2331144A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7222208A FR2189021A1 (en) 1972-06-20 1972-06-20 Non-arthrogenic immunological adjuvants - obtained by extraction of lipid-free mycobacterial residues
FR7316130A FR2227862A1 (en) 1973-05-04 1973-05-04 Non-arthrogenic immunological adjuvants - obtained by extraction of lipid-free mycobacterial residues

Publications (1)

Publication Number Publication Date
DE2331144A1 true DE2331144A1 (de) 1974-01-10

Family

ID=26217170

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2331144A Pending DE2331144A1 (de) 1972-06-20 1973-06-19 Wasserloesliche extrakte von mycobacterien

Country Status (10)

Country Link
US (1) US3956481A (US07860544-20101228-C00003.png)
JP (1) JPS4954590A (US07860544-20101228-C00003.png)
CA (1) CA1006836A (US07860544-20101228-C00003.png)
CH (2) CH602117A5 (US07860544-20101228-C00003.png)
DE (1) DE2331144A1 (US07860544-20101228-C00003.png)
GB (1) GB1439847A (US07860544-20101228-C00003.png)
HU (1) HU172600B (US07860544-20101228-C00003.png)
IL (1) IL42545A (US07860544-20101228-C00003.png)
NL (1) NL7308450A (US07860544-20101228-C00003.png)
SE (1) SE7604289L (US07860544-20101228-C00003.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026746A1 (de) * 1979-10-02 1981-04-08 Ciba-Geigy Ag Kombinationspräparate zur Anwendung in einem Verfahren zur Steigerung der Wirkung von Antibiotika, antibiotische Präparate mit gesteigerter Wirksamkeit und Verfahren zu deren Herstellung
EP0056560A1 (de) * 1981-01-19 1982-07-28 Ciba-Geigy Ag Antibiotische Präparate mit gesteigerter Wirksamkeit, Verfahren zu deren Herstellung und Verfahren zur Steigerung der antibiotischen Wirkung von Antibiotika
FR2552326A1 (fr) * 1983-09-23 1985-03-29 Ribi Immunochem Research Inc Composition d'extrait soluble de pyridine et d'endotoxine detoxifiee raffinee et son utilisation
EP0681479B1 (en) * 1993-01-29 1999-04-28 Vetrepharm, Inc. Immunotherapeutic composition

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2320107A1 (fr) * 1975-08-05 1977-03-04 Anvar Nouveaux adjuvants immunologiques, procede pour leur obtention et compositions les contenant
FR2321896A1 (fr) * 1975-08-29 1977-03-25 Anvar Agents adjuvants immunologiques actifs en solution aqueuse
JPS54140710A (en) * 1978-03-10 1979-11-01 Mitsui Toatsu Chem Inc Anti-tumor substance and its preparation
JPS5846363Y2 (ja) * 1978-10-30 1983-10-21 三洋電機株式会社 太陽熱集熱器
FR2444464A1 (fr) * 1978-12-19 1980-07-18 Fabre Sa Pierre Proteoglycanes bacteriens purifies, procede pour leur preparation et vaccin les contenant
JPS568320A (en) * 1979-07-04 1981-01-28 Chisato Maruyama Drug for tumor immunotherapy comprising lipopolysaccharide as active constituent
FI75578C (fi) * 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
JPS5632490A (en) * 1979-08-28 1981-04-01 Mitsui Toatsu Chem Inc Antitumor active substance and its pharmaceutical
JPS5632489A (en) * 1979-08-28 1981-04-01 Mitsui Toatsu Chem Inc Antitumor active substance and its pharmaceutical
FR2490495A1 (fr) * 1980-09-19 1982-03-26 Roussel Uclaf Nouvelles glycoproteines hydrosolubles immunostimulantes extraites de klebsiella pneumoniae, leur procede d'obtention, leur application a titre de medicaments et les compositions les renfermant
FR2490496A1 (fr) * 1980-09-19 1982-03-26 Roussel Uclaf Nouvelles glycoproteines immunostimulantes extraites de klebsiella pneumoniae, leur procede d'obtention, leur application a titre de medicaments et les compositions les renfermant
US4503048A (en) * 1982-06-30 1985-03-05 Ribi Immunochem Research, Inc. Pyridine soluble extract of a microorganism
US4505903A (en) * 1982-06-30 1985-03-19 Ribi Immunochem Research, Inc. Pyridine soluble extract of a microorganism
US4504473A (en) * 1982-06-30 1985-03-12 Ribi Immunochem Research, Inc. Pyridine soluble extract of a microorganism
CA1209504A (en) * 1982-06-30 1986-08-12 John L. Cantrell Pyridine soluble extract of a microorganism
US4613504A (en) * 1983-09-23 1986-09-23 Ribi Immunochem Research, Inc. Pyridine-soluble extracts of microorganisms
ATE154759T1 (de) * 1990-11-08 1997-07-15 Univ London Mycobacterium als adjuvans für antigene
US5985287A (en) * 1996-08-29 1999-11-16 Genesis Research And Development Corporation Limited Compounds and methods for treatment and diagnosis of mycobacterial infections
US6406704B1 (en) 1996-08-29 2002-06-18 Genesis Research And Development Corporation Limited Compounds and methods for treatment and diagnosis of mycobacterial infections
US6160093A (en) * 1996-08-29 2000-12-12 Genesis Researth And Development Corporation Limited Compounds and methods for treatment and diagnosis of mycobacterial infections
US6284255B1 (en) * 1996-08-29 2001-09-04 Genesis Research & Development Corporation Limited Compounds and methods for treatment and diagnosis of mycobacterial infections
JP2001519785A (ja) * 1997-04-02 2001-10-23 バイオニケ ライフ サイエンシーズ インコーポレイテッド 局所的障害および創傷の治療のための細菌細胞壁抽出物の使用
US5968524A (en) * 1997-12-23 1999-10-19 Genesis Research & Development Corp. Methods and compounds for the treatment of immunologically-mediated psoriasis
US6328978B1 (en) 1997-12-23 2001-12-11 Genesis Research & Development Corp. Ltd. Methods for the treatment of immunologically-mediated skin disorders
US20040247622A1 (en) * 1999-06-02 2004-12-09 Genesis Research And Development Corporation Limited Methods and compounds for the treatment of immunologically-mediated diseases using Mycobacterium vaccae
US6350457B1 (en) 1999-06-02 2002-02-26 Genesis Research & Development Corporation Limited Methods and compounds for the treatment of immunologically-mediated diseases using mycobacterium vaccae
KR101096577B1 (ko) * 2010-03-09 2011-12-21 백태현 항산균 세포벽골격의 제조 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3529057A (en) * 1964-08-14 1970-09-15 Takeda Chemical Industries Ltd Purified periodic acid-oxidized mucopeptide of mycobacteria cell walls constituting a vaccine enhancing nonspecific host resistance against pathogenic bacterial infections

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026746A1 (de) * 1979-10-02 1981-04-08 Ciba-Geigy Ag Kombinationspräparate zur Anwendung in einem Verfahren zur Steigerung der Wirkung von Antibiotika, antibiotische Präparate mit gesteigerter Wirksamkeit und Verfahren zu deren Herstellung
EP0056560A1 (de) * 1981-01-19 1982-07-28 Ciba-Geigy Ag Antibiotische Präparate mit gesteigerter Wirksamkeit, Verfahren zu deren Herstellung und Verfahren zur Steigerung der antibiotischen Wirkung von Antibiotika
FR2552326A1 (fr) * 1983-09-23 1985-03-29 Ribi Immunochem Research Inc Composition d'extrait soluble de pyridine et d'endotoxine detoxifiee raffinee et son utilisation
EP0681479B1 (en) * 1993-01-29 1999-04-28 Vetrepharm, Inc. Immunotherapeutic composition

Also Published As

Publication number Publication date
SE7604289L (sv) 1976-04-12
CH592452A5 (US07860544-20101228-C00003.png) 1977-10-31
US3956481A (en) 1976-05-11
IL42545A0 (en) 1973-08-29
CA1006836A (en) 1977-03-15
CH602117A5 (US07860544-20101228-C00003.png) 1978-07-31
JPS4954590A (US07860544-20101228-C00003.png) 1974-05-27
NL7308450A (US07860544-20101228-C00003.png) 1973-12-27
IL42545A (en) 1977-05-31
GB1439847A (en) 1976-06-16
HU172600B (en) 1977-11-28

Similar Documents

Publication Publication Date Title
DE2331144A1 (de) Wasserloesliche extrakte von mycobacterien
DE2954387C2 (de) Die tumorspezifische Immunität vergrößernder Bakterienzellenextrakt und Verfahren zu seiner Herstellung
DE3407823C2 (US07860544-20101228-C00003.png)
EP0049847B1 (de) Alpha-Amylaseinaktivator, Verfahren zu seiner Herstellung, Mittel auf Basis dieses Inaktivators sowie dieser Inaktivator zur Regulierung des Blutzuckerspiegels
DE69529288T2 (de) Wasserlösliche polyen-konjugate
DE2433883A1 (de) Geschuetztes polypeptid, im wesentlichen nicht immunogene, enzymisch aktive substanz sowie verfahren zum weitgehenden unterdruekken der immunogenizitaet eines polypeptids
DE2659808C3 (de) Proteingebundene Polysaccharide und deren Verwendung zur Bekämpfung von Tumoren
DE2638762A1 (de) Wasserloesliche adjuvantien, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
CH650799A5 (de) Verfahren zur herstellung von lipopolysacchariden mit antitumoraktivitaet und immunotherapeutische mittel gegen tumore.
IE51590B1 (en) Glycoproteins
DE2457090C2 (de) Verfahren zur Herstellung von Impfstoffen sowie Antibronchialimpfstoff
DE2024586C3 (US07860544-20101228-C00003.png)
DE3109335A1 (de) Die neue, physiologisch wirksame substanz ebelacton und verfahren zur herstellung derselben
DE69731891T2 (de) Verfahren zur reinigung von gbs-toxin/cm101
DE2919132A1 (de) Substanz ks-2-b, verfahren zu deren herstellung und diese substanz enthaltende mittel
DD202168A5 (de) Verfahren zur herstellung eines glycoproteins
DE2307051C3 (de) Verfahren zum Reinigen von langsamen a - und ß -Glykoproteinen aus Mikrobenkörpern und diese enthaltende pharmazeutische Zusammensetzungen
DE3543267C2 (de) Acylglykan-Extrakte von Klebsiella, deren Gewinnungsverfahren und deren Verwendung als Arzneimittel
DD222895A5 (de) Verfahren zur herstellung eines hypotriglyceridemisch aktiven polysaccharids
EP0395851B1 (de) Glykoproteine aus Avena sativa, Verfahren zu ihrer Herstellung und ihre Verwendung als pharmazeutischer Wirkstoff
IE46195B1 (en) Microbial fractions
DE2152112C3 (de) Impfstoff gegen Pseudomonas aeruginosa
DE3716669A1 (de) Verfahren zur herstellung von zellwandkomponenten aus archaebakterien und deren verwendung als arzneimittel
DE3207019A1 (de) Biologisch wirksame proteinverbindung, verfahren zu ihrer herstellung und mittel, enthaltend die verbindung
DE4028018A1 (de) Extrazellulaeres exopolymer: herstellungsverfahren und pharmazeutische zubereitungen, in denen es enthalten ist

Legal Events

Date Code Title Description
OHA Expiration of time for request for examination