DE2318361A1 - 1,2,3,6-tetrahydro-1,3-dimethyl-2,6dioxopurin-7-acetat des 2-eckige klammer auf (2-dimethylaminoaethyl)-(p-methoxybenzyl) amino eckige klammer zu pyridins - Google Patents
1,2,3,6-tetrahydro-1,3-dimethyl-2,6dioxopurin-7-acetat des 2-eckige klammer auf (2-dimethylaminoaethyl)-(p-methoxybenzyl) amino eckige klammer zu pyridinsInfo
- Publication number
- DE2318361A1 DE2318361A1 DE2318361A DE2318361A DE2318361A1 DE 2318361 A1 DE2318361 A1 DE 2318361A1 DE 2318361 A DE2318361 A DE 2318361A DE 2318361 A DE2318361 A DE 2318361A DE 2318361 A1 DE2318361 A1 DE 2318361A1
- Authority
- DE
- Germany
- Prior art keywords
- acetate
- bronchodilator
- antihistamine
- diuretic
- theophyline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001387 anti-histamine Effects 0.000 title description 2
- 239000000739 antihistaminic agent Substances 0.000 title description 2
- 229940124630 bronchodilator Drugs 0.000 title description 2
- 239000002934 diuretic Substances 0.000 title description 2
- 230000001882 diuretic effect Effects 0.000 title description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 title 1
- 230000000747 cardiac effect Effects 0.000 title 1
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 title 1
- 229960000582 mepyramine Drugs 0.000 title 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title 1
- 239000002904 solvent Substances 0.000 claims abstract description 7
- 239000000725 suspension Substances 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 6
- HCYFGRCYSCXKNQ-UHFFFAOYSA-N 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)acetic acid Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)=O)C=N2 HCYFGRCYSCXKNQ-UHFFFAOYSA-N 0.000 claims description 4
- -1 p-methoxybenzyl Chemical group 0.000 claims description 4
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 3
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 101100322245 Caenorhabditis elegans des-2 gene Proteins 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 5
- 239000012535 impurity Substances 0.000 abstract description 2
- UVGQQNBBUCSYEY-UHFFFAOYSA-N 3-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid Chemical compound CN1C(N(C=2N=CN(C2C1=O)CC(=O)O)C)=O.CN(CCC=1C(=NC=CC1)NCC1=CC=C(C=C1)OC)C UVGQQNBBUCSYEY-UHFFFAOYSA-N 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000000047 product Substances 0.000 description 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 239000000496 cardiotonic agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2318361A DE2318361A1 (de) | 1973-04-12 | 1973-04-12 | 1,2,3,6-tetrahydro-1,3-dimethyl-2,6dioxopurin-7-acetat des 2-eckige klammer auf (2-dimethylaminoaethyl)-(p-methoxybenzyl) amino eckige klammer zu pyridins |
| BE135720A BE804938A (fr) | 1973-04-12 | 1973-09-17 | Procede d'obtention de 1,2,3,6-tetrahydro-1,3-dimethyle-2,6-diosopurin-7- acetate de 2-(2- dimethylami noethyl) (p-methoxy-benzyl)aminopyridine |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2318361A DE2318361A1 (de) | 1973-04-12 | 1973-04-12 | 1,2,3,6-tetrahydro-1,3-dimethyl-2,6dioxopurin-7-acetat des 2-eckige klammer auf (2-dimethylaminoaethyl)-(p-methoxybenzyl) amino eckige klammer zu pyridins |
| BE135720A BE804938A (fr) | 1973-04-12 | 1973-09-17 | Procede d'obtention de 1,2,3,6-tetrahydro-1,3-dimethyle-2,6-diosopurin-7- acetate de 2-(2- dimethylami noethyl) (p-methoxy-benzyl)aminopyridine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2318361A1 true DE2318361A1 (de) | 1974-10-31 |
| DE2318361C2 DE2318361C2 (enrdf_load_stackoverflow) | 1987-05-27 |
Family
ID=25647710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2318361A Granted DE2318361A1 (de) | 1973-04-12 | 1973-04-12 | 1,2,3,6-tetrahydro-1,3-dimethyl-2,6dioxopurin-7-acetat des 2-eckige klammer auf (2-dimethylaminoaethyl)-(p-methoxybenzyl) amino eckige klammer zu pyridins |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE804938A (enrdf_load_stackoverflow) |
| DE (1) | DE2318361A1 (enrdf_load_stackoverflow) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1012763A (fr) * | 1949-11-15 | 1952-07-17 | Rhone Poulenc Sa | Chloro-8 théophyllinate de nu-(diméthylaminoéthyl)-nu-(p. méthoxybenzyl) alpha-aminopyridine |
| US2942000A (en) * | 1958-03-22 | 1960-06-21 | Lab Delagrange Soc D Applic Ph | Derivative of theophylline-7-acetic acid |
-
1973
- 1973-04-12 DE DE2318361A patent/DE2318361A1/de active Granted
- 1973-09-17 BE BE135720A patent/BE804938A/xx not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1012763A (fr) * | 1949-11-15 | 1952-07-17 | Rhone Poulenc Sa | Chloro-8 théophyllinate de nu-(diméthylaminoéthyl)-nu-(p. méthoxybenzyl) alpha-aminopyridine |
| US2942000A (en) * | 1958-03-22 | 1960-06-21 | Lab Delagrange Soc D Applic Ph | Derivative of theophylline-7-acetic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2318361C2 (enrdf_load_stackoverflow) | 1987-05-27 |
| BE804938A (fr) | 1974-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8128 | New person/name/address of the agent |
Representative=s name: SCHOENWALD, K., DR.-ING. FUES, J., DIPL.-CHEM. DR. |
|
| 8127 | New person/name/address of the applicant |
Owner name: LABORATORIOS KNOLL-MADE, S.A., MADRID, ES |
|
| 8128 | New person/name/address of the agent |
Representative=s name: MUTZBAUER, H., DIPL.-CHEM. DR.RER.NAT., PAT.-ASS., |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |