DE2310471A1 - Verfahren zur herstellung von serinoder serinolderivaten - Google Patents
Verfahren zur herstellung von serinoder serinolderivatenInfo
- Publication number
- DE2310471A1 DE2310471A1 DE19732310471 DE2310471A DE2310471A1 DE 2310471 A1 DE2310471 A1 DE 2310471A1 DE 19732310471 DE19732310471 DE 19732310471 DE 2310471 A DE2310471 A DE 2310471A DE 2310471 A1 DE2310471 A1 DE 2310471A1
- Authority
- DE
- Germany
- Prior art keywords
- atcc
- aldehyde
- candida
- arthrobacter
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 22
- 238000004519 manufacturing process Methods 0.000 title description 4
- 238000006243 chemical reaction Methods 0.000 claims description 42
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- 150000001299 aldehydes Chemical class 0.000 claims description 33
- 239000000243 solution Substances 0.000 claims description 22
- 108090000790 Enzymes Proteins 0.000 claims description 21
- 102000004190 Enzymes Human genes 0.000 claims description 21
- -1 saturated aliphatic aldehyde Chemical class 0.000 claims description 21
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 20
- 244000005700 microbiome Species 0.000 claims description 19
- 239000004471 Glycine Substances 0.000 claims description 18
- KJJPLEZQSCZCKE-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical class OCC(N)CO KJJPLEZQSCZCKE-UHFFFAOYSA-N 0.000 claims description 11
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 6
- 241000222050 Vanrija humicola Species 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
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- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
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- 241000222175 Diutina rugosa Species 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
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- 241000203720 Pimelobacter simplex Species 0.000 claims description 3
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- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
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- 239000011589 pyridoxal 5'-phosphate Substances 0.000 claims description 3
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- 229910052736 halogen Inorganic materials 0.000 claims description 2
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- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/828—Aerobacter
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S435/88—Serratia
- Y10S435/881—Serratia marcescens
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/882—Staphylococcus
- Y10S435/883—Staphylococcus aureus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/91—Xanthomonas
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2265072A JPS5246313B2 (enExample) | 1972-03-04 | 1972-03-04 | |
| JP3729672A JPS516239B2 (enExample) | 1972-04-13 | 1972-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2310471A1 true DE2310471A1 (de) | 1973-09-06 |
Family
ID=26359910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732310471 Pending DE2310471A1 (de) | 1972-03-04 | 1973-03-02 | Verfahren zur herstellung von serinoder serinolderivaten |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3871958A (enExample) |
| CH (1) | CH570364A5 (enExample) |
| DE (1) | DE2310471A1 (enExample) |
| FR (1) | FR2174964B1 (enExample) |
| GB (1) | GB1417067A (enExample) |
| NL (1) | NL7302882A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3019069A1 (de) * | 1979-05-24 | 1980-12-04 | Lepetit Spa | Verfahren zur herstellung eines serinderivats |
| DE3428442A1 (de) * | 1983-08-01 | 1985-02-21 | Mitsui Toatsu Chemicals, Inc., Tokio/Tokyo | Verfahren zur herstellung von ss-phenylserin |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4183786A (en) * | 1976-11-30 | 1980-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for production of L-serine |
| US4873359A (en) * | 1985-10-21 | 1989-10-10 | W. R. Grace & Co. - Conn. | Process for preparing as partyl-phenylalanine dipeptides |
| US4810817A (en) * | 1985-10-21 | 1989-03-07 | W. R. Grace & Co. | Aspartyl-beta substituted phenylalanine dipeptides |
| US5102792A (en) * | 1987-08-13 | 1992-04-07 | W. R. Grace & Co.-Conn. | Selective production of L-serine derivative isomers |
| US4950606A (en) * | 1989-06-22 | 1990-08-21 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
| US5169780A (en) * | 1989-06-22 | 1992-12-08 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
| US5300437A (en) * | 1989-06-22 | 1994-04-05 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
| EP0446798B1 (en) * | 1990-03-13 | 1994-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl- and 1-alkynylaryl-2-amino-1, 3-propanediols and related compounds, a process and intermediates for their preparation and their use as medicaments |
| US5360811A (en) * | 1990-03-13 | 1994-11-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents |
| US5266468A (en) * | 1990-06-04 | 1993-11-30 | University Of Notre Dame Du Lac | Process for preparing β-hydroxy-α amino acids |
| NZ238342A (en) * | 1990-06-04 | 1993-10-26 | Univ Notre Dame Du Lac | Preparation of beta-hydroxy-alphaamino acids useful as intermediates in the preparation of beta-lactam antibiotics |
| US5346828A (en) * | 1991-03-27 | 1994-09-13 | Celgene Corporation | Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase |
| JP3532922B2 (ja) * | 1994-03-03 | 2004-05-31 | ダイセル化学工業株式会社 | （ｒ）−２−アミノ−１−フェニルエタノールまたはそのハロゲン置換体の製造方法、光学活性フェニルセリンまたはそのハロゲン置換体の製造方法、新規化合物３−（３−クロロフェニル）セリン |
| US5614615A (en) * | 1995-03-21 | 1997-03-25 | The Scripps Research Institute | Sialyl Lewis X mimetics incorporating fucopeptides |
| US5599915A (en) * | 1995-03-21 | 1997-02-04 | The Scripps Research Institute | Sialyl Lewis X mimetics |
| WO2000048997A1 (fr) | 1999-02-16 | 2000-08-24 | Kaneka Corporation | DERIVES D'ACETYLPYRIDINE SUBSTITUEE ET PROCEDE DE PREPARATION D'INTERMEDIAIRES POUR AGONISTE DU RECEPTEUR ADRENERGIQUE β3 OPTIQUEMENT ACTIF, FAISANT APPEL A CES DERIVES |
| US8314151B2 (en) | 2008-04-29 | 2012-11-20 | Enzo Therapeutics, Inc. | Sphingosine kinase type 1 inhibitors, and processes for using same |
| US8372888B2 (en) * | 2008-04-29 | 2013-02-12 | Enzo Therapeutics, Inc. | Sphingosine kinase type 1 inhibitors, compositions and processes for using same |
| US10660879B2 (en) | 2017-06-23 | 2020-05-26 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
| US10675255B2 (en) | 2017-06-23 | 2020-06-09 | Enzo Bochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
| CN114176084B (zh) * | 2021-12-06 | 2022-09-20 | 南京天秾生物技术有限公司 | 2-氨基-3-羟基-3-甲基丁酸和/或2-氨基-3-(4-羟基苯基)丁酸的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA948578A (en) * | 1970-02-25 | 1974-06-04 | Hideaki Yamada | Process for preparing l-serine |
| JPS5212273B1 (enExample) * | 1970-05-06 | 1977-04-06 |
-
1973
- 1973-02-28 US US336808A patent/US3871958A/en not_active Expired - Lifetime
- 1973-03-01 NL NL7302882A patent/NL7302882A/xx not_active Application Discontinuation
- 1973-03-02 FR FR7307624A patent/FR2174964B1/fr not_active Expired
- 1973-03-02 CH CH311173A patent/CH570364A5/xx not_active IP Right Cessation
- 1973-03-02 GB GB1038673A patent/GB1417067A/en not_active Expired
- 1973-03-02 DE DE19732310471 patent/DE2310471A1/de active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3019069A1 (de) * | 1979-05-24 | 1980-12-04 | Lepetit Spa | Verfahren zur herstellung eines serinderivats |
| DE3428442A1 (de) * | 1983-08-01 | 1985-02-21 | Mitsui Toatsu Chemicals, Inc., Tokio/Tokyo | Verfahren zur herstellung von ss-phenylserin |
Also Published As
| Publication number | Publication date |
|---|---|
| US3871958A (en) | 1975-03-18 |
| FR2174964B1 (enExample) | 1977-07-29 |
| CH570364A5 (enExample) | 1975-12-15 |
| NL7302882A (enExample) | 1973-09-07 |
| FR2174964A1 (enExample) | 1973-10-19 |
| GB1417067A (en) | 1975-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHA | Expiration of time for request for examination |