DE2307010C2 - Verfahren zur Herstellung von LH- und FSH-Releasing Hormon, hierbei eingesetzte Zwischenprodukte und Verfahren zu deren Herstellung - Google Patents
Verfahren zur Herstellung von LH- und FSH-Releasing Hormon, hierbei eingesetzte Zwischenprodukte und Verfahren zu deren HerstellungInfo
- Publication number
- DE2307010C2 DE2307010C2 DE2307010A DE2307010A DE2307010C2 DE 2307010 C2 DE2307010 C2 DE 2307010C2 DE 2307010 A DE2307010 A DE 2307010A DE 2307010 A DE2307010 A DE 2307010A DE 2307010 C2 DE2307010 C2 DE 2307010C2
- Authority
- DE
- Germany
- Prior art keywords
- solution
- ester
- acid
- mixture
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 125000002707 L-tryptophyl group Chemical group [H]C1=C([H])C([H])=C2C(C([C@](N([H])[H])(C(=O)[*])[H])([H])[H])=C([H])N([H])C2=C1[H] 0.000 description 1
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- TYQYRKDGHAPZRF-INIZCTEOSA-N benzyl (2s)-2-amino-3-(1h-indol-3-yl)propanoate Chemical compound O=C([C@H](CC=1C2=CC=CC=C2NC=1)N)OCC1=CC=CC=C1 TYQYRKDGHAPZRF-INIZCTEOSA-N 0.000 description 1
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- 125000000623 heterocyclic group Chemical group 0.000 description 1
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- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 150000007524 organic acids Chemical class 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00226508A US3835108A (en) | 1972-02-15 | 1972-02-15 | Process for preparing the releasing hormone of luteinizing hormone(lh)and of follicle stimulating hormone(fsh),salts and compositions thereof,and intermediates therefor |
| US24346572A | 1972-04-12 | 1972-04-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2307010A1 DE2307010A1 (de) | 1973-08-23 |
| DE2307010C2 true DE2307010C2 (de) | 1986-08-21 |
Family
ID=26920599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2307010A Expired DE2307010C2 (de) | 1972-02-15 | 1973-02-13 | Verfahren zur Herstellung von LH- und FSH-Releasing Hormon, hierbei eingesetzte Zwischenprodukte und Verfahren zu deren Herstellung |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5729462B2 (en:Method) |
| CA (1) | CA1025441A (en:Method) |
| CH (1) | CH589608A5 (en:Method) |
| DE (1) | DE2307010C2 (en:Method) |
| FR (1) | FR2181730B1 (en:Method) |
| GB (3) | GB1425513A (en:Method) |
| IL (3) | IL48514A (en:Method) |
| NZ (1) | NZ169577A (en:Method) |
| SE (1) | SE403772B (en:Method) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68992A (en) * | 1982-06-29 | 1991-06-10 | Astra Laekemedel Ab | Alpha-bromo diethyl carbonate and process for the preparation of ethoxycarbonyloxy esters of penicillanic acids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS528831B2 (en:Method) * | 1971-10-04 | 1977-03-11 |
-
1973
- 1973-01-17 IL IL48514A patent/IL48514A/en unknown
- 1973-01-17 IL IL41313A patent/IL41313A/en unknown
- 1973-01-17 NZ NZ169577A patent/NZ169577A/xx unknown
- 1973-02-13 DE DE2307010A patent/DE2307010C2/de not_active Expired
- 1973-02-14 GB GB3217475A patent/GB1425513A/en not_active Expired
- 1973-02-14 CH CH210773A patent/CH589608A5/xx not_active IP Right Cessation
- 1973-02-14 SE SE7302099A patent/SE403772B/xx unknown
- 1973-02-14 GB GB718073A patent/GB1425511A/en not_active Expired
- 1973-02-14 FR FR7305151A patent/FR2181730B1/fr not_active Expired
- 1973-02-14 GB GB3217675A patent/GB1425512A/en not_active Expired
- 1973-02-15 CA CA163,972A patent/CA1025441A/en not_active Expired
- 1973-02-15 JP JP1884473A patent/JPS5729462B2/ja not_active Expired
-
1975
- 1975-11-21 IL IL48514A patent/IL48514A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH589608A5 (en:Method) | 1977-07-15 |
| FR2181730A1 (en:Method) | 1973-12-07 |
| IL48514A0 (en) | 1976-01-30 |
| GB1425513A (en) | 1976-02-18 |
| IL41313A (en) | 1976-08-31 |
| NZ169577A (en) | 1984-09-28 |
| JPS5729462B2 (en:Method) | 1982-06-23 |
| IL41313A0 (en) | 1973-03-30 |
| DE2307010A1 (de) | 1973-08-23 |
| FR2181730B1 (en:Method) | 1977-07-15 |
| GB1425511A (en) | 1976-02-18 |
| GB1425512A (en) | 1976-02-18 |
| IL48514A (en) | 1976-08-31 |
| JPS4886868A (en:Method) | 1973-11-15 |
| CA1025441A (en) | 1978-01-31 |
| SE403772B (sv) | 1978-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition |