DE2261561C3 - Verfahren zur Durchführung von auf Konkurrenz-Reaktionen beruhenden Analysen - Google Patents
Verfahren zur Durchführung von auf Konkurrenz-Reaktionen beruhenden AnalysenInfo
- Publication number
- DE2261561C3 DE2261561C3 DE2261561A DE2261561A DE2261561C3 DE 2261561 C3 DE2261561 C3 DE 2261561C3 DE 2261561 A DE2261561 A DE 2261561A DE 2261561 A DE2261561 A DE 2261561A DE 2261561 C3 DE2261561 C3 DE 2261561C3
- Authority
- DE
- Germany
- Prior art keywords
- phase
- liquid
- tube
- compound
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 17
- 230000002860 competitive effect Effects 0.000 title claims description 5
- 238000004458 analytical method Methods 0.000 title description 5
- 239000012071 phase Substances 0.000 claims description 25
- 239000007791 liquid phase Substances 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 239000007790 solid phase Substances 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 9
- 238000005259 measurement Methods 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 230000002441 reversible effect Effects 0.000 claims description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 12
- 230000000694 effects Effects 0.000 description 7
- 102000004877 Insulin Human genes 0.000 description 6
- 108090001061 Insulin Proteins 0.000 description 6
- 229940125396 insulin Drugs 0.000 description 6
- 230000002285 radioactive effect Effects 0.000 description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 4
- 239000013078 crystal Substances 0.000 description 3
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 235000009518 sodium iodide Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T7/00—Details of radiation-measuring instruments
- G01T7/02—Collecting means for receiving or storing samples to be investigated and possibly directly transporting the samples to the measuring arrangement; particularly for investigating radioactive fluids
Landscapes
- High Energy & Nuclear Physics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Measurement Of Radiation (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5856671A GB1411382A (en) | 1971-12-16 | 1971-12-16 | Methods of analysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2261561A1 DE2261561A1 (de) | 1973-07-12 |
| DE2261561B2 DE2261561B2 (de) | 1980-01-03 |
| DE2261561C3 true DE2261561C3 (de) | 1980-09-04 |
Family
ID=10481917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2261561A Expired DE2261561C3 (de) | 1971-12-16 | 1972-12-15 | Verfahren zur Durchführung von auf Konkurrenz-Reaktionen beruhenden Analysen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3883738A (enrdf_load_html_response) |
| JP (1) | JPS5229956B2 (enrdf_load_html_response) |
| DE (1) | DE2261561C3 (enrdf_load_html_response) |
| FR (1) | FR2167046A5 (enrdf_load_html_response) |
| GB (1) | GB1411382A (enrdf_load_html_response) |
| SE (1) | SE390066B (enrdf_load_html_response) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS544479B2 (enrdf_load_html_response) * | 1974-02-09 | 1979-03-07 | ||
| SE401405B (sv) * | 1976-08-16 | 1978-05-02 | Thorell Jan Ivan | Sett vid en analys, vid vilken ett radioaktivt emne fordelas mellan en flytande och en fast fas |
| SE444989B (sv) * | 1979-12-17 | 1986-05-20 | Jan Ivan Thorell | Reagenskomposition for radioimmunologiska bestemningsmetoder |
| US4394391A (en) * | 1980-02-19 | 1983-07-19 | Thorell Jan Ivan | Radioimmunoassay reagents |
| US4315151A (en) * | 1980-07-07 | 1982-02-09 | Beckman Instruments, Inc. | Detecting phase separation in liquid scintillation samples |
| US4333010A (en) * | 1981-05-08 | 1982-06-01 | Miller William H | Dose calibrator linearity evaluation |
| JPH0695143B2 (ja) * | 1983-05-27 | 1994-11-24 | 富士写真フイルム株式会社 | 放射線の強度測定法およびその方法に用いられる放射線測定容器 |
| US5073341A (en) * | 1985-08-21 | 1991-12-17 | Biotope, Inc. | Devices for conducting specific binding assays |
| EP0233939B1 (en) * | 1985-08-21 | 1991-11-13 | Biotope, Inc. | Methods and devices for separating, mixing, and detecting components in specific binding assays |
| WO1989005456A1 (en) * | 1987-12-01 | 1989-06-15 | Biotope, Inc. | Methods and devices for conducting assays |
| US5274239A (en) * | 1992-07-23 | 1993-12-28 | Sunol Technologies, Inc. | Shielded dose calibration apparatus |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3050628A (en) * | 1957-06-19 | 1962-08-21 | Kartridg Pak Co | Method of determining composition of an oil and water mixture |
| US2927209A (en) * | 1957-07-05 | 1960-03-01 | Jones Richard Norman | Spectrometric cell structure and charging method therefor |
| NL264183A (enrdf_load_html_response) * | 1960-05-02 | |||
| US3451777A (en) * | 1965-08-20 | 1969-06-24 | Walter Di Giulio | Method and apparatus for determining the thyroid hormone content of blood |
| GB1189328A (en) * | 1967-09-12 | 1970-04-22 | Atomic Energy Authority Uk | Improvements in or relating to Particle Size Analysis |
| US3666854A (en) * | 1969-07-30 | 1972-05-30 | Nuclear Med Lab | Test for thyroid hormone |
-
1971
- 1971-12-16 GB GB5856671A patent/GB1411382A/en not_active Expired
-
1972
- 1972-12-08 US US313263A patent/US3883738A/en not_active Expired - Lifetime
- 1972-12-14 JP JP47125752A patent/JPS5229956B2/ja not_active Expired
- 1972-12-15 FR FR7244676A patent/FR2167046A5/fr not_active Expired
- 1972-12-15 SE SE7216434A patent/SE390066B/xx unknown
- 1972-12-15 DE DE2261561A patent/DE2261561C3/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5229956B2 (enrdf_load_html_response) | 1977-08-04 |
| GB1411382A (en) | 1975-10-22 |
| DE2261561B2 (de) | 1980-01-03 |
| DE2261561A1 (de) | 1973-07-12 |
| JPS4866892A (enrdf_load_html_response) | 1973-09-13 |
| FR2167046A5 (enrdf_load_html_response) | 1973-08-17 |
| SE390066B (sv) | 1976-11-29 |
| US3883738A (en) | 1975-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |