DE2245402C3 - Xyloseisomerase-Enzymzubereitung, Verfahren zu deren Herstellung und Verwendung derselben - Google Patents
Xyloseisomerase-Enzymzubereitung, Verfahren zu deren Herstellung und Verwendung derselbenInfo
- Publication number
- DE2245402C3 DE2245402C3 DE2245402A DE2245402A DE2245402C3 DE 2245402 C3 DE2245402 C3 DE 2245402C3 DE 2245402 A DE2245402 A DE 2245402A DE 2245402 A DE2245402 A DE 2245402A DE 2245402 C3 DE2245402 C3 DE 2245402C3
- Authority
- DE
- Germany
- Prior art keywords
- xylose
- mutant
- enzyme
- medium
- streptomyces
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108700040099 Xylose isomerases Proteins 0.000 title claims description 29
- 238000002360 preparation method Methods 0.000 title claims description 25
- 238000000034 method Methods 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title description 16
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 82
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 57
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 41
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 41
- 230000000694 effects Effects 0.000 claims description 30
- 244000005700 microbiome Species 0.000 claims description 22
- 241000187747 Streptomyces Species 0.000 claims description 18
- 229910017052 cobalt Inorganic materials 0.000 claims description 17
- 239000010941 cobalt Substances 0.000 claims description 17
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 17
- 235000015097 nutrients Nutrition 0.000 claims description 16
- 239000008121 dextrose Substances 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 13
- 241000187134 Streptomyces olivochromogenes Species 0.000 claims description 9
- 229940079919 digestives enzyme preparation Drugs 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 description 54
- 108090000790 Enzymes Proteins 0.000 description 54
- 229940088598 enzyme Drugs 0.000 description 54
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 53
- 239000002609 medium Substances 0.000 description 40
- 239000008103 glucose Substances 0.000 description 34
- 108090000769 Isomerases Proteins 0.000 description 25
- 102000004195 Isomerases Human genes 0.000 description 25
- 239000006188 syrup Substances 0.000 description 23
- 235000020357 syrup Nutrition 0.000 description 23
- 229920002472 Starch Polymers 0.000 description 20
- 235000019698 starch Nutrition 0.000 description 20
- 239000008107 starch Substances 0.000 description 20
- 239000001963 growth medium Substances 0.000 description 19
- 238000006243 chemical reaction Methods 0.000 description 18
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 238000000855 fermentation Methods 0.000 description 15
- 230000004151 fermentation Effects 0.000 description 15
- 229960002737 fructose Drugs 0.000 description 13
- 229930091371 Fructose Natural products 0.000 description 12
- 239000005715 Fructose Substances 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 11
- 238000006317 isomerization reaction Methods 0.000 description 11
- 229920001817 Agar Polymers 0.000 description 10
- 239000008272 agar Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
- 239000000049 pigment Substances 0.000 description 8
- 240000008042 Zea mays Species 0.000 description 7
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 7
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 7
- 235000005822 corn Nutrition 0.000 description 7
- 238000011081 inoculation Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- 150000001720 carbohydrates Chemical class 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 208000007976 Ketosis Diseases 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 238000005189 flocculation Methods 0.000 description 5
- 230000016615 flocculation Effects 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000004471 Glycine Substances 0.000 description 4
- 235000010633 broth Nutrition 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 150000002584 ketoses Chemical class 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 241000203809 Actinomycetales Species 0.000 description 3
- RFSUNEUAIZKAJO-VRPWFDPXSA-N D-Fructose Natural products OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-VRPWFDPXSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 244000061456 Solanum tuberosum Species 0.000 description 3
- 235000002595 Solanum tuberosum Nutrition 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 3
- 235000019341 magnesium sulphate Nutrition 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 150000002823 nitrates Chemical class 0.000 description 3
- 150000002826 nitrites Chemical class 0.000 description 3
- 238000009633 stab culture Methods 0.000 description 3
- 241000186361 Actinobacteria <class> Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 102100029359 Cytochrome P450 2C8 Human genes 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 101000919358 Homo sapiens Cytochrome P450 2C8 Proteins 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 229940077731 carbohydrate nutrients Drugs 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 229920001221 xylan Polymers 0.000 description 2
- 150000004823 xylans Chemical class 0.000 description 2
- PJVXUVWGSCCGHT-ZPYZYFCMSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;(3s,4r,5r)-1,3,4,5,6-pentahydroxyhexan-2-one Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO PJVXUVWGSCCGHT-ZPYZYFCMSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- ZAQJHHRNXZUBTE-WUJLRWPWSA-N D-xylulose Chemical compound OC[C@@H](O)[C@H](O)C(=O)CO ZAQJHHRNXZUBTE-WUJLRWPWSA-N 0.000 description 1
- -1 Dextrose anhydride Chemical class 0.000 description 1
- 229920002245 Dextrose equivalent Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 241000187217 Streptomyces griseoruber Species 0.000 description 1
- 241000187411 Streptomyces phaeochromogenes Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- 230000004140 ketosis Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000006225 natural substrate Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00181639A US3813318A (en) | 1971-09-17 | 1971-09-17 | Production of xylose (dextrose) isomerase enzyme preparations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2245402A1 DE2245402A1 (de) | 1973-03-22 |
| DE2245402B2 DE2245402B2 (de) | 1979-03-29 |
| DE2245402C3 true DE2245402C3 (de) | 1979-11-22 |
Family
ID=22665141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2245402A Expired DE2245402C3 (de) | 1971-09-17 | 1972-09-15 | Xyloseisomerase-Enzymzubereitung, Verfahren zu deren Herstellung und Verwendung derselben |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US3813318A (Direct) |
| JP (1) | JPS5645589B2 (Direct) |
| AU (1) | AU476885B2 (Direct) |
| BE (1) | BE788843A (Direct) |
| BR (1) | BR7206440D0 (Direct) |
| CA (1) | CA986438A (Direct) |
| CH (1) | CH576524A5 (Direct) |
| DE (1) | DE2245402C3 (Direct) |
| ES (1) | ES406665A1 (Direct) |
| FR (1) | FR2153100B1 (Direct) |
| GB (3) | GB1411763A (Direct) |
| IT (1) | IT970699B (Direct) |
| NL (1) | NL7212631A (Direct) |
| TR (1) | TR17546A (Direct) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137126A (en) * | 1975-05-03 | 1979-01-30 | Givaudan Corporation | Process for preparing glucose isomerase using streptomyces glaucescens mutants |
| US4230802A (en) * | 1976-01-05 | 1980-10-28 | Anheuser-Busch, Incorporated | Unrefined glucose syrup as substrate by glucose isomerizing enzyme in producing fructose from glucose |
| JPS52155889A (en) * | 1976-06-21 | 1977-12-24 | Tokyo Shibaura Electric Co | Scintillation camera |
| JPS6047067B2 (ja) * | 1977-01-17 | 1985-10-19 | 日本精工株式会社 | 球面研削盤のドレツシング方法 |
| BG32193A1 (en) * | 1979-11-29 | 1982-06-15 | Popov | Method for obtaining of glucoseisomerase |
| BG32192A1 (en) * | 1979-11-29 | 1982-06-15 | Popov | Method for obtaining of glucoseisomerase |
| US4490468A (en) * | 1980-04-23 | 1984-12-25 | Purdue Research Foundation | Production of ethanol by yeast using xylulose |
| US4777776A (en) * | 1982-04-26 | 1988-10-18 | Chris Morrell | Roof panel construction |
| US4492755A (en) * | 1982-06-30 | 1985-01-08 | Nabisco Brands, Inc. | Process for isomerizing L-mannose to L-fructose |
| US4467033A (en) * | 1982-06-30 | 1984-08-21 | Nabisco Brands, Inc. | Process for oxidizing L-sorbitol to L-fructose |
| DK111185A (da) * | 1985-03-12 | 1986-09-13 | Novo Industri As | Xyloseisomerase, fremgangsmaade til fremstilling deraf, immobiliseret xyloseisomerase og fremgangsmaade til isomerisering af glucose til fructose |
-
0
- BE BE788843D patent/BE788843A/xx not_active IP Right Cessation
-
1971
- 1971-09-17 US US00181639A patent/US3813318A/en not_active Expired - Lifetime
-
1972
- 1972-08-18 IT IT28303/72A patent/IT970699B/it active
- 1972-09-12 JP JP9162672A patent/JPS5645589B2/ja not_active Expired
- 1972-09-14 ES ES406665A patent/ES406665A1/es not_active Expired
- 1972-09-15 DE DE2245402A patent/DE2245402C3/de not_active Expired
- 1972-09-15 BR BR006440/72A patent/BR7206440D0/pt unknown
- 1972-09-15 AU AU46737/72A patent/AU476885B2/en not_active Expired
- 1972-09-15 CH CH1358672A patent/CH576524A5/xx not_active IP Right Cessation
- 1972-09-15 TR TR17546A patent/TR17546A/xx unknown
- 1972-09-17 GB GB4191972A patent/GB1411763A/en not_active Expired
- 1972-09-17 GB GB2061675A patent/GB1411765A/en not_active Expired
- 1972-09-17 GB GB2061575A patent/GB1411764A/en not_active Expired
- 1972-09-18 NL NL7212631A patent/NL7212631A/xx unknown
- 1972-09-18 FR FR7233033A patent/FR2153100B1/fr not_active Expired
- 1972-09-18 CA CA152,000A patent/CA986438A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU476885B2 (en) | 1976-10-07 |
| GB1411764A (en) | 1975-10-29 |
| JPS4836394A (Direct) | 1973-05-29 |
| CA986438A (en) | 1976-03-30 |
| BR7206440D0 (pt) | 1973-08-30 |
| ES406665A1 (es) | 1975-09-16 |
| GB1411765A (en) | 1975-10-29 |
| AU4673772A (en) | 1974-03-21 |
| TR17546A (tr) | 1975-07-23 |
| FR2153100A1 (Direct) | 1973-04-27 |
| NL7212631A (Direct) | 1973-03-20 |
| JPS5645589B2 (Direct) | 1981-10-27 |
| BE788843A (fr) | 1973-03-15 |
| GB1411763A (en) | 1975-10-29 |
| DE2245402B2 (de) | 1979-03-29 |
| IT970699B (it) | 1974-04-20 |
| DE2245402A1 (de) | 1973-03-22 |
| US3813318A (en) | 1974-05-28 |
| CH576524A5 (Direct) | 1976-06-15 |
| FR2153100B1 (Direct) | 1977-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) |