DE2235597A1 - 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung - Google Patents

1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE2235597A1
DE2235597A1 DE2235597A DE2235597A DE2235597A1 DE 2235597 A1 DE2235597 A1 DE 2235597A1 DE 2235597 A DE2235597 A DE 2235597A DE 2235597 A DE2235597 A DE 2235597A DE 2235597 A1 DE2235597 A1 DE 2235597A1
Authority
DE
Germany
Prior art keywords
oxy
tetrahydronaphth
piperazine
compounds
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2235597A
Other languages
German (de)
English (en)
Inventor
Karl Dr Med Dietmann
Gisbert Dr Med Sponer
Kurt Dr Ing Stach
Ernst-Christian Dr Rer N Witte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE2235597A priority Critical patent/DE2235597A1/de
Priority to US05/370,068 priority patent/US3947446A/en
Priority to CA176,440A priority patent/CA1003836A/en
Priority to ES416929A priority patent/ES416929A1/es
Priority to ZA734811A priority patent/ZA734811B/xx
Priority to GB3373273A priority patent/GB1376588A/en
Priority to AR249099A priority patent/AR196775A1/es
Priority to CH1191576A priority patent/CH583722A5/xx
Priority to CH1042073A priority patent/CH583721A5/xx
Priority to DD172339A priority patent/DD106842A5/xx
Priority to AT636673A priority patent/AT330188B/de
Priority to NL737310041A priority patent/NL149168B/xx
Priority to FR7326491A priority patent/FR2193598B1/fr
Priority to HUBO1452A priority patent/HU165887B/hu
Priority to JP8249373A priority patent/JPS5331158B2/ja
Publication of DE2235597A1 publication Critical patent/DE2235597A1/de
Priority to AT202375A priority patent/AT330190B/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2235597A 1972-07-20 1972-07-20 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung Pending DE2235597A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE2235597A DE2235597A1 (de) 1972-07-20 1972-07-20 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung
US05/370,068 US3947446A (en) 1972-07-20 1973-06-14 Novel 1-[3-(5,6,7,8-tetrahydronaphth-1-yloxy)-propyl]-piperazine compounds and therapeutic compositions
CA176,440A CA1003836A (en) 1972-07-20 1973-07-13 1-(3-(5,6,7,8-tetrahydronaphth-1-yloxy)-propyl)-piperazine derivatives
ES416929A ES416929A1 (es) 1972-07-20 1973-07-14 Procedimiento para la preparacion de derivados de 1-(3-(5, 6,7,8-tetrahidronaft-1-il-oxi)-propil)-piperazina.
ZA734811A ZA734811B (en) 1972-07-20 1973-07-16 1-(3-(5,6,7,8-tetrahydronapht-1-yloxy)-propyl)-piperazine derivatives
GB3373273A GB1376588A (en) 1972-07-20 1973-07-16 Piperazine derivatives
AR249099A AR196775A1 (es) 1972-07-20 1973-07-16 Procedimiento para la preparacion de derivados de 1-(3-(5,6,7,8-tetrahidronaft-1-ii-oxi)-propil)- piperazina
CH1191576A CH583722A5 (US20020167097A1-20021114-C00005.png) 1972-07-20 1973-07-17
CH1042073A CH583721A5 (US20020167097A1-20021114-C00005.png) 1972-07-20 1973-07-17
DD172339A DD106842A5 (US20020167097A1-20021114-C00005.png) 1972-07-20 1973-07-18
AT636673A AT330188B (de) 1972-07-20 1973-07-19 Verfahren zur herstellung von neuen 1-(3- (5,6,7,8-tetrahydronaphth-1-yl-oxy) -propyl)-piperazin-derivaten und deren salzen
NL737310041A NL149168B (nl) 1972-07-20 1973-07-19 Werkwijze voor het bereiden van een geneesmiddel met bloeddruk-verlagende werking, waarin als actieve verbinding een veretherd 1-(3-hydroxypropyl)-4-fenyl- of -4-(fenylalkyl)-piperazine-derivaat is opgenomen, het volgens deze werkwijze verkregen geneesmiddel en werkwijze voor het bereiden van de actieve verbinding.
FR7326491A FR2193598B1 (US20020167097A1-20021114-C00005.png) 1972-07-20 1973-07-19
HUBO1452A HU165887B (US20020167097A1-20021114-C00005.png) 1972-07-20 1973-07-19
JP8249373A JPS5331158B2 (US20020167097A1-20021114-C00005.png) 1972-07-20 1973-07-20
AT202375A AT330190B (de) 1972-07-20 1975-03-17 Verfahren zur herstellung von neuen 1-(3- (5,6,7,8-tetrahydronaphth-1-yl-oxy) -propyl)-piperazin-derivaten und deren salzen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2235597A DE2235597A1 (de) 1972-07-20 1972-07-20 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DE2235597A1 true DE2235597A1 (de) 1974-01-31

Family

ID=5851155

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2235597A Pending DE2235597A1 (de) 1972-07-20 1972-07-20 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

Country Status (14)

Country Link
US (1) US3947446A (US20020167097A1-20021114-C00005.png)
JP (1) JPS5331158B2 (US20020167097A1-20021114-C00005.png)
AR (1) AR196775A1 (US20020167097A1-20021114-C00005.png)
AT (1) AT330188B (US20020167097A1-20021114-C00005.png)
CA (1) CA1003836A (US20020167097A1-20021114-C00005.png)
CH (2) CH583721A5 (US20020167097A1-20021114-C00005.png)
DD (1) DD106842A5 (US20020167097A1-20021114-C00005.png)
DE (1) DE2235597A1 (US20020167097A1-20021114-C00005.png)
ES (1) ES416929A1 (US20020167097A1-20021114-C00005.png)
FR (1) FR2193598B1 (US20020167097A1-20021114-C00005.png)
GB (1) GB1376588A (US20020167097A1-20021114-C00005.png)
HU (1) HU165887B (US20020167097A1-20021114-C00005.png)
NL (1) NL149168B (US20020167097A1-20021114-C00005.png)
ZA (1) ZA734811B (US20020167097A1-20021114-C00005.png)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2408804A1 (de) * 1974-02-23 1975-09-04 Boehringer Mannheim Gmbh 1- eckige klammer auf 3-(naphth-1-yloxy)-2-hydroxy-propyl eckige klammer zu piperazin-derivate und verfahren zu ihrer herstellung
DE2814168A1 (de) * 1977-04-04 1978-10-05 Degussa Neue 1- eckige klammer auf 3-(3,4,5- trimethoxyphenoxy)-2-hydroxypropyl eckige klammer zu -4-aryl-piperazin-derivate und verfahren zu ihrer herstellung
EP0401652A1 (de) * 1989-06-07 1990-12-12 Roche Diagnostics GmbH Hydroxylierte 1-Phenyl-4-[3-(naphth-1-yl-oxy)-2-hydroxypropyl]-piperazine, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
WO1994000441A1 (en) * 1992-06-26 1994-01-06 Farmitalia Carlo Erba S.R.L. N(hetero)-aryl-n(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity
WO1999058527A2 (en) * 1998-05-14 1999-11-18 EGIS Gyógyszergyár Rt. Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658762A1 (de) * 1976-12-24 1978-06-29 Hoechst Ag Neue o-alkylierte oxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4101723A (en) * 1977-04-05 1978-07-18 E. R. Squibb & Sons, Inc. Substituted piperazinopropanols
US4259327A (en) * 1979-04-02 1981-03-31 Merck & Co., Inc. Substituted aminoalkoxypyridines, compositions and use thereof
US4255426A (en) * 1979-07-09 1981-03-10 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP1425261A2 (de) * 2001-08-31 2004-06-09 Bayer Chemicals AG Verfahren zur herstellung von 4-amino-1-naphtholethern

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317034A (en) * 1970-11-06 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy- or -phenylthiopropyl-piperazine derivatives

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2408804A1 (de) * 1974-02-23 1975-09-04 Boehringer Mannheim Gmbh 1- eckige klammer auf 3-(naphth-1-yloxy)-2-hydroxy-propyl eckige klammer zu piperazin-derivate und verfahren zu ihrer herstellung
DE2814168A1 (de) * 1977-04-04 1978-10-05 Degussa Neue 1- eckige klammer auf 3-(3,4,5- trimethoxyphenoxy)-2-hydroxypropyl eckige klammer zu -4-aryl-piperazin-derivate und verfahren zu ihrer herstellung
EP0401652A1 (de) * 1989-06-07 1990-12-12 Roche Diagnostics GmbH Hydroxylierte 1-Phenyl-4-[3-(naphth-1-yl-oxy)-2-hydroxypropyl]-piperazine, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
US5037828A (en) * 1989-06-07 1991-08-06 Boehringer Mannheim Gmbh Piperazine derivatives, uses thereof and pharmaceutical compositions containing them
WO1994000441A1 (en) * 1992-06-26 1994-01-06 Farmitalia Carlo Erba S.R.L. N(hetero)-aryl-n(hetero)-tetralin-alkyl-piperazine having serotoninergic, dopaminergic and adrenergic activity
WO1999058527A2 (en) * 1998-05-14 1999-11-18 EGIS Gyógyszergyár Rt. Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
WO1999058527A3 (en) * 1998-05-14 2000-01-27 Egyt Gyogyszervegyeszeti Gyar Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient

Also Published As

Publication number Publication date
US3947446A (en) 1976-03-30
FR2193598A1 (US20020167097A1-20021114-C00005.png) 1974-02-22
DD106842A5 (US20020167097A1-20021114-C00005.png) 1974-07-05
JPS4943990A (US20020167097A1-20021114-C00005.png) 1974-04-25
FR2193598B1 (US20020167097A1-20021114-C00005.png) 1977-07-15
HU165887B (US20020167097A1-20021114-C00005.png) 1974-12-28
AR196775A1 (es) 1974-02-19
ES416929A1 (es) 1976-03-01
CH583722A5 (US20020167097A1-20021114-C00005.png) 1977-01-14
AT330188B (de) 1976-06-25
ZA734811B (en) 1974-07-31
NL149168B (nl) 1976-04-15
CA1003836A (en) 1977-01-18
NL7310041A (US20020167097A1-20021114-C00005.png) 1974-01-22
GB1376588A (en) 1974-12-04
CH583721A5 (US20020167097A1-20021114-C00005.png) 1977-01-14
JPS5331158B2 (US20020167097A1-20021114-C00005.png) 1978-08-31
ATA636673A (de) 1975-09-15

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