WO1999058527A3 - Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient - Google Patents

Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient Download PDF

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Publication number
WO1999058527A3
WO1999058527A3 PCT/HU1999/000038 HU9900038W WO9958527A3 WO 1999058527 A3 WO1999058527 A3 WO 1999058527A3 HU 9900038 W HU9900038 W HU 9900038W WO 9958527 A3 WO9958527 A3 WO 9958527A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutical composition
active ingredient
same
composition containing
Prior art date
Application number
PCT/HU1999/000038
Other languages
French (fr)
Other versions
WO1999058527A2 (en
Inventor
Bela Agai
Jozsef Reiter
Gyula Simig
Endre Rivo
Zoltan Tamas Nagy
Levente Ondi
Megyeri Katalin Ivanicsne
Kovacs Aniko Miklosne
Gyoenoes Ildiko Nagyne
Szabolcs Kertesz
Gabor Szenasi
Eva Schmidt
Katalin Pallagi
Istvan Gacsalyi
Istvan Gyertyan
Tamas Szabados
Gyoergy Levay
Andras Egyed
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Bela Agai
Jozsef Reiter
Gyula Simig
Endre Rivo
Zoltan Tamas Nagy
Levente Ondi
Megyeri Katalin Ivanicsne
Kovacs Aniko Miklosne
Gyoenoes Ildiko Nagyne
Szabolcs Kertesz
Gabor Szenasi
Eva Schmidt
Katalin Pallagi
Istvan Gacsalyi
Istvan Gyertyan
Tamas Szabados
Gyoergy Levay
Andras Egyed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HUP9801085 external-priority
Priority claimed from HU9801085A external-priority patent/HU9801085A3/en
Priority claimed from HU9801086A external-priority patent/HU9801086A3/en
Priority to PL99345309A priority Critical patent/PL345309A1/en
Priority to CA002332275A priority patent/CA2332275A1/en
Priority to AU40529/99A priority patent/AU753706B2/en
Application filed by Egyt Gyogyszervegyeszeti Gyar, Bela Agai, Jozsef Reiter, Gyula Simig, Endre Rivo, Zoltan Tamas Nagy, Levente Ondi, Megyeri Katalin Ivanicsne, Kovacs Aniko Miklosne, Gyoenoes Ildiko Nagyne, Szabolcs Kertesz, Gabor Szenasi, Eva Schmidt, Katalin Pallagi, Istvan Gacsalyi, Istvan Gyertyan, Tamas Szabados, Gyoergy Levay, Andras Egyed filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to KR1020007012773A priority patent/KR20010043618A/en
Priority to SK1721-2000A priority patent/SK17212000A3/en
Priority to EP99923772A priority patent/EP1077973A2/en
Priority to JP2000548331A priority patent/JP2002514643A/en
Publication of WO1999058527A2 publication Critical patent/WO1999058527A2/en
Publication of WO1999058527A3 publication Critical patent/WO1999058527A3/en
Priority to HR20000750A priority patent/HRP20000750A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

The invention refers to novel benzofuran derivatives of formula (I), a process for preparing these compounds and to pharmaceutical compositions containing these active substances.
PCT/HU1999/000038 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient WO1999058527A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2000548331A JP2002514643A (en) 1998-05-14 1999-05-13 A benzofuran derivative, a pharmaceutical composition containing the same and a method for producing the active ingredient thereof.
EP99923772A EP1077973A2 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
SK1721-2000A SK17212000A3 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
CA002332275A CA2332275A1 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
AU40529/99A AU753706B2 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
PL99345309A PL345309A1 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
KR1020007012773A KR20010043618A (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
HR20000750A HRP20000750A2 (en) 1998-05-14 2000-11-03 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU9801085A HU9801085A3 (en) 1998-05-14 1998-05-14 Piperazinyl-alkyl-benzofurane derivatives, pharmaceutical compositions containing them as active ingredient and process for producing the active ingredient
HUP9801085 1998-05-14
HUP9801086 1998-05-14
HU9801086A HU9801086A3 (en) 1998-05-14 1998-05-14 Benzofurane derivatives, pharmaceutical compositions containing them as active ingredient process for producing the active ingredient and intermediates of them

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09700345 A-371-Of-International 2000-12-27
US10/736,714 Division US20040186170A1 (en) 1998-05-14 2003-12-15 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient

Publications (2)

Publication Number Publication Date
WO1999058527A2 WO1999058527A2 (en) 1999-11-18
WO1999058527A3 true WO1999058527A3 (en) 2000-01-27

Family

ID=26318308

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU1999/000038 WO1999058527A2 (en) 1998-05-14 1999-05-13 Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient

Country Status (9)

Country Link
EP (1) EP1077973A2 (en)
JP (1) JP2002514643A (en)
KR (1) KR20010043618A (en)
AU (1) AU753706B2 (en)
CA (1) CA2332275A1 (en)
HR (1) HRP20000750A2 (en)
PL (1) PL345309A1 (en)
SK (1) SK17212000A3 (en)
WO (1) WO1999058527A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1248786A1 (en) * 1999-12-20 2002-10-16 Eli Lilly And Company Benzofuran derivatives
US6844344B2 (en) 1999-12-20 2005-01-18 Eli Lilly And Company Benzofuran derivatives
FR2845992B1 (en) 2002-10-16 2005-02-04 Pf Medicament 3- (CYCLOPENTEN-1YL) -BENZYL-OU3- (CYCLOPENTEN-1YL) -HETEROARYLMETHYL-AMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF SCHIZOPHRENIA
CN101120008A (en) * 2005-02-17 2008-02-06 拜尔农作物科学股份公司 Improved process for preparing (disubstitutedpropenyl) phenylalkyl substituted dihydrobenzofurans
HU230729B1 (en) * 2007-05-30 2017-12-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság New benzofuran derivatives as selective inhibitors of 5-ht7 and process for their preparation
HU230761B1 (en) * 2007-05-30 2018-03-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság New benzofuran derivatives as selective inhibitors of 5-ht6 and process for their preparation
GB201312499D0 (en) * 2013-07-12 2013-08-28 Isis Innovation Therapeutic compounds

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH474511A (en) * 1966-06-24 1969-06-30 F. Hoffmann-La Roche & Co. Aktiengesellschaft
DE2235597A1 (en) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh SINGLE SQUARE CLIP ON 3- (5,6,7,8TETRAHYDRONAPHTH-1-YL-OXY) -PROPYL SQUARE CLIP FOR -PIPERAZINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION
DE2724083A1 (en) * 1976-05-31 1978-02-23 Parcor BENZO (B) FURANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEANS CONTAINING THE SAME
US4110536A (en) * 1977-04-18 1978-08-29 Miles Laboratories, Inc. Derivatives of 5-(indol-3-yl)hydantoin
WO1986002550A1 (en) * 1984-10-23 1986-05-09 Rorer International (Overseas) Inc. Bicyclic benzo-oxy heterocyclic ethers and thioethers as h2-receptors antagonists
GB2221680A (en) * 1988-08-12 1990-02-14 Merck & Co Inc Novel 5-hydroxy-2,3-dihydrobenzorfurans as inhibitors of leukotriene bio- synthesis
EP0445862A2 (en) * 1990-03-06 1991-09-11 Janssen Pharmaceutica N.V. N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2H-benzopyran)carboxamide derivatives
FR2681319A1 (en) * 1991-09-12 1993-03-19 Synthelabo 1-(Phenoxyalkyl)piperidine derivatives, their preparation and their application in therapeutics
WO1996010027A1 (en) * 1994-09-27 1996-04-04 Janssen Pharmaceutica N.V. N-substituted piperidinyl bicyclic benzoate derivatives
WO1996016060A1 (en) * 1994-11-24 1996-05-30 Janssen Pharmaceutica N.V. Enterokinetic benzamide
WO1996033186A1 (en) * 1995-04-18 1996-10-24 Pharmacia & Upjohn S.P.A. Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
WO1997023216A1 (en) * 1995-12-22 1997-07-03 Warner-Lambert Company 4-substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
WO1997030031A1 (en) * 1996-02-15 1997-08-21 Janssen Pharmaceutica N.V. Esters of 3-hydroxy-piperidinemethanol derivatives

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH474511A (en) * 1966-06-24 1969-06-30 F. Hoffmann-La Roche & Co. Aktiengesellschaft
DE2235597A1 (en) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh SINGLE SQUARE CLIP ON 3- (5,6,7,8TETRAHYDRONAPHTH-1-YL-OXY) -PROPYL SQUARE CLIP FOR -PIPERAZINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION
DE2724083A1 (en) * 1976-05-31 1978-02-23 Parcor BENZO (B) FURANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEANS CONTAINING THE SAME
US4110536A (en) * 1977-04-18 1978-08-29 Miles Laboratories, Inc. Derivatives of 5-(indol-3-yl)hydantoin
WO1986002550A1 (en) * 1984-10-23 1986-05-09 Rorer International (Overseas) Inc. Bicyclic benzo-oxy heterocyclic ethers and thioethers as h2-receptors antagonists
GB2221680A (en) * 1988-08-12 1990-02-14 Merck & Co Inc Novel 5-hydroxy-2,3-dihydrobenzorfurans as inhibitors of leukotriene bio- synthesis
EP0445862A2 (en) * 1990-03-06 1991-09-11 Janssen Pharmaceutica N.V. N-(4-piperidinyl)(dihydrobenzofuran or dihydro-2H-benzopyran)carboxamide derivatives
FR2681319A1 (en) * 1991-09-12 1993-03-19 Synthelabo 1-(Phenoxyalkyl)piperidine derivatives, their preparation and their application in therapeutics
WO1996010027A1 (en) * 1994-09-27 1996-04-04 Janssen Pharmaceutica N.V. N-substituted piperidinyl bicyclic benzoate derivatives
WO1996016060A1 (en) * 1994-11-24 1996-05-30 Janssen Pharmaceutica N.V. Enterokinetic benzamide
WO1996033186A1 (en) * 1995-04-18 1996-10-24 Pharmacia & Upjohn S.P.A. Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
WO1997023216A1 (en) * 1995-12-22 1997-07-03 Warner-Lambert Company 4-substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
WO1997030031A1 (en) * 1996-02-15 1997-08-21 Janssen Pharmaceutica N.V. Esters of 3-hydroxy-piperidinemethanol derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. B. HANSEN ET AL., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 2, 1997, pages 103 - 111, XP004054789 *

Also Published As

Publication number Publication date
AU753706B2 (en) 2002-10-24
HRP20000750A2 (en) 2001-06-30
KR20010043618A (en) 2001-05-25
JP2002514643A (en) 2002-05-21
AU4052999A (en) 1999-11-29
SK17212000A3 (en) 2001-05-10
WO1999058527A2 (en) 1999-11-18
PL345309A1 (en) 2001-12-03
EP1077973A2 (en) 2001-02-28
CA2332275A1 (en) 1999-11-18

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