DE2228363A1 - 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel - Google Patents

1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Info

Publication number
DE2228363A1
DE2228363A1 DE2228363A DE2228363A DE2228363A1 DE 2228363 A1 DE2228363 A1 DE 2228363A1 DE 2228363 A DE2228363 A DE 2228363A DE 2228363 A DE2228363 A DE 2228363A DE 2228363 A1 DE2228363 A1 DE 2228363A1
Authority
DE
Germany
Prior art keywords
formula
straight
meaning
ester
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2228363A
Other languages
German (de)
English (en)
Inventor
Friedrich Dr Bossert
Horst Dr Meyer
Wulf Dr Vater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE2228363A priority Critical patent/DE2228363A1/de
Priority to SU1926944A priority patent/SU511856A3/ru
Priority to US366578A priority patent/US3923818A/en
Priority to IL7342458A priority patent/IL42458A/en
Priority to JP48063442A priority patent/JPS4948680A/ja
Priority to HUBA2938A priority patent/HU166354B/hu
Priority to CA173,419A priority patent/CA999592A/en
Priority to CS7600001302A priority patent/CS178897B2/cs
Priority to IE932/73A priority patent/IE37773B1/xx
Priority to CS7600001304A priority patent/CS178899B2/cs
Priority to FR7320978A priority patent/FR2187347B1/fr
Priority to AT177075*7A priority patent/AT329561B/de
Priority to CH725776A priority patent/CH593260A5/xx
Priority to GB2746373A priority patent/GB1425059A/en
Priority to CH250477A priority patent/CH589058A5/xx
Priority to CS7300004161A priority patent/CS178888B2/cs
Priority to CH250377A priority patent/CH591444A5/xx
Priority to CH725876A priority patent/CH589628A5/xx
Priority to ZA733880A priority patent/ZA733880B/xx
Priority to AU56725/73A priority patent/AU473996B2/en
Priority to CS7600001305A priority patent/CS178900B2/cs
Priority to CH836973A priority patent/CH591443A5/xx
Priority to AT507473A priority patent/AT328447B/de
Priority to BE132064A priority patent/BE800679A/xx
Priority to CS7600001303A priority patent/CS178898B2/cs
Priority to CH725976A priority patent/CH589629A5/xx
Priority to CH725676A priority patent/CH588462A5/xx
Priority to DD171438A priority patent/DD109383A5/xx
Priority to NL7308059A priority patent/NL7308059A/xx
Priority to ES415749A priority patent/ES415749A1/es
Publication of DE2228363A1 publication Critical patent/DE2228363A1/de
Priority to SU2038435A priority patent/SU507234A3/ru
Priority to SU2038430A priority patent/SU510997A3/ru
Priority to SU2050564A priority patent/SU512708A3/ru
Priority to SU2050563A priority patent/SU509221A3/ru
Priority to US05/501,226 priority patent/US3959296A/en
Priority to US05/548,521 priority patent/US3968117A/en
Priority to AT177175A priority patent/AT332405B/de
Priority to ES440621A priority patent/ES440621A1/es
Priority to ES440619A priority patent/ES440619A1/es
Priority to ES440622A priority patent/ES440622A1/es
Priority to ES440620A priority patent/ES440620A1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE2228363A 1972-06-10 1972-06-10 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel Pending DE2228363A1 (de)

Priority Applications (41)

Application Number Priority Date Filing Date Title
DE2228363A DE2228363A1 (de) 1972-06-10 1972-06-10 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
SU1926944A SU511856A3 (ru) 1972-06-10 1973-05-31 Способ получени 1,4-дигидропиридинов или их солей
US366578A US3923818A (en) 1972-06-10 1973-06-04 1,4-Dihydropyridines
IL7342458A IL42458A (en) 1972-06-10 1973-06-07 1,4-dihydropyridines their production and pharmaceutical compositions containing them
JP48063442A JPS4948680A (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-07
HUBA2938A HU166354B (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-07
CA173,419A CA999592A (en) 1972-06-10 1973-06-07 1,4-dihydropyridines, their production and use
CH836973A CH591443A5 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
CS7600001303A CS178898B2 (en) 1972-06-10 1973-06-08 Method for production of new 4-phenyl-1,4-dihydropyridines
CS7600001304A CS178899B2 (en) 1972-06-10 1973-06-08 Method for production of new 4-phenyl-1,4-dihydropyridines
FR7320978A FR2187347B1 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
AT177075*7A AT329561B (de) 1972-06-10 1973-06-08 Verfahren zur herstellung neuer 1,4-dihydropyridine
CH725776A CH593260A5 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
GB2746373A GB1425059A (en) 1972-06-10 1973-06-08 1,4-dihydropyridines their production and their medicinal use
CH250477A CH589058A5 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
CS7300004161A CS178888B2 (en) 1972-06-10 1973-06-08 Method for prouduction of new 4-phenyl-1,4-dihydropyridines
CH250377A CH591444A5 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
CH725876A CH589628A5 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
ZA733880A ZA733880B (en) 1972-06-10 1973-06-08 1,4-dihydropyridines,their production,and their medicinal use
AU56725/73A AU473996B2 (en) 1972-06-10 1973-06-08 New 1, 4-dihydropyridines, their production, and their medicinal use
CS7600001305A CS178900B2 (en) 1972-06-10 1973-06-08 Method for production of new 4-phenyl-1,4-dihydropyridines
CS7600001302A CS178897B2 (en) 1972-06-10 1973-06-08 Method for production of new 4-phenyl-1,4-dihydropyridines
AT507473A AT328447B (de) 1972-06-10 1973-06-08 Verfahren zur herstellung neuer 1,4-dihydropyridine
BE132064A BE800679A (fr) 1972-06-10 1973-06-08 Nouvelle 1,4-dihydropyridines leur procede de preparation et medicament les contenant
IE932/73A IE37773B1 (en) 1972-06-10 1973-06-08 New 1,4-dihydropyridines their production and their medicinal use
CH725976A CH589629A5 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
CH725676A CH588462A5 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
DD171438A DD109383A5 (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
NL7308059A NL7308059A (US20100223739A1-20100909-C00005.png) 1972-06-10 1973-06-08
ES415749A ES415749A1 (es) 1972-06-10 1973-06-09 Procedimientos para la obtencion de 1,4-dihidropiridinas.
SU2038435A SU507234A3 (ru) 1972-06-10 1974-06-27 Способ получени 1,4-дигидропиридинов или их солей
SU2038430A SU510997A3 (ru) 1972-06-10 1974-06-27 Способ получени 1,4дигидропиридинов или их солей
SU2050564A SU512708A3 (ru) 1972-06-10 1974-07-23 Способ получени 1,4-дигидропиридинов или их солей
SU2050563A SU509221A3 (ru) 1972-06-10 1974-07-23 Способ получени 1,4-дигидро-пиридинов или их солей
US05/501,226 US3959296A (en) 1972-06-10 1974-08-28 1,4-Dihydropyridines
US05/548,521 US3968117A (en) 1972-06-10 1975-02-10 1,4-Dihydropyridines
AT177175A AT332405B (de) 1972-06-10 1975-03-07 Verfahren zur herstellung neuer 1,4-dihydropyridine
ES440621A ES440621A1 (es) 1972-06-10 1975-09-01 Procedimiento para la obtencion de 1,4-dihidropiridinas.
ES440619A ES440619A1 (es) 1972-06-10 1975-09-01 Procedimiento para la obtencion de 1,4-dihidropiridinas.
ES440622A ES440622A1 (es) 1972-06-10 1975-09-01 Procedimiento para la obtencion de 1,4-dihidropiridinas.
ES440620A ES440620A1 (es) 1972-06-10 1975-09-01 Procedimiento para la obtencion de 1,4-dihidropiridinas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2228363A DE2228363A1 (de) 1972-06-10 1972-06-10 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DE2228363A1 true DE2228363A1 (de) 1974-01-03

Family

ID=5847399

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2228363A Pending DE2228363A1 (de) 1972-06-10 1972-06-10 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Country Status (19)

Country Link
US (1) US3923818A (US20100223739A1-20100909-C00005.png)
JP (1) JPS4948680A (US20100223739A1-20100909-C00005.png)
AT (2) AT328447B (US20100223739A1-20100909-C00005.png)
AU (1) AU473996B2 (US20100223739A1-20100909-C00005.png)
BE (1) BE800679A (US20100223739A1-20100909-C00005.png)
CA (1) CA999592A (US20100223739A1-20100909-C00005.png)
CH (7) CH591444A5 (US20100223739A1-20100909-C00005.png)
CS (5) CS178888B2 (US20100223739A1-20100909-C00005.png)
DD (1) DD109383A5 (US20100223739A1-20100909-C00005.png)
DE (1) DE2228363A1 (US20100223739A1-20100909-C00005.png)
ES (5) ES415749A1 (US20100223739A1-20100909-C00005.png)
FR (1) FR2187347B1 (US20100223739A1-20100909-C00005.png)
GB (1) GB1425059A (US20100223739A1-20100909-C00005.png)
HU (1) HU166354B (US20100223739A1-20100909-C00005.png)
IE (1) IE37773B1 (US20100223739A1-20100909-C00005.png)
IL (1) IL42458A (US20100223739A1-20100909-C00005.png)
NL (1) NL7308059A (US20100223739A1-20100909-C00005.png)
SU (5) SU511856A3 (US20100223739A1-20100909-C00005.png)
ZA (1) ZA733880B (US20100223739A1-20100909-C00005.png)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088274A1 (de) * 1982-03-05 1983-09-14 Bayer Ag Neue 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihrer Verwendung in Arzneimitteln
DE3529997A1 (de) * 1984-08-22 1986-03-06 Glaxo S.P.A., Verona Substituierte 4-phenyl-1,4-dihydropyridincarbonsaeureester
EP0330470A2 (en) * 1988-02-24 1989-08-30 Ajinomoto Co., Inc. 1,4-Dihydropyridine derivatives useful against tumour cells
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
WO2005016885A2 (en) * 2003-08-14 2005-02-24 Artesian Therapeutics, Inc. COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981882A (en) * 1972-08-31 1976-09-21 Bayer Aktiengesellschaft Process for preparing 4-aryl of hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
US3971796A (en) * 1973-07-12 1976-07-27 Bayer Aktiengesellschaft 1,4-Dihydropyridine esters
US4466972A (en) * 1977-06-20 1984-08-21 Sandoz Ltd. Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4252956A (en) * 1979-03-19 1981-02-24 Vigante Brigita A Derivatives of 1,4-dihydropyridine-3-carbothiol acids
GB2111978B (en) * 1981-10-19 1985-05-01 Maruko Pharmaceutical Co 1 4-dihydropyridine compounds
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
JPS60210640A (ja) * 1984-10-05 1985-10-23 Hitachi Chem Co Ltd 積層板の製造法
GB8503429D0 (en) * 1985-02-11 1985-03-13 Ici Plc Chemical compounds
GB8503425D0 (en) * 1985-02-11 1985-03-13 Ici Plc Alkanolamine derivatives
GB8503428D0 (en) * 1985-02-11 1985-03-13 Ici Plc Nitrogen-containing compounds
GB8503427D0 (en) * 1985-02-11 1985-03-13 Ici Plc Basic compounds
US4593033A (en) * 1985-04-24 1986-06-03 Merck & Co., Inc. Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
US4605660A (en) * 1985-06-03 1986-08-12 Merck & Co., Inc. Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers
US4670443A (en) * 1985-07-02 1987-06-02 Merck & Co., Inc. Benzo(f)isoquinoline compounds useful as calcium entry blockers
DE3675747D1 (de) * 1985-08-21 1991-01-03 Glaxo Spa 1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung.
DK397686A (da) * 1985-08-21 1987-02-22 Glaxo Spa Heterocycliske forbindelser
US4735956A (en) * 1985-09-13 1988-04-05 Merck & Co., Inc. Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
US4721708A (en) * 1985-11-26 1988-01-26 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use
US4788203A (en) * 1985-11-26 1988-11-29 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
FR2672890A1 (fr) * 1991-02-20 1992-08-21 Inst Investigacion Desarrol Derives de 2,6-dimethyl-4-(4'-hydroxy-3',5'-di-t-butylphenyl)-1,4-dihydropyridine, leur procede de preparation et leur utilisation comme capteurs de radicaux libres.
AU8430098A (en) * 1998-07-23 2000-02-14 Ing-Jun Chen Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
US20030153773A1 (en) * 2002-02-14 2003-08-14 Wayne Gregory S. Process for the production of dihydropyridines
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
CA2969926C (en) 2009-02-20 2018-05-15 2-Bbb Medicines B.V. Glutathione-based drug delivery system
IL295075A (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
DE2003146A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088274A1 (de) * 1982-03-05 1983-09-14 Bayer Ag Neue 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihrer Verwendung in Arzneimitteln
DE3529997A1 (de) * 1984-08-22 1986-03-06 Glaxo S.P.A., Verona Substituierte 4-phenyl-1,4-dihydropyridincarbonsaeureester
EP0330470A2 (en) * 1988-02-24 1989-08-30 Ajinomoto Co., Inc. 1,4-Dihydropyridine derivatives useful against tumour cells
EP0330470A3 (en) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. 1,4-dihydropyridine derivatives useful against tumour cells
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
WO2005016885A2 (en) * 2003-08-14 2005-02-24 Artesian Therapeutics, Inc. COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE
WO2005016885A3 (en) * 2003-08-14 2005-06-23 Artesian Therapeutics Inc COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE

Also Published As

Publication number Publication date
CS178900B2 (en) 1977-10-31
IL42458A (en) 1977-07-31
FR2187347A1 (US20100223739A1-20100909-C00005.png) 1974-01-18
CS178899B2 (en) 1977-10-31
CH591443A5 (US20100223739A1-20100909-C00005.png) 1977-09-15
NL7308059A (US20100223739A1-20100909-C00005.png) 1973-12-12
AU473996B2 (en) 1976-07-08
DD109383A5 (US20100223739A1-20100909-C00005.png) 1974-11-05
ES440622A1 (es) 1977-03-01
JPS4948680A (US20100223739A1-20100909-C00005.png) 1974-05-11
US3923818A (en) 1975-12-02
CS178888B2 (en) 1977-10-31
ES440620A1 (es) 1977-03-01
CH591444A5 (US20100223739A1-20100909-C00005.png) 1977-09-15
ATA507473A (de) 1975-06-15
IE37773B1 (en) 1977-10-12
BE800679A (fr) 1973-12-10
ATA177075A (de) 1975-08-15
SU509221A3 (ru) 1976-03-30
ES415749A1 (es) 1976-06-16
CH589058A5 (US20100223739A1-20100909-C00005.png) 1977-06-30
CS178898B2 (en) 1977-10-31
FR2187347B1 (US20100223739A1-20100909-C00005.png) 1977-09-09
IL42458A0 (en) 1973-08-29
CA999592A (en) 1976-11-09
ES440621A1 (es) 1977-03-01
CH593260A5 (US20100223739A1-20100909-C00005.png) 1977-11-30
ES440619A1 (es) 1977-03-01
SU507234A3 (ru) 1976-03-15
GB1425059A (en) 1976-02-18
CH588462A5 (US20100223739A1-20100909-C00005.png) 1977-06-15
SU512708A3 (ru) 1976-04-30
AT329561B (de) 1976-05-25
SU511856A3 (ru) 1976-04-25
CS178897B2 (en) 1977-10-31
IE37773L (en) 1973-12-10
ZA733880B (en) 1974-05-29
AT328447B (de) 1976-03-25
SU510997A3 (ru) 1976-04-15
CH589628A5 (US20100223739A1-20100909-C00005.png) 1977-07-15
AU5672573A (en) 1974-12-12
HU166354B (US20100223739A1-20100909-C00005.png) 1975-03-28
CH589629A5 (US20100223739A1-20100909-C00005.png) 1977-07-15

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