DE2228363A1 - 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel - Google Patents
1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittelInfo
- Publication number
- DE2228363A1 DE2228363A1 DE2228363A DE2228363A DE2228363A1 DE 2228363 A1 DE2228363 A1 DE 2228363A1 DE 2228363 A DE2228363 A DE 2228363A DE 2228363 A DE2228363 A DE 2228363A DE 2228363 A1 DE2228363 A1 DE 2228363A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- straight
- meaning
- ester
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (41)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2228363A DE2228363A1 (de) | 1972-06-10 | 1972-06-10 | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
SU1926944A SU511856A3 (ru) | 1972-06-10 | 1973-05-31 | Способ получени 1,4-дигидропиридинов или их солей |
US366578A US3923818A (en) | 1972-06-10 | 1973-06-04 | 1,4-Dihydropyridines |
IL7342458A IL42458A (en) | 1972-06-10 | 1973-06-07 | 1,4-dihydropyridines their production and pharmaceutical compositions containing them |
JP48063442A JPS4948680A (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-07 | |
HUBA2938A HU166354B (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-07 | |
CA173,419A CA999592A (en) | 1972-06-10 | 1973-06-07 | 1,4-dihydropyridines, their production and use |
CH836973A CH591443A5 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
CS7600001303A CS178898B2 (en) | 1972-06-10 | 1973-06-08 | Method for production of new 4-phenyl-1,4-dihydropyridines |
CS7600001304A CS178899B2 (en) | 1972-06-10 | 1973-06-08 | Method for production of new 4-phenyl-1,4-dihydropyridines |
FR7320978A FR2187347B1 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
AT177075*7A AT329561B (de) | 1972-06-10 | 1973-06-08 | Verfahren zur herstellung neuer 1,4-dihydropyridine |
CH725776A CH593260A5 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
GB2746373A GB1425059A (en) | 1972-06-10 | 1973-06-08 | 1,4-dihydropyridines their production and their medicinal use |
CH250477A CH589058A5 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
CS7300004161A CS178888B2 (en) | 1972-06-10 | 1973-06-08 | Method for prouduction of new 4-phenyl-1,4-dihydropyridines |
CH250377A CH591444A5 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
CH725876A CH589628A5 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
ZA733880A ZA733880B (en) | 1972-06-10 | 1973-06-08 | 1,4-dihydropyridines,their production,and their medicinal use |
AU56725/73A AU473996B2 (en) | 1972-06-10 | 1973-06-08 | New 1, 4-dihydropyridines, their production, and their medicinal use |
CS7600001305A CS178900B2 (en) | 1972-06-10 | 1973-06-08 | Method for production of new 4-phenyl-1,4-dihydropyridines |
CS7600001302A CS178897B2 (en) | 1972-06-10 | 1973-06-08 | Method for production of new 4-phenyl-1,4-dihydropyridines |
AT507473A AT328447B (de) | 1972-06-10 | 1973-06-08 | Verfahren zur herstellung neuer 1,4-dihydropyridine |
BE132064A BE800679A (fr) | 1972-06-10 | 1973-06-08 | Nouvelle 1,4-dihydropyridines leur procede de preparation et medicament les contenant |
IE932/73A IE37773B1 (en) | 1972-06-10 | 1973-06-08 | New 1,4-dihydropyridines their production and their medicinal use |
CH725976A CH589629A5 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
CH725676A CH588462A5 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
DD171438A DD109383A5 (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
NL7308059A NL7308059A (US20100056889A1-20100304-C00004.png) | 1972-06-10 | 1973-06-08 | |
ES415749A ES415749A1 (es) | 1972-06-10 | 1973-06-09 | Procedimientos para la obtencion de 1,4-dihidropiridinas. |
SU2038435A SU507234A3 (ru) | 1972-06-10 | 1974-06-27 | Способ получени 1,4-дигидропиридинов или их солей |
SU2038430A SU510997A3 (ru) | 1972-06-10 | 1974-06-27 | Способ получени 1,4дигидропиридинов или их солей |
SU2050564A SU512708A3 (ru) | 1972-06-10 | 1974-07-23 | Способ получени 1,4-дигидропиридинов или их солей |
SU2050563A SU509221A3 (ru) | 1972-06-10 | 1974-07-23 | Способ получени 1,4-дигидро-пиридинов или их солей |
US05/501,226 US3959296A (en) | 1972-06-10 | 1974-08-28 | 1,4-Dihydropyridines |
US05/548,521 US3968117A (en) | 1972-06-10 | 1975-02-10 | 1,4-Dihydropyridines |
AT177175A AT332405B (de) | 1972-06-10 | 1975-03-07 | Verfahren zur herstellung neuer 1,4-dihydropyridine |
ES440621A ES440621A1 (es) | 1972-06-10 | 1975-09-01 | Procedimiento para la obtencion de 1,4-dihidropiridinas. |
ES440619A ES440619A1 (es) | 1972-06-10 | 1975-09-01 | Procedimiento para la obtencion de 1,4-dihidropiridinas. |
ES440622A ES440622A1 (es) | 1972-06-10 | 1975-09-01 | Procedimiento para la obtencion de 1,4-dihidropiridinas. |
ES440620A ES440620A1 (es) | 1972-06-10 | 1975-09-01 | Procedimiento para la obtencion de 1,4-dihidropiridinas. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2228363A DE2228363A1 (de) | 1972-06-10 | 1972-06-10 | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2228363A1 true DE2228363A1 (de) | 1974-01-03 |
Family
ID=5847399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2228363A Pending DE2228363A1 (de) | 1972-06-10 | 1972-06-10 | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Country Status (19)
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0088274A1 (de) * | 1982-03-05 | 1983-09-14 | Bayer Ag | Neue 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihrer Verwendung in Arzneimitteln |
DE3529997A1 (de) * | 1984-08-22 | 1986-03-06 | Glaxo S.P.A., Verona | Substituierte 4-phenyl-1,4-dihydropyridincarbonsaeureester |
EP0330470A2 (en) * | 1988-02-24 | 1989-08-30 | Ajinomoto Co., Inc. | 1,4-Dihydropyridine derivatives useful against tumour cells |
US5216172A (en) * | 1988-02-24 | 1993-06-01 | Ajinomoto Co., Inc. | 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells |
WO2005016885A2 (en) * | 2003-08-14 | 2005-02-24 | Artesian Therapeutics, Inc. | COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3981882A (en) * | 1972-08-31 | 1976-09-21 | Bayer Aktiengesellschaft | Process for preparing 4-aryl of hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester |
US3971796A (en) * | 1973-07-12 | 1976-07-27 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine esters |
US4466972A (en) * | 1977-06-20 | 1984-08-21 | Sandoz Ltd. | Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them |
DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4252956A (en) * | 1979-03-19 | 1981-02-24 | Vigante Brigita A | Derivatives of 1,4-dihydropyridine-3-carbothiol acids |
GB2111978B (en) * | 1981-10-19 | 1985-05-01 | Maruko Pharmaceutical Co | 1 4-dihydropyridine compounds |
IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
JPS60210640A (ja) * | 1984-10-05 | 1985-10-23 | Hitachi Chem Co Ltd | 積層板の製造法 |
GB8503429D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Chemical compounds |
GB8503425D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Alkanolamine derivatives |
GB8503428D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Nitrogen-containing compounds |
GB8503427D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Basic compounds |
US4593033A (en) * | 1985-04-24 | 1986-06-03 | Merck & Co., Inc. | Substituted indeno[2,1-c] pyridines useful as calcium channel blockers |
US4605660A (en) * | 1985-06-03 | 1986-08-12 | Merck & Co., Inc. | Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers |
US4670443A (en) * | 1985-07-02 | 1987-06-02 | Merck & Co., Inc. | Benzo(f)isoquinoline compounds useful as calcium entry blockers |
DE3675747D1 (de) * | 1985-08-21 | 1991-01-03 | Glaxo Spa | 1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung. |
DK397686A (da) * | 1985-08-21 | 1987-02-22 | Glaxo Spa | Heterocycliske forbindelser |
US4735956A (en) * | 1985-09-13 | 1988-04-05 | Merck & Co., Inc. | Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers |
US4721708A (en) * | 1985-11-26 | 1988-01-26 | Merck & Co., Inc. | Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use |
US4788203A (en) * | 1985-11-26 | 1988-11-29 | Merck & Co., Inc. | Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders |
IT1204462B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
IT1204460B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
FR2672890A1 (fr) * | 1991-02-20 | 1992-08-21 | Inst Investigacion Desarrol | Derives de 2,6-dimethyl-4-(4'-hydroxy-3',5'-di-t-butylphenyl)-1,4-dihydropyridine, leur procede de preparation et leur utilisation comme capteurs de radicaux libres. |
AU8430098A (en) * | 1998-07-23 | 2000-02-14 | Ing-Jun Chen | Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity |
JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
US20030153773A1 (en) * | 2002-02-14 | 2003-08-14 | Wayne Gregory S. | Process for the production of dihydropyridines |
DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
CA2969926C (en) | 2009-02-20 | 2018-05-15 | 2-Bbb Medicines B.V. | Glutathione-based drug delivery system |
IL295075A (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1923990C3 (de) * | 1969-05-10 | 1978-11-23 | Bayer Ag | Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern |
DE2003146A1 (de) * | 1970-01-24 | 1971-07-29 | Bayer Ag | Neue 1,4-Dihydropyridinderivate |
-
1972
- 1972-06-10 DE DE2228363A patent/DE2228363A1/de active Pending
-
1973
- 1973-05-31 SU SU1926944A patent/SU511856A3/ru active
- 1973-06-04 US US366578A patent/US3923818A/en not_active Expired - Lifetime
- 1973-06-07 CA CA173,419A patent/CA999592A/en not_active Expired
- 1973-06-07 JP JP48063442A patent/JPS4948680A/ja active Pending
- 1973-06-07 IL IL7342458A patent/IL42458A/en unknown
- 1973-06-07 HU HUBA2938A patent/HU166354B/hu unknown
- 1973-06-08 AU AU56725/73A patent/AU473996B2/en not_active Expired
- 1973-06-08 NL NL7308059A patent/NL7308059A/xx not_active Application Discontinuation
- 1973-06-08 CS CS7300004161A patent/CS178888B2/cs unknown
- 1973-06-08 CH CH250377A patent/CH591444A5/xx not_active IP Right Cessation
- 1973-06-08 FR FR7320978A patent/FR2187347B1/fr not_active Expired
- 1973-06-08 CH CH725776A patent/CH593260A5/xx not_active IP Right Cessation
- 1973-06-08 BE BE132064A patent/BE800679A/xx unknown
- 1973-06-08 CS CS7600001304A patent/CS178899B2/cs unknown
- 1973-06-08 CS CS7600001302A patent/CS178897B2/cs unknown
- 1973-06-08 DD DD171438A patent/DD109383A5/xx unknown
- 1973-06-08 CH CH836973A patent/CH591443A5/xx not_active IP Right Cessation
- 1973-06-08 AT AT507473A patent/AT328447B/de not_active IP Right Cessation
- 1973-06-08 CS CS7600001303A patent/CS178898B2/cs unknown
- 1973-06-08 GB GB2746373A patent/GB1425059A/en not_active Expired
- 1973-06-08 CH CH725676A patent/CH588462A5/xx not_active IP Right Cessation
- 1973-06-08 AT AT177075*7A patent/AT329561B/de not_active IP Right Cessation
- 1973-06-08 CH CH725876A patent/CH589628A5/xx not_active IP Right Cessation
- 1973-06-08 CS CS7600001305A patent/CS178900B2/cs unknown
- 1973-06-08 IE IE932/73A patent/IE37773B1/xx unknown
- 1973-06-08 ZA ZA733880A patent/ZA733880B/xx unknown
- 1973-06-08 CH CH250477A patent/CH589058A5/xx not_active IP Right Cessation
- 1973-06-08 CH CH725976A patent/CH589629A5/xx not_active IP Right Cessation
- 1973-06-09 ES ES415749A patent/ES415749A1/es not_active Expired
-
1974
- 1974-06-27 SU SU2038435A patent/SU507234A3/ru active
- 1974-06-27 SU SU2038430A patent/SU510997A3/ru active
- 1974-07-23 SU SU2050563A patent/SU509221A3/ru active
- 1974-07-23 SU SU2050564A patent/SU512708A3/ru active
-
1975
- 1975-09-01 ES ES440621A patent/ES440621A1/es not_active Expired
- 1975-09-01 ES ES440622A patent/ES440622A1/es not_active Expired
- 1975-09-01 ES ES440619A patent/ES440619A1/es not_active Expired
- 1975-09-01 ES ES440620A patent/ES440620A1/es not_active Expired
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0088274A1 (de) * | 1982-03-05 | 1983-09-14 | Bayer Ag | Neue 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihrer Verwendung in Arzneimitteln |
DE3529997A1 (de) * | 1984-08-22 | 1986-03-06 | Glaxo S.P.A., Verona | Substituierte 4-phenyl-1,4-dihydropyridincarbonsaeureester |
EP0330470A2 (en) * | 1988-02-24 | 1989-08-30 | Ajinomoto Co., Inc. | 1,4-Dihydropyridine derivatives useful against tumour cells |
EP0330470A3 (en) * | 1988-02-24 | 1992-01-02 | Ajinomoto Co., Inc. | 1,4-dihydropyridine derivatives useful against tumour cells |
US5216172A (en) * | 1988-02-24 | 1993-06-01 | Ajinomoto Co., Inc. | 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells |
WO2005016885A2 (en) * | 2003-08-14 | 2005-02-24 | Artesian Therapeutics, Inc. | COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE |
WO2005016885A3 (en) * | 2003-08-14 | 2005-06-23 | Artesian Therapeutics Inc | COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE |
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Legal Events
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OD | Request for examination | ||
OHN | Withdrawal |