DE2224430C3 - Zahnsteinbildung verhindernde Mund- und Zahnpflegemittel - Google Patents
Zahnsteinbildung verhindernde Mund- und ZahnpflegemittelInfo
- Publication number
- DE2224430C3 DE2224430C3 DE19722224430 DE2224430A DE2224430C3 DE 2224430 C3 DE2224430 C3 DE 2224430C3 DE 19722224430 DE19722224430 DE 19722224430 DE 2224430 A DE2224430 A DE 2224430A DE 2224430 C3 DE2224430 C3 DE 2224430C3
- Authority
- DE
- Germany
- Prior art keywords
- acid
- oral
- dicarboxylic acid
- weight
- tartar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000006558 Dental Calculus Diseases 0.000 title description 23
- 230000015572 biosynthetic process Effects 0.000 title description 13
- 239000002253 acid Substances 0.000 claims description 25
- 150000007513 acids Chemical class 0.000 claims description 19
- -1 alkyl radical Chemical class 0.000 description 17
- 239000000606 toothpaste Substances 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 229910052586 apatite Inorganic materials 0.000 description 12
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 239000002324 mouth wash Substances 0.000 description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 8
- 229910019142 PO4 Inorganic materials 0.000 description 7
- 239000010452 phosphate Substances 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 229940051866 mouthwash Drugs 0.000 description 6
- 238000007127 saponification reaction Methods 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 229940034610 toothpaste Drugs 0.000 description 5
- SNSWUGOOACKRRJ-UHFFFAOYSA-N 3-phosphonobutane-1,2,3-tricarboxylic acid Chemical compound OC(=O)C(P(O)(O)=O)(C)C(C(O)=O)CC(O)=O SNSWUGOOACKRRJ-UHFFFAOYSA-N 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 239000011976 maleic acid Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- ZCURVRPNFDBOMR-UHFFFAOYSA-N 2-methyl-2-phosphonobutanedioic acid Chemical compound OC(=O)C(P(O)(O)=O)(C)CC(O)=O ZCURVRPNFDBOMR-UHFFFAOYSA-N 0.000 description 3
- KMDMOMDSEVTJTI-UHFFFAOYSA-N 2-phosphonobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)P(O)(O)=O KMDMOMDSEVTJTI-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 150000001447 alkali salts Chemical class 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- WDNCLONWSMYKBT-UHFFFAOYSA-N 2,3-dimethyl-2-phosphonobutanedioic acid Chemical compound OC(=O)C(C)C(C)(C(O)=O)P(O)(O)=O WDNCLONWSMYKBT-UHFFFAOYSA-N 0.000 description 2
- GAPYCUKJBQZFAZ-UHFFFAOYSA-N 2-(1,1-diphosphonoethyl)butanedioic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(C)C(C(O)=O)CC(O)=O GAPYCUKJBQZFAZ-UHFFFAOYSA-N 0.000 description 2
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000003863 ammonium salts Chemical group 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 235000019983 sodium metaphosphate Nutrition 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000002344 surface layer Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- BOCRYUUKCRMISL-UHFFFAOYSA-N (3-methyl-2-phosphonobutan-2-yl)phosphonic acid Chemical compound CC(C)C(C)(P(O)(O)=O)P(O)(O)=O BOCRYUUKCRMISL-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- OWWOMIFQTFZNGK-UHFFFAOYSA-N 1-phosphonobutylphosphonic acid Chemical compound CCCC(P(O)(O)=O)P(O)(O)=O OWWOMIFQTFZNGK-UHFFFAOYSA-N 0.000 description 1
- COKIOUWMXONTKQ-UHFFFAOYSA-N 1-phosphonopropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(C(O)=O)C(C(O)=O)P(O)(O)=O COKIOUWMXONTKQ-UHFFFAOYSA-N 0.000 description 1
- IVFGIXMLURJXBZ-UHFFFAOYSA-N 1-phosphonopropylphosphonic acid Chemical compound CCC(P(O)(O)=O)P(O)(O)=O IVFGIXMLURJXBZ-UHFFFAOYSA-N 0.000 description 1
- VRVIZPQGOLYUMG-UHFFFAOYSA-N 2-(diphosphonomethyl)-2-methylbutanedioic acid Chemical compound OC(=O)CC(C)(C(P(O)(O)=O)P(O)(O)=O)C(O)=O VRVIZPQGOLYUMG-UHFFFAOYSA-N 0.000 description 1
- YWKQEXLPAVPUHI-UHFFFAOYSA-N 2-methyl-3-phosphonobutane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(C)(C(O)=O)C(C)(C(O)=O)P(O)(O)=O YWKQEXLPAVPUHI-UHFFFAOYSA-N 0.000 description 1
- MHYDVLPLHCJLEK-UHFFFAOYSA-N 2-methyl-3-phosphonobutanedioic acid Chemical compound OC(=O)C(C)C(C(O)=O)P(O)(O)=O MHYDVLPLHCJLEK-UHFFFAOYSA-N 0.000 description 1
- HAEFDDOAYBQRGK-UHFFFAOYSA-N 2-methylpropylphosphonic acid Chemical compound CC(C)CP(O)(O)=O HAEFDDOAYBQRGK-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- MYWGVBFSIIZBHJ-UHFFFAOYSA-N 4-phosphonobutane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(C(O)=O)C(C(O)=O)CP(O)(O)=O MYWGVBFSIIZBHJ-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- IEPRKVQEAMIZSS-UHFFFAOYSA-N Di-Et ester-Fumaric acid Natural products CCOC(=O)C=CC(=O)OCC IEPRKVQEAMIZSS-UHFFFAOYSA-N 0.000 description 1
- IEPRKVQEAMIZSS-WAYWQWQTSA-N Diethyl maleate Chemical compound CCOC(=O)\C=C/C(=O)OCC IEPRKVQEAMIZSS-WAYWQWQTSA-N 0.000 description 1
- GGLIEWRLXDLBBF-UHFFFAOYSA-N Dulcin Chemical compound CCOC1=CC=C(NC(N)=O)C=C1 GGLIEWRLXDLBBF-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229920000877 Melamine resin Polymers 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 240000007673 Origanum vulgare Species 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 229920001807 Urea-formaldehyde Polymers 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 231100000460 acute oral toxicity Toxicity 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- NRIMHVFWRMABGJ-UHFFFAOYSA-N bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid Chemical compound C1C2C(C(=O)O)=C(C(O)=O)C1C=C2 NRIMHVFWRMABGJ-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- DLEPCXYNAPUMDZ-UHFFFAOYSA-N butan-2-ylphosphonic acid Chemical compound CCC(C)P(O)(O)=O DLEPCXYNAPUMDZ-UHFFFAOYSA-N 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- XUYJLQHKOGNDPB-UHFFFAOYSA-N carboxymethyl phosphonic acid Natural products OC(=O)CP(O)(O)=O XUYJLQHKOGNDPB-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940018557 citraconic acid Drugs 0.000 description 1
- 239000011538 cleaning material Substances 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- LXCYSACZTOKNNS-UHFFFAOYSA-N diethoxy(oxo)phosphanium Chemical compound CCO[P+](=O)OCC LXCYSACZTOKNNS-UHFFFAOYSA-N 0.000 description 1
- CZHYKKAKFWLGJO-UHFFFAOYSA-N dimethyl phosphite Chemical compound COP([O-])OC CZHYKKAKFWLGJO-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- NWNUTSZTAUGIGA-UHFFFAOYSA-N dulcin Natural products C12CC(C)(C)CCC2(C(=O)OC2C(C(O)C(O)C(COC3C(C(O)C(O)CO3)O)O2)O)C(O)CC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1OC1OC(CO)C(O)C(O)C1O NWNUTSZTAUGIGA-UHFFFAOYSA-N 0.000 description 1
- 239000008126 dulcin Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- HVXZTKUWRZCWHG-UHFFFAOYSA-N methyl 2-diethoxyphosphorylpropanoate Chemical compound CCOP(=O)(OCC)C(C)C(=O)OC HVXZTKUWRZCWHG-UHFFFAOYSA-N 0.000 description 1
- 229940050176 methyl chloride Drugs 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- ATLPLEZDTSBZQG-UHFFFAOYSA-N propan-2-ylphosphonic acid Chemical compound CC(C)P(O)(O)=O ATLPLEZDTSBZQG-UHFFFAOYSA-N 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000010672 sassafras oil Substances 0.000 description 1
- 238000009991 scouring Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-O triethanolammonium Chemical class OCC[NH+](CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722224430 DE2224430C3 (de) | 1972-05-19 | 1972-05-19 | Zahnsteinbildung verhindernde Mund- und Zahnpflegemittel |
| NL7305611A NL180977C (nl) | 1972-05-19 | 1973-04-19 | Werkwijze ter bereiding van een mond- en tandverzorgingsmiddel, dat een tandsteenbestrijdingsmiddel bevat. |
| BE131206A BE799654A (fr) | 1972-05-19 | 1973-05-17 | Dentifrices empechant la formation de tartre |
| FR7317952A FR2185385B1 (cg-RX-API-DMAC10.html) | 1972-05-19 | 1973-05-17 | |
| CH715173A CH581469A5 (cg-RX-API-DMAC10.html) | 1972-05-19 | 1973-05-18 | |
| AT435773A AT324569B (de) | 1972-05-19 | 1973-05-18 | Mund- und zahnpflegemittel |
| IT6845173A IT1046490B (it) | 1972-05-19 | 1973-05-18 | Mezzo per l igiene della bocca e dei denti per prevenire la concrezione di tartaro dentario |
| GB2375973A GB1394172A (en) | 1972-05-19 | 1973-05-18 | Mouth and teeth care means for the prevention of tartar formation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722224430 DE2224430C3 (de) | 1972-05-19 | 1972-05-19 | Zahnsteinbildung verhindernde Mund- und Zahnpflegemittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2224430A1 DE2224430A1 (de) | 1973-12-06 |
| DE2224430B2 DE2224430B2 (de) | 1980-02-14 |
| DE2224430C3 true DE2224430C3 (de) | 1980-10-09 |
Family
ID=5845319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19722224430 Expired DE2224430C3 (de) | 1972-05-19 | 1972-05-19 | Zahnsteinbildung verhindernde Mund- und Zahnpflegemittel |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT324569B (cg-RX-API-DMAC10.html) |
| BE (1) | BE799654A (cg-RX-API-DMAC10.html) |
| CH (1) | CH581469A5 (cg-RX-API-DMAC10.html) |
| DE (1) | DE2224430C3 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2185385B1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB1394172A (cg-RX-API-DMAC10.html) |
| IT (1) | IT1046490B (cg-RX-API-DMAC10.html) |
| NL (1) | NL180977C (cg-RX-API-DMAC10.html) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE431285B (sv) * | 1976-08-16 | 1984-01-30 | Colgate Palmolive Co | Munvardskomposition innehallande en fosfonforening, for minskning av missfergning bildad av ett ingaende kvevehaltigt antibakteriellt plaquehemmande medel |
| NZ194476A (en) * | 1979-08-24 | 1982-05-25 | Colgate Palmolive Co | Oral composition comprising a 2-phosphonobutane-1,2,4 tricarboxylic acid compound |
| US4348381A (en) * | 1981-05-06 | 1982-09-07 | Colgate-Palmolive Company | Dental remineralization composition |
| DE3345781A1 (de) * | 1983-12-17 | 1985-06-27 | Henkel KGaA, 4000 Düsseldorf | Mund- und zahnpflegemittel |
| DE3439094A1 (de) * | 1984-10-25 | 1986-05-07 | Henkel KGaA, 4000 Düsseldorf | Mund- und zahnpflegemittel |
| ZA86450B (en) * | 1985-02-04 | 1987-08-26 | Colgate Palmolive Co | Oral preparation |
| DE3841775A1 (de) * | 1988-12-12 | 1990-06-13 | Henkel Kgaa | Zahnpaste |
| US5252641A (en) * | 1990-02-21 | 1993-10-12 | Institut Francais Du Petrole | Process for production of bituminous compositions containing polymeric residues |
| DE4007431A1 (de) * | 1990-03-09 | 1991-09-12 | Henkel Kgaa | Den zahnschmelz schuetzende mund- und zahnpflegemittel |
| DE102011082891A1 (de) | 2011-09-16 | 2013-03-21 | Wacker Chemie Ag | Konservierungsmittel enthaltend Glykolipide |
| ES2659741T3 (es) | 2012-01-30 | 2018-03-19 | Symrise Ag | Preparaciones |
| EP2849718B1 (de) | 2012-05-16 | 2017-02-01 | Symrise AG | Mischungen mit verbesserter kühlwirkung |
| EP2725026B1 (de) | 2012-10-29 | 2017-09-06 | Symrise AG | Heterozyklische neoflavonoide mit geschmacksmaskierenden eigenschaften |
| DE202012013357U1 (de) | 2012-12-12 | 2016-07-29 | Symrise Ag | Zubereitungen |
| CN105025870B (zh) | 2012-12-12 | 2018-02-02 | 西姆莱斯股份公司 | 组合物 |
| WO2014131532A1 (de) | 2013-02-27 | 2014-09-04 | Symrise Ag | Stoffgemische enthaltend vanillin und vanillylvanillat |
| EP2865372B1 (de) | 2013-10-22 | 2020-07-22 | Symrise AG | Wirkstoffkapseln |
| EP2865739B1 (de) | 2013-10-28 | 2018-09-19 | Symrise AG | Verwendung von Lactonen |
| ES2738355T3 (es) | 2013-10-31 | 2020-01-22 | Symrise Ag | Mezcla de sustancias |
| EP2883459B1 (de) | 2013-12-16 | 2018-04-04 | Symrise AG | Zubereitungen zur oralen Aufnahme |
| ES2759797T3 (es) | 2014-04-01 | 2020-05-12 | Symrise Ag | Mezclas de sustancias |
| EP2932956B1 (de) | 2014-04-14 | 2017-12-27 | Symrise AG | Kapseln mit hoher Wirkstoffbeladung |
| EP2954785B1 (de) | 2014-06-13 | 2018-06-06 | Symrise AG | Neue Stoffmischung zur Verbesserung des Süssgeschmacks enthaltend Rubusosid oder alpha-Glycosylrubusosid |
| EP2960235B1 (de) | 2014-06-25 | 2018-09-26 | Symrise AG | Tetrahydrofuranderivate als riechstoffe |
| EP3061500B1 (de) | 2015-02-25 | 2019-07-10 | Symrise AG | Stabile Dispersion |
| EP3093002B1 (de) | 2015-05-15 | 2018-04-25 | Symrise AG | Flüssige kühlstoffzubereitungen |
| EP3383200B1 (de) | 2015-12-01 | 2019-11-06 | Symrise AG | Stoffgemische |
| WO2017140336A1 (de) | 2016-02-15 | 2017-08-24 | Symrise Ag | Riechstoffmischungen enthaltend ester und ketone |
| CN109310130B (zh) | 2016-05-05 | 2022-05-17 | 西姆莱斯股份公司 | 清凉物质混合物 |
| CN109310595A (zh) | 2016-05-14 | 2019-02-05 | 西姆莱斯股份公司 | 含有薄荷醇的香料制剂 |
| WO2018114073A1 (de) | 2016-12-21 | 2018-06-28 | Symrise Ag | Riechstoffmischung |
| CN110167667B (zh) | 2016-12-22 | 2022-09-20 | 科勒纸业公司 | 微胶囊 |
| WO2018233841A1 (de) | 2017-06-22 | 2018-12-27 | Symrise Ag | Geschmacksmodulierende aromastoffe |
| WO2020147934A1 (de) | 2019-01-15 | 2020-07-23 | Symrise Ag | Diester von pflanzlichem 1,3-propandiol |
| EP3689324B1 (de) | 2019-02-04 | 2024-11-20 | Symrise AG | Neue kühlstoffe und zubereitungen, die diese enthalten |
| US20230139835A1 (en) | 2020-02-12 | 2023-05-04 | Savanna Ingredients Gmbh | Allulose in crystalline form |
| EP3864966A1 (de) | 2020-02-12 | 2021-08-18 | Savanna Ingredients GmbH | Orale zubereitungen mit kristalliner allulose |
| WO2022105986A1 (de) | 2020-11-17 | 2022-05-27 | Symrise Ag | Neue kühlstoffe und zubereitungen, die diese enthalten |
| WO2023117119A1 (de) | 2021-12-23 | 2023-06-29 | Symrise Ag | Wirkstoffe mit mundwässerndem und kribbelndem/prickelndem effekt und zubereitungen, die diese enthalten |
| WO2023143741A1 (de) | 2022-01-28 | 2023-08-03 | Symrise Ag | Neue kühlstoffe und zubereitungen, die diese enthalten |
| WO2025026525A1 (de) | 2023-07-28 | 2025-02-06 | Symrise Ag | Heterozyklische verbindungen als physiologische kühlstoffe |
-
1972
- 1972-05-19 DE DE19722224430 patent/DE2224430C3/de not_active Expired
-
1973
- 1973-04-19 NL NL7305611A patent/NL180977C/xx not_active IP Right Cessation
- 1973-05-17 BE BE131206A patent/BE799654A/xx not_active IP Right Cessation
- 1973-05-17 FR FR7317952A patent/FR2185385B1/fr not_active Expired
- 1973-05-18 GB GB2375973A patent/GB1394172A/en not_active Expired
- 1973-05-18 IT IT6845173A patent/IT1046490B/it active
- 1973-05-18 CH CH715173A patent/CH581469A5/xx not_active IP Right Cessation
- 1973-05-18 AT AT435773A patent/AT324569B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE799654A (fr) | 1973-11-19 |
| IT1046490B (it) | 1980-06-30 |
| NL180977B (nl) | 1987-01-02 |
| GB1394172A (en) | 1975-05-14 |
| FR2185385B1 (cg-RX-API-DMAC10.html) | 1978-06-30 |
| CH581469A5 (cg-RX-API-DMAC10.html) | 1976-11-15 |
| DE2224430A1 (de) | 1973-12-06 |
| DE2224430B2 (de) | 1980-02-14 |
| NL7305611A (cg-RX-API-DMAC10.html) | 1973-11-21 |
| FR2185385A1 (cg-RX-API-DMAC10.html) | 1974-01-04 |
| NL180977C (nl) | 1987-06-01 |
| AT324569B (de) | 1975-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2224430C3 (de) | Zahnsteinbildung verhindernde Mund- und Zahnpflegemittel | |
| CH620359A5 (cg-RX-API-DMAC10.html) | ||
| DE2940460C2 (de) | Lokal anzuwendendes, saures Mittel für die Kariesprophylaxe | |
| EP0026539B1 (de) | Orale Kompositionen mit stabilisierten Zinnsalzen | |
| DE3017417C2 (cg-RX-API-DMAC10.html) | ||
| DE2922664A1 (de) | Gegen zahnsteinbildung wirksame orale zusammensetzung | |
| DE1289246C2 (de) | Zahnpflegemittel | |
| DE1617729B2 (de) | Zahnsteinbildung verhinderndes Mund- und Zahnpflegemittel | |
| EP0150374B1 (de) | Mund- und Zahnpflegemittel | |
| DE2416542A1 (de) | Mittel gegen zahnstein | |
| DE3151910C2 (cg-RX-API-DMAC10.html) | ||
| DE1908067B2 (de) | Zusammensetzungen zur verhinderung von zahnsteinbildung | |
| DE3102272A1 (de) | "gegen zahnfleischentzuendungen wirkendes mundpflegemittel" | |
| CH620358A5 (cg-RX-API-DMAC10.html) | ||
| DE69109851T2 (de) | Verbessertes mittel gegen zahnbelag bestehend aus einer mischung von morpholinoaminoalkohol und metallsalzen. | |
| CH645535A5 (de) | Keine flecken bildendes, gegen zahnfleischentzuendungen wirkendes mundpflegemittel. | |
| CH672596A5 (cg-RX-API-DMAC10.html) | ||
| DE2456693A1 (de) | Verfahren zum stabilisieren von calcium-hydrogenphosphat-anhydrid gegen die umsetzung mit fluorionen | |
| DE2523363B2 (de) | Mund- und Zahnpflegemittel | |
| DE2224516A1 (de) | Zahnsteinbildung verhindernde mundund zahnpflegemittel | |
| DE1106926B (de) | Zahnpflegemittel | |
| DE2224560A1 (de) | Zahnsteinbildung verhindernde mundund zahnpflegemittel | |
| DE2953295C2 (cg-RX-API-DMAC10.html) | ||
| DE2456667A1 (de) | Verfahren zum stabilisieren von calciumhydrogenphosphat-anhydrid gegen die umsetzung mit fluorionen | |
| DE1960068C3 (de) | Zahnpasta mit antikariogener Wirksamkeit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OGA | New person/name/address of the applicant | ||
| OD | Request for examination | ||
| C3 | Grant after two publication steps (3rd publication) |