DE2217170A1 - Zinkkomplexe des lh-releasing hormons mit protrahierter wirkung und verfahren zu ihrer herstellung - Google Patents
Zinkkomplexe des lh-releasing hormons mit protrahierter wirkung und verfahren zu ihrer herstellungInfo
- Publication number
- DE2217170A1 DE2217170A1 DE2217170A DE2217170A DE2217170A1 DE 2217170 A1 DE2217170 A1 DE 2217170A1 DE 2217170 A DE2217170 A DE 2217170A DE 2217170 A DE2217170 A DE 2217170A DE 2217170 A1 DE2217170 A1 DE 2217170A1
- Authority
- DE
- Germany
- Prior art keywords
- lrh
- production
- releasing hormone
- protracted effect
- zinc complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000694 effects Effects 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical class [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 108700012941 GNRH1 Proteins 0.000 title description 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title description 2
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title description 2
- 238000002360 preparation method Methods 0.000 claims description 9
- 150000003751 zinc Chemical class 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000000725 suspension Substances 0.000 description 5
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 4
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000001817 pituitary effect Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000008174 sterile solution Substances 0.000 description 2
- 239000011592 zinc chloride Substances 0.000 description 2
- 235000005074 zinc chloride Nutrition 0.000 description 2
- MFJCORKPUUOBMV-UHFFFAOYSA-N 1,1,2-trichloro-2-methylpropan-1-ol Chemical compound CC(C)(Cl)C(O)(Cl)Cl MFJCORKPUUOBMV-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 101100043658 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ste11 gene Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940040129 luteinizing hormone Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 1
- 229910000165 zinc phosphate Inorganic materials 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2217170A DE2217170A1 (de) | 1972-04-10 | 1972-04-10 | Zinkkomplexe des lh-releasing hormons mit protrahierter wirkung und verfahren zu ihrer herstellung |
| NL7304739A NL7304739A (enrdf_load_stackoverflow) | 1972-04-10 | 1973-04-05 | |
| DD170004A DD104430A5 (enrdf_load_stackoverflow) | 1972-04-10 | 1973-04-06 | |
| IL41980A IL41980A0 (en) | 1972-04-10 | 1973-04-09 | Zinc complex compounds of the lh-releasing hormone having prolonged activity and process for their manufacture |
| AU54261/73A AU5426173A (en) | 1972-04-10 | 1973-04-09 | Zinc complex compounds of the lh-releasing hormone having prolonged activity and process for their manufacture |
| FR7312908A FR2182950A1 (en) | 1972-04-10 | 1973-04-10 | Lrh prepns with long lasting activity - contg a zinc complex of lrh |
| BE129839A BE798002A (fr) | 1972-04-10 | 1973-04-10 | Composition a base de complexes de zinc de lrh a effet prolonge et medicaments qui en contiennent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2217170A DE2217170A1 (de) | 1972-04-10 | 1972-04-10 | Zinkkomplexe des lh-releasing hormons mit protrahierter wirkung und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2217170A1 true DE2217170A1 (de) | 1973-10-25 |
Family
ID=5841491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2217170A Pending DE2217170A1 (de) | 1972-04-10 | 1972-04-10 | Zinkkomplexe des lh-releasing hormons mit protrahierter wirkung und verfahren zu ihrer herstellung |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU5426173A (enrdf_load_stackoverflow) |
| BE (1) | BE798002A (enrdf_load_stackoverflow) |
| DD (1) | DD104430A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2217170A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2182950A1 (enrdf_load_stackoverflow) |
| IL (1) | IL41980A0 (enrdf_load_stackoverflow) |
| NL (1) | NL7304739A (enrdf_load_stackoverflow) |
-
1972
- 1972-04-10 DE DE2217170A patent/DE2217170A1/de active Pending
-
1973
- 1973-04-05 NL NL7304739A patent/NL7304739A/xx unknown
- 1973-04-06 DD DD170004A patent/DD104430A5/xx unknown
- 1973-04-09 AU AU54261/73A patent/AU5426173A/en not_active Expired
- 1973-04-09 IL IL41980A patent/IL41980A0/xx unknown
- 1973-04-10 BE BE129839A patent/BE798002A/xx unknown
- 1973-04-10 FR FR7312908A patent/FR2182950A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| FR2182950A1 (en) | 1973-12-14 |
| DD104430A5 (enrdf_load_stackoverflow) | 1974-03-12 |
| IL41980A0 (en) | 1973-06-29 |
| BE798002A (fr) | 1973-10-10 |
| NL7304739A (enrdf_load_stackoverflow) | 1973-10-12 |
| AU5426173A (en) | 1974-10-10 |
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