DE2208055A1 - Blutstillendes Präparat und Verfahren zu seiner Herstellung - Google Patents
Blutstillendes Präparat und Verfahren zu seiner HerstellungInfo
- Publication number
- DE2208055A1 DE2208055A1 DE19722208055 DE2208055A DE2208055A1 DE 2208055 A1 DE2208055 A1 DE 2208055A1 DE 19722208055 DE19722208055 DE 19722208055 DE 2208055 A DE2208055 A DE 2208055A DE 2208055 A1 DE2208055 A1 DE 2208055A1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- hemostatic
- esters
- estriol
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims description 13
- 238000000034 method Methods 0.000 title claims description 9
- 230000002439 hemostatic effect Effects 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 claims description 9
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 claims description 9
- 229960001348 estriol Drugs 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- QCTBMLYLENLHLA-UHFFFAOYSA-N aminomethylbenzoic acid Chemical compound NCC1=CC=C(C(O)=O)C=C1 QCTBMLYLENLHLA-UHFFFAOYSA-N 0.000 claims description 7
- 229960003375 aminomethylbenzoic acid Drugs 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- 239000012154 double-distilled water Substances 0.000 claims description 4
- GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 claims description 2
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 claims 2
- 244000028419 Styrax benzoin Species 0.000 claims 1
- 235000000126 Styrax benzoin Nutrition 0.000 claims 1
- 235000008411 Sumatra benzointree Nutrition 0.000 claims 1
- 235000013832 Valeriana officinalis Nutrition 0.000 claims 1
- 244000126014 Valeriana officinalis Species 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960002130 benzoin Drugs 0.000 claims 1
- 235000014121 butter Nutrition 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000019382 gum benzoic Nutrition 0.000 claims 1
- 150000004701 malic acid derivatives Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 235000016788 valerian Nutrition 0.000 claims 1
- 235000021419 vinegar Nutrition 0.000 claims 1
- 239000000052 vinegar Substances 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- LFVPBERIVUNMGV-UHFFFAOYSA-N fasudil hydrochloride Chemical compound Cl.C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 LFVPBERIVUNMGV-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 2
- 229960000401 tranexamic acid Drugs 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 229940119577 blood stop Drugs 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 150000002166 estriols Chemical class 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- -1 malic acid ester Chemical class 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT166671A AT305496B (de) | 1971-02-26 | 1971-02-26 | Verfahren zur Herstellung eines blutstillenden Präparats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2208055A1 true DE2208055A1 (de) | 1972-09-07 |
Family
ID=3518359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19722208055 Pending DE2208055A1 (de) | 1971-02-26 | 1972-02-21 | Blutstillendes Präparat und Verfahren zu seiner Herstellung |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT305496B (enExample) |
| AU (1) | AU460884B2 (enExample) |
| BE (1) | BE779323A (enExample) |
| DE (1) | DE2208055A1 (enExample) |
| FR (1) | FR2126274B1 (enExample) |
| GB (1) | GB1321399A (enExample) |
| NL (1) | NL7201376A (enExample) |
| ZA (1) | ZA721061B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272512A (en) | 1980-01-31 | 1981-06-09 | Colgate-Palmolive Company | Antigingivitis composition |
| US4272513A (en) | 1980-01-31 | 1981-06-09 | Colgate-Palmolive Company | Stabilized oral composition |
| US4309410A (en) | 1980-01-31 | 1982-01-05 | Colgate-Palmolive Company | Non-staining antigingivitis composition |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220211921A1 (en) * | 2021-01-06 | 2022-07-07 | Medtronic Inc. | Surgical system and methods of use |
-
1971
- 1971-02-26 AT AT166671A patent/AT305496B/de not_active IP Right Cessation
-
1972
- 1972-02-02 NL NL7201376A patent/NL7201376A/xx unknown
- 1972-02-14 BE BE779323A patent/BE779323A/xx unknown
- 1972-02-17 ZA ZA721061A patent/ZA721061B/xx unknown
- 1972-02-21 DE DE19722208055 patent/DE2208055A1/de active Pending
- 1972-02-22 FR FR7205902A patent/FR2126274B1/fr not_active Expired
- 1972-02-23 GB GB839072A patent/GB1321399A/en not_active Expired
- 1972-02-28 AU AU39444/72A patent/AU460884B2/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272512A (en) | 1980-01-31 | 1981-06-09 | Colgate-Palmolive Company | Antigingivitis composition |
| US4272513A (en) | 1980-01-31 | 1981-06-09 | Colgate-Palmolive Company | Stabilized oral composition |
| US4309410A (en) | 1980-01-31 | 1982-01-05 | Colgate-Palmolive Company | Non-staining antigingivitis composition |
Also Published As
| Publication number | Publication date |
|---|---|
| AT305496B (de) | 1973-02-26 |
| GB1321399A (en) | 1973-06-27 |
| BE779323A (fr) | 1972-05-30 |
| NL7201376A (enExample) | 1972-08-29 |
| FR2126274B1 (enExample) | 1975-10-10 |
| AU3944472A (en) | 1973-08-30 |
| AU460884B2 (en) | 1975-04-22 |
| FR2126274A1 (enExample) | 1972-10-06 |
| ZA721061B (en) | 1972-11-29 |
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