DE2120851A1 - Verfahren zur Zubereitung neuer substituierter Isothiozyanate des Benztriazols mit hoher antimikrobieller Wirksamkeit - Google Patents
Verfahren zur Zubereitung neuer substituierter Isothiozyanate des Benztriazols mit hoher antimikrobieller WirksamkeitInfo
- Publication number
- DE2120851A1 DE2120851A1 DE19712120851 DE2120851A DE2120851A1 DE 2120851 A1 DE2120851 A1 DE 2120851A1 DE 19712120851 DE19712120851 DE 19712120851 DE 2120851 A DE2120851 A DE 2120851A DE 2120851 A1 DE2120851 A1 DE 2120851A1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- chloroform
- benzotriazole
- new substituted
- high antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims description 6
- 230000000845 anti-microbial effect Effects 0.000 title claims description 5
- 150000002540 isothiocyanates Chemical class 0.000 title claims description 4
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 title claims description 3
- 238000000034 method Methods 0.000 title claims description 3
- 239000012964 benzotriazole Substances 0.000 title description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 26
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims 1
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims 1
- 229960004926 chlorobutanol Drugs 0.000 claims 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 2
- 239000012429 reaction media Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000223230 Trichosporon Species 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000842 anti-protozoal effect Effects 0.000 description 1
- 230000000656 anti-yeast Effects 0.000 description 1
- 239000003904 antiprotozoal agent Substances 0.000 description 1
- XDLDASNSMGOEMX-UHFFFAOYSA-N benzene benzene Chemical compound C1=CC=CC=C1.C1=CC=CC=C1 XDLDASNSMGOEMX-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C07D249/20—Benzotriazoles with aryl radicals directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS305870A CS151135B1 (enrdf_load_stackoverflow) | 1970-04-30 | 1970-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2120851A1 true DE2120851A1 (de) | 1971-11-18 |
Family
ID=5369525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712120851 Pending DE2120851A1 (de) | 1970-04-30 | 1971-04-28 | Verfahren zur Zubereitung neuer substituierter Isothiozyanate des Benztriazols mit hoher antimikrobieller Wirksamkeit |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT306009B (enrdf_load_stackoverflow) |
| CH (1) | CH555349A (enrdf_load_stackoverflow) |
| CS (1) | CS151135B1 (enrdf_load_stackoverflow) |
| DE (1) | DE2120851A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2092116B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1352024A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0235660A1 (de) * | 1986-02-27 | 1987-09-09 | Bayer Ag | Isocyanato-benzotriazole und ein Verfahren zu ihrer Herstellung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL264236A (enrdf_load_stackoverflow) * | 1960-05-07 | 1900-01-01 | ||
| BE610994A (enrdf_load_stackoverflow) * | 1960-12-01 | |||
| DE1803636B2 (de) * | 1968-10-17 | 1977-11-10 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von arylotriazolen |
-
1970
- 1970-04-30 CS CS305870A patent/CS151135B1/cs unknown
-
1971
- 1971-04-21 CH CH582071A patent/CH555349A/xx not_active IP Right Cessation
- 1971-04-28 DE DE19712120851 patent/DE2120851A1/de active Pending
- 1971-04-29 AT AT370371A patent/AT306009B/de not_active IP Right Cessation
- 1971-04-30 FR FR7115512A patent/FR2092116B1/fr not_active Expired
- 1971-04-30 GB GB1250771A patent/GB1352024A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0235660A1 (de) * | 1986-02-27 | 1987-09-09 | Bayer Ag | Isocyanato-benzotriazole und ein Verfahren zu ihrer Herstellung |
Also Published As
| Publication number | Publication date |
|---|---|
| CH555349A (de) | 1974-10-31 |
| AT306009B (de) | 1973-03-26 |
| GB1352024A (en) | 1974-05-15 |
| CS151135B1 (enrdf_load_stackoverflow) | 1973-09-17 |
| FR2092116A1 (enrdf_load_stackoverflow) | 1972-01-21 |
| FR2092116B1 (enrdf_load_stackoverflow) | 1975-04-18 |
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